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Items: 1 to 50 of 54

1.

Peripheral straightjacket (α2δ Ca2+ channel subunit) expression is required for neuropathic sensitization in Drosophila.

Khuong TM, Hamoudi Z, Manion J, Loo L, Muralidharan A, Neely GG.

Philos Trans R Soc Lond B Biol Sci. 2019 Nov 11;374(1785):20190287. doi: 10.1098/rstb.2019.0287. Epub 2019 Sep 23.

PMID:
31544607
2.

Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila.

Khuong TM, Wang QP, Manion J, Oyston LJ, Lau MT, Towler H, Lin YQ, Neely GG.

Sci Adv. 2019 Jul 10;5(7):eaaw4099. doi: 10.1126/sciadv.aaw4099. eCollection 2019 Jul.

3.

Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan.

Oyston LJ, Lin YQ, Khuong TM, Wang QP, Lau MT, Clark T, Neely GG.

Cell Stress. 2018 Aug 17;2(9):225-232. doi: 10.15698/cst2018.09.152.

4.

A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway.

Khoury S, Piltonen MH, Ton AT, Cole T, Samoshkin A, Smith SB, Belfer I, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, Neely GG, Serohijos AWR, Diatchenko L.

Ann Neurol. 2019 Aug;86(2):168-180. doi: 10.1002/ana.25521. Epub 2019 Jun 8.

PMID:
31177555
5.

Tubulin Polymerization Promoting Protein, Ringmaker, and MAP1B Homolog Futsch Coordinate Microtubule Organization and Synaptic Growth.

Shi Q, Lin YQ, Saliba A, Xie J, Neely GG, Banerjee S.

Front Cell Neurosci. 2019 May 15;13:192. doi: 10.3389/fncel.2019.00192. eCollection 2019.

6.

High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster.

May CE, Vaziri A, Lin YQ, Grushko O, Khabiri M, Wang QP, Holme KJ, Pletcher SD, Freddolino PL, Neely GG, Dus M.

Cell Rep. 2019 May 7;27(6):1675-1685.e7. doi: 10.1016/j.celrep.2019.04.027.

7.

Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote.

Lau MT, Manion J, Littleboy JB, Oyston L, Khuong TM, Wang QP, Nguyen DT, Hesselson D, Seymour JE, Neely GG.

Nat Commun. 2019 Apr 30;10(1):1655. doi: 10.1038/s41467-019-09681-1.

8.

Dissecting Motor Neuron Disease With Drosophila melanogaster.

Walters R, Manion J, Neely GG.

Front Neurosci. 2019 Apr 12;13:331. doi: 10.3389/fnins.2019.00331. eCollection 2019. Review.

9.

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism.

Valsesia A, Wang QP, Gheldof N, Carayol J, Ruffieux H, Clark T, Shenton V, Oyston LJ, Lefebvre G, Metairon S, Chabert C, Walter O, Mironova P, Lau P, Descombes P, Viguerie N, Langin D, Harper ME, Astrup A, Saris WH, Dent R, Neely GG, Hager J.

Nat Commun. 2019 Feb 1;10(1):540. doi: 10.1038/s41467-019-08492-8.

10.

RagC phosphorylation autoregulates mTOR complex 1.

Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE.

EMBO J. 2019 Feb 1;38(3). pii: e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14.

PMID:
30552228
11.

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.

Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca JE, Golenkina S, Cuiping X, Gruber S, Angjeli B, Kanitz EE, Cronin SJF, Neely GG, Wernitznig A, Humbert PO, Simpson KJ, Mitsiades CS, Richardson HE, Penninger JM.

PLoS Genet. 2018 Oct 16;14(10):e1007688. doi: 10.1371/journal.pgen.1007688. eCollection 2018 Oct.

12.

Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice.

Wang QP, Browman D, Herzog H, Neely GG.

PLoS One. 2018 Jul 5;13(7):e0199080. doi: 10.1371/journal.pone.0199080. eCollection 2018.

13.

Author Correction: A strategy for effective latent HIV reactivation using subtherapeutic drug doses.

Cotterell J, Neely GG.

Sci Rep. 2018 Mar 6;8(1):4258. doi: 10.1038/s41598-018-21977-8.

14.

A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia.

Hamoudi Z, Khuong TM, Cole T, Neely GG.

Version 2. F1000Res. 2018 Jan 23 [revised 2018 Jan 1];7:99. doi: 10.12688/f1000research.13581.2. eCollection 2018.

15.

The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ.

Cell Rep. 2017 Dec 26;21(13):3794-3806. doi: 10.1016/j.celrep.2017.12.005.

16.

A simple high throughput assay to evaluate water consumption in the fruit fly.

Lau MT, Lin YQ, Kisling S, Cotterell J, Wilson YA, Wang QP, Khuong TM, Bakhshi N, Cole TA, Oyston LJ, Cole AR, Neely GG.

Sci Rep. 2017 Dec 1;7(1):16786. doi: 10.1038/s41598-017-16849-6.

17.

A strategy for effective latent HIV reactivation using subtherapeutic drug doses.

Cotterell J, Neely GG.

Sci Rep. 2017 Nov 30;7(1):16644. doi: 10.1038/s41598-017-00097-9. Erratum in: Sci Rep. 2018 Mar 6;8(1):4258.

18.

Corrigendum to "Insulin controls food intake and energy balance via NPY neurons" [Mol Metabol 6 (2017) 574-584].

Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Bruning JC, Cooney G, Neely GG, Herzog H.

Mol Metab. 2017 Nov;6(11):1562. doi: 10.1016/j.molmet.2017.06.017. Epub 2017 Jul 8. No abstract available.

19.

Epiregulin and EGFR interactions are involved in pain processing.

Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, Sotocinal SG, Austin JS, Meloto CB, Gitt JH, Gkogkas C, Sonenberg N, Greenspan JD, Fillingim RB, Ohrbach R, Slade GD, Knott C, Dubner R, Nackley AG, Ribeiro-da-Silva A, Neely GG, Maixner W, Zaykin DV, Mogil JS, Diatchenko L.

J Clin Invest. 2017 Sep 1;127(9):3353-3366. doi: 10.1172/JCI87406. Epub 2017 Aug 7.

20.

Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake.

Wang QP, Simpson SJ, Herzog H, Neely GG.

Cell Metab. 2017 Aug 1;26(2):279-280. doi: 10.1016/j.cmet.2017.07.002.

21.

Gut Microbiota Modifies Olfactory-Guided Microbial Preferences and Foraging Decisions in Drosophila.

Wong AC, Wang QP, Morimoto J, Senior AM, Lihoreau M, Neely GG, Simpson SJ, Ponton F.

Curr Biol. 2017 Aug 7;27(15):2397-2404.e4. doi: 10.1016/j.cub.2017.07.022. Epub 2017 Jul 27.

22.

Neuroanatomy of pain-deficiency and cross-modal activation in calcium channel subunit (CACN) α2δ3 knockout mice.

Landmann J, Richter F, Oros-Peusquens AM, Shah NJ, Classen J, Neely GG, Richter A, Penninger JM, Bechmann I.

Brain Struct Funct. 2018 Jan;223(1):111-130. doi: 10.1007/s00429-017-1473-4. Epub 2017 Jul 21.

PMID:
28733833
23.

Insulin controls food intake and energy balance via NPY neurons.

Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Brüning JC, Cooney G, Neely GG, Herzog H.

Mol Metab. 2017 Apr 12;6(6):574-584. doi: 10.1016/j.molmet.2017.03.013. eCollection 2017 Jun. Erratum in: Mol Metab. 2017 Nov;6(11):1562. Neely, Greg [corrected to Neely, Greg G].

24.

Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.

Wang QP, Lin YQ, Zhang L, Wilson YA, Oyston LJ, Cotterell J, Qi Y, Khuong TM, Bakhshi N, Planchenault Y, Browman DT, Lau MT, Cole TA, Wong AC, Simpson SJ, Cole AR, Penninger JM, Herzog H, Neely GG.

Cell Metab. 2016 Jul 12;24(1):75-90. doi: 10.1016/j.cmet.2016.06.010.

25.

The transcriptional landscape of age in human peripheral blood.

Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD.

Nat Commun. 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570.

26.

Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila.

Slocumb ME, Regalado JM, Yoshizawa M, Neely GG, Masek P, Gibbs AG, Keene AC.

PLoS One. 2015 Jul 6;10(7):e0131275. doi: 10.1371/journal.pone.0131275. eCollection 2015.

27.

The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.

Nagy V, Cole T, Van Campenhout C, Khoung TM, Leung C, Vermeiren S, Novatchkova M, Wenzel D, Cikes D, Polyansky AA, Kozieradzki I, Meixner A, Bellefroid EJ, Neely GG, Penninger JM.

Cell Cycle. 2015;14(12):1799-808. doi: 10.1080/15384101.2015.1036209. Erratum in: Cell Cycle. 2015;14(19):3203.

28.

Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse.

Halstead JM, Lin YQ, Durraine L, Hamilton RS, Ball G, Neely GG, Bellen HJ, Davis I.

Biol Open. 2014 Aug 29;3(9):839-49. doi: 10.1242/bio.20149027.

29.

PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes.

Robinson JW, Leshchyns'ka I, Farghaian H, Hughes WE, Sytnyk V, Neely GG, Cole AR.

Biochem J. 2014 Nov 15;464(1):145-56. doi: 10.1042/BJ20140497.

PMID:
25083612
30.

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.

Moustaqim-Barrette A, Lin YQ, Pradhan S, Neely GG, Bellen HJ, Tsuda H.

Hum Mol Genet. 2014 Apr 15;23(8):1975-89. doi: 10.1093/hmg/ddt594. Epub 2013 Nov 23.

31.

Fruit flies as a powerful model to drive or validate pain genomics efforts.

Leung C, Wilson Y, Khuong TM, Neely GG.

Pharmacogenomics. 2013 Nov;14(15):1879-87. doi: 10.2217/pgs.13.196. Review.

PMID:
24236487
32.

Conserved systems and functional genomic assessment of nociception.

Khuong TM, Neely GG.

FEBS J. 2013 Nov;280(21):5298-306. doi: 10.1111/febs.12464. Epub 2013 Aug 27. Review.

33.

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.

Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM.

PLoS Genet. 2012;8(12):e1003071. doi: 10.1371/journal.pgen.1003071. Epub 2012 Dec 6.

34.

Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells.

Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng WL, Li T, David G, Duraine L, Lin YQ, Neely GG, Yamamoto S, Bellen HJ.

PLoS Biol. 2012;10(12):e1001438. doi: 10.1371/journal.pbio.1001438. Epub 2012 Dec 4.

35.

Drosophila as a tool for studying the conserved genetics of pain.

Milinkeviciute G, Gentile C, Neely GG.

Clin Genet. 2012 Oct;82(4):359-66. doi: 10.1111/j.1399-0004.2012.01941.x. Epub 2012 Aug 22. Review.

PMID:
22880632
36.

TrpA1 regulates thermal nociception in Drosophila.

Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM.

PLoS One. 2011;6(8):e24343. doi: 10.1371/journal.pone.0024343. Epub 2011 Aug 31.

37.

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.

Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM.

Nat Genet. 2011 Mar;43(3):212-9. doi: 10.1038/ng.767. Epub 2011 Feb 13.

PMID:
21317887
38.

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.

Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM.

Cell. 2010 Nov 12;143(4):628-38. doi: 10.1016/j.cell.2010.09.047.

39.

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.

Cell. 2010 Apr 2;141(1):142-53. doi: 10.1016/j.cell.2010.02.023.

40.

PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.

Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B.

PLoS One. 2010 Feb 22;5(2):e9350. doi: 10.1371/journal.pone.0009350.

41.

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.

Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, Neely GG, Dietzl G, Manoukian A, Funovics M, Prager G, Wagner O, Ferrandon D, Aberger F, Hui CC, Esterbauer H, Penninger JM.

Cell. 2010 Jan 8;140(1):148-60. doi: 10.1016/j.cell.2009.12.027.

42.

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection.

Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, Simoes Rde M, Gruber S, Puc U, Ebersberger I, Zoranovic T, Neely GG, von Haeseler A, Ferrandon D, Penninger JM.

Science. 2009 Jul 17;325(5938):340-3. doi: 10.1126/science.1173164. Epub 2009 Jun 11.

43.

Microbial products activate monocytic cells through detergent-resistant membrane microdomains.

Epelman S, Berenger B, Stack D, Neely GG, Ma LL, Mody CH.

Am J Respir Cell Mol Biol. 2008 Dec;39(6):657-65. doi: 10.1165/rcmb.2007-0390OC. Epub 2008 Jun 6.

PMID:
18539953
44.

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.

Cell. 2008 Apr 18;133(2):235-49. doi: 10.1016/j.cell.2008.02.043.

45.

The molecular archaeology of a mitochondrial death effector: AIF in Drosophila.

Joza N, Galindo K, Pospisilik JA, Benit P, Rangachari M, Kanitz EE, Nakashima Y, Neely GG, Rustin P, Abrams JM, Kroemer G, Penninger JM.

Cell Death Differ. 2008 Jun;15(6):1009-18. doi: 10.1038/cdd.2008.24. Epub 2008 Feb 29.

46.

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.

Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Markovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM.

Circ Res. 2007 Aug 17;101(4):e32-42. Epub 2007 Aug 2. Erratum in: Circ Res. 2008 Feb 1;102(2):e36. Makovic, Mato [corrected to Markovic, Mato].

PMID:
17673668
47.

NK cells use perforin rather than granulysin for anticryptococcal activity.

Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH.

J Immunol. 2004 Sep 1;173(5):3357-65.

48.

Different domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRs.

Epelman S, Stack D, Bell C, Wong E, Neely GG, Krutzik S, Miyake K, Kubes P, Zbytnuik LD, Ma LL, Xie X, Woods DE, Mody CH.

J Immunol. 2004 Aug 1;173(3):2031-40.

49.

Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling.

Neely GG, Epelman S, Ma LL, Colarusso P, Howlett CJ, Amankwah EK, McIntyre AC, Robbins SM, Mody CH.

J Immunol. 2004 Apr 1;172(7):4225-34.

50.

CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15.

Ma LL, Spurrell JC, Wang JF, Neely GG, Epelman S, Krensky AM, Mody CH.

J Immunol. 2002 Nov 15;169(10):5787-95.

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