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Estimating GFR in the Elderly-New Approaches to an Old Problem.

Pavkov ME, Nelson RG.

Kidney Int Rep. 2019 Apr 10;4(6):763-765. doi: 10.1016/j.ekir.2019.04.006. eCollection 2019 Jun. No abstract available.


Changes in Albuminuria But Not GFR are Associated with Early Changes in Kidney Structure in Type 2 Diabetes.

Looker HC, Mauer M, Saulnier PJ, Harder JL, Nair V, Boustany-Kari CM, Guarnieri P, Hill J, Esplin CA, Kretzler M, Nelson RG, Najafian B.

J Am Soc Nephrol. 2019 Jun;30(6):1049-1059. doi: 10.1681/ASN.2018111166.


Birthweight and early-onset type 2 diabetes in American Indians: differential effects in adolescents and young adults and additive effects of genotype, BMI and maternal diabetes.

Olaiya MT, Wedekind LE, Hanson RL, Sinha M, Kobes S, Nelson RG, Baier LJ, Knowler WC.

Diabetologia. 2019 May 20. doi: 10.1007/s00125-019-4899-9. [Epub ahead of print]


Disparities in prediabetes and type 2 diabetes prevalence between indigenous and nonindigenous populations from Southeastern Mexico: The Comitan Study.

Jimenez-Corona A, Nelson RG, Jimenez-Corona ME, Franks PW, Aguilar-Salinas CA, Graue-Hernandez EO, Hernandez-Jimenez S, Hernandez-Avila M.

J Clin Transl Endocrinol. 2019 Apr 20;16:100191. doi: 10.1016/j.jcte.2019.100191. eCollection 2019 Jun.


A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS.

Nat Med. 2019 May;25(5):805-813. doi: 10.1038/s41591-019-0415-5. Epub 2019 Apr 22.


Use of graded Semmes Weinstein monofilament testing for ascertaining peripheral neuropathy in people with and without diabetes.

Olaiya MT, Hanson RL, Kavena KG, Sinha M, Clary D, Horton MB, Nelson RG, Knowler WC.

Diabetes Res Clin Pract. 2019 May;151:1-10. doi: 10.1016/j.diabres.2019.03.029. Epub 2019 Mar 25.


Urine metabolites are associated with glomerular lesions in type 2 diabetes.

Saulnier PJ, Darshi M, Wheelock KM, Looker HC, Fufaa GD, Knowler WC, Weil EJ, Tanamas SK, Lemley KV, Saito R, Natarajan L, Nelson RG, Sharma K.

Metabolomics. 2018 Jun 8;14(6):84. doi: 10.1007/s11306-018-1380-6.


Correlation Between Baseline GFR and Subsequent Change in GFR in Norwegian Adults Without Diabetes and in Pima Indians.

Melsom T, Nair V, Schei J, Mariani L, Stefansson VTN, Harder JL, Jenssen TG, Solbu MD, Norvik JV, Looker H, Knowler WC, Kretzler M, Nelson RG, Eriksen BO.

Am J Kidney Dis. 2019 Jun;73(6):777-785. doi: 10.1053/j.ajkd.2018.11.011. Epub 2019 Jan 28.


Home-Based Kidney Care, Patient Activation, and Risk Factors for CKD Progression in Zuni Indians: A Randomized, Controlled Clinical Trial.

Nelson RG, Pankratz VS, Ghahate DM, Bobelu J, Faber T, Shah VO.

Clin J Am Soc Nephrol. 2018 Dec 7;13(12):1801-1809. doi: 10.2215/CJN.06910618. Epub 2018 Nov 15.


Tyro3 is a podocyte protective factor in glomerular disease.

Zhong F, Chen Z, Zhang L, Xie Y, Nair V, Ju W, Kretzler M, Nelson RG, Li Z, Chen H, Wang Y, Zhang A, Lee K, Liu Z, He JC.

JCI Insight. 2018 Nov 15;3(22). pii: 123482. doi: 10.1172/jci.insight.123482.


Urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes.

Looker HC, Merchant ML, Rane MJ, Nelson RG, Kimmel PL, Rovin BH, Klein JB, Mauer M; CKD Biomarkers Consortium.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1484-F1492. doi: 10.1152/ajprenal.00183.2018. Epub 2018 Aug 22.


Cytosine methylation predicts renal function decline in American Indians.

Qiu C, Hanson RL, Fufaa G, Kobes S, Gluck C, Huang J, Chen Y, Raj D, Nelson RG, Knowler WC, Susztak K.

Kidney Int. 2018 Jun;93(6):1417-1431. doi: 10.1016/j.kint.2018.01.036. Epub 2018 Apr 27.


Role of Kidney Biopsies for Biomarker Discovery in Diabetic Kidney Disease.

Looker HC, Mauer M, Nelson RG.

Adv Chronic Kidney Dis. 2018 Mar;25(2):192-201. doi: 10.1053/j.ackd.2017.11.004. Review.


The Global Epidemiology of Diabetes and Kidney Disease.

Koye DN, Magliano DJ, Nelson RG, Pavkov ME.

Adv Chronic Kidney Dis. 2018 Mar;25(2):121-132. doi: 10.1053/j.ackd.2017.10.011. Review.


Erratum. Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes. Diabetes 2013;62:3224-3231.

Weil EJ, Fufaa G, Jones LI, Lovato T, Lemley KV, Hanson RL, Knowler WC, Bennett PH, Yee B, Myers BD, Nelson RG.

Diabetes. 2018 Mar;67(3):532. doi: 10.2337/db18-er03a. Epub 2018 Jan 5. No abstract available.


Effect of severe obesity in childhood and adolescence on risk of type 2 diabetes in youth and early adulthood in an American Indian population.

Tanamas SK, Reddy SP, Chambers MA, Clark EJ, Dunnigan DL, Hanson RL, Nelson RG, Knowler WC, Sinha M.

Pediatr Diabetes. 2018 Jun;19(4):622-629. doi: 10.1111/pedi.12627. Epub 2017 Dec 28.


ORAI channels are critical for receptor-mediated endocytosis of albumin.

Zeng B, Chen GL, Garcia-Vaz E, Bhandari S, Daskoulidou N, Berglund LM, Jiang H, Hallett T, Zhou LP, Huang L, Xu ZH, Nair V, Nelson RG, Ju W, Kretzler M, Atkin SL, Gomez MF, Xu SZ.

Nat Commun. 2017 Dec 4;8(1):1920. doi: 10.1038/s41467-017-02094-y.


Growth Tracking in Severely Obese or Underweight Children.

Chambers M, Tanamas SK, Clark EJ, Dunnigan DL, Kapadia CR, Hanson RL, Nelson RG, Knowler WC, Sinha M.

Pediatrics. 2017 Dec;140(6). pii: e20172248. doi: 10.1542/peds.2017-2248. Epub 2017 Nov 7.


Serum lipids and mortality in an American Indian population: A longitudinal study.

Tanamas SK, Saulnier PJ, Hanson RL, Nelson RG, Hsueh WC, Sievers ML, Bennett PH, Knowler WC.

J Diabetes Complications. 2018 Jan;32(1):18-26. doi: 10.1016/j.jdiacomp.2017.09.015. Epub 2017 Oct 3.


White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes.

Wheelock KM, Saulnier PJ, Tanamas SK, Vijayakumar P, Weil EJ, Looker HC, Hanson RL, Lemley KV, Yee B, Knowler WC, Hadjadj S, Najafian B, Mauer M, Nelson RG.

Nephrol Dial Transplant. 2017 Dec 1;32(12):2145. doi: 10.1093/ndt/gfx303. No abstract available.


Burden of Proof-When Is Kidney Disease Attributable to Diabetes?

Saulnier PJ, Nelson RG.

Clin J Am Soc Nephrol. 2017 Dec 7;12(12):1917-1918. doi: 10.2215/CJN.10720917. Epub 2017 Oct 20. No abstract available.


A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome.

Nair V, Komorowsky CV, Weil EJ, Yee B, Hodgin J, Harder JL, Godfrey B, Ju W, Boustany-Kari CM, Schwarz M, Lemley KV, Nelson PJ, Nelson RG, Kretzler M.

Kidney Int. 2018 Feb;93(2):439-449. doi: 10.1016/j.kint.2017.08.013. Epub 2017 Oct 18.


White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes.

Wheelock KM, Saulnier PJ, Tanamas SK, Vijayakumar P, Weil EJ, Looker HC, Hanson RL, Lemley KV, Yee B, Knowler WC, Hadjadj S, Najafian B, Mauer M, Nelson RG.

Nephrol Dial Transplant. 2018 Jun 1;33(6):1001-1009. doi: 10.1093/ndt/gfx231.


Strategies to improve monitoring disease progression, assessing cardiovascular risk, and defining prognostic biomarkers in chronic kidney disease.

Pena MJ, Stenvinkel P, Kretzler M, Adu D, Agarwal SK, Coresh J, Feldman HI, Fogo AB, Gansevoort RT, Harris DC, Jha V, Liu ZH, Luyckx VA, Massy ZA, Mehta R, Nelson RG, O'Donoghue DJ, Obrador GT, Roberts CJ, Sola L, Sumaili EK, Tatiyanupanwong S, Thomas B, Wiecek A, Parikh CR, Heerspink HJL.

Kidney Int Suppl (2011). 2017 Oct;7(2):107-113. doi: 10.1016/j.kisu.2017.07.005. Epub 2017 Sep 20. Review.


Reducing major risk factors for chronic kidney disease.

Luyckx VA, Tuttle KR, Garcia-Garcia G, Gharbi MB, Heerspink HJL, Johnson DW, Liu ZH, Massy ZA, Moe O, Nelson RG, Sola L, Wheeler DC, White SL.

Kidney Int Suppl (2011). 2017 Oct;7(2):71-87. doi: 10.1016/j.kisu.2017.07.003. Epub 2017 Sep 20. Review.


Association of Serum Amyloid A with Kidney Outcomes and All-Cause Mortality in American Indians with Type 2 Diabetes.

Saulnier PJ, Dieter BP, Tanamas SK, McPherson SM, Wheelock KM, Knowler WC, Looker HC, Meek RL, Nelson RG, Tuttle KR.

Am J Nephrol. 2017;46(4):276-284. doi: 10.1159/000481269. Epub 2017 Sep 22.


Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus.

Wheelock KM, Cai J, Looker HC, Merchant ML, Nelson RG, Fufaa GD, Weil EJ, Feldman HI, Vasan RS, Kimmel PL, Rovin BH, Mauer M, Klein JB; CKD Biomarkers Consortium.

PLoS One. 2017 Jul 10;12(7):e0180964. doi: 10.1371/journal.pone.0180964. eCollection 2017.


Reading the tree leaves-how to enrich clinical trials of diabetic kidney disease.

Looker HC, Nelson RG.

Kidney Int. 2017 Jul;92(1):23-25. doi: 10.1016/j.kint.2017.03.042.


Associations between persistent organic pollutants, type 2 diabetes, diabetic nephropathy and mortality.

Grice BA, Nelson RG, Williams DE, Knowler WC, Mason C, Hanson RL, Bullard KM, Pavkov ME.

Occup Environ Med. 2017 Jul;74(7):521-527. doi: 10.1136/oemed-2016-103948. Epub 2017 Apr 24.


Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study.

Park M, Hsu CY, Go AS, Feldman HI, Xie D, Zhang X, Mifflin T, Waikar SS, Sabbisetti VS, Bonventre JV, Coresh J, Nelson RG, Kimmel PL, Kusek JW, Rahman M, Schelling JR, Vasan RS, Liu KD; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators; CKD Biomarkers Consortium.

Clin J Am Soc Nephrol. 2017 May 8;12(5):761-771. doi: 10.2215/CJN.08560816. Epub 2017 Mar 2.


Harmonic Vibrational Frequencies: Approximate Global Scaling Factors for TPSS, M06, and M11 Functional Families Using Several Common Basis Sets.

Kashinski DO, Chase GM, Nelson RG, Di Nallo OE, Scales AN, VanderLey DL, Byrd EF.

J Phys Chem A. 2017 Mar 23;121(11):2265-2273. doi: 10.1021/acs.jpca.6b12147. Epub 2017 Mar 9.


Estimation of chronic kidney disease incidence from prevalence and mortality data in American Indians with type 2 diabetes.

Vijayakumar P, Hoyer A, Nelson RG, Brinks R, Pavkov ME.

PLoS One. 2017 Feb 6;12(2):e0171027. doi: 10.1371/journal.pone.0171027. eCollection 2017.


Effect of different methods of accounting for antihypertensive treatment when assessing the relationship between diabetes or obesity and systolic blood pressure.

Tanamas SK, Hanson RL, Nelson RG, Knowler WC.

J Diabetes Complications. 2017 Apr;31(4):693-699. doi: 10.1016/j.jdiacomp.2016.12.013. Epub 2017 Jan 20.


Filtration Markers as Predictors of ESRD and Mortality: Individual Participant Data Meta-Analysis.

Inker LA, Coresh J, Sang Y, Hsu CY, Foster MC, Eckfeldt JH, Karger AB, Nelson RG, Liu X, Sarnak M, Appel LJ, Grams M, Xie D, Kimmel PL, Feldman H, Ramachandran V, Levey AS; CKD Biomarkers Consortium.

Clin J Am Soc Nephrol. 2017 Jan 6;12(1):69-78. doi: 10.2215/CJN.03660316. Epub 2016 Nov 10.


Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.

Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman HI, Vasan RS, Liu KD; CRIC Study Investigators; CKD Biomarkers Consortium.

Kidney Int. 2017 Jan;91(1):196-203. doi: 10.1016/j.kint.2016.09.003. Epub 2016 Oct 28.


Secular changes in physical growth and obesity among southwestern American Indian children over four decades.

Vijayakumar P, Wheelock KM, Kobes S, Nelson RG, Hanson RL, Knowler WC, Sinha M.

Pediatr Obes. 2018 Feb;13(2):94-102. doi: 10.1111/ijpo.12199. Epub 2016 Dec 6.


HbA1c and the Prediction of Type 2 Diabetes in Children and Adults.

Vijayakumar P, Nelson RG, Hanson RL, Knowler WC, Sinha M.

Diabetes Care. 2017 Jan;40(1):16-21. doi: 10.2337/dc16-1358. Epub 2016 Nov 3.


Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications.

Sas KM, Kayampilly P, Byun J, Nair V, Hinder LM, Hur J, Zhang H, Lin C, Qi NR, Michailidis G, Groop PH, Nelson RG, Darshi M, Sharma K, Schelling JR, Sedor JR, Pop-Busui R, Weinberg JM, Soleimanpour SA, Abcouwer SF, Gardner TW, Burant CF, Feldman EL, Kretzler M, Brosius FC 3rd, Pennathur S.

JCI Insight. 2016 Sep 22;1(15):e86976. doi: 10.1172/jci.insight.86976.


An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy.

Kato M, Wang M, Chen Z, Bhatt K, Oh HJ, Lanting L, Deshpande S, Jia Y, Lai JY, O'Connor CL, Wu Y, Hodgin JB, Nelson RG, Bitzer M, Natarajan R.

Nat Commun. 2016 Sep 30;7:12864. doi: 10.1038/ncomms12864.


Effect of Geography on the Analysis of Coccidioidomycosis-Associated Deaths, United States.

Noble JA, Nelson RG, Fufaa GD, Kang P, Shafir SC, Galgiani JN.

Emerg Infect Dis. 2016 Oct;22(10):1821-3. doi: 10.3201/eid2210.160696.


Long-term Effect of Losartan on Kidney Disease in American Indians With Type 2 Diabetes: A Follow-up Analysis of a Randomized Clinical Trial.

Tanamas SK, Saulnier PJ, Fufaa GD, Wheelock KM, Weil EJ, Hanson RL, Knowler WC, Bennett PH, Nelson RG.

Diabetes Care. 2016 Nov;39(11):2004-2010. Epub 2016 Sep 9.


Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes.

Saulnier PJ, Wheelock KM, Howell S, Weil EJ, Tanamas SK, Knowler WC, Lemley KV, Mauer M, Yee B, Nelson RG, Beisswenger PJ.

Diabetes. 2016 Dec;65(12):3744-3753. Epub 2016 Sep 8.


Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies.

Waikar SS, Sabbisetti V, Ärnlöv J, Carlsson AC, Coresh J, Feldman HI, Foster MC, Fufaa GD, Helmersson-Karlqvist J, Hsu CY, Kimmel PL, Larsson A, Liu Y, Lind L, Liu KD, Mifflin TE, Nelson RG, Risérus U, Vasan RS, Xie D, Zhang X, Bonventre JV; Chronic Kidney Disease Biomarkers Consortium Investigators.

Nephrol Dial Transplant. 2016 Sep;31(9):1460-70. doi: 10.1093/ndt/gfw203. Epub 2016 Jun 7.


Patient and Other Stakeholder Engagement in Patient-Centered Outcomes Research Institute Funded Studies of Patients with Kidney Diseases.

Cukor D, Cohen LM, Cope EL, Ghahramani N, Hedayati SS, Hynes DM, Shah VO, Tentori F, Unruh M, Bobelu J, Cohen S, Dember LM, Faber T, Fischer MJ, Gallardo R, Germain MJ, Ghahate D, Grote N, Hartwell L, Heagerty P, Kimmel PL, Kutner N, Lawson S, Marr L, Nelson RG, Porter AC, Sandy P, Struminger BB, Subramanian L, Weisbord S, Young B, Mehrotra R.

Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1703-12. doi: 10.2215/CJN.09780915. Epub 2016 May 19. Review.


Cardiometabolic risk profile based on body mass index in American Indian children and adolescents.

Wheelock KM, Fufaa GD, Nelson RG, Hanson RL, Knowler WC, Sinha M.

Pediatr Obes. 2017 Aug;12(4):295-303. doi: 10.1111/ijpo.12142. Epub 2016 May 12.


Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND).

Williams RC, Elston RC, Kumar P, Knowler WC, Abboud HE, Adler S, Bowden DW, Divers J, Freedman BI, Igo RP Jr, Ipp E, Iyengar SK, Kimmel PL, Klag MJ, Kohn O, Langefeld CD, Leehey DJ, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Rotter JI, Schelling JR, Sedor JR, Shah VO, Smith MW, Taylor KD, Thameem F, Thornley-Brown D, Winkler CA, Guo X, Zager P, Hanson RL; FIND Research Group.

BMC Genomics. 2016 May 4;17:325. doi: 10.1186/s12864-016-2654-x.


Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes.

Wheelock KM, Jaiswal M, Martin CL, Fufaa GD, Weil EJ, Lemley KV, Yee B, Feldman E, Brosius FC 3rd, Knowler WC, Nelson RG, Pop-Busui R.

J Diabetes Complications. 2016 Jul;30(5):873-9. doi: 10.1016/j.jdiacomp.2016.03.008. Epub 2016 Mar 11.


Serum β-Trace Protein and β2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study.

Foster MC, Coresh J, Hsu CY, Xie D, Levey AS, Nelson RG, Eckfeldt JH, Vasan RS, Kimmel PL, Schelling J, Simonson M, Sondheimer JH, Anderson AH, Akkina S, Feldman HI, Kusek JW, Ojo AO, Inker LA; CKD Biomarker Consortium and the CRIC Study Investigators.

Am J Kidney Dis. 2016 Jul;68(1):68-76. doi: 10.1053/j.ajkd.2016.01.015. Epub 2016 Mar 3.


Metabolic Risk Factors and Type 2 Diabetes Incidence in American Indian Children.

Wheelock KM, Sinha M, Knowler WC, Nelson RG, Fufaa GD, Hanson RL.

J Clin Endocrinol Metab. 2016 Apr;101(4):1437-44. doi: 10.1210/jc.2015-4309. Epub 2016 Feb 25.


Burden of Diabetic Peripheral Neuropathy in Pima Indians With Type 2 Diabetes.

Jaiswal M, Fufaa GD, Martin CL, Pop-Busui R, Nelson RG, Feldman EL.

Diabetes Care. 2016 Apr;39(4):e63-4. doi: 10.2337/dc16-0082. Epub 2016 Feb 23. No abstract available.

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