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Complement Seals a Virus to Block Infection.

Smith JG, Nemerow GR.

Cell Host Microbe. 2019 Apr 10;25(4):482-483. doi: 10.1016/j.chom.2019.03.010.


Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells.

Tran TTP, Eichholz K, Amelio P, Moyer C, Nemerow GR, Perreau M, Mennechet FJD, Kremer EJ.

PLoS Pathog. 2018 Aug 20;14(8):e1007127. doi: 10.1371/journal.ppat.1007127. eCollection 2018 Aug.


Revised Crystal Structure of Human Adenovirus Reveals the Limits on Protein IX Quasi-Equivalence and on Analyzing Large Macromolecular Complexes.

Kundhavai Natchiar S, Venkataraman S, Mullen TM, Nemerow GR, Reddy VS.

J Mol Biol. 2018 Oct 19;430(21):4132-4141. doi: 10.1016/j.jmb.2018.08.011. Epub 2018 Aug 17.


A single point mutation in precursor protein VI doubles the mechanical strength of human adenovirus.

van Rosmalen MGM, Nemerow GR, Wuite GJL, Roos WH.

J Biol Phys. 2018 Jun;44(2):119-132. doi: 10.1007/s10867-017-9479-y. Epub 2017 Dec 15.


Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity.

Nemerow GR, Stewart PL.

Viruses. 2016 Dec 21;8(12). pii: E337. doi: 10.3390/v8120337. Review.


A Single Maturation Cleavage Site in Adenovirus Impacts Cell Entry and Capsid Assembly.

Moyer CL, Besser ES, Nemerow GR.

J Virol. 2015 Oct 21;90(1):521-32. doi: 10.1128/JVI.02014-15. Print 2016 Jan 1.


Adenovirus tales: from the cell surface to the nuclear pore complex.

Kremer EJ, Nemerow GR.

PLoS Pathog. 2015 Jun 4;11(6):e1004821. doi: 10.1371/journal.ppat.1004821. eCollection 2015 Jun. Review. No abstract available.


Adenovirus membrane penetration: Tickling the tail of a sleeping dragon.

Wiethoff CM, Nemerow GR.

Virology. 2015 May;479-480:591-9. doi: 10.1016/j.virol.2015.03.006. Epub 2015 Mar 19. Review.


Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214.

Cassany A, Ragues J, Guan T, Bégu D, Wodrich H, Kann M, Nemerow GR, Gerace L.

J Virol. 2015 Feb;89(3):1719-30. doi: 10.1128/JVI.02639-14. Epub 2014 Nov 19.


Reply to Campos: Revised structures of adenovirus cement proteins represent a consensus model for understanding virus assembly and disassembly.

Reddy VS, Nemerow GR.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4544-5. doi: 10.1073/pnas.1417014111. Epub 2014 Oct 10. No abstract available.


Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection.

Reddy VS, Nemerow GR.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11715-20. doi: 10.1073/pnas.1408462111. Epub 2014 Jul 28.


Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative.

Sanchez-Cespedes J, Moyer CL, Whitby LR, Boger DL, Nemerow GR.

Antiviral Res. 2014 Aug;108:65-73. doi: 10.1016/j.antiviral.2014.05.010. Epub 2014 Jun 4.


Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V.

Pérez-Vargas J, Vaughan RC, Houser C, Hastie KM, Kao CC, Nemerow GR.

J Virol. 2014 Aug;88(16):9287-96. doi: 10.1128/JVI.00935-14. Epub 2014 Jun 4.


The cleaved N-terminus of pVI binds peripentonal hexons in mature adenovirus.

Snijder J, Benevento M, Moyer CL, Reddy V, Nemerow GR, Heck AJ.

J Mol Biol. 2014 May 1;426(9):1971-9. doi: 10.1016/j.jmb.2014.02.022. Epub 2014 Mar 5.


Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics.

Benevento M, Di Palma S, Snijder J, Moyer CL, Reddy VS, Nemerow GR, Heck AJ.

J Biol Chem. 2014 Apr 18;289(16):11421-30. doi: 10.1074/jbc.M113.537498. Epub 2014 Mar 3.


An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5.

Flatt JW, Kim R, Smith JG, Nemerow GR, Stewart PL.

PLoS One. 2013 Apr 19;8(4):e61571. doi: 10.1371/journal.pone.0061571. Print 2013.


Coagulation factor defends adenovirus from immune attack.

Nemerow GR.

Nat Med. 2013 Apr;19(4):406-7. doi: 10.1038/nm.3149. No abstract available.


Integrin and defensin modulate the mechanical properties of adenovirus.

Snijder J, Reddy VS, May ER, Roos WH, Nemerow GR, Wuite GJ.

J Virol. 2013 Mar;87(5):2756-66. doi: 10.1128/JVI.02516-12. Epub 2012 Dec 26.


Guiding plant virus particles to integrin-displaying cells.

Hovlid ML, Steinmetz NF, Laufer B, Lau JL, Kuzelka J, Wang Q, Hyypiä T, Nemerow GR, Kessler H, Manchester M, Finn MG.

Nanoscale. 2012 Jun 21;4(12):3698-705. doi: 10.1039/c2nr30571b. Epub 2012 May 15.


Disulfide-bond formation by a single cysteine mutation in adenovirus protein VI impairs capsid release and membrane lysis.

Moyer CL, Nemerow GR.

Virology. 2012 Jun 20;428(1):41-7. doi: 10.1016/j.virol.2012.03.024. Epub 2012 Apr 17.


Structure of human adenovirus.

Nemerow GR, Stewart PL, Reddy VS.

Curr Opin Virol. 2012 Apr;2(2):115-21. doi: 10.1016/j.coviro.2011.12.008. Epub 2012 Jan 18. Review.


Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptors.

Khare R, Reddy VS, Nemerow GR, Barry MA.

J Virol. 2012 Feb;86(4):2293-301. doi: 10.1128/JVI.05760-11. Epub 2011 Dec 7.


Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.

Won S, Eidenschenk C, Arnold CN, Siggs OM, Sun L, Brandl K, Mullen TM, Nemerow GR, Moresco EM, Beutler B.

J Virol. 2012 Feb;86(3):1802-8. doi: 10.1128/JVI.05660-11. Epub 2011 Nov 23.


Viral weapons of membrane destruction: variable modes of membrane penetration by non-enveloped viruses.

Moyer CL, Nemerow GR.

Curr Opin Virol. 2011 Jul;1(1):44-9. doi: 10.1016/j.coviro.2011.05.002. Review.


Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm.

Han M, Kickhoefer VA, Nemerow GR, Rome LH.

ACS Nano. 2011 Aug 23;5(8):6128-37. doi: 10.1021/nn2014613. Epub 2011 Jul 26.


Functional genetic and biophysical analyses of membrane disruption by human adenovirus.

Moyer CL, Wiethoff CM, Maier O, Smith JG, Nemerow GR.

J Virol. 2011 Mar;85(6):2631-41. doi: 10.1128/JVI.02321-10. Epub 2011 Jan 5.


Crystal structure of human adenovirus at 3.5 A resolution.

Reddy VS, Natchiar SK, Stewart PL, Nemerow GR.

Science. 2010 Aug 27;329(5995):1071-5. doi: 10.1126/science.1187292.


Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization.

Smith JG, Silvestry M, Lindert S, Lu W, Nemerow GR, Stewart PL.

PLoS Pathog. 2010 Jun 24;6(6):e1000959. doi: 10.1371/journal.ppat.1000959.


Crystallization and preliminary X-ray diffraction analysis of human adenovirus.

Reddy VS, Natchiar SK, Gritton L, Mullen TM, Stewart PL, Nemerow GR.

Virology. 2010 Jun 20;402(1):209-14. doi: 10.1016/j.virol.2010.03.028. Epub 2010 Apr 14.



Smith JG, Wiethoff CM, Stewart PL, Nemerow GR.

Curr Top Microbiol Immunol. 2010;343:195-224. doi: 10.1007/82_2010_16. Review.


Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection.

Nguyen EK, Nemerow GR, Smith JG.

J Virol. 2010 Apr;84(8):4041-9. doi: 10.1128/JVI.02471-09. Epub 2010 Feb 3.


Cryo-electron microscopy structure of an adenovirus-integrin complex indicates conformational changes in both penton base and integrin.

Lindert S, Silvestry M, Mullen TM, Nemerow GR, Stewart PL.

J Virol. 2009 Nov;83(22):11491-501. doi: 10.1128/JVI.01214-09. Epub 2009 Sep 2.


A new link between virus cell entry and inflammation: adenovirus interaction with integrins induces specific proinflammatory responses.

Nemerow GR.

Mol Ther. 2009 Sep;17(9):1490-1. doi: 10.1038/mt.2009.177. Review. No abstract available.


Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect.

Silvestry M, Lindert S, Smith JG, Maier O, Wiethoff CM, Nemerow GR, Stewart PL.

J Virol. 2009 Aug;83(15):7375-83. doi: 10.1128/JVI.00331-09. Epub 2009 May 20.


Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer.

Lai CY, Wiethoff CM, Kickhoefer VA, Rome LH, Nemerow GR.

ACS Nano. 2009 Mar 24;3(3):691-9. doi: 10.1021/nn8008504.


Insights into adenovirus host cell interactions from structural studies.

Nemerow GR, Pache L, Reddy V, Stewart PL.

Virology. 2009 Feb 20;384(2):380-8. doi: 10.1016/j.virol.2008.10.016. Epub 2008 Nov 20. Review.


Structural variations in species B adenovirus fibers impact CD46 association.

Pache L, Venkataraman S, Reddy VS, Nemerow GR.

J Virol. 2008 Aug;82(16):7923-31. doi: 10.1128/JVI.00754-08. Epub 2008 Jun 4.


Neutralizing antibody blocks adenovirus infection by arresting microtubule-dependent cytoplasmic transport.

Smith JG, Cassany A, Gerace L, Ralston R, Nemerow GR.

J Virol. 2008 Jul;82(13):6492-500. doi: 10.1128/JVI.00557-08. Epub 2008 Apr 30.


Conservation of fiber structure and CD46 usage by subgroup B2 adenoviruses.

Pache L, Venkataraman S, Nemerow GR, Reddy VS.

Virology. 2008 Jun 5;375(2):573-9. doi: 10.1016/j.virol.2008.02.013. Epub 2008 Mar 11.


Mechanism of adenovirus neutralization by Human alpha-defensins.

Smith JG, Nemerow GR.

Cell Host Microbe. 2008 Jan 17;3(1):11-9. doi: 10.1016/j.chom.2007.12.001.


Cell integrins: commonly used receptors for diverse viral pathogens.

Stewart PL, Nemerow GR.

Trends Microbiol. 2007 Nov;15(11):500-7. Epub 2007 Nov 7. Review.


Enhancement of gene transfer to human myeloid cells by adenovirus-fiber complexes.

Nepomuceno RR, Pache L, Nemerow GR.

Mol Ther. 2007 Mar;15(3):571-8. Epub 2006 Dec 19.


Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses.

Iacobelli-Martinez M, Nemerow GR.

J Virol. 2007 Feb;81(3):1305-12. Epub 2006 Nov 15.


Beta1 integrin mediates internalization of mammalian reovirus.

Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA, Zutter MM, Nemerow GR, Bergelson JM, Dermody TS.

J Virol. 2006 Mar;80(6):2760-70.


CD46-utilizing adenoviruses inhibit C/EBPbeta-dependent expression of proinflammatory cytokines.

Iacobelli-Martinez M, Nepomuceno RR, Connolly J, Nemerow GR.

J Virol. 2005 Sep;79(17):11259-68.


The influence of adenovirus fiber structure and function on vector development for gene therapy.

Nicklin SA, Wu E, Nemerow GR, Baker AH.

Mol Ther. 2005 Sep;12(3):384-93. Review.


Antiviral cyclic D,L-alpha-peptides: targeting a general biochemical pathway in virus infections.

Horne WS, Wiethoff CM, Cui C, Wilcoxen KM, Amorin M, Ghadiri MR, Nemerow GR.

Bioorg Med Chem. 2005 Sep 1;13(17):5145-53.


CryoEM structure at 9A resolution of an adenovirus vector targeted to hematopoietic cells.

Saban SD, Nepomuceno RR, Gritton LD, Nemerow GR, Stewart PL.

J Mol Biol. 2005 Jun 10;349(3):526-37.


Adenovirus protein VI mediates membrane disruption following capsid disassembly.

Wiethoff CM, Wodrich H, Gerace L, Nemerow GR.

J Virol. 2005 Feb;79(4):1992-2000.

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