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Items: 1 to 20 of 79

1.

The plasma metabolome as a predictor of biological aging in humans.

Johnson LC, Parker K, Aguirre BF, Nemkov TG, D'Alessandro A, Johnson SA, Seals DR, Martens CR.

Geroscience. 2019 Nov 9. doi: 10.1007/s11357-019-00123-w. [Epub ahead of print]

PMID:
31707594
2.

Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage.

Stefanoni D, Shin HKH, Baek JH, Champagne DP, Nemkov T, Thomas T, Francis RO, Zimring JC, Yoshida T, Reisz JA, Spitalnik SL, Buehler PW, D'Alessandro A.

Haematologica. 2019 Nov 7. pii: haematol.2019.229930. doi: 10.3324/haematol.2019.229930. [Epub ahead of print]

3.

Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.

Abraham AD, Esquer H, Zhou Q, Tomlinson N, Hamill BD, Abbott JM, Li L, Pike LA, Rinaldetti S, Ramirez DA, Lunghofer PJ, Gomez JD, Schaack J, Nemkov T, D'Alessandro A, Hansen KC, Gustafson DL, Messersmith WA, LaBarbera DV.

J Med Chem. 2019 Nov 27;62(22):10182-10203. doi: 10.1021/acs.jmedchem.9b01065. Epub 2019 Nov 18.

PMID:
31675229
4.

Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice.

Nohara K, Nemkov T, D'Alessandro A, Yoo SH, Chen Z.

Int J Mol Sci. 2019 Sep 1;20(17). pii: E4281. doi: 10.3390/ijms20174281.

5.

Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock.

Williams AT, Jani VP, Nemkov T, Lucas A, Yoshida T, Dunham A, Alessandro A, Cabrales P.

Shock. 2019 Aug 30. doi: 10.1097/SHK.0000000000001386. [Epub ahead of print]

PMID:
31478989
6.

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.

Nohara K, Mallampalli V, Nemkov T, Wirianto M, Yang J, Ye Y, Sun Y, Han L, Esser KA, Mileykovskaya E, D'Alessandro A, Green CB, Takahashi JS, Dowhan W, Yoo SH, Chen Z.

Nat Commun. 2019 Aug 28;10(1):3923. doi: 10.1038/s41467-019-11926-y.

7.

TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging.

Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J.

Blood. 2019 Aug 29;134(9):727-740. doi: 10.1182/blood.2019000200. Epub 2019 Jul 16.

8.

Metabolic Systems Analysis of Shock-Induced Endotheliopathy (SHINE) in Trauma: A New Research Paradigm.

Henriksen HH, McGarrity S, SigurÐardóttir RS, Nemkov T, D'Alessandro A, Palsson BO, Stensballe J, Wade CE, Rolfsson Ó, Johansson PI.

Ann Surg. 2019 Jun 26. doi: 10.1097/SLA.0000000000003307. [Epub ahead of print]

PMID:
31274658
9.

Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells.

Morrison EJ, Champagne DP, Dzieciatkowska M, Nemkov T, Zimring JC, Hansen KC, Guan F, Huffman DM, Santambrogio L, D'Alessandro A.

Nutrients. 2019 Jun 14;11(6). pii: E1337. doi: 10.3390/nu11061337.

10.

Untargeted and Semi-targeted Lipid Analysis of Biological Samples Using Mass Spectrometry-Based Metabolomics.

Reisz JA, Zheng C, D'Alessandro A, Nemkov T.

Methods Mol Biol. 2019;1978:121-135. doi: 10.1007/978-1-4939-9236-2_8.

PMID:
31119660
11.

High-Throughput Metabolomics: Isocratic and Gradient Mass Spectrometry-Based Methods.

Nemkov T, Reisz JA, Gehrke S, Hansen KC, D'Alessandro A.

Methods Mol Biol. 2019;1978:13-26. doi: 10.1007/978-1-4939-9236-2_2.

PMID:
31119654
12.

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.

Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J.

Clin Cancer Res. 2019 Jul 1;25(13):4079-4090. doi: 10.1158/1078-0432.CCR-18-3223. Epub 2019 Apr 2.

PMID:
30940653
13.

Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collection.

Catala A, Culp-Hill R, Nemkov T, D'Alessandro A.

Metabolomics. 2018 Jul 12;14(7):100. doi: 10.1007/s11306-018-1395-z.

PMID:
30830393
14.

Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel.

Gehrke S, Rice S, Stefanoni D, Wilkerson RB, Nemkov T, Reisz JA, Hansen KC, Lucas A, Cabrales P, Drew K, D'Alessandro A.

J Proteome Res. 2019 Apr 5;18(4):1827-1841. doi: 10.1021/acs.jproteome.9b00018. Epub 2019 Feb 28.

PMID:
30793910
15.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2019 Feb 11;35(2):333-335. doi: 10.1016/j.ccell.2019.01.013. No abstract available.

16.

Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.

Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB.

Blood Transfus. 2019 Sep;17(5):347-356. doi: 10.2450/2018.0188-18. Epub 2018 Dec 13.

17.

Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes.

Rogers SC, Dosier LB, McMahon TJ, Zhu H, Timm D, Zhang H, Herbert J, Atallah J, Palmer GM, Cook A, Ernst M, Prakash J, Terng M, Towfighi P, Doctor R, Said A, Joens MS, Fitzpatrick JAJ, Hanna G, Lin X, Reisz JA, Nemkov T, D'Alessandro A, Doctor A.

PLoS One. 2018 Dec 21;13(12):e0209201. doi: 10.1371/journal.pone.0209201. eCollection 2018.

18.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT.

Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005. Erratum in: Cancer Cell. 2019 Feb 11;35(2):333-335.

19.

Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics.

D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Transfusion. 2019 Jan;59(1):89-100. doi: 10.1111/trf.14979. Epub 2018 Oct 24.

PMID:
30353560
20.

Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.

Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE.

Mol Metab. 2018 Dec;18:25-41. doi: 10.1016/j.molmet.2018.09.008. Epub 2018 Sep 28.

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