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Radiation-induced Amplification of TGFB1-induced Mesenchymal Stem Cell-mediated Sodium Iodide Symporter (NIS) Gene 131 I Therapy.

Schug C, Kitzberger C, Sievert W, Spellerberg R, Tutter M, Schmohl KA, Eberlein B, Biedermann T, Steiger K, Zach C, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C.

Clin Cancer Res. 2019 Jun 13. pii: clincanres.4092.2018. doi: 10.1158/1078-0432.CCR-18-4092. [Epub ahead of print]


Tetrac as an anti-angiogenic agent in cancer.

Schmohl KA, Nelson PJ, Spitzweg C.

Endocr Relat Cancer. 2019 Jun 1;26(6):R287-R304. doi: 10.1530/ERC-19-0058. Review.


Core fucosylated glycan-dependent inhibitory effect of QSOX1-S on invasion and metastasis of hepatocellular carcinoma.

Zhang XF, Wang J, Jia HL, Zhu WW, Lu L, Ye QH, Nelson PJ, Qin Y, Gao DM, Zhou HJ, Qin LX.

Cell Death Discov. 2019 Apr 3;5:84. doi: 10.1038/s41420-019-0164-8. eCollection 2019.


Corrigendum to "Targeting cancer stem cells and their niche: Perspectives for future therapeutic targets and strategies" [Semin. Cancer Biol. (2018) (August) pii: S1044-579X(18)30045-2, 139-155].

Zhao Y, Dong Q, Li J, Zhang K, Qin J, Zhao J, Sun Q, Wang Z, Wartmann T, Jauch KW, Nelson PJ, Qin L, Bruns C.

Semin Cancer Biol. 2019 Mar 5. pii: S1044-579X(18)30179-2. doi: 10.1016/j.semcancer.2018.12.001. [Epub ahead of print] No abstract available.


Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells: Results from the phase 1/2 TREAT-ME-1 trial.

von Einem JC, Guenther C, Volk HD, Grütz G, Hirsch D, Salat C, Stoetzer O, Nelson PJ, Michl M, Modest DP, Holch JW, Angele M, Bruns C, Niess H, Heinemann V.

Int J Cancer. 2019 Feb 23. doi: 10.1002/ijc.32230. [Epub ahead of print]


A Novel Approach for Image-Guided 131I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery.

Schug C, Gupta A, Urnauer S, Steiger K, Cheung PF, Neander C, Savvatakis K, Schmohl KA, Trajkovic-Arsic M, Schwenk N, Schwaiger M, Nelson PJ, Siveke JT, Spitzweg C.

Mol Cancer Res. 2019 Jan;17(1):310-320. doi: 10.1158/1541-7786.MCR-18-0185. Epub 2018 Sep 17.


TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer.

Schug C, Urnauer S, Jaeckel C, Schmohl KA, Tutter M, Steiger K, Schwenk N, Schwaiger M, Wagner E, Nelson PJ, Spitzweg C.

Endocr Relat Cancer. 2019 Jan 1;26(1):89-101. doi: 10.1530/ERC-18-0173.


Synthesis of next generation dual-responsive cross-linked nanoparticles and their application to anti-cancer drug delivery.

Schwarzenböck C, Nelson PJ, Huss R, Rieger B.

Nanoscale. 2018 Aug 30;10(34):16062-16068. doi: 10.1039/c8nr04760j.


Targeting cancer stem cells and their niche: perspectives for future therapeutic targets and strategies.

Zhao Y, Dong Q, Li J, Zhang K, Qin J, Zhao J, Sun Q, Wang Z, Wartmann T, Jauch KW, Nelson PJ, Qin L, Bruns C.

Semin Cancer Biol. 2018 Dec;53:139-155. doi: 10.1016/j.semcancer.2018.08.002. Epub 2018 Aug 3. Review. Erratum in: Semin Cancer Biol. 2019 Mar 5;:.


Studies on the Biocompatibility of Poly(diethyl vinyl-phosphonate) with a New Fluorescent Marker.

Schwarzenböck C, Vagin SI, Heinz WR, Nelson PJ, Rieger B.

Macromol Rapid Commun. 2018 Aug;39(15):e1800259. doi: 10.1002/marc.201800259. Epub 2018 Jun 11.


External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery.

Schug C, Sievert W, Urnauer S, Müller AM, Schmohl KA, Wechselberger A, Schwenk N, Lauber K, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C.

Hum Gene Ther. 2018 Nov;29(11):1287-1300. doi: 10.1089/hum.2018.025. Epub 2018 May 3.


Fluorescent Polyvinylphosphonate Bioconjugates for Selective Cellular Delivery.

Schwarzenböck C, Schaffer A, Nößner E, Nelson PJ, Huss R, Rieger B.

Chemistry. 2018 Feb 21;24(11):2584-2587. doi: 10.1002/chem.201706034. Epub 2018 Jan 25.


Lymphotoxin expression in human and murine renal allografts.

Seeger H, Lindenmeyer MT, Cohen CD, Jaeckel C, Nelson PJ, Chen J, Edenhofer I, Kozakowski N, Regele H, Boehmig G, Brandt S, Wuethrich RP, Heikenwalder M, Fehr T, Segerer S.

PLoS One. 2018 Jan 4;13(1):e0189396. doi: 10.1371/journal.pone.0189396. eCollection 2018.


Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies.

Augsburger D, Nelson PJ, Kalinski T, Udelnow A, Knösel T, Hofstetter M, Qin JW, Wang Y, Gupta AS, Bonifatius S, Li M, Bruns CJ, Zhao Y.

Oncotarget. 2017 Aug 10;8(61):104638-104653. doi: 10.18632/oncotarget.20136. eCollection 2017 Nov 28. Review.


Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells - TREAT-ME-1 - a phase I, first in human, first in class trial.

von Einem JC, Peter S, Günther C, Volk HD, Grütz G, Salat C, Stoetzer O, Nelson PJ, Michl M, Modest DP, Holch JW, Angele M, Bruns C, Niess H, Heinemann V.

Oncotarget. 2017 Sep 16;8(46):80156-80166. doi: 10.18632/oncotarget.20964. eCollection 2017 Oct 6.


A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome.

Nair V, Komorowsky CV, Weil EJ, Yee B, Hodgin J, Harder JL, Godfrey B, Ju W, Boustany-Kari CM, Schwarz M, Lemley KV, Nelson PJ, Nelson RG, Kretzler M.

Kidney Int. 2018 Feb;93(2):439-449. doi: 10.1016/j.kint.2017.08.013. Epub 2017 Oct 18.


Reintroducing the Sodium-Iodide Symporter to Anaplastic Thyroid Carcinoma.

Schmohl KA, Dolp P, Schug C, Knoop K, Klutz K, Schwenk N, Bartenstein P, Nelson PJ, Ogris M, Wagner E, Spitzweg C.

Thyroid. 2017 Dec;27(12):1534-1543. doi: 10.1089/thy.2017.0290. Epub 2017 Nov 10.


Defining Renal Neoplastic Disease, One Cell at a Time: Mass Cytometry, a New Tool for the Study of Kidney Biology and Disease.

Nelson PJ, Kretzler M.

Am J Kidney Dis. 2017 Dec;70(6):758-761. doi: 10.1053/j.ajkd.2017.08.009. Epub 2017 Oct 12. No abstract available.


Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration.

Zhong C, Shi D, Zheng Y, Nelson PJ, Bao Q.

Nanoscale Res Lett. 2017 Sep 15;12(1):533. doi: 10.1186/s11671-017-2305-4.


The hormetic functions of Wnt pathways in tubular injury.

Gröne EF, Federico G, Nelson PJ, Arnold B, Gröne HJ.

Pflugers Arch. 2017 Aug;469(7-8):899-906. doi: 10.1007/s00424-017-2018-7. Epub 2017 Jul 6. Review.


Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy.

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G, Noessner E.

Cancer Res. 2017 Jul 1;77(13):3577-3590. doi: 10.1158/0008-5472.CAN-16-1922. Epub 2017 May 22.


Sodium storage in human tissues is mediated by glycosaminoglycan expression.

Fischereder M, Michalke B, Schmöckel E, Habicht A, Kunisch R, Pavelic I, Szabados B, Schönermarck U, Nelson PJ, Stangl M.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F319-F325. doi: 10.1152/ajprenal.00703.2016. Epub 2017 Apr 26.


Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene.

Schmohl KA, Gupta A, Grünwald GK, Trajkovic-Arsic M, Klutz K, Braren R, Schwaiger M, Nelson PJ, Ogris M, Wagner E, Siveke JT, Spitzweg C.

Oncotarget. 2017 May 16;8(20):33393-33404. doi: 10.18632/oncotarget.16499.


miR-221 Mediates Chemoresistance of Esophageal Adenocarcinoma by Direct Targeting of DKK2 Expression.

Wang Y, Zhao Y, Herbst A, Kalinski T, Qin J, Wang X, Jiang Z, Benedix F, Franke S, Wartman T, Camaj P, Halangk W, Kolligs FT, Jauch KW, Nelson PJ, Bruns CJ.

Ann Surg. 2016 Nov;264(5):804-814.


Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.

Federico G, Meister M, Mathow D, Heine GH, Moldenhauer G, Popovic ZV, Nordström V, Kopp-Schneider A, Hielscher T, Nelson PJ, Schaefer F, Porubsky S, Fliser D, Arnold B, Gröne HJ.

JCI Insight. 2016 Jan 21;1(1):e84916. doi: 10.1172/jci.insight.84916.


A vector platform for the rapid and efficient engineering of stable complex transgenes.

Jäckel C, Nogueira MS, Ehni N, Kraus C, Ranke J, Dohmann M, Noessner E, Nelson PJ.

Sci Rep. 2016 Oct 3;6:34365. doi: 10.1038/srep34365.


The relatively poor correlation between random and 24-hour urine protein excretion in patients with biopsy-proven glomerular diseases.

Hogan MC, Reich HN, Nelson PJ, Adler SG, Cattran DC, Appel GB, Gipson DS, Kretzler M, Troost JP, Lieske JC.

Kidney Int. 2016 Nov;90(5):1080-1089. doi: 10.1016/j.kint.2016.06.020. Epub 2016 Aug 12.


Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery.

Müller AM, Schmohl KA, Knoop K, Schug C, Urnauer S, Hagenhoff A, Clevert DA, Ingrisch M, Niess H, Carlsen J, Zach C, Wagner E, Bartenstein P, Nelson PJ, Spitzweg C.

Oncotarget. 2016 Aug 23;7(34):54795-54810. doi: 10.18632/oncotarget.10758.


Harnessing mesenchymal stem cell homing as an anticancer therapy.

Hagenhoff A, Bruns CJ, Zhao Y, von Lüttichau I, Niess H, Spitzweg C, Nelson PJ.

Expert Opin Biol Ther. 2016 Sep;16(9):1079-92. doi: 10.1080/14712598.2016.1196179. Epub 2016 Jun 13. Review.


Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells.

Zhao L, Zhao Y, Schwarz B, Mysliwietz J, Hartig R, Camaj P, Bao Q, Jauch KW, Guba M, Ellwart JW, Nelson PJ, Bruns CJ.

Int J Oncol. 2016 Jul;49(1):99-110. doi: 10.3892/ijo.2016.3512. Epub 2016 May 10.


Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.

Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, Rohde V, Bechmann I, Lodygin D, Odoardi F, Flügel A.

Nature. 2016 Feb 18;530(7590):349-53. doi: 10.1038/nature16939. Epub 2016 Feb 10.


p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation.

Höfig I, Ingawale Y, Atkinson MJ, Hertlein H, Nelson PJ, Rosemann M.

Stem Cells Int. 2016;2016:6429853. doi: 10.1155/2016/6429853. Epub 2015 Dec 16.


Complete Remission in the Nephrotic Syndrome Study Network.

Gipson DS, Troost JP, Lafayette RA, Hladunewich MA, Trachtman H, Gadegbeku CA, Sedor JR, Holzman LB, Moxey-Mims MM, Perumal K, Kaskel FJ, Nelson PJ, Tuttle KR, Bagnasco SM, Hogan MC, Dell KM, Appel GB, Lieske JC, Ilori TO, Sethna CB, Fervenza FC, Hogan SL, Nachman PH, Rosenberg AZ, Greenbaum LA, Meyers KE, Hewitt SM, Choi MJ, Kopp JB, Zhdanova O, Hodgin JB, Johnstone DB, Adler SG, Avila-Casado C, Neu AM, Hingorani SR, Lemley KV, Nast CC, Brady TM, Barisoni-Thomas L, Fornoni A, Jennette JC, Cattran DC, Palmer MB, Gibson KL, Reich HN, Mokrzycki MH, Sambandam KK, Zilleruelo GE, Licht C, Sampson MG, Song P, Mariani LH, Kretzler M.

Clin J Am Soc Nephrol. 2016 Jan 7;11(1):81-9. doi: 10.2215/CJN.02560315. Epub 2015 Dec 10.


Establishment of an Effective Radioiodide Thyroid Ablation Protocol in Mice.

Schmohl KA, Müller AM, Schwenk N, Knoop K, Rijntjes E, Köhrle J, Heuer H, Bartenstein P, Göke B, Nelson PJ, Spitzweg C.

Eur Thyroid J. 2015 Sep;4(Suppl 1):74-80. doi: 10.1159/000381019. Epub 2015 May 23.


Strategy and rationale for urine collection protocols employed in the NEPTUNE study.

Hogan MC, Lieske JC, Lienczewski CC, Nesbitt LL, Wickman LT, Heyer CM, Harris PC, Ward CJ, Sundsbak JL, Manganelli L, Ju W, Kopp JB, Nelson PJ, Adler SG, Reich HN, Holzmann LB, Kretzler M, Bitzer M.

BMC Nephrol. 2015 Nov 17;16:190. doi: 10.1186/s12882-015-0185-3.


Podoplanin increases migration and angiogenesis in malignant glioma.

Grau SJ, Trillsch F, Tonn JC, Goldbrunner RH, Noessner E, Nelson PJ, von Luettichau I.

Int J Clin Exp Pathol. 2015 Jul 1;8(7):8663-70. eCollection 2015.


Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3.

Schmohl KA, Müller AM, Wechselberger A, Rühland S, Salb N, Schwenk N, Heuer H, Carlsen J, Göke B, Nelson PJ, Spitzweg C.

Endocr Relat Cancer. 2015 Dec;22(6):941-52. doi: 10.1530/ERC-15-0245. Epub 2015 Aug 25.


Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial.

Niess H, von Einem JC, Thomas MN, Michl M, Angele MK, Huss R, Günther C, Nelson PJ, Bruns CJ, Heinemann V.

BMC Cancer. 2015 Apr 8;15:237. doi: 10.1186/s12885-015-1241-x.


Quantification of in vitro mesenchymal stem cell invasion into tumor spheroids using selective plane illumination microscopy.

Rühland S, Wechselberger A, Spitzweg C, Huss R, Nelson PJ, Harz H.

J Biomed Opt. 2015 Apr;20(4):040501. doi: 10.1117/1.JBO.20.4.040501.


Mesenchymal stem cell-mediated, tumor stroma-targeted radioiodine therapy of metastatic colon cancer using the sodium iodide symporter as theranostic gene.

Knoop K, Schwenk N, Schmohl K, Müller A, Zach C, Cyran C, Carlsen J, Böning G, Bartenstein P, Göke B, Wagner E, Nelson PJ, Spitzweg C.

J Nucl Med. 2015 Apr;56(4):600-6. doi: 10.2967/jnumed.114.146662. Epub 2015 Mar 5.


Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular "pseudoinflammation" contributing to an aggressive phenotype.

Niess H, Camaj P, Mair R, Renner A, Zhao Y, Jäckel C, Nelson PJ, Jauch KW, Bruns CJ.

Oncotarget. 2015 Feb 20;6(5):3306-18.


Antisense inhibition of microRNA-21 and microRNA-221 in tumor-initiating stem-like cells modulates tumorigenesis, metastasis, and chemotherapy resistance in pancreatic cancer.

Zhao Y, Zhao L, Ischenko I, Bao Q, Schwarz B, Nieß H, Wang Y, Renner A, Mysliwietz J, Jauch KW, Nelson PJ, Ellwart JW, Bruns CJ, Camaj P.

Target Oncol. 2015 Dec;10(4):535-48. doi: 10.1007/s11523-015-0360-2. Epub 2015 Feb 3.


Immunity unmasks APOL1 in collapsing glomerulopathy.

McNicholas BA, Nelson PJ.

Kidney Int. 2015 Feb;87(2):270-2. doi: 10.1038/ki.2014.325.


Group interpersonal and social rhythm therapy for bipolar depression.

Hoberg AA, Ponto J, Nelson PJ, Frye MA.

Perspect Psychiatr Care. 2013 Oct;49(4):226-34. doi: 10.1111/ppc.12008. Epub 2013 Jan 18.


Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.

Niess H, Camaj P, Renner A, Ischenko I, Zhao Y, Krebs S, Mysliwietz J, Jäckel C, Nelson PJ, Blum H, Jauch KW, Ellwart JW, Bruns CJ.

Target Oncol. 2015 Jun;10(2):215-27. doi: 10.1007/s11523-014-0323-z. Epub 2014 Jun 22.


Membrane-anchored chemokine fusion proteins: A novel class of adjuvants for immunotherapy.

Nelson PJ, Muenchmeier N.

Oncoimmunology. 2013 Nov 1;2(11):e26619. Epub 2013 Oct 10.


Cell surface engineering using glycosylphosphatidylinositol anchored tissue inhibitor of matrix metalloproteinase-1 stimulates cutaneous wound healing.

Djafarzadeh R, Conrad C, Notohamiprodjo S, Hipp S, Niess H, Bruns CJ, Nelson PJ.

Wound Repair Regen. 2014 Jan-Feb;22(1):70-6. doi: 10.1111/wrr.12132.


Hypoxia-independent gene expression mediated by SOX9 promotes aggressive pancreatic tumor biology.

Camaj P, Jäckel C, Krebs S, De Toni EN, Blum H, Jauch KW, Nelson PJ, Bruns CJ.

Mol Cancer Res. 2014 Mar;12(3):421-32. doi: 10.1158/1541-7786.MCR-13-0351. Epub 2013 Dec 3.


A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy.

Muenchmeier N, Boecker S, Bankel L, Hinz L, Rieth N, Lapa C, Mendler AN, Noessner E, Mocikat R, Nelson PJ.

PLoS One. 2013 Aug 30;8(8):e72749. doi: 10.1371/journal.pone.0072749. eCollection 2013.


Stem cell-like side populations in esophageal cancer: a source of chemotherapy resistance and metastases.

Zhao Y, Bao Q, Schwarz B, Zhao L, Mysliwietz J, Ellwart J, Renner A, Hirner H, Niess H, Camaj P, Angele M, Gros S, Izbicki J, Jauch KW, Nelson PJ, Bruns CJ.

Stem Cells Dev. 2014 Jan 15;23(2):180-92. doi: 10.1089/scd.2013.0103. Epub 2013 Nov 13.


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