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CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.

Racioppi L, Nelson ER, Huang W, Mukherjee D, Lawrence SA, Lento W, Masci AM, Jiao Y, Park S, York B, Liu Y, Baek AE, Drewry DH, Zuercher WJ, Bertani FR, Businaro L, Geradts J, Hall A, Means AR, Chao N, Chang CY, McDonnell DP.

Nat Commun. 2019 Jun 4;10(1):2450. doi: 10.1038/s41467-019-10424-5.


Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages.

Shahoei SH, Kim YC, Cler SJ, Ma L, Anakk S, Kemper JK, Nelson ER.

Endocrinology. 2019 Jul 1;160(7):1573-1589. doi: 10.1210/en.2019-00025.


Host CYP27A1 expression is essential for ovarian cancer progression.

He S, Ma L, Baek AE, Vardanyan A, Vembar V, Chen JJ, Nelson AT, Burdette JE, Nelson ER.

Endocr Relat Cancer. 2019 May 1. pii: ERC-18-0572.R1. doi: 10.1530/ERC-18-0572. [Epub ahead of print]


Nuclear receptors, cholesterol homeostasis and the immune system.

Shahoei SH, Nelson ER.

J Steroid Biochem Mol Biol. 2019 Jul;191:105364. doi: 10.1016/j.jsbmb.2019.04.013. Epub 2019 Apr 16. Review.


Oxysterols and nuclear receptors.

Ma L, Nelson ER.

Mol Cell Endocrinol. 2019 Mar 15;484:42-51. doi: 10.1016/j.mce.2019.01.016. Epub 2019 Jan 18. Review.


Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations.

Yu L, Wang L, Mao C, Duraki D, Kim JE, Huang R, Helferich WG, Nelson ER, Park BH, Shapiro DJ.

Cancer Lett. 2019 Feb 1;442:373-382. doi: 10.1016/j.canlet.2018.10.041. Epub 2018 Nov 9.


Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells.

Pomatto V, Cottone E, Cocci P, Mozzicafreddo M, Mosconi G, Nelson ER, Palermo FA, Bovolin P.

J Steroid Biochem Mol Biol. 2018 Apr;178:322-332. doi: 10.1016/j.jsbmb.2018.01.014. Epub 2018 Feb 2.


The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.

Baek AE, Yu YA, He S, Wardell SE, Chang CY, Kwon S, Pillai RV, McDowell HB, Thompson JW, Dubois LG, Sullivan PM, Kemper JK, Gunn MD, McDonnell DP, Nelson ER.

Nat Commun. 2017 Oct 11;8(1):864. doi: 10.1038/s41467-017-00910-z.


27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator.

He S, Nelson ER.

Maturitas. 2017 Oct;104:29-35. doi: 10.1016/j.maturitas.2017.07.014. Epub 2017 Jul 31. Review.


The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer.

Nelson ER.

Mol Cell Endocrinol. 2018 May 5;466:73-80. doi: 10.1016/j.mce.2017.09.021. Epub 2017 Sep 15. Review.


Utility of Sox10 labeling in metastatic breast carcinomas.

Nelson ER, Sharma R, Argani P, Cimino-Mathews A.

Hum Pathol. 2017 Sep;67:205-210. doi: 10.1016/j.humpath.2017.08.011. Epub 2017 Aug 23.


CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer.

Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Thompson JW, Dubois LG, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ.

Cancer Res. 2017 Apr 1;77(7):1662-1673. doi: 10.1158/0008-5472.CAN-16-2738. Epub 2017 Jan 27.


Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.

Nelson ER, Li S, Kennedy M, Payne S, Kilibarda K, Groth J, Bowie M, Parilla-Castellar E, de Ridder G, Marcom PK, Lyes M, Peterson BL, Cook M, Pizzo SV, McDonnell DP, Bachelder RE.

Oncotarget. 2016 Dec 20;7(51):84030-84042. doi: 10.18632/oncotarget.12767.


Thyroid hormone regulates vitellogenin by inducing estrogen receptor alpha in the goldfish liver.

Nelson ER, Habibi HR.

Mol Cell Endocrinol. 2016 Nov 15;436:259-67. doi: 10.1016/j.mce.2016.08.045. Epub 2016 Aug 30.


Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response.

Zheng X, Andruska N, Lambrecht MJ, He S, Parissenti A, Hergenrother PJ, Nelson ER, Shapiro DJ.

Oncotarget. 2016 Jul 24;9(19):14741-14753. doi: 10.18632/oncotarget.10819. eCollection 2018 Mar 13.


Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers.

Ma L, Liu TW, Wallig MA, Dobrucki IT, Dobrucki LW, Nelson ER, Swanson KS, Smith AM.

ACS Nano. 2016 Jul 26;10(7):6952-62. doi: 10.1021/acsnano.6b02878. Epub 2016 Jun 23.


The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer.

Baek AE, Nelson ER.

Horm Cancer. 2016 Aug;7(4):219-28. doi: 10.1007/s12672-016-0262-5. Epub 2016 Mar 28. Review.


A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.

Yu YR, O'Koren EG, Hotten DF, Kan MJ, Kopin D, Nelson ER, Que L, Gunn MD.

PLoS One. 2016 Mar 3;11(3):e0150606. doi: 10.1371/journal.pone.0150606. eCollection 2016.


Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol.

Nelson ER.

Methods Mol Biol. 2016;1366:431-443. doi: 10.1007/978-1-4939-3127-9_34.


Evaluating the landscape of fear between apex predatory sharks and mobile sea turtles across a large dynamic seascape.

Hammerschlag N, Broderick AC, Coker JW, Coyne MS, Dodd M, Frick MG, Godfrey MH, Godley BJ, Griffin DB, Hartog K, Murphy SR, Murphy TM, Nelson ER, Williams KL, Witt MJ, Hawkes LA.

Ecology. 2015 Aug;96(8):2117-26.


Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.

Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP.

Endocr Relat Cancer. 2015 Oct;22(5):713-24. doi: 10.1530/ERC-15-0287. Epub 2015 Jul 10.


A primer for billing in interventional pain management.

Yong RJ, Nelson ER, Urman RD, Kaye AD.

J Med Pract Manage. 2015 Mar-Apr;30(6 Spec No):51-4.


Medication errors in anesthesia.

Prabhakar A, Malapero RJ, Gabriel RA, Kaye AD, Elhassan AO, Nelson ER, Bates DW, Urman RD.

J Med Pract Manage. 2015 Mar-Apr;30(6 Spec No):41-3. Review.


The foreign body response: at the interface of surgery and bioengineering.

Major MR, Wong VW, Nelson ER, Longaker MT, Gurtner GC.

Plast Reconstr Surg. 2015 May;135(5):1489-98. doi: 10.1097/PRS.0000000000001193. Review.


Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.

Glass OK, Inman BA, Broadwater G, Courneya KS, Mackey JR, Goruk S, Nelson ER, Jasper J, Field CJ, Bain JR, Muehlbauer M, Stevens RD, Hirschey MD, Jones LW.

Br J Cancer. 2015 Mar 3;112(5):825-31. doi: 10.1038/bjc.2014.662. Epub 2015 Jan 13.


Cholesterol and breast cancer pathophysiology.

Nelson ER, Chang CY, McDonnell DP.

Trends Endocrinol Metab. 2014 Dec;25(12):649-55. doi: 10.1016/j.tem.2014.10.001. Epub 2014 Nov 4. Review.


Loss of keratinocyte focal adhesion kinase stimulates dermal proteolysis through upregulation of MMP9 in wound healing.

Wong VW, Garg RK, Sorkin M, Rustad KC, Akaishi S, Levi K, Nelson ER, Tran M, Rennert R, Liu W, Longaker MT, Dauskardt RH, Gurtner GC.

Ann Surg. 2014 Dec;260(6):1138-46. doi: 10.1097/SLA.0000000000000219.


Copper signaling axis as a target for prostate cancer therapeutics.

Safi R, Nelson ER, Chitneni SK, Franz KJ, George DJ, Zalutsky MR, McDonnell DP.

Cancer Res. 2014 Oct 15;74(20):5819-31. doi: 10.1158/0008-5472.CAN-13-3527.


The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.

McDonnell DP, Chang CY, Nelson ER.

Climacteric. 2014 Dec;17 Suppl 2:60-5. doi: 10.3109/13697137.2014.966949. Epub 2014 Oct 16.


"A to p" screw versus posterolateral plate for posterior malleolus fixation in trimalleolar ankle fractures.

OʼConnor TJ, Mueller B, Ly TV, Jacobson AR, Nelson ER, Cole PA.

J Orthop Trauma. 2015 Apr;29(4):e151-6. doi: 10.1097/BOT.0000000000000230.


Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.

Wright TM, Wardell SE, Jasper JS, Stice JP, Safi R, Nelson ER, McDonnell DP.

Mol Cancer Res. 2014 Dec;12(12):1829-39. doi: 10.1158/1541-7786.MCR-14-0195. Epub 2014 Aug 6.


From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).

Wardell SE, Nelson ER, McDonnell DP.

Steroids. 2014 Nov;90:30-8. doi: 10.1016/j.steroids.2014.07.013. Epub 2014 Jul 30.


Obesity, cholesterol metabolism, and breast cancer pathogenesis.

McDonnell DP, Park S, Goulet MT, Jasper J, Wardell SE, Chang CY, Norris JD, Guyton JR, Nelson ER.

Cancer Res. 2014 Sep 15;74(18):4976-82. doi: 10.1158/0008-5472.CAN-14-1756. Epub 2014 Jul 24.


27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.

Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP.

Science. 2013 Nov 29;342(6162):1094-8. doi: 10.1126/science.1241908.


Molecular analysis and differentiation capacity of adipose-derived stem cells from lymphedema tissue.

Levi B, Glotzbach JP, Sorkin M, Hyun J, Januszyk M, Wan DC, Li S, Nelson ER, Longaker MT, Gurtner GC.

Plast Reconstr Surg. 2013 Sep;132(3):580-9. doi: 10.1097/PRS.0b013e31829ace13.


Estrogen receptor function and regulation in fish and other vertebrates.

Nelson ER, Habibi HR.

Gen Comp Endocrinol. 2013 Oct 1;192:15-24. doi: 10.1016/j.ygcen.2013.03.032. Epub 2013 Apr 11. Review.


Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease.

Wardell SE, Nelson ER, Chao CA, McDonnell DP.

Clin Cancer Res. 2013 May 1;19(9):2420-31. doi: 10.1158/1078-0432.CCR-12-3771. Epub 2013 Mar 27.


The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.

Nelson ER, Wardell SE, McDonnell DP.

Bone. 2013 Mar;53(1):42-50. doi: 10.1016/j.bone.2012.11.011. Epub 2012 Nov 17. Review.


The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.

Wang X, Liao S, Nelson ER, Schmalzigaug R, Spurney RF, Guilak F, Premont RT, Gesty-Palmer D.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):407-12. doi: 10.1016/j.bbrc.2012.07.111. Epub 2012 Jul 27.


Heterotopic ossification following burn injury: the role of stem cells.

Nelson ER, Wong VW, Krebsbach PH, Wang SC, Levi B.

J Burn Care Res. 2012 Jul-Aug;33(4):463-70. doi: 10.1097/BCR.0b013e31825af547. Review.


Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.

Jones LW, Antonelli J, Masko EM, Broadwater G, Lascola CD, Fels D, Dewhirst MW, Dyck JR, Nagendran J, Flores CT, Betof AS, Nelson ER, Pollak M, Dash RC, Young ME, Freedland SJ.

J Appl Physiol (1985). 2012 Jul;113(2):263-72. doi: 10.1152/japplphysiol.01575.2011. Epub 2012 May 17.


Stem cells: update and impact on craniofacial surgery.

Levi B, Glotzbach JP, Wong VW, Nelson ER, Hyun J, Wan DC, Gurtner GC, Longaker MT.

J Craniofac Surg. 2012 Jan;23(1):319-22. doi: 10.1097/SCS.0b013e318241dbaf. Review. No abstract available.


Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.

Wong VW, Rustad KC, Akaishi S, Sorkin M, Glotzbach JP, Januszyk M, Nelson ER, Levi K, Paterno J, Vial IN, Kuang AA, Longaker MT, Gurtner GC.

Nat Med. 2011 Dec 11;18(1):148-52. doi: 10.1038/nm.2574.


New insights into thyroid hormone function and modulation of reproduction in goldfish.

Habibi HR, Nelson ER, Allan ER.

Gen Comp Endocrinol. 2012 Jan 1;175(1):19-26. doi: 10.1016/j.ygcen.2011.11.003. Epub 2011 Nov 11. Review.


Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.

Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18348-53. doi: 10.1073/pnas.1108856108. Epub 2011 Oct 31.


Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme.

Nelson ER, Levi B, Sorkin M, James AW, Liu KJ, Quarto N, Longaker MT.

PLoS One. 2011;6(10):e25847. doi: 10.1371/journal.pone.0025847. Epub 2011 Oct 14.


Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair.

Levi B, Hyun JS, Nelson ER, Li S, Montoro DT, Wan DC, Jia FJ, Glotzbach JC, James AW, Lee M, Huang M, Quarto N, Gurtner GC, Wu JC, Longaker MT.

Stem Cells. 2011 Dec;29(12):2018-29. doi: 10.1002/stem.757.


Commentary on role of apoptosis in retinoic Acid-induced cleft palate.

Nelson ER, Levi B, Longaker MT.

J Craniofac Surg. 2011 Sep;22(5):1572-3. doi: 10.1097/SCS.0b013e31822e5ea6. No abstract available.


CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling.

Levi B, Wan DC, Glotzbach JP, Hyun J, Januszyk M, Montoro D, Sorkin M, James AW, Nelson ER, Li S, Quarto N, Lee M, Gurtner GC, Longaker MT.

J Biol Chem. 2011 Nov 11;286(45):39497-509. doi: 10.1074/jbc.M111.256529. Epub 2011 Sep 23.


The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.

Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP.

Endocrinology. 2011 Dec;152(12):4691-705. doi: 10.1210/en.2011-1298. Epub 2011 Sep 20.

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