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Distinct clinical and biological implications of CUX1 in myeloid neoplasms.

Aly M, Ramdzan ZM, Nagata Y, Balasubramanian SK, Hosono N, Makishima H, Visconte V, Kuzmanovic T, Adema V, Nazha A, Przychodzen BP, Kerr CM, Sekeres MA, Abazeed ME, Nepveu A, Maciejewski JP.

Blood Adv. 2019 Jul 23;3(14):2164-2178. doi: 10.1182/bloodadvances.2018028423.


Preeclampsia and Long-term Renal Function in Women Who Underwent Kidney Transplantation.

Vannevel V, Claes K, Baud D, Vial Y, Golshayan D, Yoon EW, Hodges R, Le Nepveu A, Kerr PG, Kennedy C, Higgins M, Resch E, Klaritsch P, Van Mieghem T.

Obstet Gynecol. 2018 Jan;131(1):57-62. doi: 10.1097/AOG.0000000000002404.


CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide.

Kaur S, Ramdzan ZM, Guiot MC, Li L, Leduy L, Ramotar D, Sabri S, Abdulkarim B, Nepveu A.

Neuro Oncol. 2018 Mar 27;20(4):484-493. doi: 10.1093/neuonc/nox178.


The DNA repair function of CUX1 contributes to radioresistance.

Ramdzan ZM, Ginjala V, Pinder JB, Chung D, Donovan CM, Kaur S, Leduy L, Dellaire G, Ganesan S, Nepveu A.

Oncotarget. 2017 Mar 21;8(12):19021-19038. doi: 10.18632/oncotarget.14875.


Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence.

Revandkar A, Perciato ML, Toso A, Alajati A, Chen J, Gerber H, Dimitrov M, Rinaldi A, Delaleu N, Pasquini E, D'Antuono R, Pinton S, Losa M, Gnetti L, Arribas A, Fraering P, Bertoni F, Nepveu A, Alimonti A.

Nat Commun. 2016 Dec 12;7:13719. doi: 10.1038/ncomms13719.


Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair.

Kaur S, Coulombe Y, Ramdzan ZM, Leduy L, Masson JY, Nepveu A.

J Biol Chem. 2016 Oct 21;291(43):22769-22780. Epub 2016 Sep 2.


CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage.

Pal R, Ramdzan ZM, Kaur S, Duquette PM, Marcotte R, Leduy L, Davoudi S, Lamarche-Vane N, Iulianella A, Nepveu A.

J Biol Chem. 2015 Sep 11;290(37):22520-31. doi: 10.1074/jbc.M115.651042. Epub 2015 Jul 28.


The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.

Ramdzan ZM, Pal R, Kaur S, Leduy L, Bérubé G, Davoudi S, Vadnais C, Nepveu A.

Oncotarget. 2015 Feb 28;6(6):3613-26.


Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers.

Vadnais C, Shooshtarizadeh P, Rajadurai CV, Lesurf R, Hulea L, Davoudi S, Cadieux C, Hallett M, Park M, Nepveu A.

Biol Open. 2014 Sep 12;3(10):937-46. doi: 10.1242/bio.20148193.


CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.

Ramdzan ZM, Nepveu A.

Nat Rev Cancer. 2014 Oct;14(10):673-82. doi: 10.1038/nrc3805. Epub 2014 Sep 5. Review.


RAS transformation requires CUX1-dependent repair of oxidative DNA damage.

Ramdzan ZM, Vadnais C, Pal R, Vandal G, Cadieux C, Leduy L, Davoudi S, Hulea L, Yao L, Karnezis AN, Paquet M, Dankort D, Nepveu A.

PLoS Biol. 2014 Mar 11;12(3):e1001807. doi: 10.1371/journal.pbio.1001807. eCollection 2014 Mar.


Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array.

Vadnais C, Awan AA, Harada R, Clermont PL, Leduy L, Bérubé G, Nepveu A.

BMC Genomics. 2013 Apr 16;14:258. doi: 10.1186/1471-2164-14-258.


CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.

Vadnais C, Davoudi S, Afshin M, Harada R, Dudley R, Clermont PL, Drobetsky E, Nepveu A.

Nucleic Acids Res. 2012 May;40(10):4483-95. doi: 10.1093/nar/gks041. Epub 2012 Feb 8.


CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases.

Hulea L, Nepveu A.

Gene. 2012 Apr 10;497(1):18-26. doi: 10.1016/j.gene.2012.01.039. Epub 2012 Jan 28. Review.


Chromatin affinity purification.

Harada R, Nepveu A.

Methods Mol Biol. 2012;809:237-53. doi: 10.1007/978-1-61779-376-9_16.


MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.

Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K.

Nat Commun. 2011 Jun 7;2:338. doi: 10.1038/ncomms1345. Erratum in: Nat Commun. 2012;3:985.


Gene signatures of genomic instability as prognostic tools for breast cancer.

Sansregret L, Nepveu A.

Future Oncol. 2011 May;7(5):591-4. doi: 10.2217/fon.11.34. No abstract available.


Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure.

Sansregret L, Vadnais C, Livingstone J, Kwiatkowski N, Awan A, Cadieux C, Leduy L, Hallett MT, Nepveu A.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1949-54. doi: 10.1073/pnas.1008403108. Epub 2011 Jan 18.


Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle.

Sansregret L, Gallo D, Santaguida M, Leduy L, Harada R, Nepveu A.

J Biol Chem. 2010 Oct 22;285(43):32834-43. doi: 10.1074/jbc.M110.156406. Epub 2010 Aug 19.


Stefin B interacts with histones and cathepsin L in the nucleus.

Ceru S, Konjar S, Maher K, Repnik U, Krizaj I, Bencina M, Renko M, Nepveu A, Zerovnik E, Turk B, Kopitar-Jerala N.

J Biol Chem. 2010 Mar 26;285(13):10078-86. doi: 10.1074/jbc.M109.034793. Epub 2010 Jan 14.


Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types.

Cadieux C, Kedinger V, Yao L, Vadnais C, Drossos M, Paquet M, Nepveu A.

Cancer Res. 2009 Sep 15;69(18):7188-97. doi: 10.1158/0008-5472.CAN-08-4899. Epub 2009 Sep 8.


Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice.

Siam R, Harada R, Cadieux C, Battat R, Vadnais C, Nepveu A.

Mol Cancer. 2009 Aug 5;8:60. doi: 10.1186/1476-4598-8-60.


p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin.

Kedinger V, Sansregret L, Harada R, Vadnais C, Cadieux C, Fathers K, Park M, Nepveu A.

J Biol Chem. 2009 Oct 2;284(40):27701-11. doi: 10.1074/jbc.M109.031849. Epub 2009 Jul 27.


CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase.

Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J.

Mol Cell Biol. 2009 Jan;29(2):570-81. doi: 10.1128/MCB.01275-08. Epub 2008 Nov 17.


USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.

Lu Y, Adegoke OA, Nepveu A, Nakayama KI, Bedard N, Cheng D, Peng J, Wing SS.

Mol Cell Biol. 2009 Jan;29(2):547-58. doi: 10.1128/MCB.00329-08. Epub 2008 Nov 17. Erratum in: Mol Cell Biol. 2009 Jun;29(11):3241.


CUX1 transcription factor is a downstream effector of the proteinase-activated receptor 2 (PAR2).

Wilson BJ, Harada R, LeDuy L, Hollenberg MD, Nepveu A.

J Biol Chem. 2009 Jan 2;284(1):36-45. doi: 10.1074/jbc.M803808200. Epub 2008 Oct 24.


Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line.

Goulet B, Markovic Y, Leduy L, Nepveu A.

Mol Cancer Res. 2008 Apr;6(4):644-53. doi: 10.1158/1541-7786.MCR-07-0268.


Polycystic kidneys caused by sustained expression of Cux1 isoform p75.

Cadieux C, Harada R, Paquet M, Côté O, Trudel M, Nepveu A, Bouchard M.

J Biol Chem. 2008 May 16;283(20):13817-24. doi: 10.1074/jbc.M709332200. Epub 2008 Mar 20.


p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes.

Truscott M, Harada R, Vadnais C, Robert F, Nepveu A.

Mol Cell Biol. 2008 May;28(10):3127-38. doi: 10.1128/MCB.02089-07. Epub 2008 Mar 17.


The multiple roles of CUX1: insights from mouse models and cell-based assays.

Sansregret L, Nepveu A.

Gene. 2008 Apr 15;412(1-2):84-94. doi: 10.1016/j.gene.2008.01.017. Epub 2008 Feb 2. Review.


Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes.

Harada R, Vadnais C, Sansregret L, Leduy L, Bérubé G, Robert F, Nepveu A.

Nucleic Acids Res. 2008 Jan;36(1):189-202. Epub 2007 Nov 14.


Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.

Goulet B, Sansregret L, Leduy L, Bogyo M, Weber E, Chauhan SS, Nepveu A.

Mol Cancer Res. 2007 Sep;5(9):899-907.


Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells.

Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A.

J Biol Chem. 2007 Oct 12;282(41):30216-26. Epub 2007 Aug 6.


Transgenic mice expressing the p75 CCAAT-displacement protein/Cut homeobox isoform develop a myeloproliferative disease-like myeloid leukemia.

Cadieux C, Fournier S, Peterson AC, Bédard C, Bedell BJ, Nepveu A.

Cancer Res. 2006 Oct 1;66(19):9492-501.


A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L.

Goulet B, Truscott M, Nepveu A.

Biol Chem. 2006 Sep;387(9):1285-93.


The p110 isoform of the CDP/Cux transcription factor accelerates entry into S phase.

Sansregret L, Goulet B, Harada R, Wilson B, Leduy L, Bertoglio J, Nepveu A.

Mol Cell Biol. 2006 Mar;26(6):2441-55.


Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1.

Santaguida M, Nepveu A.

J Biol Chem. 2005 Sep 23;280(38):32712-21. Epub 2005 Aug 3.


Biochemical characterization of the mammalian Cux2 protein.

Gingras H, Cases O, Krasilnikova M, Bérubé G, Nepveu A.

Gene. 2005 Jan 3;344:273-85. Epub 2004 Dec 10.


The N-terminal region of the CCAAT displacement protein (CDP)/Cux transcription factor functions as an autoinhibitory domain that modulates DNA binding.

Truscott M, Raynal L, Wang Y, Bérubé G, Leduy L, Nepveu A.

J Biol Chem. 2004 Nov 26;279(48):49787-94. Epub 2004 Sep 17.


Complete and limited proteolysis in cell cycle progression.

Goulet B, Nepveu A.

Cell Cycle. 2004 Aug;3(8):986-9. Epub 2004 Aug 16. Review.


A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

Goulet B, Baruch A, Moon NS, Poirier M, Sansregret LL, Erickson A, Bogyo M, Nepveu A.

Mol Cell. 2004 Apr 23;14(2):207-19.


Binding of CCAAT displacement protein CDP to adenovirus packaging sequences.

Erturk E, Ostapchuk P, Wells SI, Yang J, Gregg K, Nepveu A, Dudley JP, Hearing P.

J Virol. 2003 Jun;77(11):6255-64.


CDP/Cux stimulates transcription from the DNA polymerase alpha gene promoter.

Truscott M, Raynal L, Premdas P, Goulet B, Leduy L, Bérubé G, Nepveu A.

Mol Cell Biol. 2003 Apr;23(8):3013-28.


Characterization of a tissue-specific CDP/Cux isoform, p75, activated in breast tumor cells.

Goulet B, Watson P, Poirier M, Leduy L, Bérubé G, Meterissian S, Jolicoeur P, Nepveu A.

Cancer Res. 2002 Nov 15;62(22):6625-33.


Expression of N-terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas.

Moon NS, Rong Zeng W, Premdas P, Santaguida M, Bérubé G, Nepveu A.

Int J Cancer. 2002 Aug 1;100(4):429-32.


Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).

Santaguida M, Ding Q, Bérubé G, Truscott M, Whyte P, Nepveu A.

J Biol Chem. 2001 Dec 7;276(49):45780-90. Epub 2001 Oct 2.


S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein.

Moon NS, Premdas P, Truscott M, Leduy L, Bérubé G, Nepveu A.

Mol Cell Biol. 2001 Sep;21(18):6332-45.


The role of CDP in the negative regulation of CXCL1 gene expression.

Nirodi C, Hart J, Dhawan P, Moon NS, Nepveu A, Richmond A.

J Biol Chem. 2001 Jul 13;276(28):26122-31. Epub 2001 May 22.

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