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Items: 1 to 50 of 55

1.

Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy.

Nehls M.

J Mol Psychiatry. 2016 Jul 15;4:3. doi: 10.1186/s40303-016-0018-8. eCollection 2016. Review.

2.

Pillars article: new member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature. 1994. 372: 103-107.

Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T.

J Immunol. 2015 Feb 1;194(3):849-53. No abstract available.

3.

An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice.

Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, Hanke P, Schropp P, Mühlstedt S, Zorn C, Huber M, Schmittwolf C, Jagla W, Yu P, Kerkau T, Schulze H, Nehls M, Nieswandt B.

J Clin Invest. 2007 Nov;117(11):3540-50.

4.

Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis.

Quezada-Calvillo R, Robayo-Torres CC, Opekun AR, Sen P, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Wattler S, Nehls MC, Sterchi EE, Nichols BL.

J Nutr. 2007 Jul;137(7):1725-33.

PMID:
17585022
5.

N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.

Grosse J, Tarnow P, Römpler H, Schneider B, Sedlmeier R, Huffstadt U, Korthaus D, Nehls M, Wattler S, Schöneberg T, Biebermann H, Augustin M.

Physiol Genomics. 2006 Aug 16;26(3):209-17. Epub 2006 May 23.

6.

Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.

Grosse J, Chitu V, Marquardt A, Hanke P, Schmittwolf C, Zeitlmann L, Schropp P, Barth B, Yu P, Paffenholz R, Stumm G, Nehls M, Stanley ER.

Blood. 2006 Apr 15;107(8):3350-8. Epub 2006 Jan 5.

7.

Efficient and fast targeted production of murine models based on ENU mutagenesis.

Augustin M, Sedlmeier R, Peters T, Huffstadt U, Kochmann E, Simon D, Schöniger M, Garke-Mayerthaler S, Laufs J, Mayhaus M, Franke S, Klose M, Graupner A, Kurzmann M, Zinser C, Wolf A, Voelkel M, Kellner M, Kilian M, Seelig S, Koppius A, Teubner A, Korthaus D, Nehls M, Wattler S.

Mamm Genome. 2005 Jun;16(6):405-13.

PMID:
16075367
8.

Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.

Yu P, Constien R, Dear N, Katan M, Hanke P, Bunney TD, Kunder S, Quintanilla-Martinez L, Huffstadt U, Schröder A, Jones NP, Peters T, Fuchs H, de Angelis MH, Nehls M, Grosse J, Wabnitz P, Meyer TP, Yasuda K, Schiemann M, Schneider-Fresenius C, Jagla W, Russ A, Popp A, Josephs M, Marquardt A, Laufs J, Schmittwolf C, Wagner H, Pfeffer K, Mudde GC.

Immunity. 2005 Apr;22(4):451-65.

9.

Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.

Koh DW, Lawler AM, Poitras MF, Sasaki M, Wattler S, Nehls MC, Stöger T, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17699-704. Epub 2004 Dec 10.

10.

The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3.

Runkel F, Marquardt A, Stoeger C, Kochmann E, Simon D, Kohnke B, Korthaus D, Wattler F, Fuchs H, Hrabé de Angelis M, Stumm G, Nehls M, Wattler S, Franz T, Augustin M.

Genomics. 2004 Nov;84(5):824-35.

PMID:
15475261
11.

Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice.

Schneider B, Hanke P, Jagla W, Wattler S, Nehls M, Grosse J, Schröder A, Laufs J.

Genes Immun. 2004 Aug;5(5):375-80.

PMID:
15175647
12.

A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity.

Meyer CW, Korthaus D, Jagla W, Cornali E, Grosse J, Fuchs H, Klingenspor M, Roemheld S, Tschöp M, Heldmaier G, De Angelis MH, Nehls M.

Endocrinology. 2004 May;145(5):2531-41. Epub 2004 Jan 15.

PMID:
14726450
13.

Diverse psychotomimetics act through a common signaling pathway.

Svenningsson P, Tzavara ET, Carruthers R, Rachleff I, Wattler S, Nehls M, McKinzie DL, Fienberg AA, Nomikos GG, Greengard P.

Science. 2003 Nov 21;302(5649):1412-5.

14.

A mouse model for cystinuria type I.

Peters T, Thaete C, Wolf S, Popp A, Sedlmeier R, Grosse J, Nehls MC, Russ A, Schlueter V.

Hum Mol Genet. 2003 Sep 1;12(17):2109-20.

PMID:
12923163
15.

Random mutagenesis in the mouse as a tool in drug discovery.

Russ A, Stumm G, Augustin M, Sedlmeier R, Wattler S, Nehls M.

Drug Discov Today. 2002 Dec 1;7(23):1175-83. Review.

PMID:
12547018
16.

Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver.

Krause A, Sillard R, Kleemeier B, Klüver E, Maronde E, Conejo-García JR, Forssmann WG, Schulz-Knappe P, Nehls MC, Wattler F, Wattler S, Adermann K.

Protein Sci. 2003 Jan;12(1):143-52.

17.

Deductive genomics: a functional approach to identify innovative drug targets in the post-genome era.

Stumm G, Russ A, Nehls M.

Am J Pharmacogenomics. 2002;2(4):263-71. Review.

PMID:
12421097
18.

Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk.

Kortenjann M, Nehls M, Smith AJ, Carsetti R, Schüler J, Köhler G, Boehm T.

Eur J Immunol. 2001 Dec;31(12):3580-7.

19.

Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes.

Kortenjann M, Wehrle C, Nehls MC, Boehm T.

Gene. 2001 Oct 31;278(1-2):161-5.

PMID:
11707333
20.

Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system.

Matalon R, Rady PL, Platt KA, Skinner HB, Quast MJ, Campbell GA, Matalon K, Ceci JD, Tyring SK, Nehls M, Surendran S, Wei J, Ezell EL, Szucs S.

J Gene Med. 2000 May-Jun;2(3):165-75.

PMID:
10894262
21.

Eomesodermin is required for mouse trophoblast development and mesoderm formation.

Russ AP, Wattler S, Colledge WH, Aparicio SA, Carlton MB, Pearce JJ, Barton SC, Surani MA, Ryan K, Nehls MC, Wilson V, Evans MJ.

Nature. 2000 Mar 2;404(6773):95-9.

PMID:
10716450
22.

Identification of a mammalian angiopoietin-related protein expressed specifically in liver.

Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, Walker KM, Chen LH, Wattler S, Nehls M, Lewis KB.

Genomics. 1999 Dec 15;62(3):477-82.

PMID:
10644446
23.
24.

Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.

Bals R, Wang X, Meegalla RL, Wattler S, Weiner DJ, Nehls MC, Wilson JM.

Infect Immun. 1999 Jul;67(7):3542-7.

25.

Construction of gene targeting vectors from lambda KOS genomic libraries.

Wattler S, Kelly M, Nehls M.

Biotechniques. 1999 Jun;26(6):1150-6, 1158, 1160.

26.

Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily.

Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M.

Protein Sci. 1999 Apr;8(4):810-9.

27.

Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.

Schmidt M, Lohmann B, Hammer K, Haupenthal S, Nehls MV, Jakobs KH.

Mol Pharmacol. 1998 Jun;53(6):1139-48.

PMID:
9614219
28.
29.
30.
31.

Identification of interaction partners for the basic-helix-loop-helix protein E47.

Dear TN, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, Boehm T.

Oncogene. 1997 Feb 27;14(8):891-8.

33.

Shear stress inhibits apoptosis of human endothelial cells.

Dimmeler S, Haendeler J, Rippmann V, Nehls M, Zeiher AM.

FEBS Lett. 1996 Dec 9;399(1-2):71-4.

34.

Two genetically separable steps in the differentiation of thymic epithelium.

Nehls M, Kyewski B, Messerle M, Waldschütz R, Schüddekopf K, Smith AJ, Boehm T.

Science. 1996 May 10;272(5263):886-9.

PMID:
8629026
35.

Genomic Organization of the ATM gene.

Uziel T, Savitsky K, Platzer M, Ziv Y, Helbitz T, Nehls M, Boehm T, Rosenthal A, Shiloh Y, Rotman G.

Genomics. 1996 Apr 15;33(2):317-20.

PMID:
8660985
36.

Transcription factors that control development of the thymic microenvironment.

Boehm T, Nehls M, Kyewski B.

Immunol Today. 1995 Dec;16(12):555-6. Review. No abstract available.

PMID:
8579744
37.

Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells.

Messerle M, Follo M, Nehls M, Eggert H, Boehm T.

Cytokines Mol Ther. 1995 Jun;1(2):139-43.

PMID:
9384671
38.

An intragenic deletion in the human PTPN6 gene affects transcriptional activity.

Nehls M, Schorpp M, Boehm T.

Hum Genet. 1995 Jun;95(6):713-5.

PMID:
7789961
39.

YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11.

Nehls M, Lüno K, Schorpp M, Pfeifer D, Krause S, Matysiak-Scholze U, Dierbach H, Boehm T.

Mamm Genome. 1995 May;6(5):321-31.

PMID:
7626882
40.

A rapid and efficient alternative to sonication in shot-gun sequencing projects.

Nehls M, Boehm T.

Trends Genet. 1995 Feb;11(2):39. No abstract available.

PMID:
7716804
41.

New member of the winged-helix protein family disrupted in mouse and rat nude mutations.

Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T.

Nature. 1994 Nov 3;372(6501):103-7.

PMID:
7969402
42.

The sequence complexity of exons trapped from the mouse genome.

Nehls M, Pfeifer D, Micklem G, Schmoor C, Boehm T.

Curr Biol. 1994 Nov 1;4(11):983-9.

PMID:
7874497
43.

Two large insert vectors, lambda PS and lambda KO, facilitate rapid mapping and targeted disruption of mammalian genes.

Nehls M, Messerle M, Sirulnik A, Smith AJ, Boehm T.

Biotechniques. 1994 Oct;17(4):770-5.

PMID:
7833040
44.

DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism.

Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M.

Mol Cell Biol. 1994 Sep;14(9):5950-60.

46.

A yeast artificial chromosome contig on mouse chromosome 11 encompassing the nu locus.

Nehls M, Lüno K, Schorpp M, Krause S, Matysiak-Scholze U, Prokop CM, Hedrich HJ, Boehm T.

Eur J Immunol. 1994 Jul;24(7):1721-3.

PMID:
8026534
48.

Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast.

Nehls MC, Brenner DA, Gruss HJ, Dierbach H, Mertelsmann R, Herrmann F.

J Clin Invest. 1993 Dec;92(6):2916-21. Retraction in: J Clin Invest. 2003 Oct;112(8):1265.

49.

Preparation of strand-specific cDNA from amplified sources.

Nehls M, Boehm T.

Trends Genet. 1993 Nov;9(11):376-7. No abstract available.

PMID:
8310534
50.

S-300 gel matrix irreversibly binds single-stranded nucleic acids.

Nehls M, Boehm T.

Trends Genet. 1993 Oct;9(10):336-7. No abstract available.

PMID:
8273146

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