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Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer.

Kleczko EK, Kwak JW, Schenk EL, Nemenoff RA.

Front Immunol. 2019 May 10;10:954. doi: 10.3389/fimmu.2019.00954. eCollection 2019. Review.


Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.

Bullock BL, Kimball AK, Poczobutt JM, Neuwelt AJ, Li HY, Johnson AM, Kwak JW, Kleczko EK, Kaspar RE, Wagner EK, Hopp K, Schenk EL, Weiser-Evans MC, Clambey ET, Nemenoff RA.

Life Sci Alliance. 2019 May 27;2(3). pii: e201900328. doi: 10.26508/lsa.201900328. Print 2019 Jun.


Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors Through TGF-β1.

Sippel TR, Johnson AM, Li HY, Hanson D, Nguyen TT, Bullock BL, Poczobutt JM, Kwak JW, Kleczko EK, Weiser-Evans MC, Nemenoff RA.

Mol Cancer Res. 2019 May 14. pii: molcanres.0236.2019. doi: 10.1158/1541-7786.MCR-19-0236. [Epub ahead of print]


Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin.

Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML.

Mol Pharmacol. 2019 Jan;95(1):20-32. doi: 10.1124/mol.118.113159. Epub 2018 Nov 7.


CD8+ T cells modulate autosomal dominant polycystic kidney disease progression.

Kleczko EK, Marsh KH, Tyler LC, Furgeson SB, Bullock BL, Altmann CJ, Miyazaki M, Gitomer BY, Harris PC, Weiser-Evans MCM, Chonchol MB, Clambey ET, Nemenoff RA, Hopp K.

Kidney Int. 2018 Dec;94(6):1127-1140. doi: 10.1016/j.kint.2018.06.025. Epub 2018 Sep 21.


Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia.

Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA.

Cancer Res. 2018 Sep 1;78(17):4971-4983. doi: 10.1158/0008-5472.CAN-17-3822. Epub 2018 Jul 11.


Adenoviral vectors transduce alveolar macrophages in lung cancer models.

Tippimanchai DD, Nolan K, Poczobutt J, Verzosa G, Li H, Scarborough H, Huang J, Young C, DeGregori J, Nemenoff RA, Malkoski SP.

Oncoimmunology. 2018 Mar 6;7(6):e1438105. doi: 10.1080/2162402X.2018.1438105. eCollection 2018.


Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II.

Li HY, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, Neuwelt A, Poczobutt JM, Sippel TR, Keith RL, Weiser-Evans MCM, Clambey E, Nemenoff RA.

Oncoimmunology. 2018 Feb 13;7(5):e1423182. doi: 10.1080/2162402X.2017.1423182. eCollection 2018.


PTEN deficiency promotes pathological vascular remodeling of human coronary arteries.

Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MC.

JCI Insight. 2018 Feb 22;3(4). pii: 97228. doi: 10.1172/jci.insight.97228. eCollection 2018 Feb 22.


A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data.

Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET.

J Immunol. 2018 Jan 1;200(1):3-22. doi: 10.4049/jimmunol.1701494.


Bone marrow-derived cPLA2α contributes to renal fibrosis progression.

Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB.

J Lipid Res. 2018 Feb;59(2):380-390. doi: 10.1194/jlr.M082362. Epub 2017 Dec 11.


Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA.

Cancer Res. 2018 Jan 1;78(1):143-156. doi: 10.1158/0008-5472.CAN-17-0240. Epub 2017 Nov 8.


The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade.

Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA.

Cancer Immunol Res. 2017 Sep;5(9):767-777. doi: 10.1158/2326-6066.CIR-16-0365. Epub 2017 Aug 17.


Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4.

Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A, Dong XR, Poczobutt J, Nemenoff RA, Weiser-Evans MC.

Circ Res. 2017 Jan 20;120(2):296-311. doi: 10.1161/CIRCRESAHA.116.309322. Epub 2016 Nov 9.


Cytosolic phospholipase A2α increases proliferation and de-differentiation of human renal tubular epithelial cells.

Montford JR, Lehman AM, Scobey MS, Weiser-Evans MC, Nemenoff RA, Furgeson SB.

Prostaglandins Other Lipid Mediat. 2016 Nov;126:1-8. doi: 10.1016/j.prostaglandins.2016.08.001. Epub 2016 Aug 21.


Never make assumptions: the complicated role of complement in urinary tract infections.

Thurman JM, Nemenoff RA.

Kidney Int. 2016 Sep;90(3):469-71. doi: 10.1016/j.kint.2016.05.023.


Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation.

Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC.

Nat Commun. 2016 Mar 4;7:10830. doi: 10.1038/ncomms10830.


Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer.

Poczobutt JM, De S, Yadav VK, Nguyen TT, Li H, Sippel TR, Weiser-Evans MC, Nemenoff RA.

J Immunol. 2016 Mar 15;196(6):2847-59. doi: 10.4049/jimmunol.1502364. Epub 2016 Feb 12.


Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.

Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA.

J Immunol. 2016 Jan 15;196(2):891-901. doi: 10.4049/jimmunol.1501648. Epub 2015 Dec 11.


CD4 T cell knockout does not protect against kidney injury and worsens cancer.

Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL.

J Mol Med (Berl). 2016 Apr;94(4):443-55. doi: 10.1007/s00109-015-1366-z. Epub 2015 Dec 1.


Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells.

Lehman AM, Montford JR, Horita H, Ostriker AC, Weiser-Evans MC, Nemenoff RA, Furgeson SB.

Mol Pharmacol. 2014 Nov;86(5):570-9. doi: 10.1124/mol.114.092163. Epub 2014 Aug 28.


Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma.

Marek LA, Hinz TK, von Mässenhausen A, Olszewski KA, Kleczko EK, Boehm D, Weiser-Evans MC, Nemenoff RA, Hoffmann H, Warth A, Gozgit JM, Perner S, Heasley LE.

Mol Cancer Res. 2014 Oct;12(10):1460-9. doi: 10.1158/1541-7786.MCR-14-0038. Epub 2014 Jun 25.


Vascular smooth muscle cell-derived transforming growth factor-β promotes maturation of activated, neointima lesion-like macrophages.

Ostriker A, Horita HN, Poczobutt J, Weiser-Evans MC, Nemenoff RA.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):877-86. doi: 10.1161/ATVBAHA.114.303214. Epub 2014 Feb 13.


Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.

Poczobutt JM, Gijon M, Amin J, Hanson D, Li H, Walker D, Weiser-Evans M, Lu X, Murphy RC, Nemenoff RA.

PLoS One. 2013 Nov 11;8(11):e79633. doi: 10.1371/journal.pone.0079633. eCollection 2013.


Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension.

Horita H, Furgeson SB, Ostriker A, Olszewski KA, Sullivan T, Villegas LR, Levine M, Parr JE, Cool CD, Nemenoff RA, Weiser-Evans MC.

J Am Heart Assoc. 2013 May 31;2(3):e000188. doi: 10.1161/JAHA.113.000188.


Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo.

Yu JA, Mauchley D, Li H, Meng X, Nemenoff RA, Fullerton DA, Weyant MJ.

J Thorac Cardiovasc Surg. 2012 Nov;144(5):1185-91. doi: 10.1016/j.jtcvs.2012.08.003.


Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells.

Yu JA, Li H, Meng X, Fullerton DA, Nemenoff RA, Mitchell JD, Weyant MJ.

J Thorac Cardiovasc Surg. 2012 Dec;144(6):1479-85. doi: 10.1016/j.jtcvs.2012.08.064. Epub 2012 Sep 29.


Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.

Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA.

Circ Res. 2012 Mar 2;110(5):739-48. doi: 10.1161/CIRCRESAHA.111.258426. Epub 2012 Jan 26.


Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

Li H, Sorenson AL, Poczobutt J, Amin J, Joyal T, Sullivan T, Crossno JT Jr, Weiser-Evans MC, Nemenoff RA.

PLoS One. 2011;6(12):e28133. doi: 10.1371/journal.pone.0028133. Epub 2011 Dec 1.


Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.

Horita HN, Simpson PA, Ostriker A, Furgeson S, Van Putten V, Weiser-Evans MC, Nemenoff RA.

Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2909-19. doi: 10.1161/ATVBAHA.111.233585. Epub 2011 Sep 22.


SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation.

Nemenoff RA, Horita H, Ostriker AC, Furgeson SB, Simpson PA, VanPutten V, Crossno J, Offermanns S, Weiser-Evans MC.

Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1300-8. doi: 10.1161/ATVBAHA.111.223701. Epub 2011 Mar 17.


Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.

Tennis MA, Van Scoyk MM, Freeman SV, Vandervest KM, Nemenoff RA, Winn RA.

Mol Cancer Res. 2010 Jun;8(6):833-43. doi: 10.1158/1541-7786.MCR-09-0400. Epub 2010 May 25.


Recombinant human erythropoietin dosing errors due to concentrated EPO.

Spiegel DM, Nemenoff RA.

Clin Nephrol. 2010 Jun;73(6):446-8.


Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1.

Tennis MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA.

Neoplasia. 2010 Mar;12(3):244-53.


Altered expression of genes profiles modulated by a combination of Astragali Radix and Angelicae Sinensis Radix in obstructed rat kidney.

Meng L, Van Putten V, Qu L, Nemenoff RA, Shang MY, Cai SQ, Li X.

Planta Med. 2010 Sep;76(13):1431-8. doi: 10.1055/s-0029-1240943. Epub 2010 Mar 1.


Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.

Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC.

Cardiovasc Res. 2010 May 1;86(2):274-82. doi: 10.1093/cvr/cvp425. Epub 2010 Jan 5.


Participation of ATP7A in macrophage mediated oxidation of LDL.

Qin Z, Konaniah ES, Neltner B, Nemenoff RA, Hui DY, Weintraub NL.

J Lipid Res. 2010 Jun;51(6):1471-7. doi: 10.1194/jlr.M003426. Epub 2009 Nov 23.


Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis.

Weiser-Evans MC, Wang XQ, Amin J, Van Putten V, Choudhary R, Winn RA, Scheinman R, Simpson P, Geraci MW, Nemenoff RA.

Cancer Res. 2009 Mar 1;69(5):1733-8. doi: 10.1158/0008-5472.CAN-08-3766. Epub 2009 Feb 10.


Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9.

Wang XQ, Li H, Van Putten V, Winn RA, Heasley LE, Nemenoff RA.

Mol Biol Cell. 2009 Feb;20(3):791-800. doi: 10.1091/mbc.E08-07-0732. Epub 2008 Nov 26.


Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells.

Marek L, Ware KE, Fritzsche A, Hercule P, Helton WR, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA Jr, Heasley LE.

Mol Pharmacol. 2009 Jan;75(1):196-207. doi: 10.1124/mol.108.049544. Epub 2008 Oct 10.


Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.

Neil JR, Johnson KM, Nemenoff RA, Schiemann WP.

Carcinogenesis. 2008 Nov;29(11):2227-35. doi: 10.1093/carcin/bgn202. Epub 2008 Aug 25.


Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-gamma Ligands in Lung Cancer.

Nemenoff RA, Weiser-Evans M, Winn RA.

PPAR Res. 2008;2008:156875. doi: 10.1155/2008/156875.


Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.

Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Weiser-Evans MC.

Circ Res. 2008 May 9;102(9):1036-45. doi: 10.1161/CIRCRESAHA.107.169896. Epub 2008 Mar 13.


Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB.

Bren-Mattison Y, Meyer AM, Van Putten V, Li H, Kuhn K, Stearman R, Weiser-Evans M, Winn RA, Heasley LE, Nemenoff RA.

Mol Pharmacol. 2008 Mar;73(3):709-17. Epub 2007 Nov 30.


C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion.

Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM.

J Immunol. 2007 Feb 1;178(3):1819-28.


Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.

Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT Jr, Heasley LE, Nemenoff RA.

J Biol Chem. 2006 Sep 15;281(37):26943-50. Epub 2006 Jul 11.


Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.

Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC.

Circ Res. 2006 Mar 31;98(6):846-55. Epub 2006 Feb 16.


Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice.

Meyer AM, Dwyer-Nield LD, Hurteau G, Keith RL, Ouyang Y, Freed BM, Kisley LR, Geraci MW, Bonventre JV, Nemenoff RA, Malkinson AM.

Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1260-6. Epub 2006 Jan 27.

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