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Items: 1 to 50 of 285

1.

Production and Thermal Exchange of Conditional Peptide-MHC I Multimers.

Luimstra JJ, Franken KLMC, Garstka MA, Drijfhout JW, Neefjes J, Ovaa H.

Curr Protoc Immunol. 2019 Sep;126(1):e85. doi: 10.1002/cpim.85.

2.

Occupational risk of salmonellosis and campylobacteriosis: a nationwide population-based registry study.

Duijster JW, Franz E, Neefjes JJC, Mughini-Gras L.

Occup Environ Med. 2019 Sep;76(9):617-624. doi: 10.1136/oemed-2019-105868.

PMID:
31413185
3.

Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer.

Berner F, Bomze D, Diem S, Ali OH, Fässler M, Ring S, Niederer R, Ackermann CJ, Baumgaertner P, Pikor N, Cruz CG, van de Veen W, Akdis M, Nikolaev S, Läubli H, Zippelius A, Hartmann F, Cheng HW, Hönger G, Recher M, Goldman J, Cozzio A, Früh M, Neefjes J, Driessen C, Ludewig B, Hegazy AN, Jochum W, Speiser DE, Flatz L.

JAMA Oncol. 2019 Jul 1;5(7):1043-1047. doi: 10.1001/jamaoncol.2019.0402. Erratum in: JAMA Oncol. 2019 Jul 1;5(7):1070.

4.

Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis.

Spits M, Janssen LJ, Voortman LM, Kooij R, Neefjes ACM, Ovaa H, Neefjes J.

J Cell Sci. 2019 May 15;132(10). pii: jcs225524. doi: 10.1242/jcs.225524.

5.

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.

Sapmaz A, Berlin I, Bos E, Wijdeven RH, Janssen H, Konietzny R, Akkermans JJ, Erson-Bensan AE, Koning RI, Kessler BM, Neefjes J, Ovaa H.

Nat Commun. 2019 Mar 29;10(1):1454. doi: 10.1038/s41467-019-09437-x.

6.

Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.

Döring M, Blees H, Koller N, Tischer-Zimmermann S, Müsken M, Henrich F, Becker J, Grabski E, Wang J, Janssen H, Zuschratter W, Neefjes J, Klawonn F, Eiz-Vesper B, Tampé R, Kalinke U.

Blood Adv. 2019 Mar 26;3(6):839-850. doi: 10.1182/bloodadvances.2018027268.

7.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR, Leusen JHW, Scheeren FA, Schumacher TN.

Nat Med. 2019 Apr;25(4):612-619. doi: 10.1038/s41591-019-0356-z. Epub 2019 Mar 4.

PMID:
30833751
8.

The labyrinth unfolds: architectural rearrangements of the endolysosomal system in antigen-presenting cells.

Perrin P, Jongsma ML, Neefjes J, Berlin I.

Curr Opin Immunol. 2019 Jun;58:1-8. doi: 10.1016/j.coi.2018.12.004. Epub 2019 Feb 7. Review.

9.

Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors.

Grimm SH, Gagestein B, Keijzer JF, Liu N, Wijdeven RH, Lenselink EB, Tuin AW, van den Nieuwendijk AMCH, van Westen GJP, van Boeckel CAA, Overkleeft HS, Neefjes J, van der Stelt M.

Bioorg Med Chem. 2019 Mar 1;27(5):692-699. doi: 10.1016/j.bmc.2019.01.006. Epub 2019 Jan 14.

10.

Towards an understanding of C9orf82 protein/CAAP1 function.

Aslam MA, Alemdehy MF, Pritchard CEJ, Song JY, Muhaimin FI, Wijdeven RH, Huijbers IJ, Neefjes J, Jacobs H.

PLoS One. 2019 Jan 10;14(1):e0210526. doi: 10.1371/journal.pone.0210526. eCollection 2019.

11.

Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome-Inhibitor Interaction Landscapes.

Janssen APA, Grimm SH, Wijdeven RHM, Lenselink EB, Neefjes J, van Boeckel CAA, van Westen GJP, van der Stelt M.

J Chem Inf Model. 2019 Mar 25;59(3):1221-1229. doi: 10.1021/acs.jcim.8b00640. Epub 2018 Nov 8.

12.

Loss of the GPI-anchor in B-lymphoblastic leukemia by epigenetic downregulation of PIGH expression.

Loeff FC, Rijs K, van Egmond EHM, Zoutman WH, Qiao X, Kroes WGM, Veld SAJ, Griffioen M, Vermeer MH, Neefjes J, Frederik Falkenburg JH, Halkes CJM, Jedema I.

Am J Hematol. 2019 Jan;94(1):93-102. doi: 10.1002/ajh.25337. Epub 2018 Nov 25.

13.

Bacterial infections and cancer.

van Elsland D, Neefjes J.

EMBO Rep. 2018 Nov;19(11). pii: e46632. doi: 10.15252/embr.201846632. Epub 2018 Oct 22. Review.

14.

TBC1D5 controls the GTPase cycle of Rab7b.

Borg Distefano M, Hofstad Haugen L, Wang Y, Perdreau-Dahl H, Kjos I, Jia D, Morth JP, Neefjes J, Bakke O, Progida C.

J Cell Sci. 2018 Sep 3;131(17). pii: jcs216630. doi: 10.1242/jcs.216630.

15.

Chemical and genetic control of IFNγ-induced MHCII expression.

Wijdeven RH, van Luijn MM, Wierenga-Wolf AF, Akkermans JJ, van den Elsen PJ, Hintzen RQ, Neefjes J.

EMBO Rep. 2018 Sep;19(9). pii: e45553. doi: 10.15252/embr.201745553. Epub 2018 Jul 18.

16.

Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates.

Schunselaar LM, Monkhorst K, van der Noort V, Wijdeven R, Peters D, Zwart W, Neefjes J, Baas P.

J Thorac Oncol. 2018 Oct;13(10):1577-1587. doi: 10.1016/j.jtho.2018.06.008. Epub 2018 Jun 27.

17.

Mechanisms of lysosomal positioning and movement.

Cabukusta B, Neefjes J.

Traffic. 2018 Oct;19(10):761-769. doi: 10.1111/tra.12587. Epub 2018 Jul 17. Review.

18.

Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens.

van Elsland DM, Pujals S, Bakkum T, Bos E, Oikonomeas-Koppasis N, Berlin I, Neefjes J, Meijer AH, Koster AJ, Albertazzi L, van Kasteren SI.

Chembiochem. 2018 Jun 5. doi: 10.1002/cbic.201800230. [Epub ahead of print]

19.

Sponge-supported cultures of primary head and neck tumors for an optimized preclinical model.

Dohmen AJC, Sanders J, Canisius S, Jordanova ES, Aalbersberg EA, van den Brekel MWM, Neefjes J, Zuur CL.

Oncotarget. 2018 May 18;9(38):25034-25047. doi: 10.18632/oncotarget.25244. eCollection 2018 May 18.

20.

Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases.

Mulder MPC, Merkx R, Witting KF, Hameed DS, El Atmioui D, Lelieveld L, Liebelt F, Neefjes J, Berlin I, Vertegaal ACO, Ovaa H.

Angew Chem Int Ed Engl. 2018 Jul 16;57(29):8958-8962. doi: 10.1002/anie.201803483. Epub 2018 Jun 14.

21.

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells.

Luimstra JJ, Garstka MA, Roex MCJ, Redeker A, Janssen GMC, van Veelen PA, Arens R, Falkenburg JHF, Neefjes J, Ovaa H.

J Exp Med. 2018 May 7;215(5):1493-1504. doi: 10.1084/jem.20180156. Epub 2018 Apr 17.

22.

Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck.

Lamers M, Berlin I, Neefjes J.

Curr Biol. 2018 Jan 22;28(2):R83-R86. doi: 10.1016/j.cub.2017.11.059.

23.

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1157. doi: 10.1083/JCB.20170320601192018c. Epub 2018 Jan 23. No abstract available.

24.

Increased colon cancer risk after severe Salmonella infection.

Mughini-Gras L, Schaapveld M, Kramers J, Mooij S, Neefjes-Borst EA, Pelt WV, Neefjes J.

PLoS One. 2018 Jan 17;13(1):e0189721. doi: 10.1371/journal.pone.0189721. eCollection 2018.

25.

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1129-1142. doi: 10.1083/jcb.201703206. Epub 2018 Jan 16. Erratum in: J Cell Biol. 2018 Jan 23;:.

26.

The EGFR odyssey - from activation to destruction in space and time.

Bakker J, Spits M, Neefjes J, Berlin I.

J Cell Sci. 2017 Dec 15;130(24):4087-4096. doi: 10.1242/jcs.209197. Epub 2017 Nov 27. Review.

27.

Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity.

Dohmen AJC, Qiao X, Duursma A, Wijdeven RH, Lieftink C, Hageman F, Morris B, Halonen P, Vens C, van den Brekel MWM, Ovaa H, Neefjes J, Zuur CL.

Oncotarget. 2017 May 19;8(43):73925-73937. doi: 10.18632/oncotarget.18034. eCollection 2017 Sep 26.

28.

Chemical Profiling of Primary Mesothelioma Cultures Defines Subtypes with Different Expression Profiles and Clinical Responses.

Schunselaar LM, Quispel-Janssen JMMF, Kim Y, Alifrangis C, Zwart W, Baas P, Neefjes J.

Clin Cancer Res. 2018 Apr 1;24(7):1761-1770. doi: 10.1158/1078-0432.CCR-17-1345. Epub 2017 Oct 24.

29.

Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition.

Quispel-Janssen JM, Badhai J, Schunselaar L, Price S, Brammeld J, Iorio F, Kolluri K, Garnett M, Berns A, Baas P, McDermott U, Neefjes J, Alifrangis C.

Clin Cancer Res. 2018 Jan 1;24(1):84-94. doi: 10.1158/1078-0432.CCR-17-1172. Epub 2017 Oct 23.

30.

Stop or Go? Endosome Positioning in the Establishment of Compartment Architecture, Dynamics, and Function.

Neefjes J, Jongsma MML, Berlin I.

Trends Cell Biol. 2017 Aug;27(8):580-594. doi: 10.1016/j.tcb.2017.03.002. Epub 2017 Mar 28. Review.

PMID:
28363667
31.

Moving and positioning the endolysosomal system.

Bonifacino JS, Neefjes J.

Curr Opin Cell Biol. 2017 Aug;47:1-8. doi: 10.1016/j.ceb.2017.01.008. Epub 2017 Feb 21. Review.

32.

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer.

Gagnaire A, Nadel B, Raoult D, Neefjes J, Gorvel JP.

Nat Rev Microbiol. 2017 Feb;15(2):109-128. doi: 10.1038/nrmicro.2016.171. Epub 2017 Jan 3. Review.

PMID:
28045107
33.

Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics.

Wijdeven RH, Pang B, Assaraf YG, Neefjes J.

Drug Resist Updat. 2016 Sep;28:65-81. doi: 10.1016/j.drup.2016.07.001. Epub 2016 Jul 16. Review.

PMID:
27620955
34.

Present Yourself! By MHC Class I and MHC Class II Molecules.

Rock KL, Reits E, Neefjes J.

Trends Immunol. 2016 Nov;37(11):724-737. doi: 10.1016/j.it.2016.08.010. Epub 2016 Sep 7. Review.

35.

Immunoproteasomes and immunotherapy-a smoking gun for lung cancer?

Spits M, Neefjes J.

J Thorac Dis. 2016 Jul;8(7):E558-63. doi: 10.21037/jtd.2016.05.21.

36.

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport.

Jongsma ML, Berlin I, Wijdeven RH, Janssen L, Janssen GM, Garstka MA, Janssen H, Mensink M, van Veelen PA, Spaapen RM, Neefjes J.

Cell. 2016 Jun 30;166(1):152-66. doi: 10.1016/j.cell.2016.05.078.

37.

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.

Wijdeven RH, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, Neefjes J.

Nat Commun. 2016 Jun 10;7:11808. doi: 10.1038/ncomms11808.

38.

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H.

Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16.

39.

Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes.

Stolze SC, Liu N, Wijdeven RH, Tuin AW, van den Nieuwendijk AM, Florea BI, van der Stelt M, van der Marel GA, Neefjes JJ, Overkleeft HS.

Mol Biosyst. 2016 May 24;12(6):1809-17. doi: 10.1039/c6mb00257a.

PMID:
27138522
40.

A catalogue of treatment and technologies for malignant pleural mesothelioma.

Schunselaar LM, Quispel-Janssen JM, Neefjes JJ, Baas P.

Expert Rev Anticancer Ther. 2016;16(4):455-63. doi: 10.1586/14737140.2016.1162100. Review.

PMID:
26943000
41.

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.

Unanue ER, Turk V, Neefjes J.

Annu Rev Immunol. 2016 May 20;34:265-97. doi: 10.1146/annurev-immunol-041015-055420. Epub 2016 Feb 22. Review.

PMID:
26907214
42.

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.

van der Kant R, Jonker CT, Wijdeven RH, Bakker J, Janssen L, Klumperman J, Neefjes J.

J Biol Chem. 2015 Dec 18;290(51):30280-90. doi: 10.1074/jbc.M115.688440. Epub 2015 Oct 13.

43.

ER contact sites direct late endosome transport.

Wijdeven RH, Jongsma ML, Neefjes J, Berlin I.

Bioessays. 2015 Dec;37(12):1298-302. doi: 10.1002/bies.201500095. Epub 2015 Oct 6. Review.

PMID:
26440125
44.

Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules.

Berkers CR, de Jong A, Schuurman KG, Linnemann C, Meiring HD, Janssen L, Neefjes JJ, Schumacher TN, Rodenko B, Ovaa H.

J Immunol. 2015 Nov 1;195(9):4085-95. doi: 10.4049/jimmunol.1402455. Epub 2015 Sep 23.

45.

Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review.

Dohmen AJ, Swartz JE, Van Den Brekel MW, Willems SM, Spijker R, Neefjes J, Zuur CL.

Cancers (Basel). 2015 Aug 28;7(3):1716-42. doi: 10.3390/cancers7030858. Review.

46.

Expanding the peptidome for immunotherapy.

Neefjes J.

Blood. 2015 Sep 3;126(10):1154-6. doi: 10.1182/blood-2015-07-657130. No abstract available.

PMID:
26337350
47.

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13.

Bentin Toaldo C, Alexi X, Beelen K, Kok M, Hauptmann M, Jansen M, Berns E, Neefjes J, Linn S, Michalides R, Zwart W.

BMC Cancer. 2015 Aug 14;15:588. doi: 10.1186/s12885-015-1591-4.

48.

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.

Wijdeven RH, Pang B, van der Zanden SY, Qiao X, Blomen V, Hoogstraat M, Lips EH, Janssen L, Wessels L, Brummelkamp TR, Neefjes J.

Cancer Res. 2015 Oct 1;75(19):4176-87. doi: 10.1158/0008-5472.CAN-15-0380. Epub 2015 Aug 10.

49.

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.

Scanu T, Spaapen RM, Bakker JM, Pratap CB, Wu LE, Hofland I, Broeks A, Shukla VK, Kumar M, Janssen H, Song JY, Neefjes-Borst EA, te Riele H, Holden DW, Nath G, Neefjes J.

Cell Host Microbe. 2015 Jun 10;17(6):763-74. doi: 10.1016/j.chom.2015.05.002. Epub 2015 May 28.

50.

Chemical profiling of the genome with anti-cancer drugs defines target specificities.

Pang B, de Jong J, Qiao X, Wessels LF, Neefjes J.

Nat Chem Biol. 2015 Jul;11(7):472-80. doi: 10.1038/nchembio.1811. Epub 2015 May 11.

PMID:
25961671

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