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Items: 1 to 50 of 85

1.

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.

Yukawa T, Nara Y, Kono M, Sato A, Oda T, Takagi T, Sato T, Banno Y, Taya N, Imada T, Shiokawa Z, Negoro N, Kawamoto T, Koyama R, Uchiyama N, Skene R, Hoffman I, Chen CH, Sang B, Snell G, Katsuyama R, Yamamoto S, Shirai J.

J Med Chem. 2019 Feb 14;62(3):1167-1179. doi: 10.1021/acs.jmedchem.8b01181. Epub 2019 Feb 4.

PMID:
30652849
2.

Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.

Mikami S, Kawasaki M, Ikeda S, Negoro N, Nakamura S, Nomura I, Ashizawa T, Kokubo H, Hoffman ID, Zou H, Oki H, Uchiyama N, Hiura Y, Miyamoto M, Itou Y, Nakashima M, Iwashita H, Taniguchi T.

Chem Pharm Bull (Tokyo). 2017;65(11):1058-1077. doi: 10.1248/cpb.c17-00564.

3.

Parallel fluorescent probe synthesis based on the large-scale preparation of BODIPY FL propionic acid.

Katoh T, Yoshikawa M, Yamamoto T, Arai R, Nii N, Tomata Y, Suzuki S, Koyama R, Negoro N, Yogo T.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1145-1148. doi: 10.1016/j.bmcl.2017.01.076. Epub 2017 Jan 28.

PMID:
28174108
4.

Analysis of bone metabolism during early stage and clinical benefits of early intervention with alendronate in patients with systemic rheumatic diseases treated with high-dose glucocorticoid: Early DIagnosis and Treatment of OsteopoRosis in Japan (EDITOR-J) study.

Tanaka Y, Mori H, Aoki T, Atsumi T, Kawahito Y, Nakayama H, Tohma S, Yamanishi Y, Hasegawa H, Tanimura K, Negoro N, Ueki Y, Kawakami A, Eguchi K, Saito K, Okada Y.

J Bone Miner Metab. 2016 Nov;34(6):646-654. Epub 2015 Aug 26.

PMID:
26308708
5.

Fasiglifam (TAK-875) has dual potentiating mechanisms via Gαq-GPR40/FFAR1 signaling branches on glucose-dependent insulin secretion.

Sakuma K, Yabuki C, Maruyama M, Abiru A, Komatsu H, Negoro N, Tsujihata Y, Takeuchi K, Habata Y, Mori M.

Pharmacol Res Perspect. 2016 Apr 27;4(3):e00237. doi: 10.1002/prp2.237. eCollection 2016 Jun.

6.

Transcription factor Tbx6 plays a central role in fate determination between mesenchyme and muscle in embryos of the ascidian, Halocynthia roretzi.

Kumano G, Negoro N, Nishida H.

Dev Growth Differ. 2014 May;56(4):310-22. doi: 10.1111/dgd.12133. Epub 2014 Apr 11.

PMID:
24720515
7.

Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists.

Sato K, Sugimoto H, Rikimaru K, Imoto H, Kamaura M, Negoro N, Tsujihata Y, Miyashita H, Odani T, Murata T.

Bioorg Med Chem. 2014 Mar 1;22(5):1649-66. doi: 10.1016/j.bmc.2014.01.028. Epub 2014 Jan 28.

PMID:
24508142
8.

Formation of a new benzotriquinane skeleton via intramolecular photocycloaddition reactions of a phenylethynes moiety to a 1-cyanonaphthalene ring system.

Mizuno K, Negoro N, Nagayama Y, Maeda H, Ikeda H.

Photochem Photobiol Sci. 2014 Feb;13(2):145-8. doi: 10.1039/c3pp50243k.

PMID:
24108514
9.

TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats.

Ito R, Tsujihata Y, Matsuda-Nagasumi K, Mori I, Negoro N, Takeuchi K.

Br J Pharmacol. 2013 Oct;170(3):568-80. doi: 10.1111/bph.12297.

10.

Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.

Negoro N, Sasaki S, Mikami S, Ito M, Tsujihata Y, Ito R, Suzuki M, Takeuchi K, Suzuki N, Miyazaki J, Santou T, Odani T, Kanzaki N, Funami M, Morohashi A, Nonaka M, Matsunaga S, Yasuma T, Momose Y.

J Med Chem. 2012 Apr 26;55(8):3960-74. doi: 10.1021/jm300170m. Epub 2012 Apr 18.

PMID:
22490067
11.

Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.

Mikami S, Kitamura S, Negoro N, Sasaki S, Suzuki M, Tsujihata Y, Miyazaki T, Ito R, Suzuki N, Miyazaki J, Santou T, Kanzaki N, Funami M, Tanaka T, Yasuma T, Momose Y.

J Med Chem. 2012 Apr 26;55(8):3756-76. doi: 10.1021/jm2016123. Epub 2012 Apr 11.

PMID:
22428944
12.

Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.

Negoro N, Sasaki S, Ito M, Kitamura S, Tsujihata Y, Ito R, Suzuki M, Takeuchi K, Suzuki N, Miyazaki J, Santou T, Odani T, Kanzaki N, Funami M, Tanaka T, Yasuma T, Momose Y.

J Med Chem. 2012 Feb 23;55(4):1538-52. doi: 10.1021/jm2012968. Epub 2012 Feb 10.

PMID:
22242551
13.
14.
15.

TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.

Tsujihata Y, Ito R, Suzuki M, Harada A, Negoro N, Yasuma T, Momose Y, Takeuchi K.

J Pharmacol Exp Ther. 2011 Oct;339(1):228-37. doi: 10.1124/jpet.111.183772. Epub 2011 Jul 13.

PMID:
21752941
17.

Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists.

Sasaki S, Kitamura S, Negoro N, Suzuki M, Tsujihata Y, Suzuki N, Santou T, Kanzaki N, Harada M, Tanaka Y, Kobayashi M, Tada N, Funami M, Tanaka T, Yamamoto Y, Fukatsu K, Yasuma T, Momose Y.

J Med Chem. 2011 Mar 10;54(5):1365-78. doi: 10.1021/jm101405t. Epub 2011 Feb 14.

PMID:
21319751
18.

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.

Negoro N, Sasaki S, Mikami S, Ito M, Suzuki M, Tsujihata Y, Ito R, Harada A, Takeuchi K, Suzuki N, Miyazaki J, Santou T, Odani T, Kanzaki N, Funami M, Tanaka T, Kogame A, Matsunaga S, Yasuma T, Momose Y.

ACS Med Chem Lett. 2010 Jun 18;1(6):290-4. doi: 10.1021/ml1000855. eCollection 2010 Sep 9.

19.

Possible de novo CTG repeat expansion in the DMPK gene of a patient with cardiomyopathy.

Furutama D, Negoro N, Terasaki F, Tsuji-Matsuyama K, Sakai R, Maeda T, Tanaka T, Hoshiga M, Ishihara T, Ohsawa N, Hanafusa T.

J Clin Neurosci. 2010 Mar;17(3):408-9. doi: 10.1016/j.jocn.2009.06.010. Epub 2010 Jan 13.

PMID:
20074967
20.

Switching to aggressive statin improves vascular endothelial function in patients with stable coronary artery disease.

Hoshiga M, Arishiro K, Nakakoji T, Miyazaki N, Negoro N, Okabe T, Kohbayashi E, Ishihara T, Hanafusa T.

J Atheroscler Thromb. 2010 Jul 30;17(7):705-11. Epub 2010 Jan 12.

21.

Rabbit plaque models closely resembling lesions in human coronary artery disease.

Okabe T, Hoshiga M, Negoro N, Nakakoji T, Arishiro K, Ishihara T, Ueno H, Hanafusa T.

Int J Cardiol. 2011 Mar 3;147(2):271-7. doi: 10.1016/j.ijcard.2009.09.528. Epub 2009 Nov 6.

PMID:
19896731
22.

[A case of Churg-Strauss syndrome following corticosteroid withdrawal].

Sunami K, Takayama M, Okabe Y, Yamane H, Tochino Y, Kodama T, Negoro N.

Nihon Jibiinkoka Gakkai Kaiho. 2009 Jun;112(6):487-90. Japanese.

PMID:
19610591
23.

Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury.

Ii M, Hoshiga M, Negoro N, Fukui R, Nakakoji T, Kohbayashi E, Shibata N, Furutama D, Ishihara T, Hanafusa T, Losordo DW, Ohsawa N.

Atherosclerosis. 2009 Sep;206(1):77-85. doi: 10.1016/j.atherosclerosis.2009.02.021. Epub 2009 Feb 27.

24.

Microarray analysis of glomerular gene expression in murine lupus nephritis.

Teramoto K, Negoro N, Kitamoto K, Iwai T, Iwao H, Okamura M, Miura K.

J Pharmacol Sci. 2008 Jan;106(1):56-67. Epub 2008 Jan 11.

25.
26.

Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits.

Arishiro K, Hoshiga M, Negoro N, Jin D, Takai S, Miyazaki M, Ishihara T, Hanafusa T.

J Am Coll Cardiol. 2007 Apr 3;49(13):1482-9. Epub 2007 Mar 21.

28.

Vascular Behçet's disease with coronary artery aneurysm.

Arishiro K, Nariyama J, Hoshiga M, Nakagawa A, Okabe T, Nakakoji T, Negoro N, Ishihara T, Hanafusa T.

Intern Med. 2006;45(15):903-7. Epub 2006 Sep 1.

29.

Evidence of active endocarditis, caused by Gemella morbillorum, related to acute embolic stroke.

Murai M, Fukumoto H, Negoro N, Sano K, Nishimoto M, Muraoka H, Hazui H, Morita H, Hanafusa T.

Int J Cardiol. 2006 Sep 20;112(2):e17-8. Epub 2006 Aug 28. No abstract available.

PMID:
16935365
30.

Location of out-of-hospital cardiac arrests in Takatsuki City: where should automated external defibrillator be placed.

Muraoka H, Ohishi Y, Hazui H, Negoro N, Murai M, Kawakami M, Nishihara I, Fukumoto H, Morita H, Hanafusa T.

Circ J. 2006 Jul;70(7):827-31.

31.

Serum heart-type fatty acid-binding protein concentration positively correlates with the length of aortic dissection.

Hazui H, Negoro N, Nishimoto M, Muraoka H, Murai M, Takeshita H, Ohishi Y, Fukumoto H, Morita H, Hanafusa T.

Circ J. 2005 Aug;69(8):958-61.

32.

Simple and useful tests for discriminating between acute aortic dissection of the ascending aorta and acute myocardial infarction in the emergency setting.

Hazui H, Fukumoto H, Negoro N, Hoshiga M, Muraoka H, Nishimoto M, Morita H, Hanafusa T.

Circ J. 2005 Jun;69(6):677-82.

33.

Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment.

Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T.

Int J Cardiol. 2006 Apr 4;108(2):281-3. No abstract available.

PMID:
15913812
34.

Re-entry circuit in ventricular tachycardia due to focal fatty-fibrosis in a patient with myotonic dystrophy.

Muraoka H, Negoro N, Terasaki F, Nakakoji T, Kojima S, Hoshiga M, Sugino M, Hosokawa T, Ishihara T, Hanafusa T.

Intern Med. 2005 Feb;44(2):129-35.

35.

Clinical significance of von Willebrand factor in patients with adult dermatomyositis.

Komiya T, Negoro N, Kondo K, Miura K, Hirota Y, Yoshikawa J.

Clin Rheumatol. 2005 Aug;24(4):352-7. Epub 2004 Nov 23.

PMID:
15565394
36.

Axillo-axillary bypass for in-stent restenosis in Takayasu arteritis.

Mieno S, Horimoto H, Arishiro K, Negoro N, Hoshiga M, Ishihara T, Hanafusa T, Sasaki S.

Int J Cardiol. 2004 Mar;94(1):131-2.

PMID:
14996490
37.

Different migratory and proliferative properties of smooth muscle cells of coronary and femoral artery.

Nishiguchi F, Fukui R, Hoshiga M, Negoro N, Ii M, Nakakohji T, Kohbayashi E, Ishihara T, Hanafusa T.

Atherosclerosis. 2003 Nov;171(1):39-47.

PMID:
14642404
38.

Successful catheter interventional therapy for acute coronary syndrome secondary to kawasaki disease in young adults.

Negoro N, Nariyama J, Nakagawa A, Katayama H, Okabe T, Hazui H, Yokota N, Kojima S, Hoshiga M, Morita H, Ishihara T, Hanafusa T.

Circ J. 2003 Apr;67(4):362-5.

39.

[Two cases of systemic lupus erythematosus accompanied by antiphospholipid syndrome nephropathy without immune complex nephritis].

Komiya T, Okamura M, Kawakami K, Okazaki M, Tsukamoto J, Okada S, Sumi T, Negoro N, Yoshikawa J.

Nihon Jinzo Gakkai Shi. 2002 Dec;44(8):817-22. Japanese.

PMID:
12607972
40.

Long-term observation of avascular necrosis of the femoral head in systemic lupus erythematosus: an MRI study.

Yoshida T, Kanayama Y, Okamura M, Negoro N, Inoue T, Yoshikawa J.

Clin Exp Rheumatol. 2002 Jul-Aug;20(4):525-30.

PMID:
12175107
41.

Beraprost sodium regulates cell cycle in vascular smooth muscle cells through cAMP signaling by preventing down-regulation of p27(Kip1).

Ii M, Hoshiga M, Fukui R, Negoro N, Nakakoji T, Nishiguchi F, Kohbayashi E, Ishihara T, Hanafusa T.

Cardiovasc Res. 2001 Dec;52(3):500-8.

PMID:
11738067
42.

Psoriasis in a patient with juvenile rheumatoid arthritis.

Kono T, Ishii M, Taniguchi S, Negoro N.

Dermatology. 2000;201(3):275-6.

PMID:
11096206
43.

Increased migration in late G(1) phase in cultured smooth muscle cells.

Fukui R, Amakawa M, Hoshiga M, Shibata N, Kohbayashi E, Seto M, Sasaki Y, Ueno T, Negoro N, Nakakoji T, Ii M, Nishiguchi F, Ishihara T, Ohsawa N.

Am J Physiol Cell Physiol. 2000 Oct;279(4):C999-1007.

44.

Angiographically demonstrated coronary collaterals predict residual viable myocardium in patients with chronic myocardial infarction: a regional metabolic study.

Fukai M, Ii M, Nakakoji T, Kawakatsu M, Nariyama J, Yokota N, Negoro N, Kojima S, Ohkubo T, Hoshiga M, Nakajima O, Ishihara T.

J Cardiol. 2000 Feb;35(2):103-11.

PMID:
10713931
45.

Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.

Kono T, Ishii M, Negoro N, Taniguchi S.

J Am Acad Dermatol. 2000 Mar;42(3):519-20.

PMID:
10688731
46.

The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells.

Negoro N, Hoshiga M, Seto M, Kohbayashi E, Ii M, Fukui R, Shibata N, Nakakoji T, Nishiguchi F, Sasaki Y, Ishihara T, Ohsawa N.

Biochem Biophys Res Commun. 1999 Aug 19;262(1):211-5.

PMID:
10448094
47.

Inhibition of smooth muscle cell migration by the p21 cyclin-dependent kinase inhibitor (Cip1).

Fukui R, Shibata N, Kohbayashi E, Amakawa M, Furutama D, Hoshiga M, Negoro N, Nakakouji T, Ii M, Ishihara T, Ohsawa N.

Atherosclerosis. 1997 Jul 11;132(1):53-9.

PMID:
9247359
48.

Enhanced gene expression of scavenger receptor in peripheral blood monocytes from patients on cuprophane haemodialysis.

Konishi Y, Okamura M, Konishi M, Negoro N, Yoshida T, Inoue T, Kanayama Y, Yoshikawa J.

Nephrol Dial Transplant. 1997 Jun;12(6):1167-72.

PMID:
9198046
49.

Anti-angiogenic compound (TNP-470) inhibits mesangial cell proliferation in vitro and in vivo.

Haraguchi M, Okamura M, Konishi M, Konishi Y, Negoro N, Inoue T, Kanayama Y, Yoshikawa J.

Kidney Int. 1997 Jun;51(6):1838-46.

50.

Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages.

Umetani N, Kanayama Y, Okamura M, Negoro N, Takeda T.

Biochim Biophys Acta. 1996 Oct 18;1303(3):199-206.

PMID:
8908154

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