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Did you mean nelf (279 results)?
NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma.
Dang H, Pomyen Y, Martin SP, Dominguez DA, Yim SY, Lee JS, Budhu A, Shah AP, Bodzin AS, Wang XW. Dang H, et al. Sci Rep. 2019 Mar 4;9(1):3369. doi: 10.1038/s41598-019-39727-9. Sci Rep. 2019. PMID: 30833661 Free PMC article.
Due to the failure of these strategies to provide accurate diagnostics and prognostic value, we have developed a Negative Elongation Factor E (NELFE)-Dependent MYC Target (NDMT) gene signature. This signature, which consists of genes regulated by MYC and NELFE, an R …
Due to the failure of these strategies to provide accurate diagnostics and prognostic value, we have developed a Negative Elongation Factor …
NELFE promoted pancreatic cancer metastasis and the epithelial-to-mesenchymal transition by decreasing the stabilization of NDRG2 mRNA.
Han L, Zan Y, Huang C, Zhang S. Han L, et al. Int J Oncol. 2019 Dec;55(6):1313-1323. doi: 10.3892/ijo.2019.4890. Epub 2019 Oct 2. Int J Oncol. 2019. PMID: 31638184 Free PMC article.
NELFE and NDRG2 were then knocked-down by short hairpin (sh)RNA. ...NELFE expression was increased in PC tissues compared with the paired non-cancerous tissues. ...
NELFE and NDRG2 were then knocked-down by short hairpin (sh)RNA. ...NELFE expression was increased in PC tissues compared with …
The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2.
Chen C, Zheng Q, Pan S, Chen W, Huang J, Cao Y, Tu Y, Li Z, Yu C, Jie Z. Chen C, et al. Front Oncol. 2021 Jul 6;11:677111. doi: 10.3389/fonc.2021.677111. eCollection 2021. Front Oncol. 2021. PMID: 34295816 Free PMC article.
Therefore, NELFE at least partially functions as an oncogene through E2F2. Moreover, CIBERSORTx analysis of the proportion of tumor-infiltrating immune cells (TICs) revealed that immune cells are correlated with NELFE and E2F2 expression, suggesting that NELFE …
Therefore, NELFE at least partially functions as an oncogene through E2F2. Moreover, CIBERSORTx analysis of the proportion of tumor-i …
Overexpression of NELFE contributes to gastric cancer progression via Wnt/beta-catenin signaling-mediated activation of CSNK2B expression.
Yu S, Li L, Cai H, He B, Gao Y, Li Y. Yu S, et al. J Exp Clin Cancer Res. 2021 Feb 1;40(1):54. doi: 10.1186/s13046-021-01848-3. J Exp Clin Cancer Res. 2021. PMID: 33526068 Free PMC article.
This study aimed to explore the expression pattern and specific function of NELFE in GC. METHODS: NELFE expression was evaluated by immunohistochemistry and qRT-PCR in GC tissues, respectively. ...CSNK2B was identified as a downstream effector of NELFE. Wnt/b …
This study aimed to explore the expression pattern and specific function of NELFE in GC. METHODS: NELFE expression was evaluat …
Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma.
Dang H, Takai A, Forgues M, Pomyen Y, Mou H, Xue W, Ray D, Ha KCH, Morris QD, Hughes TR, Wang XW. Dang H, et al. Cancer Cell. 2017 Jul 10;32(1):101-114.e8. doi: 10.1016/j.ccell.2017.06.002. Cancer Cell. 2017. PMID: 28697339 Free PMC article.
Interestingly, NELFE induces a unique tumor transcriptome by selectively regulating MYC-associated genes. Thus, our results revealed NELFE as an oncogenic protein that may contribute to transcriptome imbalance in HCC through the regulation of MYC signaling....
Interestingly, NELFE induces a unique tumor transcriptome by selectively regulating MYC-associated genes. Thus, our results revealed …
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.
Zhang J, Hu Z, Chung HH, Tian Y, Lau KW, Ser Z, Lim YT, Sobota RM, Leong HF, Chen BJ, Yeo CJ, Tan SYX, Kang J, Tan DEK, Sou IF, McClurg UL, Lakshmanan M, Vaiyapuri TS, Raju A, Wong ESM, Tergaonkar V, Rajarethinam R, Pathak E, Tam WL, Tan EY, Tee WW. Zhang J, et al. Nat Commun. 2023 Apr 28;14(1):2439. doi: 10.1038/s41467-023-38132-1. Nat Commun. 2023. PMID: 37117180 Free PMC article.
MHC Class III RNA Binding Proteins and Immunity.
Schott G, Garcia-Blanco MA. Schott G, et al. RNA Biol. 2021 May;18(5):640-646. doi: 10.1080/15476286.2020.1860388. Epub 2020 Dec 20. RNA Biol. 2021. PMID: 33280511 Free PMC article. Review.
We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regula …
We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT …
Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Kidney Cancers.
Ioannou I, Chatziantoniou A, Drenios C, Christodoulou P, Kourti M, Zaravinos A. Ioannou I, et al. Int J Mol Sci. 2023 Mar 31;24(7):6577. doi: 10.3390/ijms24076577. Int J Mol Sci. 2023. PMID: 37047552 Free PMC article.
Differential expression and upstream regulators, including transcription factors [MYC proto-oncogene (MYC), CCAAT enhancer binding protein delta (CEBPD), RELA proto-oncogene, NF-kB subunit (RELA), zinc finger MIZ-type containing 1 (ZMIZ1), negative elongation factor complex membe …
Differential expression and upstream regulators, including transcription factors [MYC proto-oncogene (MYC), CCAAT enhancer binding protein d …
Identification of metabolic pathways contributing to ER+ breast cancer disparities using a machine-learning pipeline.
Santaliz-Casiano A, Mehta D, Danciu OC, Patel H, Banks L, Zaidi A, Buckley J, Rauscher GH, Schulte L, Weller LR, Taiym D, Liko-Hazizi E, Pulliam N, Friedewald SM, Khan S, Kim JJ, Gradishar W, Hegerty S, Frasor J, Hoskins KF, Madak-Erdogan Z. Santaliz-Casiano A, et al. Sci Rep. 2023 Jul 26;13(1):12136. doi: 10.1038/s41598-023-39215-1. Sci Rep. 2023. PMID: 37495653 Free PMC article.
By mapping these metabolites to potential epigenetic regulatory mechanisms, this study identified significant associations with regulators of metabolism such as methionine adenosyltransferase 1A (MAT1A), DNA Methyltransferases and Histone methyltransferases for AA individuals, an …
By mapping these metabolites to potential epigenetic regulatory mechanisms, this study identified significant associations with regulators o …
p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P. Borisova ME, et al. Nat Commun. 2018 Mar 9;9(1):1017. doi: 10.1038/s41467-018-03417-3. Nat Commun. 2018. PMID: 29523821 Free PMC article.
Mechanistically, we show that MK2 phosphorylates the RNA-binding subunit of the NELF complex NELFE on Serine 115. NELFE phosphorylation promotes the recruitment of 14-3-3 and rapid dissociation of the NELF complex from chromatin, which is accompanied by RNA polymera …
Mechanistically, we show that MK2 phosphorylates the RNA-binding subunit of the NELF complex NELFE on Serine 115. NELFE phosph …
53 results