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Items: 47

1.

Image-Based Detection of Patient-Specific Drug-Induced Cell-Cycle Effects in Glioblastoma.

Matuszewski DJ, Wählby C, Krona C, Nelander S, Sintorn IM.

SLAS Discov. 2018 Aug 3:2472555218791414. doi: 10.1177/2472555218791414. [Epub ahead of print]

PMID:
30074852
2.

Primary glioblastoma cells for precision medicine: a quantitative portrait of genomic (in)stability during the first 30 passages.

Baskaran S, Mayrhofer M, Kultima HG, Bergström T, Elfineh L, Cavelier L, Isaksson A, Nelander S.

Neuro Oncol. 2018 Jul 5;20(8):1080-1091. doi: 10.1093/neuonc/noy024.

PMID:
29462414
3.

FC1000: normalized gene expression changes of systematically perturbed human cells.

Lönnstedt IM, Nelander S.

Stat Appl Genet Mol Biol. 2017 Sep 26;16(4):217-242. doi: 10.1515/sagmb-2016-0072.

PMID:
28862994
4.

Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Nilsson KF, Hammarström LGJ, Ernfors P.

Cell. 2017 Jul 13;170(2):407. doi: 10.1016/j.cell.2017.06.044. No abstract available.

5.

Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression.

Fedele V, Dai F, Masilamani AP, Heiland DH, Kling E, Gätjens-Sanchez AM, Ferrarese R, Platania L, Soroush D, Kim H, Nelander S, Weyerbrock A, Prinz M, Califano A, Iavarone A, Bredel M, Carro MS.

Mol Cancer Res. 2017 Aug;15(8):998-1011. doi: 10.1158/1541-7786.MCR-16-0494. Epub 2017 May 16.

6.

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.

Jiang Y, Marinescu VD, Xie Y, Jarvius M, Maturi NP, Haglund C, Olofsson S, Lindberg N, Olofsson T, Leijonmarck C, Hesselager G, Alafuzoff I, Fryknäs M, Larsson R, Nelander S, Uhrbom L.

Cell Rep. 2017 May 2;19(5):1080-1081. doi: 10.1016/j.celrep.2017.04.053. No abstract available.

7.

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.

Jiang Y, Marinescu VD, Xie Y, Jarvius M, Maturi NP, Haglund C, Olofsson S, Lindberg N, Olofsson T, Leijonmarck C, Hesselager G, Alafuzoff I, Fryknäs M, Larsson R, Nelander S, Uhrbom L.

Cell Rep. 2017 Jan 24;18(4):977-990. doi: 10.1016/j.celrep.2017.01.003. Erratum in: Cell Rep. 2017 May 2;19(5):1080-1081.

8.

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, Schmidt L, Fritz N, Dehnisch I, Kyriatzis G, Krafcikova M, Carson BB, Feenstra JM, Marinescu VD, Segerman A, Haraldsson M, Gustavsson AL, Hammarström LG, Jenmalm Jensen A, Uhrbom L, Altelaar AF, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Enger PØ, Andäng M.

Cancer Res. 2017 Apr 1;77(7):1741-1752. doi: 10.1158/0008-5472.CAN-16-2274. Epub 2017 Jan 13.

9.

c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas.

Heiland DH, Ferrarese R, Claus R, Dai F, Masilamani AP, Kling E, Weyerbrock A, Kling T, Nelander S, Carro MS.

Oncotarget. 2017 Jan 24;8(4):6940-6954. doi: 10.18632/oncotarget.14330.

10.

Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma.

Kling T, Ferrarese R, Ó hAilín D, Johansson P, Heiland DH, Dai F, Vasilikos I, Weyerbrock A, Jörnsten R, Carro MS, Nelander S.

EBioMedicine. 2016 Oct;12:72-85. doi: 10.1016/j.ebiom.2016.08.050. Epub 2016 Sep 18.

11.

Case-specific potentiation of glioblastoma drugs by pterostilbene.

Schmidt L, Baskaran S, Johansson P, Padhan N, Matuszewski D, Green LC, Elfineh L, Wee S, Häggblad M, Martens U, Westermark B, Forsberg-Nilsson K, Uhrbom L, Claesson-Welsh L, Andäng M, Sintorn IM, Lundgren B, Lönnstedt I, Krona C, Nelander S.

Oncotarget. 2016 Nov 8;7(45):73200-73215. doi: 10.18632/oncotarget.12298.

12.

Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus.

Ramachandran M, Yu D, Dyczynski M, Baskaran S, Zhang L, Lulla A, Lulla V, Saul S, Nelander S, Dimberg A, Merits A, Leja-Jarblad J, Essand M.

Clin Cancer Res. 2017 Mar 15;23(6):1519-1530. doi: 10.1158/1078-0432.CCR-16-0925. Epub 2016 Sep 16.

13.

Origin of the U87MG glioma cell line: Good news and bad news.

Allen M, Bjerke M, Edlund H, Nelander S, Westermark B.

Sci Transl Med. 2016 Aug 31;8(354):354re3. doi: 10.1126/scitranslmed.aaf6853.

PMID:
27582061
14.

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer.

Padhan N, Nordling TE, Sundström M, Åkerud P, Birgisson H, Nygren P, Nelander S, Claesson-Welsh L.

BMC Cancer. 2016 Aug 25;16(1):683. doi: 10.1186/s12885-016-2725-z.

15.

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells.

Wee B, Pietras A, Ozawa T, Bazzoli E, Podlaha O, Antczak C, Westermark B, Nelander S, Uhrbom L, Forsberg-Nilsson K, Djaballah H, Michor F, Holland EC.

Sci Rep. 2016 Jul 26;6:25956. doi: 10.1038/srep25956.

16.

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.

Mitchell JS, Li N, Weinhold N, Försti A, Ali M, van Duin M, Thorleifsson G, Johnson DC, Chen B, Halvarsson BM, Gudbjartsson DF, Kuiper R, Stephens OW, Bertsch U, Broderick P, Campo C, Einsele H, Gregory WA, Gullberg U, Henrion M, Hillengass J, Hoffmann P, Jackson GH, Johnsson E, Jöud M, Kristinsson SY, Lenhoff S, Lenive O, Mellqvist UH, Migliorini G, Nahi H, Nelander S, Nickel J, Nöthen MM, Rafnar T, Ross FM, da Silva Filho MI, Swaminathan B, Thomsen H, Turesson I, Vangsted A, Vogel U, Waage A, Walker BA, Wihlborg AK, Broyl A, Davies FE, Thorsteinsdottir U, Langer C, Hansson M, Kaiser M, Sonneveld P, Stefansson K, Morgan GJ, Goldschmidt H, Hemminki K, Nilsson B, Houlston RS.

Nat Commun. 2016 Jul 1;7:12050. doi: 10.1038/ncomms12050.

17.

Travelling wave analysis of a mathematical model of glioblastoma growth.

Gerlee P, Nelander S.

Math Biosci. 2016 Jun;276:75-81. doi: 10.1016/j.mbs.2016.03.004. Epub 2016 Mar 25.

PMID:
27021919
18.

Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells.

Darmanis S, Gallant CJ, Marinescu VD, Niklasson M, Segerman A, Flamourakis G, Fredriksson S, Assarsson E, Lundberg M, Nelander S, Westermark B, Landegren U.

Cell Rep. 2016 Jan 12;14(2):380-9. doi: 10.1016/j.celrep.2015.12.021. Epub 2015 Dec 31.

19.

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.

Xie Y, Bergström T, Jiang Y, Johansson P, Marinescu VD, Lindberg N, Segerman A, Wicher G, Niklasson M, Baskaran S, Sreedharan S, Everlien I, Kastemar M, Hermansson A, Elfineh L, Libard S, Holland EC, Hesselager G, Alafuzoff I, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L.

EBioMedicine. 2015 Aug 15;2(10):1351-63. doi: 10.1016/j.ebiom.2015.08.026. eCollection 2015 Oct.

20.

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.

Dijksterhuis JP, Arthofer E, Marinescu VD, Nelander S, Uhlén M, Pontén F, Mulder J, Schulte G.

Exp Cell Res. 2015 Dec 10;339(2):280-8. doi: 10.1016/j.yexcr.2015.10.022. Epub 2015 Oct 25.

PMID:
26511503
21.

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells.

Roy A, Coum A, Marinescu VD, Põlajeva J, Smits A, Nelander S, Uhrbom L, Westermark B, Forsberg-Nilsson K, Pontén F, Tchougounova E.

Oncotarget. 2015 Sep 15;6(27):23647-61.

22.

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.

Swaminathan B, Thorleifsson G, Jöud M, Ali M, Johnsson E, Ajore R, Sulem P, Halvarsson BM, Eyjolfsson G, Haraldsdottir V, Hultman C, Ingelsson E, Kristinsson SY, Kähler AK, Lenhoff S, Masson G, Mellqvist UH, Månsson R, Nelander S, Olafsson I, Sigurðardottir O, Steingrimsdóttir H, Vangsted A, Vogel U, Waage A, Nahi H, Gudbjartsson DF, Rafnar T, Turesson I, Gullberg U, Stefánsson K, Hansson M, Thorsteinsdóttir U, Nilsson B.

Nat Commun. 2015 May 26;6:7213. doi: 10.1038/ncomms8213.

23.

Efficient exploration of pan-cancer networks by generalized covariance selection and interactive web content.

Kling T, Johansson P, Sanchez J, Marinescu VD, Jörnsten R, Nelander S.

Nucleic Acids Res. 2015 Sep 3;43(15):e98. doi: 10.1093/nar/gkv413. Epub 2015 May 7.

24.

Selective calcium sensitivity in immature glioma cancer stem cells.

Wee S, Niklasson M, Marinescu VD, Segerman A, Schmidt L, Hermansson A, Dirks P, Forsberg-Nilsson K, Westermark B, Uhrbom L, Linnarsson S, Nelander S, Andäng M.

PLoS One. 2014 Dec 22;9(12):e115698. doi: 10.1371/journal.pone.0115698. eCollection 2014.

25.

Avoiding pitfalls in L1-regularised inference of gene networks.

Tjärnberg A, Nordling TE, Studham M, Nelander S, Sonnhammer EL.

Mol Biosyst. 2015 Jan;11(1):287-96. doi: 10.1039/c4mb00419a. Epub 2014 Nov 7.

PMID:
25377664
26.

Functional association networks as priors for gene regulatory network inference.

Studham ME, Tjärnberg A, Nordling TE, Nelander S, Sonnhammer EL.

Bioinformatics. 2014 Jun 15;30(12):i130-8. doi: 10.1093/bioinformatics/btu285.

27.

Bridging the gaps in systems biology.

Cvijovic M, Almquist J, Hagmar J, Hohmann S, Kaltenbach HM, Klipp E, Krantz M, Mendes P, Nelander S, Nielsen J, Pagnani A, Przulj N, Raue A, Stelling J, Stoma S, Tobin F, Wodke JA, Zecchina R, Jirstrand M.

Mol Genet Genomics. 2014 Oct;289(5):727-34. doi: 10.1007/s00438-014-0843-3. Epub 2014 Apr 13. Review.

PMID:
24728588
28.

RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Forsberg Nilsson K, Hammarström LGJ, Ernfors P.

Cell. 2014 Apr 10;157(2):313-328. doi: 10.1016/j.cell.2014.02.021. Epub 2014 Mar 20. Retraction in: Cell. 2017 Jul 13;170(2):407.

29.

Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions.

Schmidt L, Kling T, Monsefi N, Olsson M, Hansson C, Baskaran S, Lundgren B, Martens U, Häggblad M, Westermark B, Forsberg Nilsson K, Uhrbom L, Karlsson-Lindahl L, Gerlee P, Nelander S.

Neuro Oncol. 2013 Nov;15(11):1469-78. doi: 10.1093/neuonc/not111. Epub 2013 Oct 6.

30.

Searching for synergies: matrix algebraic approaches for efficient pair screening.

Gerlee P, Schmidt L, Monsefi N, Kling T, Jörnsten R, Nelander S.

PLoS One. 2013 Jul 25;8(7):e68598. doi: 10.1371/journal.pone.0068598. Print 2013.

31.

The impact of phenotypic switching on glioblastoma growth and invasion.

Gerlee P, Nelander S.

PLoS Comput Biol. 2012;8(6):e1002556. doi: 10.1371/journal.pcbi.1002556. Epub 2012 Jun 14.

32.

Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.

Persson M, Andrén Y, Moskaluk CA, Frierson HF Jr, Cooke SL, Futreal PA, Kling T, Nelander S, Nordkvist A, Persson F, Stenman G.

Genes Chromosomes Cancer. 2012 Aug;51(8):805-17. doi: 10.1002/gcc.21965. Epub 2012 Apr 16.

PMID:
22505352
33.

System-scale network modeling of cancer using EPoC.

Abenius T, Jörnsten R, Kling T, Schmidt L, Sánchez J, Nelander S.

Adv Exp Med Biol. 2012;736:617-43. doi: 10.1007/978-1-4419-7210-1_37.

PMID:
22161356
34.

Network modeling of the transcriptional effects of copy number aberrations in glioblastoma.

Jörnsten R, Abenius T, Kling T, Schmidt L, Johansson E, Nordling TE, Nordlander B, Sander C, Gennemark P, Funa K, Nilsson B, Lindahl L, Nelander S.

Mol Syst Biol. 2011 Apr 26;7:486. doi: 10.1038/msb.2011.17.

35.

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2.

Schultz N, Marenstein DR, De Angelis DA, Wang WQ, Nelander S, Jacobsen A, Marks DS, Massagué J, Sander C.

Silence. 2011 Mar 14;2:3. doi: 10.1186/1758-907X-2-3.

36.

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S.

Nat Genet. 2010 Aug;42(8):715-21. doi: 10.1038/ng.619. Epub 2010 Jul 4.

37.

Models from experiments: combinatorial drug perturbations of cancer cells.

Nelander S, Wang W, Nilsson B, She QB, Pratilas C, Rosen N, Gennemark P, Sander C.

Mol Syst Biol. 2008;4:216. doi: 10.1038/msb.2008.53. Epub 2008 Sep 2.

38.

Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin.

Petit MM, Lindskog H, Larsson E, Wasteson P, Athley E, Breuer S, Angstenberger M, Hertfelder D, Mattsson E, Nordheim A, Nelander S, Lindahl P.

Circ Res. 2008 Jul 3;103(1):61-9. doi: 10.1161/CIRCRESAHA.108.177436. Epub 2008 May 29.

PMID:
18511849
39.

Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle?

Larsson E, McLean SE, Mecham RP, Lindahl P, Nelander S.

Mol Genet Genomics. 2008 Aug;280(2):127-37. doi: 10.1007/s00438-008-0349-y. Epub 2008 May 29.

PMID:
18509681
40.

An improved method for detecting and delineating genomic regions with altered gene expression in cancer.

Nilsson B, Johansson M, Heyden A, Nelander S, Fioretos T.

Genome Biol. 2008 Jan 21;9(1):R13. doi: 10.1186/gb-2008-9-1-r13.

41.

Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies.

Nilsson B, Håkansson P, Johansson M, Nelander S, Fioretos T.

Genome Biol. 2007;8(5):R74.

42.

DNA microarray study on gene expression profiles in co-cultured endothelial and smooth muscle cells in response to 4- and 24-h shear stress.

Heydarkhan-Hagvall S, Chien S, Nelander S, Li YC, Yuan S, Lao J, Haga JH, Lian I, Nguyen P, Risberg B, Li YS.

Mol Cell Biochem. 2006 Jan;281(1-2):1-15.

PMID:
16328952
43.

Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics.

Akerblad P, Månsson R, Lagergren A, Westerlund S, Basta B, Lind U, Thelin A, Gisler R, Liberg D, Nelander S, Bamberg K, Sigvardsson M.

Physiol Genomics. 2005 Oct 17;23(2):206-16. Epub 2005 Aug 16.

44.

Neural cell adhesion molecule-deficient beta-cell tumorigenesis results in diminished extracellular matrix molecule expression and tumour cell-matrix adhesion.

Håkansson J, Xian X, He L, Ståhlberg A, Nelander S, Samuelsson T, Kubista M, Semb H.

Tumour Biol. 2005 Mar-Apr;26(2):103-12.

PMID:
15897690
45.

Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals.

Nelander S, Larsson E, Kristiansson E, Månsson R, Nerman O, Sigvardsson M, Mostad P, Lindahl P.

BMC Genomics. 2005 May 9;6:68.

46.

Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.

Duan RD, Bergman T, Xu N, Wu J, Cheng Y, Duan J, Nelander S, Palmberg C, Nilsson A.

J Biol Chem. 2003 Oct 3;278(40):38528-36. Epub 2003 Jul 28.

47.

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