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Items: 28


Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria.

Mullins AJ, Murray JAH, Bull MJ, Jenner M, Jones C, Webster G, Green AE, Neill DR, Connor TR, Parkhill J, Challis GL, Mahenthiralingam E.

Nat Microbiol. 2019 Jun;4(6):996-1005. doi: 10.1038/s41564-019-0383-z. Epub 2019 Mar 4.


Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.

Subramanian K, Neill DR, Malak HA, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren PÅ, Plant L, Kadioglu A, Henriques-Normark B.

Nat Microbiol. 2019 Jan;4(1):62-70. doi: 10.1038/s41564-018-0280-x. Epub 2018 Nov 12.


Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa.

Bricio-Moreno L, Sheridan VH, Goodhead I, Armstrong S, Wong JKL, Waters EM, Sarsby J, Panagiotou S, Dunn J, Chakraborty A, Fang Y, Griswold KE, Winstanley C, Fothergill JL, Kadioglu A, Neill DR.

Nat Commun. 2018 Jul 6;9(1):2635. doi: 10.1038/s41467-018-04996-x.


E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.

Miyashita L, Suri R, Dearing E, Mudway I, Dove RE, Neill DR, Van Zyl-Smit R, Kadioglu A, Grigg J.

Eur Respir J. 2018 Feb 7;51(2). pii: 1701592. doi: 10.1183/13993003.01592-2017. Print 2018 Feb.


Innate lymphoid cells and parasites: Ancient foes with shared history.

Neill DR, Fallon PG.

Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12513.


Origins and evolution of innate lymphoid cells: Wardens of barrier immunity.

Neill DR, Flynn RJ.

Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12436. Epub 2017 May 22. Review.


Phage therapy is highly effective against chronic lung infections with Pseudomonas aeruginosa.

Waters EM, Neill DR, Kaman B, Sahota JS, Clokie MRJ, Winstanley C, Kadioglu A.

Thorax. 2017 Jul;72(7):666-667. doi: 10.1136/thoraxjnl-2016-209265. Epub 2017 Mar 6.


Airborne dust and high temperatures are risk factors for invasive bacterial disease.

Jusot JF, Neill DR, Waters EM, Bangert M, Collins M, Bricio Moreno L, Lawan KG, Moussa MM, Dearing E, Everett DB, Collard JM, Kadioglu A.

J Allergy Clin Immunol. 2017 Mar;139(3):977-986.e2. doi: 10.1016/j.jaci.2016.04.062. Epub 2016 Jul 14.


Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection.

Alhamdi Y, Neill DR, Abrams ST, Malak HA, Yahya R, Barrett-Jolley R, Wang G, Kadioglu A, Toh CH.

PLoS Pathog. 2015 May 14;11(5):e1004836. doi: 10.1371/journal.ppat.1004836. eCollection 2015 May.


Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice.

Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB.

Nat Biotechnol. 2015 Jan;33(1):81-8. doi: 10.1038/nbt.3037. Epub 2014 Nov 2.


Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.

Wolfmeier H, Schoenauer R, Atanassoff AP, Neill DR, Kadioglu A, Draeger A, Babiychuk EB.

Biochim Biophys Acta. 2015 Sep;1853(9):2045-54. doi: 10.1016/j.bbamcr.2014.09.005. Epub 2014 Sep 16.


Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.

Fothergill JL, Neill DR, Loman N, Winstanley C, Kadioglu A.

Nat Commun. 2014 Sep 2;5:4780. doi: 10.1038/ncomms5780.


The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa.

Neill DR, Saint GL, Bricio-Moreno L, Fothergill JL, Southern KW, Winstanley C, Christmas SE, Slupsky JR, McNamara PS, Kadioglu A, Flanagan BF.

PLoS One. 2014 May 21;9(5):e95892. doi: 10.1371/journal.pone.0095892. eCollection 2014.


A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia.

De Filippo K, Neill DR, Mathies M, Bangert M, McNeill E, Kadioglu A, Hogg N.

FASEB J. 2014 Aug;28(8):3600-8. doi: 10.1096/fj.13-247460. Epub 2014 Apr 28.


Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells.

Neill DR, Coward WR, Gritzfeld JF, Richards L, Garcia-Garcia FJ, Dotor J, Gordon SB, Kadioglu A.

Am J Respir Crit Care Med. 2014 May 15;189(10):1250-9. doi: 10.1164/rccm.201401-0128OC.


The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract.

Küng E, Coward WR, Neill DR, Malak HA, Mühlemann K, Kadioglu A, Hilty M, Hathaway LJ.

PLoS One. 2014 Mar 24;9(3):e92355. doi: 10.1371/journal.pone.0092355. eCollection 2014.


IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.

Barlow JL, Peel S, Fox J, Panova V, Hardman CS, Camelo A, Bucks C, Wu X, Kane CM, Neill DR, Flynn RJ, Sayers I, Hall IP, McKenzie AN.

J Allergy Clin Immunol. 2013 Oct;132(4):933-41. doi: 10.1016/j.jaci.2013.05.012. Epub 2013 Jun 27.


Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.

Wisby L, Fernandes VE, Neill DR, Kadioglu A, Andrew PW, Denny P.

BMC Genomics. 2013 Apr 11;14:242. doi: 10.1186/1471-2164-14-242.


Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults.

Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AK, Pennington SH, Bricio-Moreno L, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A, Gordon SB.

Am J Respir Crit Care Med. 2013 Apr 15;187(8):855-64. doi: 10.1164/rccm.201212-2277OC. Erratum in: Am J Respir Crit Care Med. 2013 May 15;187(10):1153. Bricio Moreno, Laura [corrected to Bricio-Moreno, Laura].


Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B.

Neill DR, Smeaton S, Bangert M, Kadioglu A.

J Allergy Clin Immunol. 2013 May;131(5):1433-5.e1. doi: 10.1016/j.jaci.2012.11.004. Epub 2012 Dec 20. No abstract available.


T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.

Neill DR, Fernandes VE, Wisby L, Haynes AR, Ferreira DM, Laher A, Strickland N, Gordon SB, Denny P, Kadioglu A, Andrew PW.

PLoS Pathog. 2012;8(4):e1002660. doi: 10.1371/journal.ppat.1002660. Epub 2012 Apr 19.


Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13.

Camelo A, Barlow JL, Drynan LF, Neill DR, Ballantyne SJ, Wong SH, Pannell R, Gao W, Wrigley K, Sprenkle J, McKenzie AN.

J Gastroenterol. 2012 Nov;47(11):1198-211. doi: 10.1007/s00535-012-0591-2. Epub 2012 Apr 27.


Transcription factor RORα is critical for nuocyte development.

Wong SH, Walker JA, Jolin HE, Drynan LF, Hams E, Camelo A, Barlow JL, Neill DR, Panova V, Koch U, Radtke F, Hardman CS, Hwang YY, Fallon PG, McKenzie AN.

Nat Immunol. 2012 Jan 22;13(3):229-36. doi: 10.1038/ni.2208.


Novel immunogenic peptides elicit systemic anaphylaxis in mice: implications for peptide vaccines.

Smith CM, Bradding P, Neill DR, Baxendale H, Felici F, Andrew PW.

J Immunol. 2011 Aug 1;187(3):1201-6. doi: 10.4049/jimmunol.1002152. Epub 2011 Jun 27.


Nuocytes and beyond: new insights into helminth expulsion.

Neill DR, McKenzie AN.

Trends Parasitol. 2011 May;27(5):214-21. doi: 10.1016/ Epub 2011 Feb 1. Review.


Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC.

PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191.


TH9 cell generation. TH9: the latest addition to the expanding repertoire of IL-25 targets.

Neill DR, McKenzie AN.

Immunol Cell Biol. 2010 Jul;88(5):502-4. doi: 10.1038/icb.2010.43. Epub 2010 Mar 23. No abstract available.


Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.

Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN.

Nature. 2010 Apr 29;464(7293):1367-70. doi: 10.1038/nature08900. Epub 2010 Mar 3.

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