Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 33

1.

Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaan0724. doi: 10.1126/scitranslmed.aan0724.

PMID:
30209242
2.

SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure.

Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S.

J Mol Cell Cardiol. 2018 Mar;116:81-90. doi: 10.1016/j.yjmcc.2018.02.002. Epub 2018 Feb 3.

3.

Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor.

Neef S, Steffens A, Pellicena P, Mustroph J, Lebek S, Ort KR, Schulman H, Maier LS.

J Mol Cell Cardiol. 2018 Feb;115:73-81. doi: 10.1016/j.yjmcc.2017.12.015. Epub 2017 Dec 30.

4.
5.

Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A.

Basic Res Cardiol. 2017 Sep;112(5):51. doi: 10.1007/s00395-017-0638-x. No abstract available.

PMID:
28688054
6.

Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.

Neef S, Mann C, Zwenger A, Dybkova N, Maier LS.

Basic Res Cardiol. 2017 Jul;112(4):45. doi: 10.1007/s00395-017-0637-y. Epub 2017 Jun 13.

PMID:
28612156
7.

Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A.

Basic Res Cardiol. 2017 Jul;112(4):43. doi: 10.1007/s00395-017-0635-0. Epub 2017 Jun 9. Erratum in: Basic Res Cardiol. 2017 Sep;112(5):51.

PMID:
28597249
8.

Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A.

Circ Heart Fail. 2017 May;10(5):e003840. doi: 10.1161/CIRCHEARTFAILURE.117.003840.

9.

Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.

Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):857-862. doi: 10.1007/s00210-017-1376-1. Epub 2017 Apr 27.

PMID:
28451724
10.

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T.

Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7.

PMID:
27927712
11.

CaMKII as a target for arrhythmia suppression.

Mustroph J, Neef S, Maier LS.

Pharmacol Ther. 2017 Aug;176:22-31. doi: 10.1016/j.pharmthera.2016.10.006. Epub 2016 Oct 11. Review.

PMID:
27742568
12.

Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.

Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K.

Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217c. No abstract available.

PMID:
26845407
13.

Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.

Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K.

Nat Med. 2015 Nov;21(11):1298-306. doi: 10.1038/nm.3972. Epub 2015 Oct 19. Erratum in: Nat Med. 2016 Feb;22(2):217.

PMID:
26479924
14.

Hepatic metabolism of carcinogenic β-asarone.

Cartus AT, Stegmüller S, Simson N, Wahl A, Neef S, Kelm H, Schrenk D.

Chem Res Toxicol. 2015 Sep 21;28(9):1760-73. doi: 10.1021/acs.chemrestox.5b00223. Epub 2015 Aug 26.

PMID:
26273788
15.

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction.

Unsöld B, Kaul A, Sbroggiò M, Schubert C, Regitz-Zagrosek V, Brancaccio M, Damilano F, Hirsch E, Van Bilsen M, Munts C, Sipido K, Bito V, Detre E, Wagner NM, Schäfer K, Seidler T, Vogt J, Neef S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura-Clapier R, Garnier A, Eschenhagen T, El-Armouche A, Knöll R, Tarone G, Hasenfuß G.

Cardiovasc Res. 2014 Jan 1;101(1):97-107. doi: 10.1093/cvr/cvt235. Epub 2013 Oct 15.

16.

Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.

Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME.

Circulation. 2013 Oct 15;128(16):1748-57. doi: 10.1161/CIRCULATIONAHA.113.003313. Epub 2013 Sep 12.

17.

Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.

Fischer TH, Herting J, Tirilomis T, Renner A, Neef S, Toischer K, Ellenberger D, Förster A, Schmitto JD, Gummert J, Schöndube FA, Hasenfuss G, Maier LS, Sossalla S.

Circulation. 2013 Aug 27;128(9):970-81. doi: 10.1161/CIRCULATIONAHA.113.001746. Epub 2013 Jul 19.

PMID:
23877259
18.

Enhanced Ca²+ influx through cardiac L-type Ca²+ channels maintains the systolic Ca²+ transient in early cardiac atrophy induced by mechanical unloading.

Schwoerer AP, Neef S, Broichhausen I, Jacubeit J, Tiburcy M, Wagner M, Biermann D, Didié M, Vettel C, Maier LS, Zimmermann WH, Carrier L, Eschenhagen T, Volk T, El-Armouche A, Ehmke H.

Pflugers Arch. 2013 Dec;465(12):1763-73. doi: 10.1007/s00424-013-1316-y. Epub 2013 Jul 11.

19.

Novel aspects of excitation-contraction coupling in heart failure.

Neef S, Maier LS.

Basic Res Cardiol. 2013 Jul;108(4):360. doi: 10.1007/s00395-013-0360-2. Epub 2013 Jun 6. Review.

PMID:
23740218
20.

Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.

Scharf M, Neef S, Freund R, Geers-Knörr C, Franz-Wachtel M, Brandis A, Krone D, Schneider H, Groos S, Menon MB, Chang KC, Kraft T, Meissner JD, Boheler KR, Maier LS, Gaestel M, Scheibe RJ.

Mol Cell Biol. 2013 Jul;33(13):2586-602. doi: 10.1128/MCB.01692-12. Epub 2013 Apr 22.

21.

While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice.

Neef S, Sag CM, Daut M, Bäumer H, Grefe C, El-Armouche A, DeSantiago J, Pereira L, Bers DM, Backs J, Maier LS.

J Mol Cell Cardiol. 2013 Jun;59:107-16. doi: 10.1016/j.yjmcc.2013.02.014. Epub 2013 Mar 6.

22.

Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.

Hamdani N, Krysiak J, Kreusser MM, Neef S, Dos Remedios CG, Maier LS, Krüger M, Backs J, Linke WA.

Circ Res. 2013 Feb 15;112(4):664-74. doi: 10.1161/CIRCRESAHA.111.300105. Epub 2013 Jan 2.

PMID:
23283722
23.

The Ca-calmodulin dependent kinase II: a promising target for future antiarrhythmic therapies?

Fischer TH, Neef S, Maier LS.

J Mol Cell Cardiol. 2013 May;58:182-7. doi: 10.1016/j.yjmcc.2012.11.003. Epub 2012 Nov 13. Review.

24.

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR.

Circ Res. 2011 Sep 16;109(7):758-69. doi: 10.1161/CIRCRESAHA.111.245787. Epub 2011 Jul 28.

25.

Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality.

Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH, Kockskämper J, Priori SG, Pieske B, Maier LS.

J Am Coll Cardiol. 2011 Jan 25;57(4):469-79. doi: 10.1016/j.jacc.2010.08.639.

26.

Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium.

Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K, Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS.

Circ Res. 2010 Oct 29;107(9):1150-61. doi: 10.1161/CIRCRESAHA.110.220418. Epub 2010 Sep 2.

PMID:
20814023
27.

Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.

Wittköpper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsöld B, Kirchhof P, Maier LS, Hasenfuss G, Dobrev D, Eschenhagen T, El-Armouche A.

J Clin Invest. 2010 Feb;120(2):617-26. doi: 10.1172/JCI40545. Epub 2010 Jan 11.

28.

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation.

Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, Seipelt R, Schöndube FA, Hasenfuss G, Maier LS.

Circ Res. 2010 Apr 2;106(6):1134-44. doi: 10.1161/CIRCRESAHA.109.203836. Epub 2010 Jan 7.

PMID:
20056922
29.

Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.

Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, Opiela MK, Backs J, Olson EN, Brown JH, Neef S, Maier SK, Maier LS.

Circ Heart Fail. 2009 Nov;2(6):664-75. doi: 10.1161/CIRCHEARTFAILURE.109.865279. Epub 2009 Jul 31.

30.

The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.

Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7. doi: 10.1073/pnas.0813013106. Epub 2009 Jan 28.

31.

Generation of functional murine cardiac myocytes from induced pluripotent stem cells.

Mauritz C, Schwanke K, Reppel M, Neef S, Katsirntaki K, Maier LS, Nguemo F, Menke S, Haustein M, Hescheler J, Hasenfuss G, Martin U.

Circulation. 2008 Jul 29;118(5):507-17. doi: 10.1161/CIRCULATIONAHA.108.778795. Epub 2008 Jul 14.

PMID:
18625890
32.

Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII.

Sag CM, Dybkova N, Neef S, Maier LS.

J Mol Cell Cardiol. 2007 Dec;43(6):696-709. Epub 2007 Oct 22.

PMID:
17950750

Supplemental Content

Support Center