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Items: 47

1.

Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents?

Procházková E, Hřebabecký H, Dejmek M, Šála M, Šmídková M, Tloušťová E, Zborníková E, Eyer L, Růžek D, Nencka R.

Bioorg Med Chem Lett. 2020 Feb 15;30(4):126897. doi: 10.1016/j.bmcl.2019.126897. Epub 2019 Dec 17.

PMID:
31882298
2.

Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.

Novotná B, Vaneková L, Zavřel M, Buděšínský M, Dejmek M, Smola M, Gutten O, Tehrani ZA, Pimková Polidarová M, Brázdová A, Liboska R, Štěpánek I, Vavřina Z, Jandušík T, Nencka R, Rulíšek L, Bouřa E, Brynda J, Páv O, Birkuš G.

J Med Chem. 2019 Dec 12;62(23):10676-10690. doi: 10.1021/acs.jmedchem.9b01062. Epub 2019 Nov 27.

PMID:
31715099
3.

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß.

Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H.

Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16617-16628. doi: 10.1002/anie.201907632. Epub 2019 Oct 4. Review.

4.

A novel and potent brain penetrant inhibitor of extracellular vesicle release.

Rojas C, Sala M, Thomas AG, Datta Chaudhuri A, Yoo SW, Li Z, Dash RP, Rais R, Haughey NJ, Nencka R, Slusher B.

Br J Pharmacol. 2019 Oct;176(19):3857-3870. doi: 10.1111/bph.14789. Epub 2019 Sep 4.

PMID:
31273753
5.

Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection.

Eyer L, Fojtíková M, Nencka R, Rudolf I, Hubálek Z, Ruzek D.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02093-18. doi: 10.1128/AAC.02093-18. Print 2019 Mar.

6.

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha.

Sengupta N, Jović M, Barnaeva E, Kim DW, Hu X, Southall N, Dejmek M, Mejdrova I, Nencka R, Baumlova A, Chalupska D, Boura E, Ferrer M, Marugan J, Balla T.

J Lipid Res. 2019 Mar;60(3):683-693. doi: 10.1194/jlr.D090159. Epub 2019 Jan 9.

PMID:
30626625
7.

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors.

Šebera J, Dubankova A, Sychrovský V, Ruzek D, Boura E, Nencka R.

Sci Rep. 2018 Jul 24;8(1):11132. doi: 10.1038/s41598-018-29459-7.

8.

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

Eyer L, Nencka R, de Clercq E, Seley-Radtke K, Růžek D.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618761299. doi: 10.1177/2040206618761299. Review.

9.

Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes.

Iannazzo L, Fonvielle M, Braud E, Hřebabecký H, Procházková E, Nencka R, Mathé C, Arthur M, Etheve-Quelquejeu M.

Org Biomol Chem. 2018 Mar 14;16(11):1903-1911. doi: 10.1039/c8ob00019k.

PMID:
29484333
10.

Control of α/β Anomer Formation by a 2',5' Bridge: Toward Nucleoside Derivatives Locked in the South Conformation.

Hřebabecký H, Dračínský M, Procházková E, Šála M, Mackman R, Nencka R.

J Org Chem. 2017 Nov 3;82(21):11337-11347. doi: 10.1021/acs.joc.7b01000.

PMID:
28972760
11.

Escape of Tick-Borne Flavivirus from 2'-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness.

Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D.

J Virol. 2017 Oct 13;91(21). pii: e01028-17. doi: 10.1128/JVI.01028-17. Print 2017 Nov 1.

12.

Structural basis of Zika virus methyltransferase inhibition by sinefungin.

Hercik K, Brynda J, Nencka R, Boura E.

Arch Virol. 2017 Jul;162(7):2091-2096. doi: 10.1007/s00705-017-3345-x. Epub 2017 Mar 29.

PMID:
28357511
13.

Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses.

Eyer L, Zouharová D, Širmarová J, Fojtíková M, Štefánik M, Haviernik J, Nencka R, de Clercq E, Růžek D.

Antiviral Res. 2017 Jun;142:63-67. doi: 10.1016/j.antiviral.2017.03.012. Epub 2017 Mar 21.

PMID:
28336346
14.

The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine.

Šebera J, Hattori Y, Sato D, Reha D, Nencka R, Kohno T, Kojima C, Tanaka Y, Sychrovský V.

Nucleic Acids Res. 2017 May 19;45(9):5231-5242. doi: 10.1093/nar/gkx157.

15.

Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase IIIβ (PI4KB).

Humpolickova J, Mejdrová I, Matousova M, Nencka R, Boura E.

J Med Chem. 2017 Jan 12;60(1):119-127. doi: 10.1021/acs.jmedchem.6b01466. Epub 2016 Dec 22.

PMID:
28004946
16.

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.

Mejdrová I, Chalupská D, Plačková P, Müller C, Šála M, Klíma M, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Strunin D, Weber J, Lee G, Matoušová M, Mertlíková-Kaiserová H, Ziebuhr J, Birkus G, Boura E, Nencka R.

J Med Chem. 2017 Jan 12;60(1):100-118. doi: 10.1021/acs.jmedchem.6b01465. Epub 2016 Dec 22.

PMID:
28004945
17.

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.

Hercík K, Kozak J, Šála M, Dejmek M, Hřebabecký H, Zborníková E, Smola M, Ruzek D, Nencka R, Boura E.

Antiviral Res. 2017 Jan;137:131-133. doi: 10.1016/j.antiviral.2016.11.020. Epub 2016 Nov 27.

PMID:
27902932
18.

Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus.

Eyer L, Šmídková M, Nencka R, Neča J, Kastl T, Palus M, De Clercq E, Růžek D.

Antiviral Res. 2016 Sep;133:119-29. doi: 10.1016/j.antiviral.2016.07.018. Epub 2016 Jul 28.

PMID:
27476046
19.

Single-Step Formation of Pyrimido[4,5-d]pyridazines by a Pyrimidine-Tetrazine Tandem Reaction.

Galeta J, Šála M, Dračínský M, Vrábel M, Havlas Z, Nencka R.

Org Lett. 2016 Aug 5;18(15):3594-7. doi: 10.1021/acs.orglett.6b01601. Epub 2016 Jul 8.

PMID:
27391276
20.

9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction.

Plačková P, Šála M, Šmídková M, Dejmek M, Hřebabecký H, Nencka R, Thibaut HJ, Neyts J, Mertlíková-Kaiserová H.

Free Radic Biol Med. 2016 Aug;97:223-235. doi: 10.1016/j.freeradbiomed.2016.06.004. Epub 2016 Jun 7.

21.

Nucleoside Inhibitors of Zika Virus.

Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, De Clercq E, Růžek D.

J Infect Dis. 2016 Sep 1;214(5):707-11. doi: 10.1093/infdis/jiw226. Epub 2016 May 27.

PMID:
27234417
22.

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors.

Šála M, Kögler M, Plačková P, Mejdrová I, Hřebabecký H, Procházková E, Strunin D, Lee G, Birkus G, Weber J, Mertlíková-Kaiserová H, Nencka R.

Bioorg Med Chem Lett. 2016 Jun 1;26(11):2706-12. doi: 10.1016/j.bmcl.2016.04.002. Epub 2016 Apr 5.

PMID:
27090557
23.

Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein.

Klima M, Tóth DJ, Hexnerova R, Baumlova A, Chalupska D, Tykvart J, Rezabkova L, Sengupta N, Man P, Dubankova A, Humpolickova J, Nencka R, Veverka V, Balla T, Boura E.

Sci Rep. 2016 Mar 24;6:23641. doi: 10.1038/srep23641.

24.

Benchmark Theoretical and Experimental Study on (15)N NMR Shifts of Oxidatively Damaged Guanine.

Dračínský M, Šála M, Klepetářová B, Šebera J, Fukal J, Holečková V, Tanaka Y, Nencka R, Sychrovský V.

J Phys Chem B. 2016 Feb 11;120(5):915-25. doi: 10.1021/acs.jpcb.5b11428. Epub 2016 Feb 1.

PMID:
26727398
25.

Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides.

Hřebabecký H, Procházková E, Šála M, Plačková P, Tloušťová E, Barauskas O, Lee YJ, Tian Y, Mackman R, Nencka R.

Org Biomol Chem. 2015 Sep 21;13(35):9300-13. doi: 10.1039/c5ob00987a. Epub 2015 Aug 4.

PMID:
26239898
26.

Phosphatidylinositol 4-kinases: Function, structure, and inhibition.

Boura E, Nencka R.

Exp Cell Res. 2015 Oct 1;337(2):136-45. doi: 10.1016/j.yexcr.2015.03.028. Epub 2015 Jul 14. Review. Erratum in: Exp Cell Res. 2016 Feb 1;341(1):110.

PMID:
26183104
27.

The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.

Klima M, Baumlova A, Chalupska D, Hřebabecký H, Dejmek M, Nencka R, Boura E.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1555-63. doi: 10.1107/S1399004715009505. Epub 2015 Jun 30.

PMID:
26143926
28.

Nucleoside inhibitors of tick-borne encephalitis virus.

Eyer L, Valdés JJ, Gil VA, Nencka R, Hřebabecký H, Šála M, Salát J, Černý J, Palus M, De Clercq E, Růžek D.

Antimicrob Agents Chemother. 2015 Sep;59(9):5483-93. doi: 10.1128/AAC.00807-15. Epub 2015 Jun 29.

29.

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.

Mejdrová I, Chalupská D, Kögler M, Šála M, Plačková P, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Guillon R, Strunin D, Weber J, Lee G, Birkus G, Mertlíková-Kaiserová H, Boura E, Nencka R.

J Med Chem. 2015 May 14;58(9):3767-93. doi: 10.1021/acs.jmedchem.5b00499. Epub 2015 May 4.

PMID:
25897704
30.

Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units.

Šála M, Dejmek M, Procházková E, Hřebabecký H, Rybáček J, Dračínský M, Novák P, Rosenbergová Š, Fukal J, Sychrovský V, Rosenberg I, Nencka R.

Org Biomol Chem. 2015 Mar 7;13(9):2703-15. doi: 10.1039/c4ob02193b.

PMID:
25594585
31.

Norbornane-based nucleoside and nucleotide analogues locked in North conformation.

Dejmek M, Šála M, Hřebabecký H, Dračínský M, Procházková E, Chalupská D, Klíma M, Plačková P, Hájek M, Andrei G, Naesens L, Leyssen P, Neyts J, Balzarini J, Boura E, Nencka R.

Bioorg Med Chem. 2015 Jan 1;23(1):184-91. doi: 10.1016/j.bmc.2014.11.011. Epub 2014 Nov 15.

PMID:
25435471
32.

The crystal structure of the phosphatidylinositol 4-kinase IIα.

Baumlova A, Chalupska D, Róźycki B, Jovic M, Wisniewski E, Klima M, Dubankova A, Kloer DP, Nencka R, Balla T, Boura E.

EMBO Rep. 2014 Oct;15(10):1085-92. doi: 10.15252/embr.201438841. Epub 2014 Aug 28.

33.

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus.

Dejmek M, Hřebabecký H, Šála M, Dračínský M, Procházková E, Leyssen P, Neyts J, Balzarini J, Nencka R.

Bioorg Med Chem. 2014 Jun 1;22(11):2974-83. doi: 10.1016/j.bmc.2014.04.004. Epub 2014 Apr 13.

PMID:
24775916
34.

Transport mechanisms of a novel antileukemic and antiviral compound 9-norbornyl-6-chloropurine.

Plačková P, Hřebabecký H, Šála M, Nencka R, Elbert T, Mertlíková-Kaiserová H.

J Enzyme Inhib Med Chem. 2015 Feb;30(1):57-62. doi: 10.3109/14756366.2013.879576. Epub 2014 Mar 31.

PMID:
24679051
35.

Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position.

Dejmek M, Sála M, Plačková P, Hřebabecký H, Mascarell Borredà L, Neyts J, Dračínský M, Procházková E, Jansa P, Leyssen P, Mertlíková-Kaiserová H, Nencka R.

Arch Pharm (Weinheim). 2014 Jul;347(7):478-85. doi: 10.1002/ardp.201300431. Epub 2014 Mar 20.

PMID:
24652670
36.

In vivo 5FU-exposed human medullary thyroid carcinoma cells contain a chemoresistant CD133+ tumor-initiating cell subset.

Kucerova L, Feketeova L, Kozovska Z, Poturnajova M, Matuskova M, Nencka R, Babal P.

Thyroid. 2014 Mar;24(3):520-32. doi: 10.1089/thy.2013.0277. Epub 2013 Dec 13.

37.

9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH.

Placková P, Rozumová N, Hrebabecky H, Sála M, Nencka R, Elbert T, Dvoráková A, Votruba I, Mertlíková-Kaiserová H.

Anticancer Res. 2013 Aug;33(8):3163-8.

PMID:
23898074
38.

Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose.

Dvorakova M, Nencka R, Dejmek M, Zbornikova E, Brezinova A, Pribylova M, Pohl R, Migaud ME, Vanek T.

Org Biomol Chem. 2013 Sep 14;11(34):5702-13. doi: 10.1039/c3ob41016a.

PMID:
23884430
39.

Intrinsic properties of tumour cells have a key impact on the bystander effect mediated by genetically engineered mesenchymal stromal cells.

Matuskova M, Baranovicova L, Kozovska Z, Durinikova E, Pastorakova A, Hunakova L, Waczulikova I, Nencka R, Kucerova L.

J Gene Med. 2012 Dec;14(12):776-87. doi: 10.1002/jgm.2684.

PMID:
23150190
40.

C6-substituted purine derivatives: an experimental and theoretical 1H, 13C and 15N NMR study.

Procházková E, Sála M, Nencka R, Dračínský M.

Magn Reson Chem. 2012 Mar;50(3):181-6. doi: 10.1002/mrc.2864. Epub 2012 Feb 26.

PMID:
22367771
41.

Novel substituted 9-norbornylpurines and their activities against RNA viruses.

Sála M, Hřebabecký H, Leyssen P, Dejmek M, Dračínský M, De Palma AM, Neyts J, Nencka R.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1963-8. doi: 10.1016/j.bmcl.2012.01.040. Epub 2012 Jan 25.

PMID:
22310228
42.

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.

Sála M, De Palma AM, Hřebabecký H, Dejmek M, Dračínský M, Leyssen P, Neyts J, Mertlíková-Kaiserová H, Nencka R.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4271-5. doi: 10.1016/j.bmcl.2011.05.070. Epub 2011 May 27.

PMID:
21684160
43.

Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling.

Nencka R, Sinnaeve D, Karalic I, Martins JC, Van Calenbergh S.

Org Biomol Chem. 2010 Nov 21;8(22):5234-46. doi: 10.1039/c0ob00061b. Epub 2010 Sep 21.

PMID:
20856988
44.

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.

Sála M, De Palma AM, Hrebabecký H, Nencka R, Dracínský M, Leyssen P, Neyts J, Holý A.

Bioorg Med Chem. 2010 Jun 15;18(12):4374-84. doi: 10.1016/j.bmc.2010.04.081. Epub 2010 Apr 29.

PMID:
20576576
45.

Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.

Nencka R, Votruba I, Hrebabecký H, Jansa P, Tloust'ová E, Horská K, Masojídková M, Holý A.

J Med Chem. 2007 Nov 29;50(24):6016-23. Epub 2007 Oct 27.

PMID:
17963370
46.

Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.

Nencka R, Votruba I, Hrebabecký H, Tloust'ová E, Horská K, Masojídková M, Holý A.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. Epub 2005 Dec 5.

PMID:
16337119
47.

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