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Items: 11

1.

The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3.

Joyce MG, Ekanem IS, Roitel O, Dunford AJ, Neeli R, Girvan HM, Baker GJ, Curtis RA, Munro AW, Leys D.

FEBS J. 2012 May;279(9):1694-706. doi: 10.1111/j.1742-4658.2012.08544.x. Epub 2012 Mar 16.

2.

Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer.

Girvan HM, Dunford AJ, Neeli R, Ekanem IS, Waltham TN, Joyce MG, Leys D, Curtis RA, Williams P, Fisher K, Voice MW, Munro AW.

Arch Biochem Biophys. 2011 Mar 1;507(1):75-85. doi: 10.1016/j.abb.2010.09.014. Epub 2010 Sep 22.

PMID:
20868649
3.

Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

McLean KJ, Carroll P, Lewis DG, Dunford AJ, Seward HE, Neeli R, Cheesman MR, Marsollier L, Douglas P, Smith WE, Rosenkrands I, Cole ST, Leys D, Parish T, Munro AW.

J Biol Chem. 2008 Nov 28;283(48):33406-16. doi: 10.1074/jbc.M802115200. Epub 2008 Sep 24.

4.

Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg(199) and Arg(200) mutants at the NADP(H) 2'-phosphate binding site.

Sabri M, Dunford AJ, McLean KJ, Neeli R, Scrutton NS, Leys D, Munro AW.

Biochem J. 2009 Jan 1;417(1):103-12. doi: 10.1042/BJ20080466.

PMID:
18767989
5.

Trp(359) regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA.

Neeli R, Sabri M, McLean KJ, Dunford AJ, Scrutton NS, Leys D, Munro AW.

Biochem J. 2008 May 1;411(3):563-70. doi: 10.1042/bj20071298.

PMID:
18237273
6.

Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.

McLean KJ, Dunford AJ, Neeli R, Driscoll MD, Munro AW.

Arch Biochem Biophys. 2007 Aug 15;464(2):228-40. Epub 2007 Apr 10. Review.

PMID:
17482138
7.

CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.

McLean KJ, Dunford AJ, Sabri M, Neeli R, Girvan HM, Balding PR, Leys D, Seward HE, Marshall KR, Munro AW.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1178-82. Review.

PMID:
17073780
8.

Flavocytochrome P450 BM3 and the origin of CYP102 fusion species.

Girvan HM, Waltham TN, Neeli R, Collins HF, McLean KJ, Scrutton NS, Leys D, Munro AW.

Biochem Soc Trans. 2006 Dec;34(Pt 6):1173-7. Review.

PMID:
17073779
9.

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

Neeli R, Girvan HM, Lawrence A, Warren MJ, Leys D, Scrutton NS, Munro AW.

FEBS Lett. 2005 Oct 24;579(25):5582-8. Epub 2005 Sep 28.

10.

Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme.

Warman AJ, Roitel O, Neeli R, Girvan HM, Seward HE, Murray SA, McLean KJ, Joyce MG, Toogood H, Holt RA, Leys D, Scrutton NS, Munro AW.

Biochem Soc Trans. 2005 Aug;33(Pt 4):747-53. Review.

PMID:
16042591
11.

Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes.

Neeli R, Roitel O, Scrutton NS, Munro AW.

J Biol Chem. 2005 May 6;280(18):17634-44. Epub 2005 Feb 14.

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