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Items: 30

1.

Cancer and the Dopamine D2 Receptor: A Pharmacological Perspective.

Weissenrieder JS, Neighbors JD, Mailman RB, Hohl RJ.

J Pharmacol Exp Ther. 2019 Jul;370(1):111-126. doi: 10.1124/jpet.119.256818. Epub 2019 Apr 18.

PMID:
31000578
2.

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.

Kokolus KM, Haley JS, Koubek EJ, Gowda R, Dinavahi SS, Sharma A, Claxton DF, Helm KF, Drabick JJ, Robertson GP, Neighbors JD, Hohl RJ, Schell TD.

Oncoimmunology. 2018 Nov 11;8(2):e1539614. doi: 10.1080/2162402X.2018.1539614. eCollection 2019.

PMID:
30713799
3.

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity.

Koubek EJ, Weissenrieder JS, Neighbors JD, Hohl RJ.

Lipids. 2018 Aug;53(8):767-784. doi: 10.1002/lipd.12088. Epub 2018 Oct 17. Review.

PMID:
30334267
4.

Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models.

Weissenrieder JS, Reilly JE, Neighbors JD, Hohl RJ.

Prostate. 2019 Jan;79(1):21-30. doi: 10.1002/pros.23707. Epub 2018 Aug 14.

PMID:
30106164
5.

5'-methylschweinfurthin G reduces chondrosarcoma tumor growth .

Stevens JW, Meyerholz DK, Neighbors JD, Morcuende JA.

J Orthop Res. 2018 Apr;36(4):1283-1293. doi: 10.1002/jor.23753. Epub 2017 Nov 21.

6.

Selective opioid growth factor receptor antagonists based on a stilbene isostere.

Stockdale DP, Titunick MB, Biegler JM, Reed JL, Hartung AM, Wiemer DF, McLaughlin PJ, Neighbors JD.

Bioorg Med Chem. 2017 Aug 15;25(16):4464-4474. doi: 10.1016/j.bmc.2017.06.035. Epub 2017 Jun 27.

7.

Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms.

Sedghizadeh PP, Sun S, Junka AF, Richard E, Sadrerafi K, Mahabady S, Bakhshalian N, Tjokro N, Bartoszewicz M, Oleksy M, Szymczyk P, Lundy MW, Neighbors JD, Russell RG, McKenna CE, Ebetino FH.

J Med Chem. 2017 Mar 23;60(6):2326-2343. doi: 10.1021/acs.jmedchem.6b01615. Epub 2017 Feb 13.

8.

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.

Reilly JE, Neighbors JD, Hohl RJ.

Cancer Biol Ther. 2017 Nov 2;18(11):872-882. doi: 10.1080/15384047.2016.1219817. Epub 2016 Sep 13.

9.

Corrigendum to "A selective delta opioid receptor antagonist based on a stilbene core" [Bioorg. Med. Chem. Lett. 25 (2015) 5532-5535].

Hartung AM, Navarro HA, Wiemer DF, Neighbors JD.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1645. doi: 10.1016/j.bmcl.2016.02.014. Epub 2016 Feb 11. No abstract available.

PMID:
28750745
10.

A selective delta opioid receptor antagonist based on a stilbene core.

Hartung AM, Navarro HA, Wiemer DF, Neighbors JD.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5532-5. doi: 10.1016/j.bmcl.2015.10.059. Epub 2015 Oct 23. Erratum in: Bioorg Med Chem Lett. 2016 Mar 15;26(6):1645. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1645.

11.

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines.

Kuder CH, Weivoda MM, Zhang Y, Zhu J, Neighbors JD, Wiemer DF, Hohl RJ.

Lipids. 2015 Dec;50(12):1195-207. doi: 10.1007/s11745-015-4083-z. Epub 2015 Oct 22.

12.

Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis.

Reilly JE, Neighbors JD, Tong H, Henry MD, Hohl RJ.

Clin Exp Metastasis. 2015 Aug;32(6):555-66. doi: 10.1007/s10585-015-9727-0. Epub 2015 Jun 13.

13.

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis.

Osborn-Heaford HL, Murthy S, Gu L, Larson-Casey JL, Ryan AJ, Shi L, Glogauer M, Neighbors JD, Hohl R, Carter AB.

Free Radic Biol Med. 2015 Sep;86:47-56. doi: 10.1016/j.freeradbiomed.2015.04.031. Epub 2015 May 7.

14.

Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists.

Hartung AM, Beutler JA, Navarro HA, Wiemer DF, Neighbors JD.

J Nat Prod. 2014 Feb 28;77(2):311-9. doi: 10.1021/np4009046. Epub 2014 Jan 23.

15.

Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification.

Kuder CH, Sheehy RM, Neighbors JD, Wiemer DF, Hohl RJ.

Mol Pharmacol. 2012 Jul;82(1):9-16. doi: 10.1124/mol.111.077107. Epub 2012 Mar 29.

16.

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity.

Topczewski JJ, Kuder CH, Neighbors JD, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2010 Sep 15;18(18):6734-41. doi: 10.1016/j.bmc.2010.07.056. Epub 2010 Jul 29.

17.

Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents.

Birt DF, Widrlechner MP, Hammer KD, Hillwig ML, Wei J, Kraus GA, Murphy PA, McCoy J, Wurtele ES, Neighbors JD, Wiemer DF, Maury WJ, Price JP.

Pharm Biol. 2009;47(8):774-782.

18.

A tandem cascade cyclization-electrophilic aromatic substitution: application in the total synthesis of (+)-angelichalcone.

Topczewski JJ, Callahan MP, Neighbors JD, Wiemer DF.

J Am Chem Soc. 2009 Oct 21;131(41):14630-1. doi: 10.1021/ja906468v.

PMID:
19824722
19.

Total synthesis of (+)-schweinfurthins B and E.

Topczewski JJ, Neighbors JD, Wiemer DF.

J Org Chem. 2009 Sep 18;74(18):6965-72. doi: 10.1021/jo901161m.

PMID:
19697910
20.

Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum.

Maury W, Price JP, Brindley MA, Oh C, Neighbors JD, Wiemer DF, Wills N, Carpenter S, Hauck C, Murphy P, Widrlechner MP, Delate K, Kumar G, Kraus GA, Rizshsky L, Nikolau B.

Virol J. 2009 Jul 13;6:101. doi: 10.1186/1743-422X-6-101.

21.

Synthesis and biological activity of a fluorescent schweinfurthin analogue.

Kuder CH, Neighbors JD, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2009 Jul 1;17(13):4718-23. doi: 10.1016/j.bmc.2009.04.071. Epub 2009 May 6.

PMID:
19464190
22.

A concise synthesis of pawhuskin A.

Neighbors JD, Buller MJ, Boss KD, Wiemer DF.

J Nat Prod. 2008 Nov;71(11):1949-52. doi: 10.1021/np800351c. Epub 2008 Oct 15.

PMID:
18922035
23.

BF3 x Et2O-mediated cascade cyclizations: synthesis of schweinfurthins F and G.

Mente NR, Neighbors JD, Wiemer DF.

J Org Chem. 2008 Oct 17;73(20):7963-70. doi: 10.1021/jo800951q. Epub 2008 Sep 17.

24.

Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.

Hammer KD, Hillwig ML, Neighbors JD, Sim YJ, Kohut ML, Wiemer DF, Wurtele ES, Birt DF.

Phytochemistry. 2008 Sep;69(12):2354-62. doi: 10.1016/j.phytochem.2008.06.010. Epub 2008 Aug 15.

25.

Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue.

Tong H, Wiemer AJ, Neighbors JD, Hohl RJ.

Anal Biochem. 2008 Jul 15;378(2):138-43. doi: 10.1016/j.ab.2008.04.021. Epub 2008 Apr 15.

PMID:
18457649
26.

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.

Mente NR, Wiemer AJ, Neighbors JD, Beutler JA, Hohl RJ, Wiemer DF.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):911-5. Epub 2006 Dec 12.

PMID:
17236766
27.

Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity.

Neighbors JD, Salnikova MS, Beutler JA, Wiemer DF.

Bioorg Med Chem. 2006 Mar 15;14(6):1771-84. Epub 2005 Nov 14.

PMID:
16290161
28.

Synthesis of nonracemic 3-deoxyschweinfurthin B.

Neighbors JD, Beutler JA, Wiemer DF.

J Org Chem. 2005 Feb 4;70(3):925-31.

PMID:
15675850
29.

A cascade cyclization approach to schweinfurthin B.

Treadwell EM, Neighbors JD, Wiemer DF.

Org Lett. 2002 Oct 17;4(21):3639-42.

PMID:
12375907
30.

Laparoscopic radical prostatectomy in the canine model.

Price DT, Chari RS, Neighbors JD Jr, Eubanks S, Schuessler WW, Preminger GM.

J Laparoendosc Surg. 1996 Dec;6(6):405-12.

PMID:
9025025

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