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Items: 25

1.

Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction.

Neochoritis CG, Atmaj J, Twarda-Clapa A, Surmiak E, Skalniak L, Köhler LM, Muszak D, Kurpiewska K, Kalinowska-Tłuścik J, Beck B, Holak TA, Dömling A.

Eur J Med Chem. 2019 Aug 6;182:111588. doi: 10.1016/j.ejmech.2019.111588. [Epub ahead of print]

PMID:
31421630
2.

Rapid approach to complex boronic acids.

Neochoritis CG, Shaabani S, Ahmadianmoghaddam M, Zarganes-Tzitzikas T, Gao L, Novotná M, Mitríková T, Romero AR, Irianti MI, Xu R, Olechno J, Ellson R, Helan V, Kossenjans M, Groves MR, Dömling A.

Sci Adv. 2019 Jul 5;5(7):eaaw4607. doi: 10.1126/sciadv.aaw4607. eCollection 2019 Jul.

3.

Atorvastatin (Lipitor) by MCR.

Zarganes-Tzitzikas T, Neochoritis CG, Dömling A.

ACS Med Chem Lett. 2019 Feb 7;10(3):389-392. doi: 10.1021/acsmedchemlett.8b00579. eCollection 2019 Mar 14.

4.

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists.

Neochoritis CG, Kazemi Miraki M, Abdelraheem EMM, Surmiak E, Zarganes-Tzitzikas T, Łabuzek B, Holak TA, Dömling A.

Beilstein J Org Chem. 2019 Feb 20;15:513-520. doi: 10.3762/bjoc.15.45. eCollection 2019.

5.

A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wt osteosarcoma cells.

Skalniak L, Twarda-Clapa A, Neochoritis CG, Surmiak E, Machula M, Wisniewska A, Labuzek B, Ali AM, Krzanik S, Dubin G, Groves M, Dömling A, Holak TA.

FEBS J. 2019 Apr;286(7):1360-1374. doi: 10.1111/febs.14774. Epub 2019 Feb 16.

PMID:
30715803
6.

Tetrazoles via Multicomponent Reactions.

Neochoritis CG, Zhao T, Dömling A.

Chem Rev. 2019 Feb 13;119(3):1970-2042. doi: 10.1021/acs.chemrev.8b00564. Epub 2019 Feb 1.

7.

Application of Silver Nanoparticles in the Multicomponent Reaction Domain: A Combined Catalytic Reduction Methodology to Efficiently Access Potential Hypertension or Inflammation Inhibitors.

Iordanidou D, Zarganes-Tzitzikas T, Neochoritis CG, Dömling A, Lykakis IN.

ACS Omega. 2018 Nov 30;3(11):16005-16013. doi: 10.1021/acsomega.8b02749. Epub 2018 Nov 27.

8.

Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.

Kok T, Wapenaar H, Wang K, Neochoritis CG, Zarganes-Tzitzikas T, Proietti G, Eleftheriadis N, Kurpiewska K, Kalinowska-Tłuścik J, Cool RH, Poelarends GJ, Dömling A, Dekker FJ.

Bioorg Med Chem. 2018 Mar 1;26(5):999-1005. doi: 10.1016/j.bmc.2017.12.032. Epub 2017 Dec 24.

9.

Artificial Macrocycles as Potent p53-MDM2 Inhibitors.

Estrada-Ortiz N, Neochoritis CG, Twarda-Clapa A, Musielak B, Holak TA, Dömling A.

ACS Med Chem Lett. 2017 Sep 20;8(10):1025-1030. doi: 10.1021/acsmedchemlett.7b00219. eCollection 2017 Oct 12.

10.

Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists.

Shaabani S, Neochoritis CG, Twarda-Clapa A, Musielak B, Holak TA, Dömling A.

Medchemcomm. 2017 May 1;8(5):1046-1052. doi: 10.1039/C7MD00058H. Epub 2017 Mar 15.

11.

1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.

Twarda-Clapa A, Krzanik S, Kubica K, Guzik K, Labuzek B, Neochoritis CG, Khoury K, Kowalska K, Czub M, Dubin G, Dömling A, Skalniak L, Holak TA.

J Med Chem. 2017 May 25;60(10):4234-4244. doi: 10.1021/acs.jmedchem.7b00104. Epub 2017 May 16.

PMID:
28482147
12.

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction.

Surmiak E, Neochoritis CG, Musielak B, Twarda-Clapa A, Kurpiewska K, Dubin G, Camacho C, Holak TA, Dömling A.

Eur J Med Chem. 2017 Jan 27;126:384-407. doi: 10.1016/j.ejmech.2016.11.029. Epub 2016 Nov 16.

PMID:
27907876
13.

Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.

Eleftheriadis N, Poelman H, Leus NGJ, Honrath B, Neochoritis CG, Dolga A, Dömling A, Dekker FJ.

Eur J Med Chem. 2016 Oct 21;122:786-801. doi: 10.1016/j.ejmech.2016.07.010. Epub 2016 Jul 9.

14.

How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.

Estrada-Ortiz N, Neochoritis CG, Dömling A.

ChemMedChem. 2016 Apr 19;11(8):757-72. doi: 10.1002/cmdc.201500487. Epub 2015 Dec 16. Review.

15.

2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists.

Neochoritis CG, Wang K, Estrada-Ortiz N, Herdtweck E, Kubica K, Twarda A, Zak KM, Holak TA, Dömling A.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5661-6. doi: 10.1016/j.bmcl.2015.11.019.

16.

Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors.

Wu S, Huang J, Gazzarrini S, He S, Chen L, Li J, Xing L, Li C, Chen L, Neochoritis CG, Liao GP, Zhou H, Dömling A, Moroni A, Wang W.

ChemMedChem. 2015 Nov;10(11):1837-45. doi: 10.1002/cmdc.201500318. Epub 2015 Sep 7.

PMID:
26506405
17.

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids.

Liao GP, Abdelraheem EM, Neochoritis CG, Kurpiewska K, Kalinowska-Tłuścik J, McGowan DC, Dömling A.

Org Lett. 2015 Oct 16;17(20):4980-3. doi: 10.1021/acs.orglett.5b02419. Epub 2015 Oct 6.

PMID:
26439710
18.

Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.

Eleftheriadis N, Neochoritis CG, Leus NG, van der Wouden PE, Dömling A, Dekker FJ.

J Med Chem. 2015 Oct 8;58(19):7850-62. doi: 10.1021/acs.jmedchem.5b01121. Epub 2015 Sep 16.

19.

Leuckart-Wallach Route Toward Isocyanides and Some Applications.

Neochoritis CG, Zarganes-Tzitzikas T, Stotani S, Dömling A, Herdtweck E, Khoury K, Dömling A.

ACS Comb Sci. 2015 Sep 14;17(9):493-9. doi: 10.1021/acscombsci.5b00066. Epub 2015 Aug 10.

PMID:
26226194
20.

Efficient isocyanide-less isocyanide-based multicomponent reactions.

Neochoritis CG, Stotani S, Mishra B, Dömling A.

Org Lett. 2015 Apr 17;17(8):2002-5. doi: 10.1021/acs.orglett.5b00759. Epub 2015 Mar 31.

21.

Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

Neochoritis CG, Dömling A.

Org Biomol Chem. 2014 Mar 14;12(10):1649-51. doi: 10.1039/c4ob00166d.

22.

One-pot microwave assisted synthesis of new 2-alkoxycarbonylmethylene-4-oxo-1,5-benzo-, naphtho-, and pyridodiazepines and assessment of their cytogenetic activity.

Eleftheriadis N, Neochoritis CG, Tsoleridis CA, Stephanidou-Stephanatou J, Iakovidou-Kritsi Z.

Eur J Med Chem. 2013 Sep;67:302-9. doi: 10.1016/j.ejmech.2013.06.028. Epub 2013 Jun 25.

PMID:
23871910
23.

Synthesis of 2-keto-imidazoles utilizing N-arylamino-substituted N-heterocyclic carbenes.

Zarganes-Tzitzikas T, Neochoritis CG, Stephanidou-Stephanatou J, Tsoleridis CA.

J Org Chem. 2011 Mar 4;76(5):1468-71. doi: 10.1021/jo102244x. Epub 2011 Jan 20.

PMID:
21250708
24.

One-pot microwave assisted synthesis under green chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones.

Neochoritis CG, Zarganes-Tzitzikas T, Tsoleridis CA, Stephanidou-Stephanatou J, Kontogiorgis CA, Hadjipavlou-Litina DJ, Choli-Papadopoulou T.

Eur J Med Chem. 2011 Jan;46(1):297-306. doi: 10.1016/j.ejmech.2010.11.018. Epub 2010 Nov 19.

PMID:
21146903
25.

1,5-Benzoxazepines vs 1,5-benzodiazepines. one-pot microwave-assisted synthesis and evaluation for antioxidant activity and lipid peroxidation inhibition.

Neochoritis CG, Tsoleridis CA, Stephanidou-Stephanatou J, Kontogiorgis CA, Hadjipavlou-Litina DJ.

J Med Chem. 2010 Dec 9;53(23):8409-20. doi: 10.1021/jm100739n. Epub 2010 Nov 4.

PMID:
21049954

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