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Items: 1 to 50 of 365

1.

Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation.

Satange R, Chuang CY, Neidle S, Hou MH.

Nucleic Acids Res. 2019 Sep 19;47(16):8899-8912. doi: 10.1093/nar/gkz653.

PMID:
31361900
3.

Combining 1,3-Ditriazolylbenzene and Quinoline to Discover a New G-Quadruplex-Interactive Small Molecule Active against Cancer Stem-Like Cells.

Mendes E, Cadoni E, Carneiro F, Afonso MB, Brito H, Lavrado J, Dos Santos DJVA, Vítor JB, Neidle S, Rodrigues CMP, Paulo A.

ChemMedChem. 2019 Jul 17;14(14):1325-1328. doi: 10.1002/cmdc.201900243. Epub 2019 Jun 14.

PMID:
31162877
4.

A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line.

Gunaratnam M, Collie GW, Reszka AP, Todd AK, Parkinson GN, Neidle S.

Bioorg Med Chem. 2018 Jul 15;26(11):2958-2964. doi: 10.1016/j.bmc.2018.04.050. Epub 2018 Apr 26.

PMID:
29724653
5.

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide.

Mizuta R, Devos JM, Webster J, Ling WL, Narayanan T, Round A, Munnur D, Mossou E, Farahat AA, Boykin DW, Wilson WD, Neidle S, Schweins R, Rannou P, Haertlein M, Forsyth VT, Mitchell EP.

Nanoscale. 2018 Mar 28;10(12):5550-5558. doi: 10.1039/c7nr03875e. Epub 2018 Mar 8.

6.

Accuracy of alcohol and breast cancer risk information on Drinkaware's website.

Larsen J, Wallace P, Sim F, Chick J, Jarvis S, Lidington I, Neidle S, Ogden G, Owens L.

Drug Alcohol Rev. 2018 Mar;37(3):304-306. doi: 10.1111/dar.12676. Epub 2018 Feb 12.

7.

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.

Marchetti C, Zyner KG, Ohnmacht SA, Robson M, Haider SM, Morton JP, Marsico G, Vo T, Laughlin-Toth S, Ahmed AA, Di Vita G, Pazitna I, Gunaratnam M, Besser RJ, Andrade ACG, Diocou S, Pike JA, Tannahill D, Pedley RB, Evans TRJ, Wilson WD, Balasubramanian S, Neidle S.

J Med Chem. 2018 Mar 22;61(6):2500-2517. doi: 10.1021/acs.jmedchem.7b01781. Epub 2018 Feb 7.

8.

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.

Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM.

EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850.

9.

Induced-Fit Recognition of CCG Trinucleotide Repeats by a Nickel-Chromomycin Complex Resulting in Large-Scale DNA Deformation.

Tseng WH, Chang CK, Wu PC, Hu NJ, Lee GH, Tzeng CC, Neidle S, Hou MH.

Angew Chem Int Ed Engl. 2017 Jul 17;56(30):8761-8765. doi: 10.1002/anie.201703989. Epub 2017 Jun 14.

PMID:
28544401
10.

Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.

Islam B, Stadlbauer P, Gil-Ley A, Pérez-Hernández G, Haider S, Neidle S, Bussi G, Banas P, Otyepka M, Sponer J.

J Chem Theory Comput. 2017 Jun 13;13(6):2458-2480. doi: 10.1021/acs.jctc.7b00226. Epub 2017 May 18.

11.

Folding of guanine quadruplex molecules-funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies.

Šponer J, Bussi G, Stadlbauer P, Kührová P, Banáš P, Islam B, Haider S, Neidle S, Otyepka M.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1246-1263. doi: 10.1016/j.bbagen.2016.12.008. Epub 2016 Dec 13. Review.

PMID:
27979677
12.

Preface.

Neidle S.

Bioorg Med Chem. 2016 Oct 15;24(20):4767. doi: 10.1016/j.bmc.2016.08.013. Epub 2016 Aug 10. No abstract available.

PMID:
27530502
13.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht S, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A.

J Med Chem. 2016 Jun 23;59(12):5706-20. doi: 10.1021/acs.jmedchem.6b00129. Epub 2016 Jun 6.

PMID:
27223049
14.

The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership.

Mann J, Taylor PW, Dorgan CR, Johnson PD, Wilson FX, Vickers R, Dale AG, Neidle S.

Medchemcomm. 2015 Aug 5;6(8):1420-1426. Epub 2015 Jul 20. Review.

15.

Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?

Islam B, Stadlbauer P, Neidle S, Haider S, Sponer J.

J Phys Chem B. 2016 Mar 24;120(11):2899-912. doi: 10.1021/acs.jpcb.6b01059. Epub 2016 Mar 11.

PMID:
26918369
16.

Quadruplex Nucleic Acids as Novel Therapeutic Targets.

Neidle S.

J Med Chem. 2016 Jul 14;59(13):5987-6011. doi: 10.1021/acs.jmedchem.5b01835. Epub 2016 Feb 16.

PMID:
26840940
17.

Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.

Russo Krauss I, Ramaswamy S, Neidle S, Haider S, Parkinson GN.

J Am Chem Soc. 2016 Feb 3;138(4):1226-33. doi: 10.1021/jacs.5b10492. Epub 2016 Jan 19.

PMID:
26730610
18.

Extended molecular dynamics of a c-kit promoter quadruplex.

Islam B, Stadlbauer P, Krepl M, Koca J, Neidle S, Haider S, Sponer J.

Nucleic Acids Res. 2015 Oct 15;43(18):8673-93. doi: 10.1093/nar/gkv785. Epub 2015 Aug 5.

19.

Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors.

Roe S, Gunaratnam M, Spiteri C, Sharma P, Alharthy RD, Neidle S, Moses JE.

Org Biomol Chem. 2015 Aug 21;13(31):8500-4. doi: 10.1039/c5ob01177a.

PMID:
26156660
20.

A Personal History of Quadruplex-Small Molecule Targeting.

Neidle S.

Chem Rec. 2015 Aug;15(4):691-710. doi: 10.1002/tcr.201500011. Epub 2015 Jun 19.

PMID:
26096791
21.

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer.

Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Pedley RB, Hartley JA, Neidle S.

Sci Rep. 2015 Jun 16;5:11385. doi: 10.1038/srep11385.

22.

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A.

PLoS One. 2015 May 29;10(5):e0126891. doi: 10.1371/journal.pone.0126891. eCollection 2015.

23.

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome.

Simone R, Fratta P, Neidle S, Parkinson GN, Isaacs AM.

FEBS Lett. 2015 Jun 22;589(14):1653-68. doi: 10.1016/j.febslet.2015.05.003. Epub 2015 May 13. Review.

24.

Atomic Force Microscopy and Voltammetric Investigation of Quadruplex Formation between a Triazole-Acridine Conjugate and Guanine-Containing Repeat DNA Sequences.

Chiorcea-Paquim AM, Pontinha AD, Eritja R, Lucarelli G, Sparapani S, Neidle S, Oliveira-Brett AM.

Anal Chem. 2015 Jun 16;87(12):6141-9. doi: 10.1021/acs.analchem.5b00743. Epub 2015 May 27.

PMID:
25961908
25.

Loop flexibility in human telomeric quadruplex small-molecule complexes.

Collie GW, Campbell NH, Neidle S.

Nucleic Acids Res. 2015 May 26;43(10):4785-99. doi: 10.1093/nar/gkv427. Epub 2015 May 4.

26.

Macrocyclic naphthalene diimides as G-quadruplex binders.

Marchetti C, Minarini A, Tumiatti V, Moraca F, Parrotta L, Alcaro S, Rigo R, Sissi C, Gunaratnam M, Ohnmacht SA, Neidle S, Milelli A.

Bioorg Med Chem. 2015 Jul 1;23(13):3819-30. doi: 10.1016/j.bmc.2015.03.076. Epub 2015 Apr 11.

PMID:
25935290
27.

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CM, Moreira R, Neidle S, Paulo A.

Sci Rep. 2015 Apr 8;5:9696. doi: 10.1038/srep09696.

28.

Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex.

Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJ, Paulo A.

ChemMedChem. 2015 May;10(5):836-49. doi: 10.1002/cmdc.201500067. Epub 2015 Mar 26.

PMID:
25820698
29.

Flexibility and structural conservation in a c-KIT G-quadruplex.

Wei D, Husby J, Neidle S.

Nucleic Acids Res. 2015 Jan;43(1):629-44. doi: 10.1093/nar/gku1282. Epub 2014 Dec 1.

30.

Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA.

Pontinha AD, Lombardo CM, Neidle S, Oliveira-Brett AM.

Bioelectrochemistry. 2015 Feb;101:97-105. doi: 10.1016/j.bioelechem.2014.08.010. Epub 2014 Aug 23.

PMID:
25194950
31.

Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats.

Chen YW, Jhan CR, Neidle S, Hou MH.

Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10682-6. doi: 10.1002/anie.201405637. Epub 2014 Aug 19.

PMID:
25139267
32.

Preface. Unlocking nature through Chemistry.

Neidle S.

Bioorg Med Chem. 2014 Aug 15;22(16):4355. doi: 10.1016/j.bmc.2014.06.036. Epub 2014 Jun 21. No abstract available.

PMID:
25023541
33.

Small-molecule quadruplex-targeted drug discovery.

Ohnmacht SA, Neidle S.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2602-12. doi: 10.1016/j.bmcl.2014.04.029. Epub 2014 Apr 18.

PMID:
24814531
34.

Targeting a c-MYC G-quadruplex DNA with a fragment library.

Nasiri HR, Bell NM, McLuckie KI, Husby J, Abell C, Neidle S, Balasubramanian S.

Chem Commun (Camb). 2014 Feb 18;50(14):1704-7. doi: 10.1039/c3cc48390h.

PMID:
24394582
35.

Structure-dependent binding of arylimidamides to the DNA minor groove.

Chai Y, Munde M, Kumar A, Mickelson L, Lin S, Campbell NH, Banerjee M, Akay S, Liu Z, Farahat AA, Nhili R, Depauw S, David-Cordonnier MH, Neidle S, Wilson WD, Boykin DW.

Chembiochem. 2014 Jan 3;15(1):68-79. doi: 10.1002/cbic.201300622. Epub 2013 Dec 9.

36.

Discovery of new G-quadruplex binding chemotypes.

Ohnmacht SA, Varavipour E, Nanjunda R, Pazitna I, Di Vita G, Gunaratnam M, Kumar A, Ismail MA, Boykin DW, Wilson WD, Neidle S.

Chem Commun (Camb). 2014 Jan 28;50(8):960-3. doi: 10.1039/c3cc48616h.

37.

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex.

Wei D, Todd AK, Zloh M, Gunaratnam M, Parkinson GN, Neidle S.

J Am Chem Soc. 2013 Dec 26;135(51):19319-29. doi: 10.1021/ja4101358. Epub 2013 Dec 11.

PMID:
24295054
38.

Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands.

Altieri A, Alvino A, Ohnmacht S, Ortaggi G, Neidle S, Nocioni D, Franceschin M, Bianco A.

Molecules. 2013 Oct 30;18(11):13446-70. doi: 10.3390/molecules181113446.

39.

Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule.

Welsh SJ, Dale AG, Lombardo CM, Valentine H, de la Fuente M, Schatzlein A, Neidle S.

Sci Rep. 2013 Sep 30;3:2799. doi: 10.1038/srep02799.

40.

A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus.

Shiu WK, Malkinson JP, Rahman MM, Curry J, Stapleton P, Gunaratnam M, Neidle S, Mushtaq S, Warner M, Livermore DM, Evangelopoulos D, Basavannacharya C, Bhakta S, Schindler BD, Seo SM, Coleman D, Kaatz GW, Gibbons S.

Int J Antimicrob Agents. 2013 Dec;42(6):513-8. doi: 10.1016/j.ijantimicag.2013.08.007. Epub 2013 Sep 16.

PMID:
24119569
41.

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands.

Ohnmacht SA, Ciancimino C, Vignaroli G, Gunaratnam M, Neidle S.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5351-5. doi: 10.1016/j.bmcl.2013.07.057. Epub 2013 Aug 1.

PMID:
23972440
42.

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CM, Moreira R, dos Santos DJ, Neidle S, Paulo A.

ChemMedChem. 2013 Oct;8(10):1648-61. doi: 10.1002/cmdc.201300288. Epub 2013 Aug 19.

43.

Antibacterial activity of head-to-head bis-benzimidazoles.

Moreira JB, Mann J, Neidle S, McHugh TD, Taylor PW.

Int J Antimicrob Agents. 2013 Oct;42(4):361-6. doi: 10.1016/j.ijantimicag.2013.04.033. Epub 2013 Jul 6.

PMID:
23837928
44.

Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics.

Husby J, Todd AK, Platts JA, Neidle S.

Biopolymers. 2013 Dec;99(12):989-1005. doi: 10.1002/bip.22340.

PMID:
23828641
45.

The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds.

Mpima S, Ohnmacht SA, Barletta M, Husby J, Pett LC, Gunaratnam M, Hilton ST, Neidle S.

Bioorg Med Chem. 2013 Oct 15;21(20):6162-70. doi: 10.1016/j.bmc.2013.05.027. Epub 2013 May 25.

PMID:
23769166
46.

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.

Micco M, Collie GW, Dale AG, Ohnmacht SA, Pazitna I, Gunaratnam M, Reszka AP, Neidle S.

J Med Chem. 2013 Apr 11;56(7):2959-74. doi: 10.1021/jm301899y. Epub 2013 Apr 2.

PMID:
23514618
47.

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.

Nkansah E, Shah R, Collie GW, Parkinson GN, Palmer J, Rahman KM, Bui TT, Drake AF, Husby J, Neidle S, Zinzalla G, Thurston DE, Wilderspin AF.

FEBS Lett. 2013 Apr 2;587(7):833-9. doi: 10.1016/j.febslet.2013.01.065. Epub 2013 Feb 19.

48.

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors.

Baud MG, Leiser T, Petrucci V, Gunaratnam M, Neidle S, Meyer-Almes FJ, Fuchter MJ.

Beilstein J Org Chem. 2013;9:81-8. doi: 10.3762/bjoc.9.11. Epub 2013 Jan 15.

49.

Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.

Mitchell T, Ramos-Montoya A, Di Antonio M, Murat P, Ohnmacht S, Micco M, Jurmeister S, Fryer L, Balasubramanian S, Neidle S, Neal DE.

Biochemistry. 2013 Feb 26;52(8):1429-36. doi: 10.1021/bi301349c. Epub 2013 Feb 11.

PMID:
23363071
50.

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale.

Islam B, Sgobba M, Laughton C, Orozco M, Sponer J, Neidle S, Haider S.

Nucleic Acids Res. 2013 Feb 1;41(4):2723-35. doi: 10.1093/nar/gks1331. Epub 2013 Jan 4.

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