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Contributions of Net Charge on the PlyC Endolysin CHAP Domain.

Shang X, Nelson DC.

Antibiotics (Basel). 2019 May 28;8(2). pii: E70. doi: 10.3390/antibiotics8020070.


Structure and tailspike glycosidase machinery of ORF212 from E. coli O157:H7 phage CBA120 (TSP3).

Greenfield J, Shang X, Luo H, Zhou Y, Heselpoth RD, Nelson DC, Herzberg O.

Sci Rep. 2019 May 14;9(1):7349. doi: 10.1038/s41598-019-43748-9.


The PlyB Endolysin of Bacteriophage vB_BanS_Bcp1 Exhibits Broad-Spectrum Bactericidal Activity against Bacillus cereus Sensu Lato Isolates.

Schuch R, Pelzek AJ, Nelson DC, Fischetti VA.

Appl Environ Microbiol. 2019 Apr 18;85(9). pii: e00003-19. doi: 10.1128/AEM.00003-19. Print 2019 May 1.


ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain.

Yang H, Gong Y, Zhang H, Etobayeva I, Miernikiewicz P, Luo D, Li X, Zhang X, Dąbrowska K, Nelson DC, He J, Wei H.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02043-18. doi: 10.1128/AAC.02043-18. Print 2019 Apr.


Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal.

Harhala M, Nelson DC, Miernikiewicz P, Heselpoth RD, Brzezicka B, Majewska J, Linden SB, Shang X, Szymczak A, Lecion D, Marek-Bukowiec K, Kłak M, Wojciechowicz B, Lahutta K, Konieczny A, Dąbrowska K.

Viruses. 2018 Nov 15;10(11). pii: E638. doi: 10.3390/v10110638.


Discovery and Biochemical Characterization of PlyP56, PlyN74, and PlyTB40-Bacillus Specific Endolysins.

Etobayeva I, Linden SB, Alem F, Harb L, Rizkalla L, Mosier PD, Johnson AA, Temple L, Hakami RM, Nelson DC.

Viruses. 2018 May 21;10(5). pii: E276. doi: 10.3390/v10050276.


Borrelia burgdorferi surface-located Lmp1 protein processed into region-specific polypeptides that are critical for microbial persistence.

Zhuang X, Yang X, Altieri AS, Nelson DC, Pal U.

Cell Microbiol. 2018 Sep;20(9):e12855. doi: 10.1111/cmi.12855. Epub 2018 May 25.


Short communication: Recombinant bacteriophage endolysin PlyC is nontoxic and does not alter blood neutrophil oxidative response in lactating dairy cows.

Scholte CM, Nelson DC, Garcia M, Linden SB, Elsasser TH, Kahl S, Qu Y, Moyes KM.

J Dairy Sci. 2018 Jul;101(7):6419-6423. doi: 10.3168/jds.2017-13908. Epub 2018 May 3.


Diversity of Sporosarcina-like Bacterial Strains Obtained from Meter-Scale Augmented and Stimulated Biocementation Experiments.

Graddy CMR, Gomez MG, Kline LM, Morrill SR, DeJong JT, Nelson DC.

Environ Sci Technol. 2018 Apr 3;52(7):3997-4005. doi: 10.1021/acs.est.7b04271. Epub 2018 Mar 13.


The karrikin receptor KAI2 promotes drought resistance in Arabidopsis thaliana.

Li W, Nguyen KH, Chu HD, Ha CV, Watanabe Y, Osakabe Y, Leyva-González MA, Sato M, Toyooka K, Voges L, Tanaka M, Mostofa MG, Seki M, Seo M, Yamaguchi S, Nelson DC, Tian C, Herrera-Estrella L, Tran LP.

PLoS Genet. 2017 Nov 13;13(11):e1007076. doi: 10.1371/journal.pgen.1007076. eCollection 2017 Nov.


Complete Genome Sequence of Klebsiella pneumoniae Phages SopranoGao, MezzoGao, and AltoGao.

Gao S, Linden SB, Nelson DC.

Genome Announc. 2017 Nov 9;5(45). pii: e01009-17. doi: 10.1128/genomeA.01009-17.


Evolution of strigolactone receptors by gradual neo-functionalization of KAI2 paralogues.

Bythell-Douglas R, Rothfels CJ, Stevenson DWD, Graham SW, Wong GK, Nelson DC, Bennett T.

BMC Biol. 2017 Jun 29;15(1):52. doi: 10.1186/s12915-017-0397-z.


Strigolactone Signaling and Evolution.

Waters MT, Gutjahr C, Bennett T, Nelson DC.

Annu Rev Plant Biol. 2017 Apr 28;68:291-322. doi: 10.1146/annurev-arplant-042916-040925. Epub 2017 Jan 11. Review.


Antibiofilm Activities of a Novel Chimeolysin against Streptococcus mutans under Physiological and Cariogenic Conditions.

Yang H, Bi Y, Shang X, Wang M, Linden SB, Li Y, Li Y, Nelson DC, Wei H.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7436-7443. Print 2016 Dec.


Strigolactones, super hormones in the fight against Striga.

Khosla A, Nelson DC.

Curr Opin Plant Biol. 2016 Oct;33:57-63. doi: 10.1016/j.pbi.2016.06.001. Epub 2016 Jun 16. Review.


Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus.

Becker SC, Roach DR, Chauhan VS, Shen Y, Foster-Frey J, Powell AM, Bauchan G, Lease RA, Mohammadi H, Harty WJ, Simmons C, Schmelcher M, Camp M, Dong S, Baker JR, Sheen TR, Doran KS, Pritchard DG, Almeida RA, Nelson DC, Marriott I, Lee JC, Donovan DM.

Sci Rep. 2016 Apr 28;6:25063. doi: 10.1038/srep25063.


Structural modelling and transcriptional responses highlight a clade of PpKAI2-LIKE genes as candidate receptors for strigolactones in Physcomitrella patens.

Lopez-Obando M, Conn CE, Hoffmann B, Bythell-Douglas R, Nelson DC, Rameau C, Bonhomme S.

Planta. 2016 Jun;243(6):1441-53. doi: 10.1007/s00425-016-2481-y. Epub 2016 Mar 15.


A bacteriophage endolysin that eliminates intracellular streptococci.

Shen Y, Barros M, Vennemann T, Gallagher DT, Yin Y, Linden SB, Heselpoth RD, Spencer DJ, Donovan DM, Moult J, Fischetti VA, Heinrich F, Lösche M, Nelson DC.

Elife. 2016 Mar 15;5. pii: e13152. doi: 10.7554/eLife.13152.


Smoke and Hormone Mirrors: Action and Evolution of Karrikin and Strigolactone Signaling.

Morffy N, Faure L, Nelson DC.

Trends Genet. 2016 Mar;32(3):176-188. doi: 10.1016/j.tig.2016.01.002. Epub 2016 Feb 2. Review.


Evidence that KARRIKIN-INSENSITIVE2 (KAI2) Receptors may Perceive an Unknown Signal that is not Karrikin or Strigolactone.

Conn CE, Nelson DC.

Front Plant Sci. 2016 Jan 8;6:1219. doi: 10.3389/fpls.2015.01219. eCollection 2015.


Functional redundancy in the control of seedling growth by the karrikin signaling pathway.

Stanga JP, Morffy N, Nelson DC.

Planta. 2016 Jun;243(6):1397-406. doi: 10.1007/s00425-015-2458-2. Epub 2016 Jan 11.


A chimeolysin with extended-spectrum streptococcal host range found by an induced lysis-based rapid screening method.

Yang H, Linden SB, Wang J, Yu J, Nelson DC, Wei H.

Sci Rep. 2015 Nov 26;5:17257. doi: 10.1038/srep17257.


SMAX1-LIKE/D53 Family Members Enable Distinct MAX2-Dependent Responses to Strigolactones and Karrikins in Arabidopsis.

Soundappan I, Bennett T, Morffy N, Liang Y, Stanga JP, Abbas A, Leyser O, Nelson DC.

Plant Cell. 2015 Nov;27(11):3143-59. doi: 10.1105/tpc.15.00562. Epub 2015 Nov 6.


Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection.

Yang X, Lin YP, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U.

Cell Microbiol. 2016 Jan;18(1):97-110. doi: 10.1111/cmi.12487. Epub 2015 Aug 31.


PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasitic plants.

Conn CE, Bythell-Douglas R, Neumann D, Yoshida S, Whittington B, Westwood JH, Shirasu K, Bond CS, Dyer KA, Nelson DC.

Science. 2015 Jul 31;349(6247):540-3. doi: 10.1126/science.aab1140.


Increasing the stability of the bacteriophage endolysin PlyC using rationale-based FoldX computational modeling.

Heselpoth RD, Yin Y, Moult J, Nelson DC.

Protein Eng Des Sel. 2015 Apr;28(4):85-92. doi: 10.1093/protein/gzv004. Epub 2015 Mar 3.


Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection.

Schmelcher M, Shen Y, Nelson DC, Eugster MR, Eichenseher F, Hanke DC, Loessner MJ, Dong S, Pritchard DG, Lee JC, Becker SC, Foster-Frey J, Donovan DM.

J Antimicrob Chemother. 2015 May;70(5):1453-65. doi: 10.1093/jac/dku552. Epub 2015 Jan 27.


Quantitative analysis of the thermal stability of the gamma phage endolysin PlyG: a biophysical and kinetic approach to assaying therapeutic potential.

Heselpoth RD, Owens JM, Nelson DC.

Virology. 2015 Mar;477:125-132. doi: 10.1016/j.virol.2014.11.003. Epub 2014 Nov 26.


Characterization of AlgMsp, an alginate lyase from Microbulbifer sp. 6532A.

Swift SM, Hudgens JW, Heselpoth RD, Bales PM, Nelson DC.

PLoS One. 2014 Nov 19;9(11):e112939. doi: 10.1371/journal.pone.0112939. eCollection 2014.


Biochemical and biophysical characterization of PlyGRCS, a bacteriophage endolysin active against methicillin-resistant Staphylococcus aureus.

Linden SB, Zhang H, Heselpoth RD, Shen Y, Schmelcher M, Eichenseher F, Nelson DC.

Appl Microbiol Biotechnol. 2015 Jan;99(2):741-52. doi: 10.1007/s00253-014-5930-1. Epub 2014 Jul 20.


Complete Genome Sequence of Bacillus cereus Sensu Lato Bacteriophage Bcp1.

Schuch R, Pelzek AJ, Fazzini MM, Nelson DC, Fischetti VA.

Genome Announc. 2014 Jun 12;2(3). pii: e00334-14. doi: 10.1128/genomeA.00334-14.


Complete Genome Sequence of Staphylococcus aureus Phage GRCS.

Swift SM, Nelson DC.

Genome Announc. 2014 Apr 10;2(2). pii: e00209-14. doi: 10.1128/genomeA.00209-14.


Crystal structure of ORF210 from E. coli O157:H1 phage CBA120 (TSP1), a putative tailspike protein.

Chen C, Bales P, Greenfield J, Heselpoth RD, Nelson DC, Herzberg O.

PLoS One. 2014 Mar 26;9(3):e93156. doi: 10.1371/journal.pone.0093156. eCollection 2014.


Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10.

Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini M, Burgin A, Chen C, Cochran FV, Craig TK, Das R, Fass D, Garcia-Doval C, Herzberg O, Lorimer D, Luecke H, Ma X, Nelson DC, van Raaij MJ, Rohwer F, Segall A, Seguritan V, Zeth K, Schwede T.

Proteins. 2014 Feb;82 Suppl 2:26-42. doi: 10.1002/prot.24489. Erratum in: Proteins. 2015 Jun;83(6):1198.


Determining carbapenemase activity with 18O labeling and targeted mass spectrometry.

Wang M, Shen Y, Turko IV, Nelson DC, Li S.

Anal Chem. 2013 Nov 19;85(22):11014-9. doi: 10.1021/ac402627k. Epub 2013 Oct 29.


SUPPRESSOR OF MORE AXILLARY GROWTH2 1 controls seed germination and seedling development in Arabidopsis.

Stanga JP, Smith SM, Briggs WR, Nelson DC.

Plant Physiol. 2013 Sep;163(1):318-30. doi: 10.1104/pp.113.221259. Epub 2013 Jul 26.


Purification and Characterization of Biofilm-Associated EPS Exopolysaccharides from ESKAPE Organisms and Other Pathogens.

Bales PM, Renke EM, May SL, Shen Y, Nelson DC.

PLoS One. 2013 Jun 21;8(6):e67950. doi: 10.1371/journal.pone.0067950. Print 2013.


Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin.

Shen Y, Köller T, Kreikemeyer B, Nelson DC.

J Antimicrob Chemother. 2013 Aug;68(8):1818-24. doi: 10.1093/jac/dkt104. Epub 2013 Apr 4.


Critical cell wall hole size for lysis in Gram-positive bacteria.

Mitchell GJ, Wiesenfeld K, Nelson DC, Weitz JS.

J R Soc Interface. 2013 Jan 9;10(80):20120892. doi: 10.1098/rsif.2012.0892. Print 2013 Mar 6.


A new screening method for the directed evolution of thermostable bacteriolytic enzymes.

Heselpoth RD, Nelson DC.

J Vis Exp. 2012 Nov 7;(69). pii: 4216. doi: 10.3791/4216.


X-ray crystal structure of the streptococcal specific phage lysin PlyC.

McGowan S, Buckle AM, Mitchell MS, Hoopes JT, Gallagher DT, Heselpoth RD, Shen Y, Reboul CF, Law RH, Fischetti VA, Whisstock JC, Nelson DC.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12752-7. doi: 10.1073/pnas.1208424109. Epub 2012 Jul 17.


Endolysins as antimicrobials.

Nelson DC, Schmelcher M, Rodriguez-Rubio L, Klumpp J, Pritchard DG, Dong S, Donovan DM.

Adv Virus Res. 2012;83:299-365. doi: 10.1016/B978-0-12-394438-2.00007-4. Review.


Regulation of seed germination and seedling growth by chemical signals from burning vegetation.

Nelson DC, Flematti GR, Ghisalberti EL, Dixon KW, Smith SM.

Annu Rev Plant Biol. 2012;63:107-30. doi: 10.1146/annurev-arplant-042811-105545. Epub 2012 Feb 9. Review.


Specialisation within the DWARF14 protein family confers distinct responses to karrikins and strigolactones in Arabidopsis.

Waters MT, Nelson DC, Scaffidi A, Flematti GR, Sun YK, Dixon KW, Smith SM.

Development. 2012 Apr;139(7):1285-95. doi: 10.1242/dev.074567. Epub 2012 Feb 22.


Ratiometric fluorescence detection of pathogenic bacteria resistant to broad-spectrum β-lactam antibiotics.

Zhang J, Shen Y, May SL, Nelson DC, Li S.

Angew Chem Int Ed Engl. 2012 Feb 20;51(8):1865-8. doi: 10.1002/anie.201107810. Epub 2012 Jan 13. No abstract available.


Cysteine proteinase SpeB from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins.

Nelson DC, Garbe J, Collin M.

Biol Chem. 2011 Dec;392(12):1077-88. doi: 10.1515/BC.2011.208. Review.


Smoke signals and seed dormancy: where next for MAX2?

Waters MT, Smith SM, Nelson DC.

Plant Signal Behav. 2011 Sep;6(9):1418-22. doi: 10.4161/psb.6.9.17303.


Effects of environmental factors on microbial induced calcium carbonate precipitation.

Mortensen BM, Haber MJ, DeJong JT, Caslake LF, Nelson DC.

J Appl Microbiol. 2011 Aug;111(2):338-49. doi: 10.1111/j.1365-2672.2011.05065.x. Epub 2011 Jun 30.


F-box protein MAX2 has dual roles in karrikin and strigolactone signaling in Arabidopsis thaliana.

Nelson DC, Scaffidi A, Dun EA, Waters MT, Flematti GR, Dixon KW, Beveridge CA, Ghisalberti EL, Smith SM.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8897-902. doi: 10.1073/pnas.1100987108. Epub 2011 May 9.

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