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Items: 38

1.

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis.

Sun X, Yi Y, Yan Z, Rosen BH, Liang B, Winter MC, Evans TIA, Rotti PG, Yang Y, Gray JS, Park SY, Zhou W, Zhang Y, Moll SR, Woody L, Tran DM, Jiang L, Vonk AM, Beekman JM, Negulescu P, Van Goor F, Fiorino DF, Gibson-Corley KN, Engelhardt JF.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaau7531. doi: 10.1126/scitranslmed.aau7531.

PMID:
30918114
2.

Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.

Hadida S, Van Goor F, Zhou J, Arumugam V, McCartney J, Hazlewood A, Decker C, Negulescu P, Grootenhuis PD.

J Med Chem. 2014 Dec 11;57(23):9776-95. doi: 10.1021/jm5012808. Epub 2014 Dec 2.

PMID:
25441013
3.

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

Van Goor F, Hadida S, Grootenhuis PD, Burton B, Stack JH, Straley KS, Decker CJ, Miller M, McCartney J, Olson ER, Wine JJ, Frizzell RA, Ashlock M, Negulescu PA.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8. doi: 10.1073/pnas.1105787108. Epub 2011 Oct 5.

4.

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.

Van Goor F, Hadida S, Grootenhuis PD, Burton B, Cao D, Neuberger T, Turnbull A, Singh A, Joubran J, Hazlewood A, Zhou J, McCartney J, Arumugam V, Decker C, Yang J, Young C, Olson ER, Wine JJ, Frizzell RA, Ashlock M, Negulescu P.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30. doi: 10.1073/pnas.0904709106. Epub 2009 Oct 21.

5.

Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential.

Huang CJ, Harootunian A, Maher MP, Quan C, Raj CD, McCormack K, Numann R, Negulescu PA, González JE.

Nat Biotechnol. 2006 Apr;24(4):439-46. Epub 2006 Mar 19.

PMID:
16550174
6.

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules.

Van Goor F, Straley KS, Cao D, González J, Hadida S, Hazlewood A, Joubran J, Knapp T, Makings LR, Miller M, Neuberger T, Olson E, Panchenko V, Rader J, Singh A, Stack JH, Tung R, Grootenhuis PD, Negulescu P.

Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1117-30. Epub 2006 Jan 27.

7.

Identification of signal transduction pathways used by orphan g protein-coupled receptors.

Bresnick JN, Skynner HA, Chapman KL, Jack AD, Zamiara E, Negulescu P, Beaumont K, Patel S, McAllister G.

Assay Drug Dev Technol. 2003 Apr;1(2):239-49.

PMID:
15090189
8.

Detection of beta-lactamase reporter gene expression by flow cytometry.

Knapp T, Hare E, Feng L, Zlokarnik G, Negulescu P.

Cytometry A. 2003 Feb;51(2):68-78.

9.

Cellular biosensors for drug discovery.

Durick K, Negulescu P.

Biosens Bioelectron. 2001 Sep;16(7-8):587-92.

PMID:
11544053
10.

Conditionally expressed G alpha 15 couples to endogenous receptors in GH3 cells.

Offermanns S, Negulescu P, Hu YH, Simon MI.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Aug;364(2):140-8.

PMID:
11534853
11.

High-throughput screening strategies for cardiac ion channels.

Numann R, Negulescu PA.

Trends Cardiovasc Med. 2001 Feb;11(2):54-9. Review.

PMID:
11530293
12.

A fluorescent reporter assay for the detection of ligands acting through Gi protein-coupled receptors.

Xing H, Tran HC, Knapp TE, Negulescu PA, Pollok BA.

J Recept Signal Transduct Res. 2000 Nov;20(4):189-210.

PMID:
11192018
13.

A genetically encoded, fluorescent indicator for cyclic AMP in living cells.

Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T.

Nat Cell Biol. 2000 Jan;2(1):25-9.

PMID:
10620803
14.

Chipping away at GPCR function.

Beaumont K, Negulescu P.

Nat Biotechnol. 1999 Nov;17(11):1060. No abstract available.

PMID:
10545905
15.

Cell-based assays and instrumentation for screening ion-channel targets.

González JE, Oades K, Leychkis Y, Harootunian A, Negulescu PA.

Drug Discov Today. 1999 Sep;4(9):431-439.

PMID:
10461154
16.

Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening.

Mere L, Bennett T, Coassin P, England P, Hamman B, Rink T, Zimmerman S, Negulescu P.

Drug Discov Today. 1999 Aug;4(8):363-369.

PMID:
10431146
17.

Intracellular detection assays for high-throughput screening.

González JE, Negulescu PA.

Curr Opin Biotechnol. 1998 Dec;9(6):624-31. Review.

PMID:
9889144
18.

A genome-wide functional assay of signal transduction in living mammalian cells.

Whitney M, Rockenstein E, Cantin G, Knapp T, Zlokarnik G, Sanders P, Durick K, Craig FF, Negulescu PA.

Nat Biotechnol. 1998 Dec;16(13):1329-33.

PMID:
9853613
19.

A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.

Ehring GR, Kerschbaum HH, Eder C, Neben AL, Fanger CM, Khoury RM, Negulescu PA, Cahalan MD.

J Exp Med. 1998 Nov 2;188(9):1593-602.

20.

Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter.

Zlokarnik G, Negulescu PA, Knapp TE, Mere L, Burres N, Feng L, Whitney M, Roemer K, Tsien RY.

Science. 1998 Jan 2;279(5347):84-8.

21.

Ion channels, Ca2+ signaling, and reporter gene expression in antigen-specific mouse T cells.

Kerschbaum HH, Negulescu PA, Cahalan MD.

J Immunol. 1997 Aug 15;159(4):1628-38.

PMID:
9257822
22.

Polarity of T cell shape, motility, and sensitivity to antigen.

Negulescu PA, Krasieva TB, Khan A, Kerschbaum HH, Cahalan MD.

Immunity. 1996 May;4(5):421-30.

23.

La3+ and pH sensitivity of Ca2+ entry and intracellular store filling in gastric parietal cells.

Negulescu PA, Machen TE.

Am J Physiol. 1995 Nov;269(5 Pt 1):G770-8.

PMID:
7491970
24.

Intracellular calcium dependence of gene expression in single T lymphocytes.

Negulescu PA, Shastri N, Cahalan MD.

Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2873-7.

25.

Ca transport by plasma membrane and intracellular stores of gastric cells.

Negulescu PA, Machen TE.

Am J Physiol. 1993 Apr;264(4 Pt 1):C843-51.

PMID:
8476018
26.

Fish antifreeze proteins block Ca entry into rabbit parietal cells.

Negulescu PA, Rubinsky B, Fletcher GL, Machen TE.

Am J Physiol. 1992 Dec;263(6 Pt 1):C1310-3.

PMID:
1476172
27.

Calcium signaling in endothelia: cellular heterogeneity and receptor internalization.

Weintraub WH, Negulescu PA, Machen TE.

Am J Physiol. 1992 Nov;263(5 Pt 1):C1029-39.

PMID:
1332490
28.

Volume-sensitive Ca influx and release from intracellular pools in gastric parietal cells.

Negulescu PA, Munck B, Machen TE.

Am J Physiol. 1992 Sep;263(3 Pt 1):C584-9.

PMID:
1415509
29.

Carbachol-activated calcium entry into HT-29 cells is regulated by both membrane potential and cell volume.

Fischer H, Illek B, Negulescu PA, Clauss W, Machen TE.

Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1438-42.

30.

Lowering extracellular sodium or pH raises intracellular calcium in gastric cells.

Negulescu PA, Machen TE.

J Membr Biol. 1990 Jul;116(3):239-48.

PMID:
2388255
31.

Fluorescence measurements of cytosolic free Na concentration, influx and efflux in gastric cells.

Negulescu PA, Harootunian A, Tsien RY, Machen TE.

Cell Regul. 1990 Feb;1(3):259-68.

32.

Intracellular ion activities and membrane transport in parietal cells measured with fluorescent dyes.

Negulescu PA, Machen TE.

Methods Enzymol. 1990;192:38-81. No abstract available.

PMID:
2074799
33.

Intracellular Ca requirements for stimulus-secretion coupling in parietal cell.

Negulescu PA, Reenstra WW, Machen TE.

Am J Physiol. 1989 Feb;256(2 Pt 1):C241-51.

PMID:
2465690
34.

H and HCO3 transport across the basolateral membrane of the parietal cell.

Machen TE, Townsley MC, Paradiso AM, Wenzl E, Negulescu PA.

Ann N Y Acad Sci. 1989;574:447-62. No abstract available.

PMID:
2483877
35.

Release and reloading of intracellular Ca stores after cholinergic stimulation of the parietal cell.

Negulescu PA, Machen TE.

Am J Physiol. 1988 Apr;254(4 Pt 1):C498-504.

PMID:
3354649
36.

Intracellular Ca regulation during secretagogue stimulation of the parietal cell.

Negulescu PA, Machen TE.

Am J Physiol. 1988 Jan;254(1 Pt 1):C130-40.

PMID:
2447794
37.

Na+-H+ and Cl(-)-OH-(HCO3-) exchange in gastric glands.

Paradiso AM, Negulescu PA, Machen TE.

Am J Physiol. 1986 Apr;250(4 Pt 1):G524-34.

PMID:
3008575
38.

Trypsin inhibitor and proteolytic enzyme activity in dogs after ethionine-induced pancreatitis.

NEGULESCU P, HARPER HA, CRANE JT, GOLDMAN L.

Am J Surg. 1961 Aug;102:196-201. No abstract available.

PMID:
13728181

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