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Items: 1 to 50 of 356

1.

Sex and gender influence symptom manifestation and survival in multiple system atrophy.

Coon EA, Nelson RM, Sletten DM, Suarez MD, Ahlskog JE, Benarroch EE, Sandroni P, Mandrekar JN, Low PA, Singer W.

Auton Neurosci. 2019 Jul;219:49-52. doi: 10.1016/j.autneu.2019.04.002. Epub 2019 Apr 24.

PMID:
31122601
2.

Incorporating Innovative Techniques Toward Extrapolation and Efficient Pediatric Drug Development.

Gamalo-Siebers M, Hampson L, Kordy K, Weber S, Nelson RM, Portman R.

Ther Innov Regul Sci. 2019 Sep;53(5):567-578. doi: 10.1177/2168479019842541. Epub 2019 May 13.

PMID:
31084211
3.

The Potential Benefits of Research May Justify Certain Research Risks.

Wendler D, Nelson RM, Lantos JD.

Pediatrics. 2019 Mar;143(3). pii: e20181703. doi: 10.1542/peds.2018-1703. Epub 2019 Feb 20.

PMID:
30787097
4.

Advancing HIV Biomedical Prevention Research for At-Risk Adolescents.

Kapogiannis BG, Nelson RM, Siberry GK, Lee S, Hazra R.

J Acquir Immune Defic Syndr. 2018 Dec 15;79(5):535-542. doi: 10.1097/QAI.0000000000001853.

PMID:
30204722
5.

The Food and Drug Administration's Federal Review of a Pediatric Muscular Dystrophy Protocol.

Snyder DL, Nelson RM.

IRB. 2018 Jan-Feb;40(1):18-20. No abstract available.

6.

A Framework for Evaluating a Minor's Involvement in Medical Decision Making.

Snyder DL, Nelson RM.

Am J Bioeth. 2018 Mar;18(3):10-12. doi: 10.1080/15265161.2017.1418938. No abstract available.

7.

Minimal Risk in Pediatric Research: A Philosophical Review and Reconsideration.

Rossi J, Nelson RM.

Account Res. 2017;24(7):407-432. doi: 10.1080/08989621.2017.1363650. Epub 2017 Aug 4.

8.

2017 ACC/AAP/AHA Health Policy Statement on Opportunities and Challenges in Pediatric Drug Development: Learning From Sildenafil.

Sable CA, Ivy DD, Beekman RH 3rd, Clayton-Jeter HD, Jenkins KJ, Mahle WT, Morrow WR, Murphy MD, Nelson RM, Rosenthal GL, Stockbridge N, Wessel DL.

J Am Coll Cardiol. 2017 Jul 25;70(4):495-503. doi: 10.1016/j.jacc.2017.04.007. Epub 2017 Jun 29. No abstract available. Erratum in: J Am Coll Cardiol. 2017 Sep 5;70(10):1309.

9.

2017 ACC/AAP/AHA Health Policy Statement on Opportunities and Challenges in Pediatric Drug Development: Learning From Sildenafil.

Sable CA, Ivy DD, Beekman RH 3rd, Clayton-Jeter HD, Jenkins KJ, Mahle WT, Morrow WR, Murphy MD, Nelson RM, Rosenthal GL, Stockbridge N, Wessel DL.

Circ Cardiovasc Qual Outcomes. 2017 Jul;10(7). pii: e000026. doi: 10.1161/HCQ.0000000000000026. Review. No abstract available. Erratum in: Circ Cardiovasc Qual Outcomes. 2017 Nov;10(11):e000035.

10.

Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary.

Wang J, Johnson T, Sahin L, Tassinari MS, Anderson PO, Baker TE, Bucci-Rechtweg C, Burckart GJ, Chambers CD, Hale TW, Johnson-Lyles D, Nelson RM, Nguyen C, Pica-Branco D, Ren Z, Sachs H, Sauberan J, Zajicek A, Ito S, Yao LP.

Clin Pharmacol Ther. 2017 Jun;101(6):736-744. doi: 10.1002/cpt.676. Review.

11.

Meeting the goal of concurrent adolescent and adult licensure of HIV prevention and treatment strategies.

Hume M, Lewis LL, Nelson RM.

J Med Ethics. 2017 Dec;43(12):857-860. doi: 10.1136/medethics-2016-103600. Epub 2017 May 15.

12.

Genomewide analysis of admixture and adaptation in the Africanized honeybee.

Nelson RM, Wallberg A, Simões ZLP, Lawson DJ, Webster MT.

Mol Ecol. 2017 Jul;26(14):3603-3617. doi: 10.1111/mec.14122. Epub 2017 Apr 24.

PMID:
28378497
13.

Constitutive regulation of the glutamate/aspartate transporter EAAT1 by Calcium-Calmodulin-Dependent Protein Kinase II.

Chawla AR, Johnson DE, Zybura AS, Leeds BP, Nelson RM, Hudmon A.

J Neurochem. 2017 Feb;140(3):421-434. doi: 10.1111/jnc.13913. Epub 2017 Jan 12.

14.

Spinal Muscular Atrophy Type I: Is It Ethical to Standardize Supportive Care Intervention in Clinical Trials?

Finkel RS, Bishop KM, Nelson RM.

J Child Neurol. 2017 Feb;32(2):155-160. doi: 10.1177/0883073816671236. Epub 2016 Oct 22.

15.

Genetics of Interactive Behavior in Silver Foxes (Vulpes vulpes).

Nelson RM, Temnykh SV, Johnson JL, Kharlamova AV, Vladimirova AV, Gulevich RG, Shepeleva DV, Oskina IN, Acland GM, Rönnegård L, Trut LN, Carlborg Ö, Kukekova AV.

Behav Genet. 2017 Jan;47(1):88-101. doi: 10.1007/s10519-016-9815-1. Epub 2016 Oct 18.

PMID:
27757730
16.

Reliable and developmentally appropriate study end points are needed to achieve drug development for treatment of pediatric pulmonary arterial hypertension.

Sun H, Stockbridge N, Ariagno RL, Murphy D, Nelson RM, Rodriguez W.

J Perinatol. 2016 Dec;36(12):1029-1033. doi: 10.1038/jp.2016.103. Epub 2016 Jul 14. Review.

17.

A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay.

Kashem MA, Kennedy CA, Fogarty KE, Dimock JR, Zhang Y, Sanville-Ross ML, Skow DJ, Brunette SR, Swantek JL, Hummel HS, Swindle J, Nelson RM.

Assay Drug Dev Technol. 2016 Jan-Feb;14(1):39-49. doi: 10.1089/adt.2015.671. Epub 2015 Oct 1.

PMID:
26426296
18.

Ethical Considerations in Conducting Pediatric and Neonatal Research in Clinical Pharmacology.

Roth-Cline M, Nelson RM.

Curr Pharm Des. 2015;21(39):5619-35. Review.

PMID:
26323417
19.

Applying Regulatory Science to Develop Safe and Effective Medicines for Neonates: Report of the US Food and Drug Administration First Annual Neonatal Scientific Workshop, October 28-29, 2014.

Offringa M, Davis JM, Turner MA, Ward R, Bax R, Maldonado S, Sinha V, McCune SK, Zajicek A, Benjamin DK Jr, Bucci-Rechtweg C, Nelson RM.

Ther Innov Regul Sci. 2015 Sep;49(5):623-631. doi: 10.1177/2168479015597730.

PMID:
30227031
20.

Microdosing Studies in Children: A US Regulatory Perspective.

Roth-Cline M, Nelson RM.

Clin Pharmacol Ther. 2015 Sep;98(3):232-3. doi: 10.1002/cpt.165. Epub 2015 Jul 14.

PMID:
26095312
21.

The author replies.

Nelson RM.

Hastings Cent Rep. 2015 May-Jun;45(3):4. doi: 10.1002/hast.438. No abstract available.

PMID:
25944196
22.

Right job, wrong tool: a commentary on designing clinical trials for Ebola virus disease.

Nelson RM, Roth-Cline M, Prohaska K, Cox E, Borio L, Temple R.

Am J Bioeth. 2015;15(4):33-6. doi: 10.1080/15265161.2015.1010018. No abstract available.

PMID:
25856596
23.

Tablet Computing in Clinical Training of Pediatric Residents.

Howard DJ, Coovert SA, Coovert MD, Nelson RM.

Telemed J E Health. 2015 Jul;21(7):588-92. doi: 10.1089/tmj.2014.0130. Epub 2015 Mar 6.

PMID:
25748271
24.

Characterization of genetic diversity and gene mapping in two Swedish local chicken breeds.

Johansson AM, Nelson RM.

Front Genet. 2015 Feb 17;6:44. doi: 10.3389/fgene.2015.00044. eCollection 2015.

25.

SUPPORT: Risks, Harms, and Equipoise.

Nelson RM.

Hastings Cent Rep. 2015 Jan-Feb;45(1):40-2. doi: 10.1002/hast.415. No abstract available.

PMID:
25600385
26.

Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.

Harcken C, Riether D, Liu P, Razavi H, Patel U, Lee T, Bosanac T, Ward Y, Ralph M, Chen Z, Souza D, Nelson RM, Kukulka A, Fadra-Khan TN, Zuvela-Jelaska L, Patel M, Thomson DS, Nabozny GH.

ACS Med Chem Lett. 2014 Nov 20;5(12):1318-23. doi: 10.1021/ml500387y. eCollection 2014 Dec 11.

27.

Degrees of separation as a statistical tool for evaluating candidate genes.

Nelson RM, Pettersson ME.

Comput Biol Med. 2014 Dec;55:49-52. doi: 10.1016/j.compbiomed.2014.10.004. Epub 2014 Oct 14.

PMID:
25450218
28.

What is the preferred strength setting of the sinogram-affirmed iterative reconstruction algorithm in abdominal CT imaging?

Hardie AD, Nelson RM, Egbert R, Rieter WJ, Tipnis SV.

Radiol Phys Technol. 2015 Jan;8(1):60-3. doi: 10.1007/s12194-014-0288-8. Epub 2014 Aug 28.

PMID:
25164978
29.

Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 2: data extrapolation, trial design, and pharmacokinetics.

Sun H, Vesely R, Nelson RM, Taminiau J, Szitanyi P, Isaac M, Klein A, Uzu S, Griebel D, Mulberg AE; International Inflammatory Bowel Disease Working Group.

J Pediatr Gastroenterol Nutr. 2014 Jun;58(6):684-8. doi: 10.1097/MPG.0000000000000322.

PMID:
24866782
30.

A high-throughput scintillation proximity assay for sphingosine-1-phosphate lyase.

Kashem MA, Wa C, Wolak JP, Grafos NS, Ryan KR, Sanville-Ross ML, Fogarty KE, Rybina IV, Shoultz A, Molinaro T, Desai SN, Rajan A, Huber JD, Nelson RM.

Assay Drug Dev Technol. 2014 Jun;12(5):293-302. doi: 10.1089/adt.2014.575. Epub 2014 May 20.

PMID:
24846303
31.

Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore.

Razavi H, Riether D, Harcken C, Bentzien J, Dinallo RM, Souza D, Nelson RM, Kukulka A, Fadra-Khan TN, Pack EJ Jr, Zuvela-Jelaska L, Pelletier J, Panzenbeck M, Torcellini CA, Proudfoot JR, Nabozny GH, Thomson DS.

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1934-40. doi: 10.1016/j.bmcl.2014.03.005. Epub 2014 Mar 12.

PMID:
24656565
32.

Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.

Harcken C, Riether D, Kuzmich D, Liu P, Betageri R, Ralph M, Emmanuel M, Reeves JT, Berry A, Souza D, Nelson RM, Kukulka A, Fadra TN, Zuvela-Jelaska L, Dinallo R, Bentzien J, Nabozny GH, Thomson DS.

J Med Chem. 2014 Feb 27;57(4):1583-98. doi: 10.1021/jm4019178. Epub 2014 Feb 7.

PMID:
24506830
33.

Variance heterogeneity in Saccharomyces cerevisiae expression data: trans-regulation and epistasis.

Nelson RM, Pettersson ME, Li X, Carlborg Ö.

PLoS One. 2013 Nov 4;8(11):e79507. doi: 10.1371/journal.pone.0079507. eCollection 2013.

34.

A century after Fisher: time for a new paradigm in quantitative genetics.

Nelson RM, Pettersson ME, Carlborg Ö.

Trends Genet. 2013 Dec;29(12):669-76. doi: 10.1016/j.tig.2013.09.006. Epub 2013 Oct 23.

PMID:
24161664
35.

MAPfastR: quantitative trait loci mapping in outbred line crosses.

Nelson RM, Nettelblad C, Pettersson ME, Shen X, Crooks L, Besnier F, Alvarez-Castro JM, Rönnegård L, Ek W, Sheng Z, Kierczak M, Holmgren S, Carlborg O.

G3 (Bethesda). 2013 Dec 9;3(12):2147-9. doi: 10.1534/g3.113.008623.

36.

Alternate endpoints and clinical outcome assessments in pediatric ulcerative colitis registration trials.

Sun H, Lee JJ, Papadopoulos EJ, Lee CS, Nelson RM, Sachs HC, Rodriguez WJ, Mulberg AE.

J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):12-7. doi: 10.1097/MPG.0000000000000186.

PMID:
24121142
37.

Parental permission and child assent in research on children.

Roth-Cline M, Nelson RM.

Yale J Biol Med. 2013 Sep 20;86(3):291-301. eCollection 2013 Sep. Review.

38.

The next evolution.

Nelson RM.

Phys Ther. 2013 Oct;93(10):1415-25. doi: 10.2522/ptj.2013.mcmillan.lecture. Epub 2013 Aug 1. No abstract available.

PMID:
23907079
39.

Higher order interactions: detection of epistasis using machine learning and evolutionary computation.

Nelson RM, Kierczak M, Carlborg O.

Methods Mol Biol. 2013;1019:499-518. doi: 10.1007/978-1-62703-447-0_24.

PMID:
23756908
40.
41.

Selection on variance-controlling genes: adaptability or stability.

Pettersson ME, Nelson RM, Carlborg O.

Evolution. 2012 Dec;66(12):3945-9. doi: 10.1111/j.1558-5646.2012.01753.x. Epub 2012 Aug 24.

PMID:
23206148
42.

A capacity-based approach for addressing ancillary care needs: implications for research in resource limited settings.

Bright PL, Nelson RM.

J Med Ethics. 2012 Nov;38(11):672-6. doi: 10.1136/medethics-2011-100205. Epub 2012 May 5.

PMID:
22562947
43.

Factors related to voluntary parental decision-making in pediatric oncology.

Miller VA, Nelson RM.

Pediatrics. 2012 May;129(5):903-9. doi: 10.1542/peds.2011-3056. Epub 2012 Apr 16.

44.

Is there an objective way to compare research risks?

Rossi J, Nelson RM.

J Med Ethics. 2012 Jul;38(7):423-7. doi: 10.1136/medethics-2011-100194. Epub 2012 Feb 25.

PMID:
22367000
45.

Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores.

Betageri R, Gilmore T, Kuzmich D, Kirrane TM, Bentzien J, Wiedenmayer D, Bekkali Y, Regan J, Berry A, Latli B, Kukulka AJ, Fadra TN, Nelson RM, Goldrick S, Zuvela-Jelaska L, Souza D, Pelletier J, Dinallo R, Panzenbeck M, Torcellini C, Lee H, Pack E, Harcken C, Nabozny G, Thomson DS.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6842-51. doi: 10.1016/j.bmcl.2011.09.018. Epub 2011 Sep 10.

PMID:
21963986
46.

Sex ratio dependent dispersal when sex ratios vary between patches.

Nelson RM, Greeff JM.

J Theor Biol. 2011 Dec 7;290:81-7. doi: 10.1016/j.jtbi.2011.08.030. Epub 2011 Aug 27.

PMID:
21893071
47.

Ethical considerations in conducting pediatric research.

Roth-Cline M, Gerson J, Bright P, Lee CS, Nelson RM.

Handb Exp Pharmacol. 2011;205:219-44. doi: 10.1007/978-3-642-20195-0_11.

PMID:
21882114
48.

The concept of voluntary consent.

Nelson RM, Beauchamp T, Miller VA, Reynolds W, Ittenbach RF, Luce MF.

Am J Bioeth. 2011 Aug;11(8):6-16. doi: 10.1080/15265161.2011.583318.

PMID:
21806428
49.

Response to open peer commentaries on "the concept of voluntary consent".

Nelson RM, Beauchamp TL.

Am J Bioeth. 2011 Aug;11(8):W1-3. doi: 10.1080/15265161.2011.600621. No abstract available.

PMID:
21806424
50.

Relationship of external influence to parental distress in decision making regarding children with a life-threatening illness.

Miller VA, Luce MF, Nelson RM.

J Pediatr Psychol. 2011 Nov-Dec;36(10):1102-12. doi: 10.1093/jpepsy/jsr033. Epub 2011 Jun 21.

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