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Items: 1 to 50 of 169

1.

Perspective: The promise of multi-cellular engineered living systems.

Kamm RD, Bashir R, Arora N, Dar RD, Gillette MU, Griffith LG, Kemp ML, Kinlaw K, Levin M, Martin AC, McDevitt TC, Nerem RM, Powers MJ, Saif TA, Sharpe J, Takayama S, Takeuchi S, Weiss R, Ye K, Yevick HG, Zaman MH.

APL Bioeng. 2018 Oct 11;2(4):040901. doi: 10.1063/1.5038337. eCollection 2018 Dec.

2.

Overdue: a US advisory board for research integrity.

Gunsalus CK, McNutt MK, Martinson BC, Faulkner LR, Nerem RM.

Nature. 2019 Feb;566(7743):173-175. doi: 10.1038/d41586-019-00519-w. No abstract available.

PMID:
30742085
3.

miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification.

Salim MT, Esmerats JF, Arjunon S, Villa-Roel N, Nerem RM, Jo H, Yoganathan AP.

Ann Biomed Eng. 2019 Apr;47(4):1106-1115. doi: 10.1007/s10439-019-02206-3. Epub 2019 Jan 22.

PMID:
30671754
4.

Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells.

Fernandez Esmerats J, Villa-Roel N, Kumar S, Gu L, Salim MT, Ohh M, Taylor WR, Nerem RM, Yoganathan AP, Jo H.

Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):467-481. doi: 10.1161/ATVBAHA.118.312233.

PMID:
30602302
5.

Research integrity revisited.

McNutt M, Nerem RM.

Science. 2017 Apr 14;356(6334):115. doi: 10.1126/science.aan3552. Epub 2017 Apr 11. No abstract available.

PMID:
28400410
6.

Biomanufacturing of Therapeutic Cells: State of the Art, Current Challenges, and Future Perspectives.

Roh KH, Nerem RM, Roy K.

Annu Rev Chem Biomol Eng. 2016 Jun 7;7:455-78. doi: 10.1146/annurev-chembioeng-080615-033559. Review.

PMID:
27276552
7.

Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis.

Rathan S, Ankeny CJ, Arjunon S, Ferdous Z, Kumar S, Fernandez Esmerats J, Heath JM, Nerem RM, Yoganathan AP, Jo H.

Sci Rep. 2016 May 6;6:25397. doi: 10.1038/srep25397.

8.

SCIENTIFIC INTEGRITY. Self-correction in science at work.

Alberts B, Cicerone RJ, Fienberg SE, Kamb A, McNutt M, Nerem RM, Schekman R, Shiffrin R, Stodden V, Suresh S, Zuber MT, Pope BK, Jamieson KH.

Science. 2015 Jun 26;348(6242):1420-2. doi: 10.1126/science.aab3847. No abstract available.

9.

Engineering as a new frontier for translational medicine.

Chien S, Bashir R, Nerem RM, Pettigrew R.

Sci Transl Med. 2015 Apr 1;7(281):281fs13. doi: 10.1126/scitranslmed.aaa4325.

10.

A study of a three-dimensional PLGA sponge containing natural polymers co-cultured with endothelial and mesenchymal stem cells as a tissue engineering scaffold.

Shim JB, Ankeny RF, Kim H, Nerem RM, Khang G.

Biomed Mater. 2014 Aug;9(4):045015. doi: 10.1088/1748-6041/9/4/045015. Epub 2014 Jul 25.

PMID:
25065725
11.

A brief history of USNCB: motivation and formation.

Mow VC, Butler DL, Nerem RM.

J Biomech Eng. 2014 Jun;136(6):060301. doi: 10.1115/1.4027332. No abstract available.

PMID:
24687029
12.

Stem cell engineering.

Nerem RM.

Tissue Eng Part A. 2014 Mar;20(5-6):893-4. doi: 10.1089/ten.tea.2013.0764. Epub 2014 Feb 14. No abstract available.

13.

Frontiers in bioengineering research.

Bao G, Nerem RM.

Ann Biomed Eng. 2014 Feb;42(2):241-2. doi: 10.1007/s10439-014-0982-z. No abstract available.

14.

A global assessment of stem cell engineering.

Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM.

Tissue Eng Part A. 2014 Oct;20(19-20):2575-89. doi: 10.1089/ten.TEA.2013.0468. Epub 2014 Feb 28.

15.

Influence of mesenchymal stem cells on the response of endothelial cells to laminar flow and shear stress.

Hong M, Jo H, Ankeny RF, Holliday-Ankeny CJ, Kim H, Khang G, Nerem RM.

Cells Tissues Organs. 2013;198(4):289-99. doi: 10.1159/000356319. Epub 2013 Dec 10.

PMID:
24335258
16.

Fluid shear stress pre-conditioning promotes endothelial morphogenesis of embryonic stem cells within embryoid bodies.

Nsiah BA, Ahsan T, Griffiths S, Cooke M, Nerem RM, McDevitt TC.

Tissue Eng Part A. 2014 Mar;20(5-6):954-65. doi: 10.1089/ten.TEA.2013.0243. Epub 2014 Jan 24.

17.

Engineering the emergence of stem cell therapeutics.

Healy KE, McDevitt TC, Murphy WL, Nerem RM.

Sci Transl Med. 2013 Oct 16;5(207):207ed17. doi: 10.1126/scitranslmed.3007609. No abstract available.

18.

Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro.

Griffiths S, Baraniak PR, Copland IB, Nerem RM, McDevitt TC.

Cytotherapy. 2013 Dec;15(12):1469-83. doi: 10.1016/j.jcyt.2013.05.020. Epub 2013 Aug 24.

PMID:
23981539
19.

Strain magnitude-dependent calcific marker expression in valvular and vascular cells.

Ferdous Z, Jo H, Nerem RM.

Cells Tissues Organs. 2013;197(5):372-83. doi: 10.1159/000347007. Epub 2013 Mar 14.

PMID:
23548742
20.

Differentiation patterns of embryonic stem cells in two- versus three-dimensional culture.

Pineda ET, Nerem RM, Ahsan T.

Cells Tissues Organs. 2013;197(5):399-410. doi: 10.1159/000346166. Epub 2013 Feb 9.

21.

Dynamic shear stress regulation of inflammatory and thrombotic pathways in baboon endothelial outgrowth cells.

Ankeny RF, Hinds MT, Nerem RM.

Tissue Eng Part A. 2013 Jul;19(13-14):1573-82. doi: 10.1089/ten.TEA.2012.0300. Epub 2013 Mar 19.

22.

Bioengineering and the cardiovascular system.

Nerem RM.

Glob Cardiol Sci Pract. 2013 Nov 1;2013(1):29-36. doi: 10.5339/gcsp.2013.5. eCollection 2013. Review.

23.

Effects of shear stress on germ lineage specification of embryonic stem cells.

Wolfe RP, Leleux J, Nerem RM, Ahsan T.

Integr Biol (Camb). 2012 Oct;4(10):1263-73.

PMID:
22968330
24.

Maturing EPCs into endothelial cells: may the force be with the EPCs: focus on "Fluid shear stress induces differentiation of circulating phenotype endothelial progenitor cells".

Ankeny RF, Ankeny CJ, Nerem RM, Jo H.

Am J Physiol Cell Physiol. 2012 Sep 15;303(6):C589-91. doi: 10.1152/ajpcell.00224.2012. Epub 2012 Jul 3. No abstract available.

25.

Fluid shear stress alters the hemostatic properties of endothelial outgrowth cells.

Ensley AE, Nerem RM, Anderson DE, Hanson SR, Hinds MT.

Tissue Eng Part A. 2012 Jan;18(1-2):127-36. doi: 10.1089/ten.TEA.2010.0290. Epub 2011 Sep 16.

26.

Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells.

Holliday CJ, Ankeny RF, Jo H, Nerem RM.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H856-67. doi: 10.1152/ajpheart.00117.2011. Epub 2011 Jun 24.

27.

Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6.

Ankeny RF, Thourani VH, Weiss D, Vega JD, Taylor WR, Nerem RM, Jo H.

PLoS One. 2011;6(6):e20969. doi: 10.1371/journal.pone.0020969. Epub 2011 Jun 15.

28.

In vitro human tissue models--moving towards personalized regenerative medicine.

Schenke-Layland K, Nerem RM.

Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):195-6. doi: 10.1016/j.addr.2011.05.001. Epub 2011 May 18.

PMID:
21600252
29.

Differences in valvular and vascular cell responses to strain in osteogenic media.

Ferdous Z, Jo H, Nerem RM.

Biomaterials. 2011 Apr;32(11):2885-93. doi: 10.1016/j.biomaterials.2011.01.030. Epub 2011 Feb 1.

30.

Tissue engineering of a collagen-based vascular media: Demonstration of functionality.

Schutte SC, Chen Z, Brockbank KG, Nerem RM.

Organogenesis. 2010 Oct-Dec;6(4):204-11. doi: 10.4161/org.6.4.12651.

31.

Regenerative medicine: the emergence of an industry.

Nerem RM.

J R Soc Interface. 2010 Dec 6;7 Suppl 6:S771-5. doi: 10.1098/rsif.2010.0348.focus. Epub 2010 Sep 15.

32.

Fluid shear stress promotes an endothelial-like phenotype during the early differentiation of embryonic stem cells.

Ahsan T, Nerem RM.

Tissue Eng Part A. 2010 Nov;16(11):3547-53. doi: 10.1089/ten.TEA.2010.0014. Epub 2010 Aug 28.

33.

Cyclic strain improves strength and function of a collagen-based tissue-engineered vascular media.

Schutte SC, Chen Z, Brockbank KG, Nerem RM.

Tissue Eng Part A. 2010 Oct;16(10):3149-57. doi: 10.1089/ten.TEA.2010.0009.

PMID:
20504073
34.

Mesenchymal stem cells overexpressing ephrin-b2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential.

Duffy GP, D'Arcy S, Ahsan T, Nerem RM, O'Brien T, Barry F.

Tissue Eng Part A. 2010 Sep;16(9):2755-68. doi: 10.1089/ten.tea.2009.0623.

PMID:
20491587
35.

Progress in tissue engineering and regenerative medicine.

Badylak SF, Nerem RM.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3285-6. doi: 10.1073/pnas.1000256107. No abstract available.

36.

In remembrance: Michael J. Lysaght, 1942-2009.

Leonard EF, Morgan JR, Nerem RM.

Tissue Eng Part A. 2010 Mar;16(3):767-8. doi: 10.1089/ten.tea.2009.0808. No abstract available.

PMID:
20132048
37.

A novel single-step self-assembly approach for the fabrication of tissue-engineered vascular constructs.

Gauvin R, Ahsan T, Larouche D, Lévesque P, Dubé J, Auger FA, Nerem RM, Germain L.

Tissue Eng Part A. 2010 May;16(5):1737-47. doi: 10.1089/ten.TEA.2009.0313.

PMID:
20038201
38.

The impact of biomechanics in tissue engineering and regenerative medicine.

Butler DL, Goldstein SA, Guldberg RE, Guo XE, Kamm R, Laurencin CT, McIntire LV, Mow VC, Nerem RM, Sah RL, Soslowsky LJ, Spilker RL, Tranquillo RT.

Tissue Eng Part B Rev. 2009 Dec;15(4):477-84. doi: 10.1089/ten.TEB.2009.0340. Review.

39.

Bone marrow-derived mesenchymal stem cells promote angiogenic processes in a time- and dose-dependent manner in vitro.

Duffy GP, Ahsan T, O'Brien T, Barry F, Nerem RM.

Tissue Eng Part A. 2009 Sep;15(9):2459-70. doi: 10.1089/ten.TEA.2008.0341.

PMID:
19327020
40.

Human mesenchymal stem cells form multicellular structures in response to applied cyclic strain.

Doyle AM, Nerem RM, Ahsan T.

Ann Biomed Eng. 2009 Apr;37(4):783-93. doi: 10.1007/s10439-009-9644-y. Epub 2009 Jan 30.

PMID:
19184434
41.

Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammation.

Han JW, Shimada K, Ma-Krupa W, Johnson TL, Nerem RM, Goronzy JJ, Weyand CM.

Circ Res. 2008 Mar 14;102(5):546-53. doi: 10.1161/CIRCRESAHA.107.161653. Epub 2008 Jan 17.

PMID:
18202318
42.

Potential of baboon endothelial progenitor cells for tissue engineered vascular grafts.

Hinds MT, Ma M, Tran N, Ensley AE, Kladakis SM, Vartanian KB, Markway BD, Nerem RM, Hanson SR.

J Biomed Mater Res A. 2008 Sep;86(3):804-12.

PMID:
18041726
43.

Editorial: advancing tissue engineering and regenerative medicine.

Hellman KB, Nerem RM.

Tissue Eng. 2007 Dec;13(12):2823-4. No abstract available.

PMID:
18021010
44.

Endothelial connexin 37, connexin 40, and connexin 43 respond uniquely to substrate and shear stress.

Johnson TL, Nerem RM.

Endothelium. 2007 Jul-Oct;14(4-5):215-26.

PMID:
17922338
45.

Cell-based therapies: from basic biology to replacement, repair, and regeneration.

Nerem RM.

Biomaterials. 2007 Dec;28(34):5074-7. Epub 2007 Aug 8.

PMID:
17689607
46.

Poly(glycerol sebacate) supports the proliferation and phenotypic protein expression of primary baboon vascular cells.

Gao J, Ensley AE, Nerem RM, Wang Y.

J Biomed Mater Res A. 2007 Dec 15;83(4):1070-5.

PMID:
17584900
47.

Valvular endothelial cells and the mechanoregulation of valvular pathology.

Butcher JT, Nerem RM.

Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1445-57.

48.

Embryonic stem cell-derived endothelial cells may lack complete functional maturation in vitro.

McCloskey KE, Smith DA, Jo H, Nerem RM.

J Vasc Res. 2006;43(5):411-21. Epub 2006 Jul 28.

PMID:
16877873
49.

In vitro derivation and expansion of endothelial cells from embryonic stem cells.

McCloskey KE, Stice SL, Nerem RM.

Methods Mol Biol. 2006;330:287-301.

PMID:
16846032
50.

Equibiaxial strain stimulates fibroblastic phenotype shift in smooth muscle cells in an engineered tissue model of the aortic wall.

Butcher JT, Barrett BC, Nerem RM.

Biomaterials. 2006 Oct;27(30):5252-8. Epub 2006 Jun 27.

PMID:
16806457

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