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Reply: LATE to the PART-y.

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Fardo DW, Flanagan ME, Halliday G, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murray ME, Nag S, Seeley WW, Sperling RA, White CL, Schneider JA.

Brain. 2019 Sep 1;142(9):e48. doi: 10.1093/brain/awz226. No abstract available.


Reply: Limbic-predominant age-related TDP-43 encephalopathy (LATE).

Schneider JA, Nelson PT.

Brain. 2019 Aug 1;142(8):e43. doi: 10.1093/brain/awz186. No abstract available.


Clinico-Neuropathological Findings in the Oldest Old from the Georgia Centenarian Study.

Tanprasertsuk J, Johnson EJ, Johnson MA, Poon LW, Nelson PT, Davey A, Martin P, Barbey AK, Barger K, Wang XD, Scott TM.

J Alzheimers Dis. 2019;70(1):35-49. doi: 10.3233/JAD-181110.


Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA.

Brain. 2019 Jun 1;142(6):1503-1527. doi: 10.1093/brain/awz099. Erratum in: Brain. 2019 Jul 1;142(7):e37.


Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis.

Abner EL, Nelson PT, Jicha GA, Cooper GE, Fardo DW, Schmitt FA, Kryscio RJ.

J Alzheimers Dis. 2019;68(2):625-633. doi: 10.3233/JAD-181119.


Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.

Chornenkyy Y, Fardo DW, Nelson PT.

Lab Invest. 2019 Jul;99(7):993-1007. doi: 10.1038/s41374-019-0196-y. Epub 2019 Feb 11. Review.


Hippocampal Sclerosis, Argyrophilic Grain Disease, and Primary Age-Related Tauopathy.

Jicha GA, Nelson PT.

Continuum (Minneap Minn). 2019 Feb;25(1):208-233. doi: 10.1212/CON.0000000000000697.


TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.

Nelson PT, Gal Z, Wang WX, Niedowicz DM, Artiushin SC, Wycoff S, Wei A, Jicha GA, Fardo DW.

Neurobiol Dis. 2019 May;125:67-76. doi: 10.1016/j.nbd.2019.01.013. Epub 2019 Jan 23.


Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice.

Niedowicz DM, Özcan S, Nelson PT.

J Diabetes Res. 2018 Oct 29;2018:1251345. doi: 10.1155/2018/1251345. eCollection 2018.


Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.

Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR.

Nat Neurosci. 2019 Jan;22(1):144-147. doi: 10.1038/s41593-018-0277-z.


Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs.

Katsumata Y, Nelson PT, Estus S; Alzheimer's Disease Neuroimaging Initiative (ADNI), Fardo DW.

Neurobiol Aging. 2019 Feb;74:135-146. doi: 10.1016/j.neurobiolaging.2018.10.017. Epub 2018 Oct 23.


Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.

Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, Goldstein LB, Murphy RR, Nelson PT, Johnson NF, Shaw LM, Smith CD, Trojanowski JQ, Wilcock DM, Jicha GA.

J Alzheimers Dis. 2018;66(3):1095-1104. doi: 10.3233/JAD-180663.


Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study.

Trieu T, Sajjadi SA, Kawas CH, Nelson PT, Corrada MM.

Neurology. 2018 Nov 6;91(19):e1788-e1798. doi: 10.1212/WNL.0000000000006455. Epub 2018 Oct 12.


Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.

Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, Rizzu P, Cooper AA, Heutink P, Beach TG, Mattick JS, Müller F, Scherzer CR.

Nat Neurosci. 2018 Oct;21(10):1482-1492. doi: 10.1038/s41593-018-0223-0. Epub 2018 Sep 17. Erratum in: Nat Neurosci. 2019 Jan;22(1):144-147.


Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline.

Chornenkyy Y, Wang WX, Wei A, Nelson PT.

Brain Pathol. 2019 Jan;29(1):3-17. doi: 10.1111/bpa.12655. Epub 2018 Oct 9. Review.


Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques.

Abner EL, Neltner JH, Jicha GA, Patel E, Anderson SL, Wilcock DM, Van Eldik LJ, Nelson PT.

J Alzheimers Dis. 2018;64(4):1307-1324. doi: 10.3233/JAD-180514.


The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses.

Besser LM, Kukull WA, Teylan MA, Bigio EH, Cairns NJ, Kofler JK, Montine TJ, Schneider JA, Nelson PT.

J Neuropathol Exp Neurol. 2018 Aug 1;77(8):717-726. doi: 10.1093/jnen/nly049.


The human MAPT locus generates circular RNAs.

Welden JR, van Doorn J, Nelson PT, Stamm S.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2753-2760. doi: 10.1016/j.bbadis.2018.04.023. Epub 2018 May 3.


The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.

Knopman DS, Haeberlein SB, Carrillo MC, Hendrix JA, Kerchner G, Margolin R, Maruff P, Miller DS, Tong G, Tome MB, Murray ME, Nelson PT, Sano M, Mattsson N, Sultzer DL, Montine TJ, Jack CR Jr, Kolb H, Petersen RC, Vemuri P, Canniere MZ, Schneider JA, Resnick SM, Romano G, van Harten AC, Wolk DA, Bain LJ, Siemers E.

Alzheimers Dement. 2018 Apr;14(4):563-575. doi: 10.1016/j.jalz.2018.03.002. Review.


APOE DNA methylation is altered in Lewy body dementia.

Tulloch J, Leong L, Chen S, Keene CD, Millard SP, Shutes-David A, Lopez OL, Kofler J, Kaye JA, Woltjer R, Nelson PT, Neltner JH, Jicha GA, Galasko D, Masliah E, Leverenz JB, Yu CE, Tsuang D.

Alzheimers Dement. 2018 Jul;14(7):889-894. doi: 10.1016/j.jalz.2018.02.005. Epub 2018 Mar 12.


BIN1 localization is distinct from Tau tangles in Alzheimer's disease.

De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G.

Matters (Zur). 2017 Jan;2017. doi: 10.19185/matters.201611000018. Epub 2017 Jan 12.


Review: Relationship of type 2 diabetes to human brain pathology.

Pruzin JJ, Nelson PT, Abner EL, Arvanitakis Z.

Neuropathol Appl Neurobiol. 2018 Jun;44(4):347-362. doi: 10.1111/nan.12476. Epub 2018 Mar 4. Review.


Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities.

Al-Janabi OM, Panuganti P, Abner EL, Bahrani AA, Murphy R, Bardach SH, Caban-Holt A, Nelson PT, Gold BT, Smith CD, Wilcock DM, Jicha GA.

J Neuroimaging. 2018 May;28(3):301-306. doi: 10.1111/jon.12494. Epub 2018 Jan 5.


Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.

Gal J, Chen J, Katsumata Y, Fardo DW, Wang WX, Artiushin S, Price D, Anderson S, Patel E, Zhu H, Nelson PT.

J Neuropathol Exp Neurol. 2018 Jan 1;77(1):21-39. doi: 10.1093/jnen/nlx097.


The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.

Nelson PT, Abner EL, Patel E, Anderson S, Wilcock DM, Kryscio RJ, Van Eldik LJ, Jicha GA, Gal Z, Nelson RS, Nelson BG, Gal J, Azam MT, Fardo DW, Cykowski MD.

J Neuropathol Exp Neurol. 2018 Jan 1;77(1):2-20. doi: 10.1093/jnen/nlx099. Review.


MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls.

Nelson PT, Wang WX, Janse SA, Thompson KL.

Brain Res. 2018 Jan 1;1678:374-383. doi: 10.1016/j.brainres.2017.11.009. Epub 2017 Nov 13.


Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults.

Brenowitz WD, Han F, Kukull WA, Nelson PT.

Neurobiol Aging. 2018 Feb;62:64-71. doi: 10.1016/j.neurobiolaging.2017.10.004. Epub 2017 Nov 4.


Challenges and Considerations Related to Studying Dementia in Blacks/African Americans.

Ighodaro ET, Nelson PT, Kukull WA, Schmitt FA, Abner EL, Caban-Holt A, Bardach SH, Hord DC, Glover CM, Jicha GA, Van Eldik LJ, Byrd AX, Fernander A.

J Alzheimers Dis. 2017;60(1):1-10. doi: 10.3233/JAD-170242.


Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.

Ly H, Verma N, Wu F, Liu M, Saatman KE, Nelson PT, Slevin JT, Goldstein LB, Biessels GJ, Despa F.

Ann Neurol. 2017 Aug;82(2):208-222. doi: 10.1002/ana.24992. Epub 2017 Jul 29.


Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.


Hippocampal Sclerosis in Older Patients: Practical Examples and Guidance With a Focus on Cerebral Age-Related TDP-43 With Sclerosis.

Cykowski MD, Powell SZ, Schulz PE, Takei H, Rivera AL, Jackson RE, Roman G, Jicha GA, Nelson PT.

Arch Pathol Lab Med. 2017 Aug;141(8):1113-1126. doi: 10.5858/arpa.2016-0469-SA. Epub 2017 May 3.


GABAB receptor attenuation of GABAA currents in neurons of the mammalian central nervous system.

Shen W, Nan C, Nelson PT, Ripps H, Slaughter MM.

Physiol Rep. 2017 Mar;5(6). pii: e13129. doi: 10.14814/phy2.13129.


Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.

Smith VD, Bachstetter AD, Ighodaro E, Roberts K, Abner EL, Fardo DW, Nelson PT.

Brain Pathol. 2018 Mar;28(2):264-273. doi: 10.1111/bpa.12505. Epub 2017 Mar 24.


Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients: Correlation With John Cunningham Virus Antibody and Urine John Cunningham Virus DNA.

Berger JR, Miller CS, Danaher RJ, Doyle K, Simon KJ, Norton E, Gorelik L, Cahir-McFarland E, Singhal D, Hack N, Owens JR, Nelson PT, Neltner JH.

JAMA Neurol. 2017 Apr 1;74(4):437-444. doi: 10.1001/jamaneurol.2016.5537.


Outcomes after diagnosis of mild cognitive impairment in a large autopsy series.

Abner EL, Kryscio RJ, Schmitt FA, Fardo DW, Moga DC, Ighodaro ET, Jicha GA, Yu L, Dodge HH, Xiong C, Woltjer RL, Schneider JA, Cairns NJ, Bennett DA, Nelson PT.

Ann Neurol. 2017 Apr;81(4):549-559. doi: 10.1002/ana.24903. Epub 2017 Mar 22.


CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

Fardo DW, Katsumata Y, Kauwe JSK, Deming Y, Harari O, Cruchaga C; Alzheimer's Disease Neuroimaging Initiative, Nelson PT.

Exp Gerontol. 2017 Apr;90:83-89. doi: 10.1016/j.exger.2017.01.025. Epub 2017 Feb 9.


Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.

Katsumata Y, Nelson PT, Ellingson SR, Fardo DW.

Neurobiol Aging. 2017 May;53:193.e17-193.e25. doi: 10.1016/j.neurobiolaging.2017.01.003. Epub 2017 Jan 9.


Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.

Bachstetter AD, Ighodaro ET, Hassoun Y, Aldeiri D, Neltner JH, Patel E, Abner EL, Nelson PT.

Neurobiol Aging. 2017 Apr;52:98-105. doi: 10.1016/j.neurobiolaging.2016.12.028. Epub 2017 Jan 5.


Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease.

Flanagan ME, Marshall DA, Shofer JB, Montine KS, Nelson PT, Montine TJ, Keene CD.

J Neuropathol Exp Neurol. 2017 Jan 1;76(1):39-43. doi: 10.1093/jnen/nlw104.


Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease.

Dodge HH, Zhu J, Woltjer R, Nelson PT, Bennett DA, Cairns NJ, Fardo DW, Kaye JA, Lyons DE, Mattek N, Schneider JA, Silbert LC, Xiong C, Yu L, Schmitt FA, Kryscio RJ, Abner EL; SMART data consortium.

Alzheimers Dement. 2017 Jun;13(6):613-623. doi: 10.1016/j.jalz.2016.11.003. Epub 2016 Dec 23.


Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.

Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ.

Lancet Neurol. 2017 Jan;16(1):55-65. doi: 10.1016/S1474-4422(16)30291-5.


Widespread tau seeding activity at early Braak stages.

Furman JL, Vaquer-Alicea J, White CL 3rd, Cairns NJ, Nelson PT, Diamond MI.

Acta Neuropathol. 2017 Jan;133(1):91-100. doi: 10.1007/s00401-016-1644-z. Epub 2016 Nov 22.


Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging.

Nelson PT, Katsumata Y, Nho K, Artiushin SC, Jicha GA, Wang WX, Abner EL, Saykin AJ, Kukull WA; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Fardo DW.

Acta Neuropathol. 2016 Dec;132(6):841-858. Epub 2016 Nov 4.


The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project.

Kryscio RJ, Abner EL, Nelson PT, Bennett D, Schneider J, Yu L, Hemmy LS, Lim KO, Masaki K, Cairns N, Xiong C, Woltjer R, Dodge HH, Tyas S, Fardo DW, Lou W, Wan L, Schmitt FA.

J Prev Alzheimers Dis. 2016 Jun;3(2):85-91.


miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).

Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W, Kim J.

Mol Neurodegener. 2016 Jul 26;11(1):55. doi: 10.1186/s13024-016-0121-4.


Cerebrovascular pathology and Alzheimer's disease.

Nelson PT.

Lancet Neurol. 2016 Aug;15(9):895-896. doi: 10.1016/S1474-4422(16)30038-2. Epub 2016 Jun 14. No abstract available.


Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function.

Pleiss MM, Sompol P, Kraner SD, Abdul HM, Furman JL, Guttmann RP, Wilcock DM, Nelson PT, Norris CM.

Biochim Biophys Acta. 2016 Sep;1862(9):1521-32. doi: 10.1016/j.bbadis.2016.05.007. Epub 2016 May 20.


"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET.

J Neuropathol Exp Neurol. 2016 Jun;75(6):482-98. doi: 10.1093/jnen/nlw033. Epub 2016 May 21. Review.

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