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Silibinin decreases hepatic glucose production through the activation of gut-brain-liver axis in diabetic rats.

Xu F, Yang J, Negishi H, Sun Y, Li D, Zhang X, Hayashi T, Gao M, Ikeda K, Ikejima T.

Food Funct. 2018 Sep 19;9(9):4926-4935. doi: 10.1039/c8fo00565f.


Identifying a possible factor for the increased newborn size in singleton pregnancies after assisted reproductive technology using cryopreserved embryos, in comparison with fresh embryos.

Ishii R, Shoda A, Kubo M, Okazaki S, Suzuki M, Okawa R, Enomoto M, Shitanaka M, Fujita Y, Nakao K, Shimada N, Horikawa M, Negishi H, Taketani Y.

Reprod Med Biol. 2018 May 6;17(3):307-314. doi: 10.1002/rmb2.12206. eCollection 2018 Jul.


Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.

Kimura Y, Negishi H, Matsuda A, Endo N, Hangai S, Inoue A, Nishio J, Taniguchi T, Yanai H.

Cancer Sci. 2018 Sep;109(9):2687-2696. doi: 10.1111/cas.13726. Epub 2018 Aug 1.


Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.

Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5253-5258. doi: 10.1073/pnas.1803936115. Epub 2018 Apr 30.


Supramolecular protein cages constructed from a crystalline protein matrix.

Negishi H, Abe S, Yamashita K, Hirata K, Niwase K, Boudes M, Coulibaly F, Mori H, Ueno T.

Chem Commun (Camb). 2018 Feb 20;54(16):1988-1991. doi: 10.1039/c7cc08689j.


Glioblastoma fed by middle meningeal artery and displaying cyst formation soon after repeated implantation of carmustine wafers: A case report.

Yamamuro S, Hanashima Y, Yoshimura S, Aoki H, Kamiya K, Takamine Y, Negishi H, Yoshino A.

Mol Clin Oncol. 2017 Dec;7(6):953-956. doi: 10.3892/mco.2017.1455. Epub 2017 Oct 17.


S-equol Exerts Estradiol-Like Anorectic Action with Minimal Stimulation of Estrogen Receptor-α in Ovariectomized Rats.

Nishimura Y, Mabuchi K, Takano A, Hara Y, Negishi H, Morimoto K, Ueno T, Uchiyama S, Takamata A.

Front Endocrinol (Lausanne). 2017 Oct 19;8:281. doi: 10.3389/fendo.2017.00281. eCollection 2017.


The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family.

Negishi H, Taniguchi T, Yanai H.

Cold Spring Harb Perspect Biol. 2018 Nov 1;10(11). pii: a028423. doi: 10.1101/cshperspect.a028423. Review.


Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.

Sarashina-Kida H, Negishi H, Nishio J, Suda W, Nakajima Y, Yasui-Kato M, Iwaisako K, Kang S, Endo N, Yanai H, Asagiri M, Kida H, Hattori M, Kumanogoh A, Taniguchi T.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10178-10183. doi: 10.1073/pnas.1712837114. Epub 2017 Sep 6.


Quantitative diagnostic imaging of cancer tissues by using phosphor-integrated dots with ultra-high brightness.

Gonda K, Watanabe M, Tada H, Miyashita M, Takahashi-Aoyama Y, Kamei T, Ishida T, Usami S, Hirakawa H, Kakugawa Y, Hamanaka Y, Yoshida R, Furuta A, Okada H, Goda H, Negishi H, Takanashi K, Takahashi M, Ozaki Y, Yoshihara Y, Nakano Y, Ohuchi N.

Sci Rep. 2017 Aug 8;7(1):7509. doi: 10.1038/s41598-017-06534-z.


Penetration of bronchial wall by knot of absorbable monofilament suture.

Nakano T, Endo S, Negishi H, Yamamoto S.

Interact Cardiovasc Thorac Surg. 2017 Mar 1;24(3):468-470. doi: 10.1093/icvts/ivw402.


The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.

Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14097-14102. Epub 2016 Nov 21.


PGE2 induced in and released by dying cells functions as an inhibitory DAMP.

Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3844-9. doi: 10.1073/pnas.1602023113. Epub 2016 Mar 21.


Case of ovarian hyperstimulation and oocyte pick-up during very early period of unnoticed pregnancy followed by ongoing normal pregnancy.

Takenaka H, Nakao K, Horikawa M, Negishi H.

J Obstet Gynaecol Res. 2016 Apr;42(4):471-5. doi: 10.1111/jog.12919. Epub 2016 Feb 12.


S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.

Teijaro JR, Studer S, Leaf N, Kiosses WB, Nguyen N, Matsuki K, Negishi H, Taniguchi T, Oldstone MB, Rosen H.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1351-6. doi: 10.1073/pnas.1525356113. Epub 2016 Jan 19.


Efficient butanol recovery from acetone-butanol-ethanol fermentation cultures grown on sweet sorghum juice by pervaporation using silicalite-1 membrane.

Kanemoto M, Negishi H, Sakaki K, Ikegami T, Chohnan S, Nitta Y, Kurusu Y, Ohta H.

J Biosci Bioeng. 2016 Jun;121(6):697-700. doi: 10.1016/j.jbiosc.2015.11.008. Epub 2015 Dec 21.


Effects of Berberine on Adipose Tissues and Kidney Function in 3T3-L1 Cells and Spontaneously Hypertensive Rats.

Kishimoto A, Dong SF, Negishi H, Yasui N, Sun JN, Ikeda K.

Nat Prod Commun. 2015 Sep;10(9):1543-6.


Design of Enzyme-Encapsulated Protein Containers by In Vivo Crystal Engineering.

Abe S, Ijiri H, Negishi H, Yamanaka H, Sasaki K, Hirata K, Mori H, Ueno T.

Adv Mater. 2015 Dec 22;27(48):7951-6. doi: 10.1002/adma.201503827. Epub 2015 Oct 27.


Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.

Nishio J, Baba M, Atarashi K, Tanoue T, Negishi H, Yanai H, Habu S, Hori S, Honda K, Taniguchi T.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12770-5. doi: 10.1073/pnas.1516617112. Epub 2015 Sep 29.


Insulin resistance in nonobese Japanese women with polycystic ovary syndrome is associated with poorer glucose tolerance, delayed insulin secretion, and enhanced insulin response.

Negishi H, Nakao K, Kimura M, Takenaka H, Horikawa M.

Reprod Med Biol. 2015 Mar 19;14(3):123-129. doi: 10.1007/s12522-015-0204-x. eCollection 2015 Jul.


Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.

Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.

Elife. 2014 Aug 22;3:e04177. doi: 10.7554/eLife.04177.


Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats.

Nishimura Y, Mabuchi K, Taguchi S, Ikeda S, Aida E, Negishi H, Takamata A.

J Physiol Sci. 2014 May;64(3):203-11. doi: 10.1007/s12576-014-0312-0. Epub 2014 Mar 28.


Rapid detection of microbes in the dialysis solution by the microcolony fluorescence staining method (Millflex quantum).

Osono E, Kobayashi E, Inoue Y, Honda K, Kumagai T, Negishi H, Okamatsu K, Ichimura K, Kamano C, Suzuki F, Norose Y, Takahashi M, Takaku S, Fujioka N, Hayama N, Takizawa H.

Biocontrol Sci. 2014;19(1):57-60.


Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.

Yanai H, Matsuda A, An J, Koshiba R, Nishio J, Negishi H, Ikushima H, Onoe T, Ohdan H, Yoshida N, Taniguchi T.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20699-704. doi: 10.1073/pnas.1320808110. Epub 2013 Dec 3.


Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis.

Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19884-9. doi: 10.1073/pnas.1320145110. Epub 2013 Nov 18.


The IRF family transcription factors at the interface of innate and adaptive immune responses.

Ikushima H, Negishi H, Taniguchi T.

Cold Spring Harb Symp Quant Biol. 2013;78:105-16. doi: 10.1101/sqb.2013.78.020321. Epub 2013 Oct 3. Review.


Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination.

Negishi H, Mori M, Mori H, Yamori Y.

J Nutr. 2013 Nov;143(11):1794-8. doi: 10.3945/jn.113.179036. Epub 2013 Sep 4.


Caffeic acid phenethyl ester suppresses oxidative stress in 3T3-L1 adipocytes.

Yasui N, Nishiyama E, Juman S, Negishi H, Miki T, Yamori Y, Ikeda K.

J Asian Nat Prod Res. 2013 Nov;15(11):1189-96. doi: 10.1080/10286020.2013.825609. Epub 2013 Aug 8.


The IRF family of transcription factors: Inception, impact and implications in oncogenesis.

Yanai H, Negishi H, Taniguchi T.

Oncoimmunology. 2012 Nov 1;1(8):1376-1386.


Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction.

Negishi H, Miki S, Sarashina H, Taguchi-Atarashi N, Nakajima A, Matsuki K, Endo N, Yanai H, Nishio J, Honda K, Taniguchi T.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21016-21. doi: 10.1073/pnas.1219482110. Epub 2012 Dec 3.


Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5.

Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale ST, Taniguchi T.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):95-100. doi: 10.1016/j.bbrc.2012.11.006. Epub 2012 Nov 12.


Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.

Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T.

Nat Immunol. 2012 May 20;13(7):659-66. doi: 10.1038/ni.2307.


Membrane-assisted extractive butanol fermentation by Clostridium saccharoperbutylacetonicum N1-4 with 1-dodecanol as the extractant.

Tanaka S, Tashiro Y, Kobayashi G, Ikegami T, Negishi H, Sakaki K.

Bioresour Technol. 2012 Jul;116:448-52. doi: 10.1016/j.biortech.2012.03.096. Epub 2012 Apr 4.


Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary.

Kawai T, Mihara T, Kawashima I, Fujita Y, Ikeda C, Negishi H, Richards JS, Shimada M.

Reprod Toxicol. 2012 Jun;33(3):322-30. doi: 10.1016/j.reprotox.2012.01.001. Epub 2012 Jan 18.


Culturable bacterial communities on leaf sheaths and panicles of rice plants in Japan.

Shinohara H, Yoshida S, Enya J, Watanabe Y, Tsukiboshi T, Negishi H, Tsushima S.

Folia Microbiol (Praha). 2011 Nov;56(6):505-17. doi: 10.1007/s12223-011-0084-3. Epub 2011 Nov 15.


p53 negatively regulates the hepatoma growth factor HDGF.

Sasaki Y, Negishi H, Idogawa M, Yokota I, Koyama R, Kusano M, Suzuki H, Fujita M, Maruyama R, Toyota M, Saito T, Tokino T.

Cancer Res. 2011 Nov 15;71(22):7038-47. doi: 10.1158/0008-5472.CAN-11-1053. Epub 2011 Oct 17.


Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis.

Fujita Y, Mihara T, Okazaki T, Shitanaka M, Kushino R, Ikeda C, Negishi H, Liu Z, Richards JS, Shimada M.

Hum Reprod. 2011 Oct;26(10):2799-806. doi: 10.1093/humrep/der234. Epub 2011 Jul 20.


[Animal models for metabolic syndrome].

Yasui N, Ikeda K, Negishi H, Nara Y, Yamori Y.

Nihon Rinsho. 2011 Jan;69 Suppl 1:358-63. Review. Japanese. No abstract available.


New chromone derivative terminalianone from African plant Terminalia brownii Fresen (Combretaceae) in Tanzania.

Negishi H, Maoka T, Njelekela M, Yasui N, Juman S, Mtabaji J, Miki T, Nara Y, Yamori Y, Ikeda K.

J Asian Nat Prod Res. 2011 Mar;13(3):281-3. doi: 10.1080/10286020.2011.552431.


Formation of acrylamide from glucans and asparagine.

Tsutsumiuchi K, Watanabe Y, Watanabe M, Hibino M, Kambe M, Okajima N, Negishi H, Miwa J, Taniguchi H.

N Biotechnol. 2011 Oct;28(6):566-73. doi: 10.1016/j.nbt.2011.01.003. Epub 2011 Jan 18.


Dose-response effect of charged carbon beam on normal rat retina assessed by electroretinography.

Mizota A, Tanaka M, Kubota M, Negishi H, Watanabe E, Tsuji H, Miyahara N, Furusawa Y.

Int J Radiat Oncol Biol Phys. 2010 Dec 1;78(5):1532-40. doi: 10.1016/j.ijrobp.2010.07.003.


Caffeic acid phenethyl ester inhibits differentiation to adipocytes in 3T3-L1 mouse fibroblasts.

Juman S, Yasui N, Okuda H, Ueda A, Negishi H, Miki T, Ikeda K.

Biol Pharm Bull. 2010;33(9):1484-8.


Response of human fibroblasts to implant surface coated with titanium dioxide photocatalytic films.

Hoshi N, Negishi H, Okada S, Nonami T, Kimoto K.

J Prosthodont Res. 2010 Oct;54(4):185-91. doi: 10.1016/j.jpor.2010.04.005. Epub 2010 May 15.


HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani L, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T.

Nature. 2009 Nov 5;462(7269):99-103. doi: 10.1038/nature08512.


A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.

Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, Taniguchi T.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17870-5. doi: 10.1073/pnas.0909545106. Epub 2009 Oct 1.


The significance of measurement of serum unbound bilirubin concentrations in high-risk infants.

Lee YK, Daito Y, Katayama Y, Minami H, Negishi H.

Pediatr Int. 2009 Dec;51(6):795-9. doi: 10.1111/j.1442-200X.2009.02878.x. Epub 2009 Apr 3.


IL-1β stimulates IL-8 production, including prostaglandin E2 receptor EP4-triggered pathways, in synoviocyte MH7A cells.

Shibata Y, Kasai H, Shimada M, Koitabashi T, Arai T, Sai R, Terao H, Horikiri M, Negishi H, Miyazawa K, Abiko Y.

Mol Med Rep. 2009 May-Jun;2(3):359-63. doi: 10.3892/mmr_00000108.


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