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Items: 1 to 50 of 62

1.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005.

PMID:
30423294
2.

Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics.

D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Transfusion. 2018 Oct 24. doi: 10.1111/trf.14979. [Epub ahead of print]

PMID:
30353560
3.

Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.

Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE.

Mol Metab. 2018 Sep 28. pii: S2212-8778(18)30835-4. doi: 10.1016/j.molmet.2018.09.008. [Epub ahead of print]

4.

Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells.

Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A.

Transfusion. 2018 Oct 12. doi: 10.1111/trf.14936. [Epub ahead of print]

PMID:
30312994
5.

Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport.

Nemkov T, Reisz JA, Xia Y, Zimring JC, D'Alessandro A.

Expert Rev Proteomics. 2018 Nov;15(11):855-864. doi: 10.1080/14789450.2018.1531710. Epub 2018 Oct 14.

PMID:
30278801
6.

Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression.

Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK.

Mol Cancer Res. 2018 Sep 13. doi: 10.1158/1541-7786.MCR-18-0246. [Epub ahead of print]

PMID:
30213797
7.

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.

Stevens BM, Khan N, D'Alessandro A, Nemkov T, Winters A, Jones CL, Zhang W, Pollyea DA, Jordan CT.

Nat Commun. 2018 Sep 12;9(1):3694. doi: 10.1038/s41467-018-05984-x.

8.

Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.

Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):479-489. doi: 10.1165/rcmb.2018-0095OC.

PMID:
29851508
9.

Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics.

Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC.

J Biol Chem. 2018 May 4;293(18):6659-6671. doi: 10.1074/jbc.RA117.000470. Epub 2018 Mar 14.

PMID:
29540485
10.

When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies.

Reisz JA, Barrett AS, Nemkov T, Hansen KC, D'Alessandro A.

Expert Rev Proteomics. 2018 Apr;15(4):293-309. doi: 10.1080/14789450.2018.1453362. Epub 2018 Mar 21.

PMID:
29540077
11.

Correction: An autonomous metabolic role for Spen.

Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T.

PLoS Genet. 2018 Mar 6;14(3):e1007266. doi: 10.1371/journal.pgen.1007266. eCollection 2018 Mar.

12.

Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle.

Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC.

JCI Insight. 2018 Feb 8;3(3). pii: 96805. doi: 10.1172/jci.insight.96805. [Epub ahead of print]

13.

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.

14.

Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors.

Reisz JA, Tzounakas VL, Nemkov T, Voulgaridou AI, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH.

Front Med (Lausanne). 2018 Jan 11;4:248. doi: 10.3389/fmed.2017.00248. eCollection 2017.

15.

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging.

Culp-Hill R, Zheng C, Reisz JA, Smith K, Rachubinski A, Nemkov T, Butcher E, Granrath R, Hansen KC, Espinosa JM, D'Alessandro A.

Blood Adv. 2017 Dec 21;1(27):2776-2780. doi: 10.1182/bloodadvances.2017011957. eCollection 2017 Dec 26.

16.

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.

Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y.

Sci Rep. 2017 Nov 10;7(1):15281. doi: 10.1038/s41598-017-13667-8.

17.

Metabolism of Citrate and Other Carboxylic Acids in Erythrocytes As a Function of Oxygen Saturation and Refrigerated Storage.

Nemkov T, Sun K, Reisz JA, Yoshida T, Dunham A, Wen EY, Wen AQ, Roach RC, Hansen KC, Xia Y, D'Alessandro A.

Front Med (Lausanne). 2017 Oct 17;4:175. doi: 10.3389/fmed.2017.00175. eCollection 2017.

18.

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.

Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ, Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A, Kriebardis A, Antonelou M, Papassideri I, Young CT, Thomas TA, Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA, D'Alessandro A.

Haematologica. 2018 Feb;103(2):361-372. doi: 10.3324/haematol.2017.178608. Epub 2017 Oct 27.

19.

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.

Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J.

Exp Hematol. 2018 Feb;58:52-58. doi: 10.1016/j.exphem.2017.09.007. Epub 2017 Sep 22.

PMID:
28947392
20.

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis.

Henry CJ, Nemkov T, Casás-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J.

Haematologica. 2017 Dec;102(12):1985-1994. doi: 10.3324/haematol.2017.171074. Epub 2017 Sep 7.

21.

Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-β42.

Adams DJ, Nemkov TG, Mayer JP, Old WM, Stowell MHB.

PLoS One. 2017 Aug 9;12(8):e0182804. doi: 10.1371/journal.pone.0182804. eCollection 2017.

22.

The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model.

Slaughter AL, Nunns GR, D'Alessandro A, Banerjee A, Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Leasia K, Peltz ED.

Shock. 2018 May;49(5):580-590. doi: 10.1097/SHK.0000000000000948.

PMID:
28727610
23.

An autonomous metabolic role for Spen.

Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T.

PLoS Genet. 2017 Jun 22;13(6):e1006859. doi: 10.1371/journal.pgen.1006859. eCollection 2017 Jun. Erratum in: PLoS Genet. 2018 Mar 6;14 (3):e1007266.

24.

Characterization of rapid extraction protocols for high-throughput metabolomics.

Gehrke S, Reisz JA, Nemkov T, Hansen KC, D'Alessandro A.

Rapid Commun Mass Spectrom. 2017 Sep 15;31(17):1445-1452. doi: 10.1002/rcm.7916.

25.

Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine.

Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, DʼAlessandro A.

J Trauma Acute Care Surg. 2017 Oct;83(4):635-642. doi: 10.1097/TA.0000000000001504.

26.

Red blood cell proteomics update: is there more to discover?

D'Alessandro A, Dzieciatkowska M, Nemkov T, Hansen KC.

Blood Transfus. 2017 Mar;15(2):182-187. doi: 10.2450/2017.0293-16. No abstract available.

27.

Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage.

Yoshida T, Blair A, D'alessandro A, Nemkov T, Dioguardi M, Silliman CC, Dunham A.

Blood Transfus. 2017 Mar;15(2):172-181. doi: 10.2450/2017.0325-16.

28.

Omics markers of the red cell storage lesion and metabolic linkage.

D'alessandro A, Nemkov T, Reisz J, Dzieciatkowska M, Wither MJ, Hansen KC.

Blood Transfus. 2017 Mar;15(2):137-144. doi: 10.2450/2017.0341-16. Review.

29.

A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways.

Nemkov T, Hansen KC, D'Alessandro A.

Rapid Commun Mass Spectrom. 2017 Apr 30;31(8):663-673. doi: 10.1002/rcm.7834.

30.

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.

Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13.

31.

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.

Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y.

Nat Commun. 2017 Feb 7;8:14108. doi: 10.1038/ncomms14108.

32.

CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming.

Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ.

Oncotarget. 2017 Jan 24;8(4):6742-6762. doi: 10.18632/oncotarget.14272.

33.

Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.

D'Alessandro A, Nemkov T, Bogren LK, Martin SL, Hansen KC.

J Proteome Res. 2017 Feb 3;16(2):958-969. doi: 10.1021/acs.jproteome.6b00884. Epub 2016 Dec 29.

PMID:
27991798
34.

The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis.

Goddard ET, Hill RC, Nemkov T, D'Alessandro A, Hansen KC, Maller O, Mongoue-Tchokote S, Mori M, Partridge AH, Borges VF, Schedin P.

Cancer Discov. 2017 Feb;7(2):177-187. doi: 10.1158/2159-8290.CD-16-0822. Epub 2016 Dec 14.

35.

Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells.

Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT.

J Biol Chem. 2016 Nov 25;291(48):25280. No abstract available.

36.

Citrate metabolism in red blood cells stored in additive solution-3.

D'Alessandro A, Nemkov T, Yoshida T, Bordbar A, Palsson BO, Hansen KC.

Transfusion. 2017 Feb;57(2):325-336. doi: 10.1111/trf.13892. Epub 2016 Nov 4.

PMID:
27813142
37.

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. Epub 2016 Oct 10.

38.

Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques.

McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE.

JCI Insight. 2016 Oct 6;1(16):e86612.

39.

The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones.

Liu WH, Roemer SC, Zhou Y, Shen ZJ, Dennehey BK, Balsbaugh JL, Liddle JC, Nemkov T, Ahn NG, Hansen KC, Tyler JK, Churchill ME.

Elife. 2016 Sep 30;5. pii: e18023. doi: 10.7554/eLife.18023.

40.

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.

D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC.

J Proteome Res. 2016 Oct 7;15(10):3883-3895. Epub 2016 Sep 27.

41.

Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.

Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT.

J Biol Chem. 2016 Oct 14;291(42):21984-22000. Epub 2016 Aug 29. Erratum in: J Biol Chem. 2016 Nov 25;291(48):25280.

42.

Biomarkers defining the metabolic age of red blood cells during cold storage.

Paglia G, D'Alessandro A, Rolfsson Ó, Sigurjónsson ÓE, Bordbar A, Palsson S, Nemkov T, Hansen KC, Gudmundsson S, Palsson BO.

Blood. 2016 Sep 29;128(13):e43-50. doi: 10.1182/blood-2016-06-721688. Epub 2016 Aug 23.

43.

Hypertonic Saline Primes Activation of the p53-p21 Signaling Axis in Human Small Airway Epithelial Cells That Prevents Inflammation Induced by Pro-inflammatory Cytokines.

Gamboni F, Anderson C, Mitra S, Reisz JA, Nemkov T, Dzieciatkowska M, Jones KL, Hansen KC, D'Alessandro A, Banerjee A.

J Proteome Res. 2016 Oct 7;15(10):3813-3826. Epub 2016 Aug 29.

44.

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.

Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y.

Circulation. 2016 Aug 2;134(5):405-21. doi: 10.1161/CIRCULATIONAHA.116.021311.

45.

Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors.

Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH.

Data Brief. 2016 Jun 23;8:618-27. doi: 10.1016/j.dib.2016.06.018. eCollection 2016 Sep.

46.

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia.

Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y.

Nat Commun. 2016 Jul 15;7:12086. doi: 10.1038/ncomms12086.

47.

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells.

Reisz JA, Wither MJ, Dzieciatkowska M, Nemkov T, Issaian A, Yoshida T, Dunham AJ, Hill RC, Hansen KC, D'Alessandro A.

Blood. 2016 Sep 22;128(12):e32-42. doi: 10.1182/blood-2016-05-714816. Epub 2016 Jul 12.

48.

Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph.

D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC.

Blood Transfus. 2016 May;14(2):185-94. doi: 10.2450/2016.0208-15. Epub 2016 Apr 22.

49.

Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells.

Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH.

Free Radic Biol Med. 2016 Jul;96:152-65. doi: 10.1016/j.freeradbiomed.2016.04.005. Epub 2016 Apr 14.

PMID:
27094493
50.

Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans.

Newsom SA, Brozinick JT, Kiseljak-Vassiliades K, Strauss AN, Bacon SD, Kerege AA, Bui HH, Sanders P, Siddall P, Wei T, Thomas M, Kuo MS, Nemkov T, D'Alessandro A, Hansen KC, Perreault L, Bergman BC.

J Appl Physiol (1985). 2016 Jun 1;120(11):1355-63. doi: 10.1152/japplphysiol.00664.2015. Epub 2016 Mar 31.

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