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Items: 30

1.

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

Schnute ME, McReynolds MD, Kasten T, Yates M, Jerome G, Rains JW, Hall T, Chrencik J, Kraus M, Cronin CN, Saabye M, Highkin MK, Broadus R, Ogawa S, Cukyne K, Zawadzke LE, Peterkin V, Iyanar K, Scholten JA, Wendling J, Fujiwara H, Nemirovskiy O, Wittwer AJ, Nagiec MM.

Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929.

PMID:
22397330
2.

High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry.

Highkin MK, Yates MP, Nemirovskiy OV, Lamarr WA, Munie GE, Rains JW, Masferrer JL, Nagiec MM.

J Biomol Screen. 2011 Feb;16(2):272-7. doi: 10.1177/1087057110391656.

PMID:
21297110
3.

An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation.

Dufield DR, Nemirovskiy OV, Jennings MG, Tortorella MD, Malfait AM, Mathews WR.

Anal Biochem. 2010 Nov 15;406(2):113-23. doi: 10.1016/j.ab.2010.06.044. Epub 2010 Jul 23.

PMID:
20603097
5.

Pharmacokinetic/pharmacodynamic (PK/PD) differentiation of native and PEGylated recombinant human growth hormone (rhGH and PEG-rhGH) in the rat model of osteoarthritis.

Nemirovskiy O, Zheng YJ, Tung D, Korniski B, Settle S, Skepner A, Yates M, Aggarwal P, Sunyer T, Aguiar DJ.

Xenobiotica. 2010 Aug;40(8):586-92. doi: 10.3109/00498254.2010.488303.

PMID:
20509748
6.
7.

A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation.

Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, Johnston A, Murphy M, Nemirovskiy O, Ogawa S, Pegg L, Pelc M, Prinsen M, Schnute M, Wendling J, Wene S, Weinberg R, Wittwer A, Zweifel B, Masferrer J.

J Pharmacol Exp Ther. 2010 Jul;334(1):310-7. doi: 10.1124/jpet.110.165845. Epub 2010 Apr 14.

PMID:
20392816
8.

Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity.

Rajagopalan LE, Davies MS, Kahn LE, Kornmeier CM, Shimada H, Steiner TA, Zweifel BS, Wendling JM, Payne MA, Loeffler RF, Case BL, Norton MB, Parikh MD, Nemirovskiy OV, Mourey RJ, Masferrer JL, Misko TP, Kolodziej SA.

J Pharmacol Exp Ther. 2010 Jun;333(3):707-16. doi: 10.1124/jpet.110.166033. Epub 2010 Mar 12.

PMID:
20228155
9.

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.

Biochem Pharmacol. 2010 May 15;79(10):1445-54. doi: 10.1016/j.bcp.2010.01.003. Epub 2010 Jan 11.

PMID:
20067770
10.

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

Schnute ME, O'Brien PM, Nahra J, Morris M, Howard Roark W, Hanau CE, Ruminski PG, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Patt WC, Shieh HS, Collins B, Pavlovsky AG, Palmquist KE, Aston KW, Hitchcock J, Rogers MD, McDonald J, Johnson AR, Munie GE, Wittwer AJ, Man CF, Settle SL, Nemirovskiy O, Vickery LE, Agawal A, Dyer RD, Sunyer T.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. doi: 10.1016/j.bmcl.2009.11.081. Epub 2009 Nov 22.

PMID:
20005097
11.

ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).

Zack MD, Malfait AM, Skepner AP, Yates MP, Griggs DW, Hall T, Hills RL, Alston JT, Nemirovskiy OV, Radabaugh MR, Leone JW, Arner EC, Tortorella MD.

Arthritis Rheum. 2009 Sep;60(9):2704-13. doi: 10.1002/art.24753.

12.

Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development.

Karsdal MA, Henriksen K, Leeming DJ, Mitchell P, Duffin K, Barascuk N, Klickstein L, Aggarwal P, Nemirovskiy O, Byrjalsen I, Qvist P, Bay-Jensen AC, Dam EB, Madsen SH, Christiansen C.

Biomarkers. 2009 May;14(3):181-202. doi: 10.1080/13547500902777608. Review.

PMID:
19399662
13.
14.

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS' role in disease.

Nemirovskiy OV, Radabaugh MR, Aggarwal P, Funckes-Shippy CL, Mnich SJ, Meyer DM, Sunyer T, Rodney Mathews W, Misko TP.

Nitric Oxide. 2009 May;20(3):150-6. doi: 10.1016/j.niox.2008.12.005. Epub 2008 Dec 25.

PMID:
19146971
15.

Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry.

Li N, Nemirovskiy OV, Zhang Y, Yuan H, Mo J, Ji C, Zhang B, Brayman TG, Lepsy C, Heath TG, Lai Y.

Anal Biochem. 2008 Sep 15;380(2):211-22. doi: 10.1016/j.ab.2008.05.032. Epub 2008 May 27.

PMID:
18558078
16.

Discovery and development of the N-terminal procollagen type II (NPII) biomarker: a tool for measuring collagen type II synthesis.

Nemirovskiy OV, Sunyer T, Aggarwal P, Abrams M, Hellio Le Graverand MP, Mathews WR.

Osteoarthritis Cartilage. 2008 Dec;16(12):1494-500. doi: 10.1016/j.joca.2008.04.021. Epub 2008 Jun 16.

17.

Immunoaffinity liquid chromatography-tandem mass spectrometry detection of nitrotyrosine in biological fluids: development of a clinically translatable biomarker.

Radabaugh MR, Nemirovskiy OV, Misko TP, Aggarwal P, Mathews WR.

Anal Biochem. 2008 Sep 1;380(1):68-76. doi: 10.1016/j.ab.2008.05.019. Epub 2008 May 20.

PMID:
18539125
18.
19.

Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.

Hills R, Mazzarella R, Fok K, Liu M, Nemirovskiy O, Leone J, Zack MD, Arner EC, Viswanathan M, Abujoub A, Muruganandam A, Sexton DJ, Bassill GJ, Sato AK, Malfait AM, Tortorella MD.

J Biol Chem. 2007 Apr 13;282(15):11101-9. Epub 2007 Feb 20.

20.

Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo.

Nemirovskiy OV, Dufield DR, Sunyer T, Aggarwal P, Welsch DJ, Mathews WR.

Anal Biochem. 2007 Feb 1;361(1):93-101. Epub 2006 Nov 15. Erratum in: Anal Biochem. 2007 Nov 15;370(2):258.

PMID:
17187753
21.

Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis.

Hellio Le Graverand MP, Brandt KD, Mazzuca SA, Katz BP, Buck R, Lane KA, Pickering E, Nemirovskiy OV, Sunyer T, Welsch DJ.

Osteoarthritis Cartilage. 2006 Nov;14(11):1189-95. Epub 2006 Jun 6.

22.

Unexpected fragmentation of beta-substituted meso-tetraphenylporphyrins induced by high-energy collisional activation.

Domingues MR, Marques MG, Alonso CM, Neves MG, Cavaleiro JA, Ferrer-Correia AJ, Nemirovskiy OV, Gross ML.

J Am Soc Mass Spectrom. 2002 Dec;13(12):1427-31.

PMID:
12484462
23.

Differentiation of positional isomers of nitro meso-tetraphenylporphyrins by tandem mass spectrometry.

Domingues MR, Marques MG, Domingues P, Neves MG, Cavaleiro JA, Ferrer-Correia AJ, Nemirovskiy OV, Gross ML.

J Am Soc Mass Spectrom. 2001 Apr;12(4):381-4.

25.
26.

Do charge-remote fragmentations occur under matrix-assisted laser desorption ionization post-source decompositions and matrix-assisted laser desorption ionization collisionally activated decompositions?

Domingues MR, S-Marques MG, Vale CA, Neves MG, Cavaleiro JA, Ferrer-Correia AJ, Nemirovskiy OV, Gross ML.

J Am Soc Mass Spectrom. 1999 Mar;10(3):217-23.

27.

Gas phase studies of the interactions of Fe2+ with cysteine-containing peptides.

Nemirovskiy OV, Gross ML.

J Am Soc Mass Spectrom. 1998 Dec;9(12):1285-92.

28.

Determination of calcium binding sites in gas-phase small peptides by tandem mass spectrometry.

Nemirovskiy OV, Gross ML.

J Am Soc Mass Spectrom. 1998 Oct;9(10):1020-8.

29.

High- and low-energy collisionally activated decompositions of octaethylporphyrin and its metal complexes.

Domingues MR, Nemirovskiy OV, Marques MG, Neves MG, Cavaleiro JA, Ferrer-Correia AJ, Gross ML.

J Am Soc Mass Spectrom. 1998 Aug;9(8):767-74.

30.

Complexes of iron(II) with cysteine-containing peptides in the gas phase.

Nemirovskiy OV, Gross ML.

J Am Soc Mass Spectrom. 1996 Sep;7(9):977-80. doi: 10.1016/1044-0305(96)00054-2.

PMID:
24203612

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