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Items: 1 to 50 of 101

1.

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription.

Ivanov A, Lin X, Ammosova T, Ilatovskiy AV, Kumari N, Lassiter H, Afangbedji N, Niu X, Petukhov MG, Nekhai S.

Retrovirology. 2018 May 23;15(1):39. doi: 10.1186/s12977-018-0422-5.

2.

Biomarker signatures of sickle cell disease severity.

Du M, Van Ness S, Gordeuk V, Nouraie SM, Nekhai S, Gladwin M, Steinberg MH, Sebastiani P.

Blood Cells Mol Dis. 2018 May 16. pii: S1079-9796(18)30173-6. doi: 10.1016/j.bcmd.2018.05.001. [Epub ahead of print]

PMID:
29778312
3.

Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation.

Carey BD, Ammosova T, Pinkham C, Lin X, Zhou W, Liotta LA, Nekhai S, Kehn-Hall K.

J Virol. 2018 May 16. pii: JVI.02068-17. doi: 10.1128/JVI.02068-17. [Epub ahead of print]

PMID:
29769351
4.

Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.

Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Ilinykh PA, Bukreyev A, Nekhai S, Aman MJ, Kashanchi F.

Front Microbiol. 2018 Apr 17;9:692. doi: 10.3389/fmicb.2018.00692. eCollection 2018.

5.

RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.

Khaibullina A, Adjei EA, Afangbedji N, Ivanov A, Kumari N, Almeida LEF, Quezado ZMN, Nekhai S, Jerebtsova M.

Haematologica. 2018 May;103(5):787-798. doi: 10.3324/haematol.2017.180992. Epub 2018 Mar 8.

6.

RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.

Richard CA, Rincheval V, Lassoued S, Fix J, Cardone C, Esneau C, Nekhai S, Galloux M, Rameix-Welti MA, Sizun C, Eléouët JF.

PLoS Pathog. 2018 Feb 28;14(3):e1006920. doi: 10.1371/journal.ppat.1006920. eCollection 2018 Mar.

7.

Urinary orosomucoid is associated with progressive chronic kidney disease stage in patients with sickle cell anemia.

Jerebtsova M, Saraf SL, Soni S, Afangbedji N, Lin X, Raslan R, Gordeuk VR, Nekhai S.

Am J Hematol. 2018 Aug;93(4):E107-E109. doi: 10.1002/ajh.25036. Epub 2018 Feb 5. No abstract available.

PMID:
29327376
8.

Identification of ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients by proteomic analysis.

Jerebtsova M, Saraf SL, Lin X, Lee G, Adjei EA, Kumari N, Afangbedji N, Raslan R, McLean C, Gordeuk VR, Nekhai S.

Am J Hematol. 2018 Feb;93(2):E45-E47. doi: 10.1002/ajh.24965. Epub 2017 Nov 27. No abstract available.

PMID:
29127684
9.

Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03.

Lin X, Kumari N, DeMarino C, Kont YS, Ammosova T, Kulkarni A, Jerebtsova M, Vazquez-Meves G, Ivanov A, Dmytro K, Üren A, Kashanchi F, Nekhai S.

Oncotarget. 2017 Aug 7;8(44):76749-76769. doi: 10.18632/oncotarget.19999. eCollection 2017 Sep 29.

10.

Protein Phosphatase-1 -targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals.

Lin X, Ammosova T, Kumari N, Nekhai S.

Curr Pharm Des. 2017;23(28):4122-4132. doi: 10.2174/1381612823666170704123620. Review.

11.

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease.

Kumari N, Ammosova T, Diaz S, Lin X, Niu X, Ivanov A, Jerebtsova M, Dhawan S, Oneal P, Nekhai S.

Blood Adv. 2016 Dec 27;1(3):170-183. doi: 10.1182/bloodadvances.2016000745.

12.

A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR.

Hum Mol Genet. 2016 Oct 15;25(20):4601-4609. doi: 10.1093/hmg/ddw299.

PMID:
28173069
13.

Therapeutic potential of the heme oxygenase-1 inducer hemin against Ebola virus infection.

Huang H, Konduru K, Solovena V, Zhou ZH, Kumari N, Takeda K, Nekhai S, Bavari S, Kaplan GG, Yamada KM, Dhawan S.

Curr Trends Immunol. 2016;17:117-123.

14.

Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia.

Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, Nouraie M, Nekhai S, Ammosova T, Niu XM, Prchal JT, Zhang X, Gordeuk VR.

Haematologica. 2017 May;102(5):e166-e169. doi: 10.3324/haematol.2016.158170. Epub 2017 Jan 19. No abstract available.

15.

Protein Phosphatase-1 Regulates Expression of Neuregulin-1.

Ammosova T, Washington K, Rotimi J, Kumari N, Smith KA, Niu X, Jerebtsova M, Nekhai S.

Biology (Basel). 2016 Dec 2;5(4). pii: E49.

16.

miRNA-15a, miRNA-15b, and miRNA-499 are Reduced in Erythrocytes of Pre-Diabetic African-American Adults.

Fluitt MB, Kumari N, Nunlee-Bland G, Nekhai S, Gambhir KK.

Jacobs J Diabetes Endocrinol. 2016 Dec;2(1). pii: 014. Epub 2016 Nov 15.

17.

Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.

Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Nekhai S, Aman MJ, Kashanchi F.

Front Microbiol. 2016 Nov 7;7:1765. eCollection 2016. Erratum in: Front Microbiol. 2018 Apr 17;9:692.

18.

Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer.

Dai Y, Sangerman J, Nouraie M, Faller AD, Oneal P, Rock A, Owoyemi O, Niu X, Nekhai S, Maharaj D, Cui S, Taylor R, Steinberg M, Perrine S.

Am J Hematol. 2017 Jan;92(1):E10-E11. doi: 10.1002/ajh.24590. Epub 2016 Nov 18. No abstract available.

19.

Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells.

Santos S, Obukhov Y, Nekhai S, Pushkarsky T, Brichacek B, Bukrinsky M, Iordanskiy S.

Virology. 2016 Oct;497:11-22. doi: 10.1016/j.virol.2016.06.023. Epub 2016 Jul 12.

20.

Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment.

Ogunwuyi O, Kumari N, Smith KA, Bolshakov O, Adesina S, Gugssa A, Anderson WA, Nekhai S, Akala EO.

Infect Dis (Auckl). 2016 Mar 20;9:21-32. doi: 10.4137/IDRT.S38108. eCollection 2016.

21.

Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound.

Smith KA, Lin X, Bolshakov O, Griffin J, Niu X, Kovalskyy D, Ivanov A, Jerebtsova M, Taylor RE, Akala E, Nekhai S.

Sci Pharm. 2015 Jun 22;83(3):535-48. doi: 10.3797/scipharm.1502-01. Print 2015 Jul-Sep.

22.

Protein Phosphatase-1 regulates Rift Valley fever virus replication.

Baer A, Shafagati N, Benedict A, Ammosova T, Ivanov A, Hakami RM, Terasaki K, Makino S, Nekhai S, Kehn-Hall K.

Antiviral Res. 2016 Mar;127:79-89. doi: 10.1016/j.antiviral.2016.01.007. Epub 2016 Jan 20.

23.

Inhibition of HIV-1 by curcumin A, a novel curcumin analog.

Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E.

Drug Des Devel Ther. 2015 Sep 3;9:5051-60. doi: 10.2147/DDDT.S86558. eCollection 2015.

24.

Therapeutics for postexposure treatment of Ebola virus infection.

Jerebtsova M, Nekhai S.

Future Virol. 2015 Mar;10(3):221-232.

25.

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.

Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S.

Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4.

26.

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease.

Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR.

Hum Genet. 2015 Aug;134(8):895-904. doi: 10.1007/s00439-015-1572-3. Epub 2015 May 30.

27.

Quantitative mass spectrometry of urinary biomarkers.

Jerebtsova M, Nekhai S.

J Integr OMICS. 2014 Dec 1;4(2):69-78.

28.

Antiproliferative activities of Fagara xanthoxyloides and Pseudocedrela kotschyi against prostate cancer cell lines.

Kassim OO, Copeland RL, Kenguele HM, Nekhai S, Ako-Nai KA, Kanaan YM.

Anticancer Res. 2015 Mar;35(3):1453-8.

29.

Iron, inflammation, and early death in adults with sickle cell disease.

van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG 6th, Kato GJ.

Circ Res. 2015 Jan 16;116(2):298-306. doi: 10.1161/CIRCRESAHA.116.304577. Epub 2014 Nov 6.

30.

Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.

Kumari N, Iordanskiy S, Kovalskyy D, Breuer D, Niu X, Lin X, Xu M, Gavrilenko K, Kashanchi F, Dhawan S, Nekhai S.

Antimicrob Agents Chemother. 2014 Nov;58(11):6558-71. doi: 10.1128/AAC.02918-14. Epub 2014 Aug 25.

31.

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.

Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S.

Br J Pharmacol. 2014 Nov;171(22):5059-75. doi: 10.1111/bph.12863.

32.

Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription.

Ilinykh PA, Tigabu B, Ivanov A, Ammosova T, Obukhov Y, Garron T, Kumari N, Kovalskyy D, Platonov MO, Naumchik VS, Freiberg AN, Nekhai S, Bukreyev A.

J Biol Chem. 2014 Aug 15;289(33):22723-38. doi: 10.1074/jbc.M114.575050. Epub 2014 Jun 16.

33.

A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis?

Chasnyk V, Fedorova E, Egorov A, Ammosova T, Nekhai S, Kostik M, Santimov A, Dubko M, Kalashnikova O, Masalova V, Likhacheva T, Snegireva L, Grom A.

Arthritis Rheumatol. 2014 Mar;66 Suppl 3:S171. doi: 10.1002/art.38551.

34.

Regulation of CDK9 activity by phosphorylation and dephosphorylation.

Nekhai S, Petukhov M, Breuer D.

Biomed Res Int. 2014;2014:964964. doi: 10.1155/2014/964964. Epub 2014 Jan 12. Review.

35.

Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease.

Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk VR.

Circulation. 2014 Apr 22;129(16):1650-8. doi: 10.1161/CIRCULATIONAHA.113.005296. Epub 2014 Feb 10.

36.

Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme.

Ashenafi M, Ammosova T, Nekhai S, Byrnes WM.

Mol Cell Biochem. 2014 Feb;387(1-2):207-16. doi: 10.1007/s11010-013-1886-1. Epub 2013 Nov 19.

37.

Effect of congenital upregulation of hypoxia inducible factors on percentage of fetal hemoglobin in the blood.

Salomon-Andonie J, Miasnikova G, Sergueeva A, Polyakova LA, Niu X, Nekhai S, Gordeuk VR.

Blood. 2013 Oct 24;122(17):3088-9. doi: 10.1182/blood-2013-07-515973. No abstract available.

38.

Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing.

Zhang X, Zhang W, Ma SF, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Nourai M, Wade MS, Prchal JT, Garcia JGN, Machado RF, Gordeuk VR.

Blood Cells Mol Dis. 2014 Jan;52(1):35-45. doi: 10.1016/j.bcmd.2013.07.016. Epub 2013 Aug 28.

39.

Role of cellular iron and oxygen in the regulation of HIV-1 infection.

Nekhai S, Kumari N, Dhawan S.

Future Virol. 2013 Mar;8(3):301-311.

40.

Heme oxygenase-1 induction alters chemokine regulation and ameliorates human immunodeficiency virus-type-1 infection in lipopolysaccharide-stimulated macrophages.

Zhou ZH, Kumari N, Nekhai S, Clouse KA, Wahl LM, Yamada KM, Dhawan S.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):373-7. doi: 10.1016/j.bbrc.2013.04.095. Epub 2013 May 9.

41.

The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W).

Tomasic NL, Piterkova L, Huff C, Bilic E, Yoon D, Miasnikova GY, Sergueeva AI, Niu X, Nekhai S, Gordeuk V, Prchal JT.

Haematologica. 2013 Apr;98(4):560-7. doi: 10.3324/haematol.2012.070508. Epub 2013 Feb 12.

42.

Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation.

Zhou ZH, Kumari N, Catalano J, Nekhai S, Wise J, Yamada KM, Dhawan S.

Curr Trends Immunol. 2013 Jan;14:53-56.

43.

Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription.

Van Duyne R, Guendel I, Jaworski E, Sampey G, Klase Z, Chen H, Zeng C, Kovalskyy D, El Kouni MH, Lepene B, Patanarut A, Nekhai S, Price DH, Kashanchi F.

J Mol Biol. 2013 Feb 22;425(4):812-29. doi: 10.1016/j.jmb.2012.12.005. Epub 2012 Dec 13.

44.

CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.

Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, Ilatovskiy AV, Beullens M, Roane PR, Bollen M, Petukhov MG, Kashanchi F, Nekhai S.

Retrovirology. 2012 Nov 9;9:94. doi: 10.1186/1742-4690-9-94.

45.

Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin.

Nekhai S, Xu M, Foster A, Kasvosve I, Diaz S, Machado RF, Castro OL, Kato GJ, Taylor JG 6th, Gordeuk VR.

Haematologica. 2013 Mar;98(3):455-63. doi: 10.3324/haematol.2012.066530. Epub 2012 Oct 12.

46.

Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers.

Debebe Z, Nekhai S, Ashenafi M, Lovejoy DB, Kalinowski DS, Gordeuk VR, Byrnes WM, Richardson DR, Karla PK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 1;906:25-32. doi: 10.1016/j.jchromb.2012.08.011. Epub 2012 Aug 15.

47.

HIV-1 Resistant CDK2-Knockdown Macrophage-Like Cells Generated from 293T Cell-Derived Human Induced Pluripotent Stem Cells.

Jerebtsova M, Kumari N, Xu M, de Melo GB, Niu X, Jeang KT, Nekhai S.

Biology (Basel). 2012 Jul 26;1(2):175-195.

48.

Adenoviral E4 gene stimulates secretion of pigmental epithelium derived factor (PEDF) that maintains long-term survival of human glomerulus-derived endothelial cells.

Jerebtsova M, Kumari N, Obuhkov Y, Nekhai S.

Mol Cell Proteomics. 2012 Nov;11(11):1378-88. doi: 10.1074/mcp.M112.020313. Epub 2012 Aug 21.

49.

Virus-producing cells determine the host protein profiles of HIV-1 virion cores.

Santos S, Obukhov Y, Nekhai S, Bukrinsky M, Iordanskiy S.

Retrovirology. 2012 Aug 13;9:65. doi: 10.1186/1742-4690-9-65.

50.

Use of ATP analogs to inhibit HIV-1 transcription.

Narayanan A, Sampey G, Van Duyne R, Guendel I, Kehn-Hall K, Roman J, Currer R, Galons H, Oumata N, Joseph B, Meijer L, Caputi M, Nekhai S, Kashanchi F.

Virology. 2012 Oct 10;432(1):219-31. doi: 10.1016/j.virol.2012.06.007. Epub 2012 Jul 6.

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