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Items: 1 to 50 of 116

1.

HIV-1 vaccine design through minimizing envelope metastability.

He L, Kumar S, Allen JD, Huang D, Lin X, Mann CJ, Saye-Francisco KL, Copps J, Sarkar A, Blizard GS, Ozorowski G, Sok D, Crispin M, Ward AB, Nemazee D, Burton DR, Wilson IA, Zhu J.

Sci Adv. 2018 Nov 21;4(11):eaau6769. doi: 10.1126/sciadv.aau6769. eCollection 2018 Nov.

2.

PLD3 and spinocerebellar ataxia.

Gonzalez AC, Stroobants S, Reisdorf P, Gavin AL, Nemazee D, Schwudke D, D'Hooge R, Saftig P, Damme M.

Brain. 2018 Nov 1;141(11):e78. doi: 10.1093/brain/awy258. No abstract available.

PMID:
30312375
3.

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.

Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D.

Nat Immunol. 2018 Sep;19(9):942-953. doi: 10.1038/s41590-018-0179-y. Epub 2018 Aug 13.

PMID:
30111894
4.

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens.

Abbott RK, Lee JH, Menis S, Skog P, Rossi M, Ota T, Kulp DW, Bhullar D, Kalyuzhniy O, Havenar-Daughton C, Schief WR, Nemazee D, Crotty S.

Immunity. 2018 Jan 16;48(1):133-146.e6. doi: 10.1016/j.immuni.2017.11.023. Epub 2017 Dec 26.

PMID:
29287996
5.

Generation of T follicular helper cells in vitro: requirement for B-cell receptor cross-linking and cognate B- and T-cell interaction.

Kolenbrander A, Grewe B, Nemazee D, Überla K, Temchura V.

Immunology. 2018 Feb;153(2):214-224. doi: 10.1111/imm.12834. Epub 2017 Oct 9.

6.

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, Cupo A, van der Woude P, Golabek M, Sliepen K, Blane T, Kootstra N, van Breemen MJ, Pritchard LK, Stanfield RL, Crispin M, Ward AB, Stamatatos L, Klasse PJ, Moore JP, Nemazee D, Nussenzweig MC, Wilson IA, Sanders RW.

J Exp Med. 2017 Sep 4;214(9):2573-2590. doi: 10.1084/jem.20161160. Epub 2017 Aug 28.

7.

Mechanisms of central tolerance for B cells.

Nemazee D.

Nat Rev Immunol. 2017 May;17(5):281-294. doi: 10.1038/nri.2017.19. Epub 2017 Apr 3. Review.

8.

The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection.

Martinic MM, Caminschi I, O'Keeffe M, Thinnes TC, Grumont R, Gerondakis S, McKay DB, Nemazee D, Gavin AL.

J Immunol. 2017 Apr 1;198(7):2649-2660. doi: 10.4049/jimmunol.1601462. Epub 2017 Feb 15.

9.

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.

Briney B, Sok D, Jardine JG, Kulp DW, Skog P, Menis S, Jacak R, Kalyuzhniy O, de Val N, Sesterhenn F, Le KM, Ramos A, Jones M, Saye-Francisco KL, Blane TR, Spencer S, Georgeson E, Hu X, Ozorowski G, Adachi Y, Kubitz M, Sarkar A, Wilson IA, Ward AB, Nemazee D, Burton DR, Schief WR.

Cell. 2016 Sep 8;166(6):1459-1470.e11. doi: 10.1016/j.cell.2016.08.005.

10.

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.

Lai M, Gonzalez-Martin A, Cooper AB, Oda H, Jin HY, Shepherd J, He L, Zhu J, Nemazee D, Xiao C.

Nat Commun. 2016 Aug 2;7:12207. doi: 10.1038/ncomms12207.

11.

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles.

He L, de Val N, Morris CD, Vora N, Thinnes TC, Kong L, Azadnia P, Sok D, Zhou B, Burton DR, Wilson IA, Nemazee D, Ward AB, Zhu J.

Nat Commun. 2016 Jun 28;7:12041. doi: 10.1038/ncomms12041.

12.

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.

Ingale J, Stano A, Guenaga J, Sharma SK, Nemazee D, Zwick MB, Wyatt RT.

Cell Rep. 2016 May 31;15(9):1986-99. doi: 10.1016/j.celrep.2016.04.078. Epub 2016 May 19.

13.

The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

Gonzalez-Martin A, Adams BD, Lai M, Shepherd J, Salvador-Bernaldez M, Salvador JM, Lu J, Nemazee D, Xiao C.

Nat Immunol. 2016 Apr;17(4):433-40. doi: 10.1038/ni.3385. Epub 2016 Feb 22.

14.

Receptor editing and genetic variability in human autoreactive B cells.

Lang J, Ota T, Kelly M, Strauch P, Freed BM, Torres RM, Nemazee D, Pelanda R.

J Exp Med. 2016 Jan 11;213(1):93-108. doi: 10.1084/jem.20151039. Epub 2015 Dec 22.

15.

HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

Jardine JG, Ota T, Sok D, Pauthner M, Kulp DW, Kalyuzhniy O, Skog PD, Thinnes TC, Bhullar D, Briney B, Menis S, Jones M, Kubitz M, Spencer S, Adachi Y, Burton DR, Schief WR, Nemazee D.

Science. 2015 Jul 10;349(6244):156-61. doi: 10.1126/science.aac5894. Epub 2015 Jun 18.

16.

Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10.

Doyle-Cooper C, Hudson KE, Cooper AB, Ota T, Skog P, Dawson PE, Zwick MB, Schief WR, Burton DR, Nemazee D.

J Immunol. 2013 Sep 15;191(6):3186-3191. doi: 10.4049/jimmunol.1301285. Epub 2013 Aug 12.

17.

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates.

Ota T, Doyle-Cooper C, Cooper AB, Doores KJ, Aoki-Ota M, Le K, Schief WR, Wyatt RT, Burton DR, Nemazee D.

J Immunol. 2013 Sep 15;191(6):3179-85. doi: 10.4049/jimmunol.1301283. Epub 2013 Aug 12.

18.

Rational HIV immunogen design to target specific germline B cell receptors.

Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, Stamatatos L, Nemazee D, Wilson IA, Schief WR.

Science. 2013 May 10;340(6133):711-6. doi: 10.1126/science.1234150. Epub 2013 Mar 28.

19.

2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies.

Doores KJ, Huber M, Le KM, Wang SK, Doyle-Cooper C, Cooper A, Pantophlet R, Wong CH, Nemazee D, Burton DR.

J Virol. 2013 Feb;87(4):2234-41. doi: 10.1128/JVI.02820-12. Epub 2012 Dec 5.

20.

Anti-HIV B Cell lines as candidate vaccine biosensors.

Ota T, Doyle-Cooper C, Cooper AB, Huber M, Falkowska E, Doores KJ, Hangartner L, Le K, Sok D, Jardine J, Lifson J, Wu X, Mascola JR, Poignard P, Binley JM, Chakrabarti BK, Schief WR, Wyatt RT, Burton DR, Nemazee D.

J Immunol. 2012 Nov 15;189(10):4816-24. doi: 10.4049/jimmunol.1202165. Epub 2012 Oct 12.

21.

Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.

Aoki-Ota M, Torkamani A, Ota T, Schork N, Nemazee D.

J Immunol. 2012 Mar 1;188(5):2305-15. doi: 10.4049/jimmunol.1103484. Epub 2012 Jan 27.

22.

Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.

Duong BH, Ota T, Aoki-Ota M, Cooper AB, Ait-Azzouzene D, Vela JL, Gavin AL, Nemazee D.

J Immunol. 2011 Dec 1;187(11):5596-605. doi: 10.4049/jimmunol.1102479. Epub 2011 Oct 31.

23.

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.

Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B.

Nat Immunol. 2011 May;12(5):434-40. doi: 10.1038/ni.2012. Epub 2011 Mar 20.

24.

Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.

Ota T, Ota M, Duong BH, Gavin AL, Nemazee D.

J Exp Med. 2011 Mar 14;208(3):617-29. doi: 10.1084/jem.20102265. Epub 2011 Feb 28.

25.

Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.

Tiegs SL, Russell DM, Nemazee D.

J Immunol. 2011 Feb 1;186(3):1313-24. No abstract available.

26.

Regulation of the B cell receptor repertoire and self-reactivity by BAFF.

Ota M, Duong BH, Torkamani A, Doyle CM, Gavin AL, Ota T, Nemazee D.

J Immunol. 2010 Oct 1;185(7):4128-36. doi: 10.4049/jimmunol.1002176. Epub 2010 Sep 3.

27.

Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.

Aït-Azzouzene D, Kono DH, Gonzalez-Quintial R, McHeyzer-Williams LJ, Lim M, Wickramarachchi D, Gerdes T, Gavin AL, Skog P, McHeyzer-Williams MG, Nemazee D, Theofilopoulos AN.

J Immunol. 2010 Jul 15;185(2):1015-27. doi: 10.4049/jimmunol.1000698. Epub 2010 Jun 16.

28.

Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.

Duong BH, Ota T, Aït-Azzouzene D, Aoki-Ota M, Vela JL, Huber C, Walsh K, Gavin AL, Nemazee D.

J Immunol. 2010 Apr 15;184(8):4143-58. doi: 10.4049/jimmunol.0903564. Epub 2010 Mar 15.

29.

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.

Siggs OM, Berger M, Krebs P, Arnold CN, Eidenschenk C, Huber C, Pirie E, Smart NG, Khovananth K, Xia Y, McInerney G, Karlsson Hedestam GB, Nemazee D, Beutler B.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3046-51. doi: 10.1073/pnas.0915098107. Epub 2010 Jan 28.

30.

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.

Duong BH, Tian H, Ota T, Completo G, Han S, Vela JL, Ota M, Kubitz M, Bovin N, Paulson JC, Nemazee D.

J Exp Med. 2010 Jan 18;207(1):173-87. doi: 10.1084/jem.20091873. Epub 2009 Dec 28. Erratum in: J Exp Med. 2010 Feb 15;207(2):445. Paulson, James [corrected to Paulson, James C].

31.

Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.

Beck K, Peak MM, Ota T, Nemazee D, Murre C.

J Exp Med. 2009 Sep 28;206(10):2271-84. doi: 10.1084/jem.20090756. Epub 2009 Sep 14.

32.

Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE.

Ota T, Aoki-Ota M, Duong BH, Nemazee D.

J Immunol. 2009 Jun 15;182(12):8110-7. doi: 10.4049/jimmunol.0900300.

33.

FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles.

Huber C, Mårtensson A, Bokoch GM, Nemazee D, Gavin AL.

J Biol Chem. 2008 Dec 5;283(49):34002-12. doi: 10.1074/jbc.M803957200. Epub 2008 Oct 6.

34.

Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production.

Vela JL, Aït-Azzouzene D, Duong BH, Ota T, Nemazee D.

Immunity. 2008 Feb;28(2):161-70. doi: 10.1016/j.immuni.2007.12.011. Epub 2008 Feb 7.

35.

Reduced receptor editing in lupus-prone MRL/lpr mice.

Lamoureux JL, Watson LC, Cherrier M, Skog P, Nemazee D, Feeney AJ.

J Exp Med. 2007 Nov 26;204(12):2853-64. Epub 2007 Oct 29.

36.

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

Verkoczy L, Duong B, Skog P, Aït-Azzouzene D, Puri K, Vela JL, Nemazee D.

J Immunol. 2007 May 15;178(10):6332-41.

37.

Polyspecificity of T cell and B cell receptor recognition.

Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE.

Semin Immunol. 2007 Aug;19(4):216-24. Epub 2007 Mar 29. Review.

38.

Role of RS/kappaDE in B cell receptor editing.

Vela JL, Nemazee D.

Adv Exp Med Biol. 2007;596:169-72. Review. No abstract available.

PMID:
17338186
39.

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.

Gavin AL, Hoebe K, Duong B, Ota T, Martin C, Beutler B, Nemazee D.

Science. 2006 Dec 22;314(5807):1936-8.

40.

Receptor editing in lymphocyte development and central tolerance.

Nemazee D.

Nat Rev Immunol. 2006 Oct;6(10):728-40. Review.

PMID:
16998507
41.

Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.

Watson LC, Moffatt-Blue CS, McDonald RZ, Kompfner E, Ait-Azzouzene D, Nemazee D, Theofilopoulos AN, Kono DH, Feeney AJ.

J Immunol. 2006 Jul 15;177(2):1120-8.

42.

Immunology: Toll-like receptors and antibody responses.

Nemazee D, Gavin A, Hoebe K, Beutler B.

Nature. 2006 May 18;441(7091):E4; discussion E4.

44.

Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand.

Aït-Azzouzene D, Verkoczy L, Duong B, Skog P, Gavin AL, Nemazee D.

J Immunol. 2006 Jan 15;176(2):939-48.

46.

deltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models.

Gavin AL, Duong B, Skog P, Aït-Azzouzene D, Greaves DR, Scott ML, Nemazee D.

J Immunol. 2005 Jul 1;175(1):319-28.

47.

The design and implementation of the immune epitope database and analysis resource.

Peters B, Sidney J, Bourne P, Bui HH, Buus S, Doh G, Fleri W, Kronenberg M, Kubo R, Lund O, Nemazee D, Ponomarenko JV, Sathiamurthy M, Schoenberger SP, Stewart S, Surko P, Way S, Wilson S, Sette A.

Immunogenetics. 2005 Jun;57(5):326-36. Epub 2005 May 14.

48.

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

Verkoczy L, Aït-Azzouzene D, Skog P, Märtensson A, Lang J, Duong B, Nemazee D.

Immunity. 2005 Apr;22(4):519-31.

49.

The immune epitope database and analysis resource: from vision to blueprint.

Peters B, Sidney J, Bourne P, Bui HH, Buus S, Doh G, Fleri W, Kronenberg M, Kubo R, Lund O, Nemazee D, Ponomarenko JV, Sathiamurthy M, Schoenberger S, Stewart S, Surko P, Way S, Wilson S, Sette A.

PLoS Biol. 2005 Mar;3(3):e91. No abstract available.

50.

An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system.

Ait-Azzouzene D, Verkoczy L, Peters J, Gavin A, Skog P, Vela JL, Nemazee D.

J Exp Med. 2005 Mar 7;201(5):817-28. Epub 2005 Feb 28.

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