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Items: 1 to 50 of 66

1.

Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates.

Chhour M, Aubouy A, Bourgeade-Delmas S, Pério P, Ternet-Fontebasso H, Haidara M, Ferry G, Nepveu F, Boutin JA, Reybier K.

Molecules. 2019 Oct 15;24(20). pii: E3697. doi: 10.3390/molecules24203697.

2.

S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization.

Boutin JA, Bouillaud F, Janda E, Gacsalyi I, Guillaumet G, Hirsch EC, Kane DA, Nepveu F, Reybier K, Dupuis P, Bertrand M, Chhour M, Le Diguarher T, Antoine M, Brebner K, Da Costa H, Ducrot P, Giganti A, Goswami V, Guedouari H, Michel PP, Patel A, Paysant J, Stojko J, Viaud-Massuard MC, Ferry G.

Mol Pharmacol. 2019 Mar;95(3):269-285. doi: 10.1124/mol.118.114231. Epub 2018 Dec 19.

3.

Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.

Cassagnes LE, Chhour M, Pério P, Sudor J, Gayon R, Ferry G, Boutin JA, Nepveu F, Reybier K.

Free Radic Biol Med. 2018 May 20;120:56-61. doi: 10.1016/j.freeradbiomed.2018.03.002. Epub 2018 Mar 8.

PMID:
29526807
4.

LUCS (Light-Up Cell System), a universal high throughput assay for homeostasis evaluation in live cells.

Derick S, Gironde C, Perio P, Reybier K, Nepveu F, Jauneau A, Furger C.

Sci Rep. 2017 Dec 22;7(1):18069. doi: 10.1038/s41598-017-18211-2.

5.

Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives.

Cassagnes LE, Rakotoarivelo N, Sirigu S, Pério P, Najahi E, Chavas LM, Thompson A, Gayon R, Ferry G, Boutin JA, Valentin A, Reybier K, Nepveu F.

Molecules. 2017 Jan 30;22(2). pii: E210. doi: 10.3390/molecules22020210.

6.

Piceatannol and resveratrol share inhibitory effects on hydrogen peroxide release, monoamine oxidase and lipogenic activities in adipose tissue, but differ in their antilipolytic properties.

Les F, Deleruyelle S, Cassagnes LE, Boutin JA, Balogh B, Arbones-Mainar JM, Biron S, Marceau P, Richard D, Nepveu F, Mauriège P, Carpéné C.

Chem Biol Interact. 2016 Oct 25;258:115-25. doi: 10.1016/j.cbi.2016.07.014. Epub 2016 Jul 28.

PMID:
27475863
7.

Limited beneficial effects of piceatannol supplementation on obesity complications in the obese Zucker rat: gut microbiota, metabolic, endocrine, and cardiac aspects.

Hijona E, Aguirre L, Pérez-Matute P, Villanueva-Millán MJ, Mosqueda-Solis A, Hasnaoui M, Nepveu F, Senard JM, Bujanda L, Aldámiz-Echevarría L, Llarena M, Andrade F, Perio P, Leboulanger F, Hijona L, Arbones-Mainar JM, Portillo MP, Carpéné C.

J Physiol Biochem. 2016 Sep;72(3):567-82. doi: 10.1007/s13105-015-0464-2. Epub 2016 Jan 20.

PMID:
26792656
8.

In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones.

Cassagnes LE, Perio P, Ferry G, Moulharat N, Antoine M, Gayon R, Boutin JA, Nepveu F, Reybier K.

Free Radic Biol Med. 2015 Dec;89:126-34. doi: 10.1016/j.freeradbiomed.2015.07.150. Epub 2015 Sep 18.

PMID:
26386287
9.

Artemisinin nanoformulation suitable for intravenous injection: Preparation, characterization and antimalarial activities.

Ibrahim N, Ibrahim H, Sabater AM, Mazier D, Valentin A, Nepveu F.

Int J Pharm. 2015 Nov 30;495(2):671-9. doi: 10.1016/j.ijpharm.2015.09.020. Epub 2015 Sep 14.

PMID:
26383839
10.

Interaction between antimalarial 2-aryl-3H-indol-3-one derivatives and human serum albumin.

Rakotoarivelo NV, Perio P, Najahi E, Nepveu F.

J Phys Chem B. 2014 Nov 26;118(47):13477-85. doi: 10.1021/jp507569e. Epub 2014 Nov 17.

PMID:
25360713
11.

Antimalarial activities of indolones and derivatives.

Nepveu F, Najahi E, Valentin A.

Curr Top Med Chem. 2014;14(14):1643-52. Review.

PMID:
25116584
12.

2-Aryl-3H-indol-3-ones: synthesis, electrochemical behaviour and antiplasmodial activities.

Najahi E, Valentin A, Fabre PL, Reybier K, Nepveu F.

Eur J Med Chem. 2014 May 6;78:269-74. doi: 10.1016/j.ejmech.2014.03.059. Epub 2014 Mar 18.

PMID:
24686013
13.

Amino derivatives of indolone-N-oxide: preparation and antiplasmodial properties.

Najahi E, Rakotoarivelo NV, Valentin A, Nepveu F.

Eur J Med Chem. 2014 Apr 9;76:369-75. doi: 10.1016/j.ejmech.2014.02.038. Epub 2014 Feb 14.

PMID:
24594524
14.

Albumin-bound nanoparticles of practically water-insoluble antimalarial lead greatly enhance its efficacy.

Ibrahim N, Ibrahim H, Dormoi J, Briolant S, Pradines B, Moreno A, Mazier D, Legrand P, Nepveu F.

Int J Pharm. 2014 Apr 10;464(1-2):214-24. doi: 10.1016/j.ijpharm.2014.01.001. Epub 2014 Jan 8.

PMID:
24412521
15.

Atropisomerization in N-aryl-2(1H)-pyrimidin-(thi)ones: a ring-opening/rotation/ring-closure process in place of a classical rotation around the pivot bond.

Najahi E, Vanthuyne N, Nepveu F, Jean M, Alkorta I, Elguero J, Roussel C.

J Org Chem. 2013 Dec 20;78(24):12577-84. doi: 10.1021/jo402149f. Epub 2013 Dec 11.

PMID:
24304301
16.

Targeting the redox metabolism of Plasmodium falciparum.

Nepveu F, Turrini F.

Future Med Chem. 2013 Oct;5(16):1993-2006. doi: 10.4155/fmc.13.159. Review.

PMID:
24175748
17.

The catalytically active copper-amyloid-Beta state: coordination site responsible for reactive oxygen species production.

Cassagnes LE, Hervé V, Nepveu F, Hureau C, Faller P, Collin F.

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11110-3. doi: 10.1002/anie.201305372. Epub 2013 Sep 3.

PMID:
24038998
18.

Impedimetric immunosensor for the detection of circulating pro-inflammatory monocytes as infection markers.

Montrose A, Cargou S, Nepveu F, Manczak R, Gué AM, Reybier K.

Biosens Bioelectron. 2013 Nov 15;49:305-11. doi: 10.1016/j.bios.2013.05.025. Epub 2013 May 25.

PMID:
23792623
19.

Extracts of Crinum latifolium inhibit the cell viability of mouse lymphoma cell line EL4 and induce activation of anti-tumour activity of macrophages in vitro.

Nguyen HY, Vo BH, Nguyen LT, Bernad J, Alaeddine M, Coste A, Reybier K, Pipy B, Nepveu F.

J Ethnopharmacol. 2013 Aug 26;149(1):75-83. doi: 10.1016/j.jep.2013.06.002. Epub 2013 Jun 12.

PMID:
23769983
20.

Pro-oxidant properties of indolone-N-oxides in relation to their antimalarial properties.

Yen NT, Ibrahim H, Reybier K, Perio P, Souard F, Najahi E, Fabre PL, Nepveu F.

J Inorg Biochem. 2013 Sep;126:7-16. doi: 10.1016/j.jinorgbio.2013.04.012. Epub 2013 Apr 29.

PMID:
23708637
21.

Synthesis and biological evaluation of new bis-indolone-N-oxides.

Najahi E, Valentin A, Téné N, Treilhou M, Nepveu F.

Bioorg Chem. 2013 Jun;48:16-21. doi: 10.1016/j.bioorg.2013.03.001. Epub 2013 Apr 6.

PMID:
23639830
22.

Behavior of N-oxide derivatives in atmospheric pressure ionization mass spectrometry.

Ibrahim H, Couderc F, Perio P, Collin F, Nepveu F.

Rapid Commun Mass Spectrom. 2013 Mar 15;27(5):621-8. doi: 10.1002/rcm.6493.

PMID:
23413221
23.

Antibacterial, antifungal and antileishmanial activities of indolone-N-oxide derivatives.

Ibrahim H, Furiga A, Najahi E, Pigasse Hénocq C, Nallet JP, Roques C, Aubouy A, Sauvain M, Constant P, Daffé M, Nepveu F.

J Antibiot (Tokyo). 2012 Oct;65(10):499-504. doi: 10.1038/ja.2012.60. Epub 2012 Jul 25.

PMID:
22828966
24.

Electrochemical behavior of indolone-N-oxides: relationship to structure and antiplasmodial activity.

Reybier K, Nguyen TH, Ibrahim H, Perio P, Montrose A, Fabre PL, Nepveu F.

Bioelectrochemistry. 2012 Dec;88:57-64. doi: 10.1016/j.bioelechem.2012.04.001. Epub 2012 Apr 12.

PMID:
22771836
25.

New antimalarial indolone-N-oxides, generating radical species, destabilize the host cell membrane at early stages of Plasmodium falciparum growth: role of band 3 tyrosine phosphorylation.

Pantaleo A, Ferru E, Vono R, Giribaldi G, Lobina O, Nepveu F, Ibrahim H, Nallet JP, Carta F, Mannu F, Pippia P, Campanella E, Low PS, Turrini F.

Free Radic Biol Med. 2012 Jan 15;52(2):527-36. doi: 10.1016/j.freeradbiomed.2011.11.008. Epub 2011 Nov 15.

26.

Indolone-N-oxide derivatives: in vitro activity against fresh clinical isolates of Plasmodium falciparum, stage specificity and in vitro interactions with established antimalarial drugs.

Tahar R, Vivas L, Basco L, Thompson E, Ibrahim H, Boyer J, Nepveu F.

J Antimicrob Chemother. 2011 Nov;66(11):2566-72. doi: 10.1093/jac/dkr320. Epub 2011 Aug 22.

PMID:
21862474
27.

Insights into the redox cycle of human quinone reductase 2.

Reybier K, Perio P, Ferry G, Bouajila J, Delagrange P, Boutin JA, Nepveu F.

Free Radic Res. 2011 Oct;45(10):1184-95. doi: 10.3109/10715762.2011.605788. Epub 2011 Aug 9.

PMID:
21762045
28.

Synthesis of 6-amino-5-cyano-1,4-disubstituted-2(1H)-pyrimidinones via copper-(I)-catalyzed alkyne-azide 'click chemistry' and their reactivity.

Najahi E, Sudor J, Chabchoub F, Nepveu F, Zribi F, Duval R.

Molecules. 2010 Dec 3;15(12):8841-55. doi: 10.3390/molecules1512884.

29.

Interactions between antimalarial indolone-N-oxide derivatives and human serum albumin.

Ibrahim N, Ibrahim H, Kim S, Nallet JP, Nepveu F.

Biomacromolecules. 2010 Dec 13;11(12):3341-51. doi: 10.1021/bm100814n. Epub 2010 Nov 16.

PMID:
21080702
30.

Characterization of oxidative stress in Leishmaniasis-infected or LPS-stimulated macrophages using electrochemical impedance spectroscopy.

Reybier K, Ribaut C, Coste A, Launay J, Fabre PL, Nepveu F.

Biosens Bioelectron. 2010 Aug 15;25(12):2566-72. doi: 10.1016/j.bios.2010.04.021. Epub 2010 Apr 21.

PMID:
20488689
31.

Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.

Nepveu F, Kim S, Boyer J, Chatriant O, Ibrahim H, Reybier K, Monje MC, Chevalley S, Perio P, Lajoie BH, Bouajila J, Deharo E, Sauvain M, Tahar R, Basco L, Pantaleo A, Turini F, Arese P, Valentin A, Thompson E, Vivas L, Petit S, Nallet JP.

J Med Chem. 2010 Jan 28;53(2):699-714. doi: 10.1021/jm901300d.

PMID:
20014857
32.

Electrochemical impedance spectroscopy to study physiological changes affecting the red blood cell after invasion by malaria parasites.

Ribaut C, Reybier K, Reynes O, Launay J, Valentin A, Fabre PL, Nepveu F.

Biosens Bioelectron. 2009 Apr 15;24(8):2721-5. doi: 10.1016/j.bios.2008.12.018. Epub 2008 Dec 24.

PMID:
19167879
33.

Effects of fermentation on the phytochemical composition and antioxidant properties of soy germ.

Hubert J, Berger M, Nepveu F, Paul F, Daydé J.

Food Chem. 2008 Aug 15;109(4):709-21. doi: 10.1016/j.foodchem.2007.12.081. Epub 2008 Jan 26.

PMID:
26049983
34.

In Vitro and In Vivo Behaviour of In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging.

Prata MI, Ribeiro MJ, Santos AC, Peters JA, Nepveu F, Geraldes CF, de Lima JJ.

Met Based Drugs. 1998;5(5):259-64. doi: 10.1155/MBD.1998.259.

35.

Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species.

Ribaut C, Berry A, Chevalley S, Reybier K, Morlais I, Parzy D, Nepveu F, Benoit-Vical F, Valentin A.

Malar J. 2008 Mar 5;7:45. doi: 10.1186/1475-2875-7-45.

36.

Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection.

Ibrahim H, Boyer A, Bouajila J, Couderc F, Nepveu F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 15;857(1):59-66. Epub 2007 Jul 10.

PMID:
17646136
37.

Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion.

Kim S, de A Vilela GV, Bouajila J, Dias AG, Cyrino FZ, Bouskela E, Costa PR, Nepveu F.

Bioorg Med Chem. 2007 May 15;15(10):3572-8. Epub 2007 Feb 22.

PMID:
17379527
38.

A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

Garavito G, Monje MC, Maurel S, Valentin A, Nepveu F, Deharo E.

Exp Parasitol. 2007 Jul;116(3):311-3. Epub 2007 Jan 23.

PMID:
17336296
39.

Very small injected samples to study chloroquine and quinine in human serum using capillary-LC and native fluorescence.

Ibrahim H, Bouajila J, Siri N, Rozing G, Nepveu F, Couderc F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):481-7. Epub 2006 Dec 30.

PMID:
17227720
40.

Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 - estrogen has an influence on e-NOS, but not on i-NOS.

Loibl S, Bratengeier J, Farines V, von Minckwitz G, Spänkuch B, Schini-Kerth V, Nepveu F, Strebhardt K, Kaufmann M.

Pathol Res Pract. 2006;202(1):1-7. Epub 2005 Dec 2.

PMID:
16326029
41.

Radical trapping properties of imidazolyl nitrones.

Reybier K, Boyer J, Farines V, Camus F, Souchard JP, Monje MC, Bernardes-Genisson V, Goldstein S, Nepveu F.

Free Radic Res. 2006 Jan;40(1):11-20.

PMID:
16298755
42.

Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults.

Weiss K, Low DE, Cortes L, Beaupre A, Gauthier R, Gregoire P, Legare M, Nepveu F, Thibert D, Tremblay C, Tremblay J.

Can Respir J. 2004 Nov-Dec;11(8):589-93.

43.

2-substituted-3H-indol-3-one-1-oxides: preparation and radical trapping properties.

Boyer J, Bernardes-Genisson V, Farines V, Souchard JP, Nepveu F.

Free Radic Res. 2004 May;38(5):459-71.

PMID:
15293553
44.

Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle.

Chalupsky K, Lobysheva I, Nepveu F, Gadea I, Beranova P, Entlicher G, Stoclet JC, Muller B.

Biochem Pharmacol. 2004 Mar 15;67(6):1203-14.

PMID:
15006555
45.

Effect of prolonged treatment with tyramine on glucose tolerance in streptozotocin-induced diabetic rats.

Visentin V, Marq P, Bour S, Subra C, Prévot D, Morin N, Valet P, Monje MC, Nepveu F, Carpéné C.

J Physiol Biochem. 2003 Sep;59(3):225-32.

PMID:
15000454
46.

Nitric oxide released by Lactobacillus farciminis improves TNBS-induced colitis in rats.

Lamine F, Fioramonti J, Bueno L, Nepveu F, Cauquil E, Lobysheva I, Eutamène H, Théodorou V.

Scand J Gastroenterol. 2004 Jan;39(1):37-45.

PMID:
14992560
47.

Control of anthocyanin biosynthesis pathway gene expression by eutypine, a toxin from Eutypa lata, in grape cell tissue cultures.

Afifi M, El-Kereamy A, Legrand V, Chervin C, Monje MC, Nepveu F, Roustan JP.

J Plant Physiol. 2003 Aug;160(8):971-5.

PMID:
12964874
48.

S-nitrosating nitric oxide donors induce long-lasting inhibition of contraction in isolated arteries.

Alencar JL, Lobysheva I, Chalupsky K, Geffard M, Nepveu F, Stoclet JC, Muller B.

J Pharmacol Exp Ther. 2003 Oct;307(1):152-9. Epub 2003 Sep 3.

PMID:
12954813
49.

Role of S-nitrosation of cysteine residues in long-lasting inhibitory effect of nitric oxide on arterial tone.

Alencar JL, Lobysheva I, Geffard M, Sarr M, Schott C, Schini-Kerth VB, Nepveu F, Stoclet JC, Muller B.

Mol Pharmacol. 2003 May;63(5):1148-58.

PMID:
12695543
50.

Evidence that intrinsic iron but not intrinsic copper determines S-nitrosocysteine decomposition in buffer solution.

Vanin AF, Muller B, Alencar JL, Lobysheva II, Nepveu F, Stoclet JC.

Nitric Oxide. 2002 Nov;7(3):194-209.

PMID:
12381416

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