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Development and implementation of electronic health record integrated model-informed clinical decision support tools for the precision dosing of drugs.

Vinks AA, Peck RW, Neely M, Mould DR.

Clin Pharmacol Ther. 2019 Oct 16. doi: 10.1002/cpt.1679. [Epub ahead of print] Review.


Update in Antibiotic Therapy in Intensive Care Unit Report from the 2019 Nimes International Symposium.

Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B.

Anaesth Crit Care Pain Med. 2019 Oct 10. pii: S2352-5568(19)30427-8. doi: 10.1016/j.accpm.2019.09.009. [Epub ahead of print] Review.


Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11.

Shields JN, Hales EC, Ranspach LE, Luo X, Orr S, Runft D, Dombkowski A, Neely MN, Matherly LH, Taub J, Baker TR, Thummel R.

Toxics. 2019 Sep 21;7(4). pii: E50. doi: 10.3390/toxics7040050.


Huntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent.

Joshi P, Bodnya C, Ilieva I, Neely MD, Aschner M, Bowman AB.

Neurotoxicology. 2019 Sep 20;75:148-157. doi: 10.1016/j.neuro.2019.09.007. [Epub ahead of print]


Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.

Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH.

Physiol Genomics. 2019 Oct 1;51(10):506-515. doi: 10.1152/physiolgenomics.00033.2019. Epub 2019 Sep 18.


Clinical consequences of bleeding among individuals with a recent acute coronary syndrome: Insights from the APPRAISE-2 trial.

Sharma A, Hagström E, Wojdyla DM, Neely ML, Harrington RA, Wallentin L, Alexander JH, Goodman SG, Lopes RD; Apixaban for Prevention of Acute Ischemic Safety Events APPRAISE-2 Steering Committee and Investigators.

Am Heart J. 2019 Sep;215:106-113. doi: 10.1016/j.ahj.2019.05.004. Epub 2019 May 11.


Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry.

Snyder L, Neely ML, Hellkamp AS, O'Brien E, de Andrade J, Conoscenti CS, Leonard T, Bender S, Gulati M, Culver DA, Kaner RJ, Palmer S, Kim HJ; IPF-PRO™ Registry investigators.

Respir Res. 2019 May 30;20(1):105. doi: 10.1186/s12931-019-1043-9.


Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants.

Swaminathan AC, Neely ML, Frankel CW, Kelly FL, Petrovski S, Durheim MT, Bush E, Snyder L, Goldstein DB, Todd JL, Palmer SM.

Chest. 2019 Sep;156(3):477-485. doi: 10.1016/j.chest.2019.03.030. Epub 2019 Apr 9.


Optimizing Gentamicin Dosing in Pediatrics Using Monte Carlo Simulations.

Alsultan A, Abouelkheir M, Elsharawy Y, Alkoraishi A, Osman R, Neely MN, Mansy W, Algahtani S.

Pediatr Infect Dis J. 2019 Apr;38(4):390-395. doi: 10.1097/INF.0000000000002120.


Early Use of Anti-influenza Medications in Hospitalized Children With Tracheostomy.

Miyakawa R, Barreto NB, Kato RM, Neely MN, Russell CJ.

Pediatrics. 2019 Mar;143(3). pii: e20182608. doi: 10.1542/peds.2018-2608.


Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study.

Hope W, Johnstone G, Cicconi S, Felton T, Goodwin J, Whalley S, Santoyo-Castelazo A, Ramos-Martin V, Lestner J, Credidio L, Dane A, Carr DF, Pirmohamed M, Salim R, Neely M.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02353-18. doi: 10.1128/AAC.02353-18. Print 2019 Apr.


Days Alive and Out of Hospital: Exploring a Patient-Centered, Pragmatic Outcome in a Clinical Trial of Patients With Acute Coronary Syndromes.

Fanaroff AC, Cyr D, Neely ML, Bakal J, White HD, Fox KAA, Armstrong PW, Lopes RD, Ohman EM, Roe MT.

Circ Cardiovasc Qual Outcomes. 2018 Dec;11(12):e004755. doi: 10.1161/CIRCOUTCOMES.118.004755.


Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction.

Todd JL, Neely ML, Finlen Copeland CA, Frankel CW, Reynolds JM, Palmer SM.

J Heart Lung Transplant. 2019 Feb;38(2):184-193. doi: 10.1016/j.healun.2018.10.006. Epub 2018 Oct 31.


Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.

Parikh KS, Fiuzat M, Davis G, Neely M, Blain-Nelson P, Whellan DJ, Abraham WT, Adams KF Jr, Felker GM, Liggett SB, O'Connor CM, Bristow MR.

Circ Genom Precis Med. 2018 Aug;11(8):e002210. doi: 10.1161/CIRCGEN.117.002210.


The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model.

Drusano GL, Neely MN, Yamada WM, Duncanson B, Brown D, Maynard M, Vicchiarelli M, Louie A.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01682-18. doi: 10.1128/AAC.01682-18. Print 2018 Dec.


Activity of Moxifloxacin against Mycobacterium tuberculosis in Acid Phase and Nonreplicative-Persister Phenotype Phase in a Hollow-Fiber Infection Model.

Louie A, Duncanson B, Myrick J, Maynard M, Nole J, Brown D, Schmidt S, Neely M, Scanga CA, Peloquin C, Drusano GL.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01470-18. doi: 10.1128/AAC.01470-18. Print 2018 Dec.


Pharmacometric Modeling and Simulation Is Essential to Pediatric Clinical Pharmacology.

Neely M, Bayard D, Desai A, Kovanda L, Edginton A.

J Clin Pharmacol. 2018 Oct;58 Suppl 10:S73-S85. doi: 10.1002/jcph.1316. Review.


Outcomes of Patients Receiving Downstream Revascularization After Initial Medical Management for Non-ST-Segment Elevation Acute Coronary Syndromes (From the TRILOGY ACS Trial).

Hinohara TT, Roe MT, White HD, Fox KAA, Bhatt DL, Hamm C, Gurbel PA, Aylward PE, Wiviott SD, Huber K, Neely ML, Ohman EM.

Am J Cardiol. 2018 Oct 15;122(8):1322-1329. doi: 10.1016/j.amjcard.2018.06.052. Epub 2018 Jul 19.


Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children.

Philippe M, Neely M, Rushing T, Bertrand Y, Bleyzac N, Goutelle S.

Bone Marrow Transplant. 2019 Mar;54(3):448-457. doi: 10.1038/s41409-018-0281-7. Epub 2018 Aug 14.


Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.

Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF.

Blood Cells Mol Dis. 2018 Sep;72:37-43. doi: 10.1016/j.bcmd.2018.07.004. Epub 2018 Jul 21.


Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model.

Drusano GL, Myrick J, Maynard M, Nole J, Duncanson B, Brown D, Schmidt S, Neely M, Scanga CA, Peloquin C, Louie A.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00221-18. doi: 10.1128/AAC.00221-18. Print 2018 Aug.


Author Correction: Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.

Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V.

Sci Rep. 2018 May 24;8(1):8266. doi: 10.1038/s41598-018-23083-1.


Clinic Satisfaction Tool Improves Communication and Provides Real-Time Feedback.

Zakare-Fagbamila RT, Howell E, Choi AY, Cheng TZ, Clement M, Neely M, Gottfried ON.

Neurosurgery. 2019 Apr 1;84(4):908-918. doi: 10.1093/neuros/nyy137.


Early discontinuation of prasugrel or clopidogrel in acute coronary syndromes: insights from the TRILOGY ACS trial.

Yan AT, Roe MT, Neely M, Cyr DD, White H, Fox KAA, Prabhakaran D, Armstrong PW, Ohman EM, Goodman SG.

Coron Artery Dis. 2018 Sep;29(6):469-476. doi: 10.1097/MCA.0000000000000623.


Length of Stay and Hospital Revisit After Bacterial Tracheostomy-Associated Respiratory Tract Infection Hospitalizations.

Russell CJ, Mamey MR, Koh JY, Schrager SM, Neely MN, Wu S.

Hosp Pediatr. 2018 Jan 16. pii: hpeds.2017-0106. doi: 10.1542/hpeds.2017-0106. [Epub ahead of print]


Interchangeability of Generic Drugs: A Nonparametric Pharmacokinetic Model of Gabapentin Generic Drugs.

Glerum PJ, Yu Y, Yamada WM, Neely MN, Maliepaard M, Burger DM, Neef C.

Clin Pharmacol Ther. 2018 Nov;104(5):966-973. doi: 10.1002/cpt.1023. Epub 2018 Feb 13.


Risk factors for hospitalizations due to bacterial respiratory tract infections after tracheotomy.

Russell CJ, Thurm C, Hall M, Simon TD, Neely MN, Berry JG.

Pediatr Pulmonol. 2018 Mar;53(3):349-357. doi: 10.1002/ppul.23938. Epub 2018 Jan 4.


Pharmacokinetic/Pharmacodynamic Determinants of Vancomycin Efficacy in Enterococcal Bacteremia.

Jumah MTB, Vasoo S, Menon SR, De PP, Neely M, Teng CB.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01602-17. doi: 10.1128/AAC.01602-17. Print 2018 Mar.


The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma.

Shafrin J, Sullivan J, Chou JW, Neely MN, Doan JF, Maclean JR.

Cancer Manag Res. 2017 Nov 29;9:731-739. doi: 10.2147/CMAR.S148199. eCollection 2017.


Prospective Trial on the Use of Trough Concentration versus Area under the Curve To Determine Therapeutic Vancomycin Dosing.

Neely MN, Kato L, Youn G, Kraler L, Bayard D, van Guilder M, Schumitzky A, Yamada W, Jones B, Minejima E.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02042-17. doi: 10.1128/AAC.02042-17. Print 2018 Feb.


Effect of malocclusion on adults seeking orthodontic treatment.

Neely ML, Miller R, Rich SE, Will LA, Wright WG, Jones JA.

Am J Orthod Dentofacial Orthop. 2017 Dec;152(6):778-787. doi: 10.1016/j.ajodo.2017.04.023.


Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin.

Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD.

Mol Cancer Res. 2017 Dec;15(12):1704-1713. doi: 10.1158/1541-7786.MCR-17-0338. Epub 2017 Nov 8.


Sofosbuvir (SOF) Suppresses Ledipasvir (LDV)-resistant Mutants during SOF/LDV Combination Therapy against Genotype 1b Hepatitis C Virus (HCV).

Brown AN, Liu L, Rodriquez JL, Zhao L, Schuster L, Li E, Wang GP, Neely MN, Yamada W, Drusano GL.

Sci Rep. 2017 Oct 31;7(1):14421. doi: 10.1038/s41598-017-15007-2.


From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons.

Neely MD, Davison CA, Aschner M, Bowman AB.

Toxicol Sci. 2017 Oct 1;159(2):366-379. doi: 10.1093/toxsci/kfx145.


Pharmacodynamics of teicoplanin against MRSA.

Ramos-Martín V, Johnson A, McEntee L, Farrington N, Padmore K, Cojutti P, Pea F, Neely MN, Hope WW.

J Antimicrob Chemother. 2017 Dec 1;72(12):3382-3389. doi: 10.1093/jac/dkx289.


Two questions about the analysis and interpretation of randomised trials.

Samsa G, Neely M.

Int J Hyperthermia. 2018 Dec;34(8):1396-1399. doi: 10.1080/02656736.2017.1385861. Epub 2017 Oct 19.


Skin Transcriptomes of common bottlenose dolphins (Tursiops truncatus) from the northern Gulf of Mexico and southeastern U.S. Atlantic coasts.

Neely MG, Morey JS, Anderson P, Balmer BC, Ylitalo GM, Zolman ES, Speakman TR, Sinclair C, Bachman MJ, Huncik K, Kucklick J, Rosel PE, Mullin KD, Rowles TK, Schwacke LH, Van Dolah FM.

Mar Genomics. 2018 Apr;38:45-58. doi: 10.1016/j.margen.2017.08.002. Epub 2017 Aug 24.


De novo transcriptome assembly and RNA-Seq expression analysis in blood from beluga whales of Bristol Bay, AK.

Morey JS, Burek Huntington KA, Campbell M, Clauss TM, Goertz CE, Hobbs RC, Lunardi D, Moors AJ, Neely MG, Schwacke LH, Van Dolah FM.

Mar Genomics. 2017 Oct;35:77-92. doi: 10.1016/j.margen.2017.08.001. Epub 2017 Aug 9.


Tools for the Individualized Therapy of Teicoplanin for Neonates and Children.

Ramos-Martín V, Neely MN, Padmore K, Peak M, Beresford MW, Turner MA, Paulus S, López-Herce J, Hope WW.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00707-17. doi: 10.1128/AAC.00707-17. Print 2017 Oct.


Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.

Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V.

Sci Rep. 2017 Jul 13;7(1):5280. doi: 10.1038/s41598-017-05709-y. Erratum in: Sci Rep. 2018 May 24;8(1):8266.


Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation.

Woillard JB, Mourad M, Neely M, Capron A, van Schaik RH, van Gelder T, Lloberas N, Hesselink DA, Marquet P, Haufroid V, Elens L.

Front Pharmacol. 2017 Jun 8;8:358. doi: 10.3389/fphar.2017.00358. eCollection 2017.


Quantifying Vibrio cholerae Enterotoxicity in a Zebrafish Infection Model.

Mitchell KC, Breen P, Britton S, Neely MN, Withey JH.

Appl Environ Microbiol. 2017 Aug 1;83(16). pii: e00783-17. doi: 10.1128/AEM.00783-17. Print 2017 Aug 15.


Platelet-related biomarkers and their response to inhibition with aspirin and p2y12-receptor antagonists in patients with acute coronary syndrome.

Lowenstern A, Storey RF, Neely M, Sun JL, Angiolillo DJ, Cannon CP, Himmelmann A, Huber K, James SK, Katus HA, Morais J, Siegbahn A, Steg PG, Wallentin L, Becker RC; PLATO Investigators.

J Thromb Thrombolysis. 2017 Aug;44(2):145-153. doi: 10.1007/s11239-017-1516-y.


Temporal Biomarker Profiling Reveals Longitudinal Changes in Risk of Death or Myocardial Infarction in Non-ST-Segment Elevation Acute Coronary Syndrome.

Chan MY, Neely ML, Roe MT, Goodman SG, Erlinge D, Cornel JH, Winters KJ, Jakubowski JA, Zhou C, Fox KAA, Armstrong PW, White HD, Prabhakaran D, Ohman EM, Huber K; TRILOGY ACS Investigators.

Clin Chem. 2017 Jul;63(7):1214-1226. doi: 10.1373/clinchem.2016.265272. Epub 2017 May 17.


Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response.

Kovanda LL, Kolamunnage-Dona R, Neely M, Maertens J, Lee M, Hope WW.

Clin Infect Dis. 2017 Jun 1;64(11):1557-1563. doi: 10.1093/cid/cix198. Erratum in: Clin Infect Dis. 2017 Oct 15;65(8):1431-1433.


Differential occurrence, profile, and impact of first recurrent cardiovascular events after an acute coronary syndrome.

Hess CN, Clare RM, Neely ML, Tricoci P, Mahaffey KW, James SK, Alexander JH, Held C, Lopes RD, Fox KAA, White HD, Wallentin L, Armstrong PW, Harrington RA, Ohman EM, Roe MT.

Am Heart J. 2017 May;187:194-203. doi: 10.1016/j.ahj.2017.01.016. Epub 2017 Feb 21.


Pseudomonas aeruginosa and post-tracheotomy bacterial respiratory tract infection readmissions.

Russell CJ, Simon TD, Mamey MR, Newth CJL, Neely MN.

Pediatr Pulmonol. 2017 Sep;52(9):1212-1218. doi: 10.1002/ppul.23716. Epub 2017 Apr 25.


Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome.

Wang A, Kwee LC, Grass E, Neely ML, Gregory SG, Fox KAA, Armstrong PW, White HD, Ohman EM, Roe MT, Shah SH, Chan MY.

Atherosclerosis. 2017 Jun;261:19-25. doi: 10.1016/j.atherosclerosis.2017.03.041. Epub 2017 Mar 30.


Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells.

Hollmann EK, Bailey AK, Potharazu AV, Neely MD, Bowman AB, Lippmann ES.

Fluids Barriers CNS. 2017 Apr 13;14(1):9. doi: 10.1186/s12987-017-0059-0.

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