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Items: 1 to 50 of 79

1.

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation.

Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho HC, Reggiori F, Farhan H, Brodsky JL, Ferro-Novick S.

Science. 2019 Jul 5;365(6448):53-60. doi: 10.1126/science.aau9263.

PMID:
31273116
2.

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ.

Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27.

PMID:
30826182
3.

Chaperoning Endoplasmic Reticulum-Associated Degradation (ERAD) and Protein Conformational Diseases.

Needham PG, Guerriero CJ, Brodsky JL.

Cold Spring Harb Perspect Biol. 2019 Aug 1;11(8). pii: a033928. doi: 10.1101/cshperspect.a033928. Review.

PMID:
30670468
4.

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.

Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL.

Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. Epub 2018 Nov 15.

PMID:
30528127
5.

Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model.

Hager NA, Krasowski CJ, Mackie TD, Kolb AR, Needham PG, Augustine AA, Dempsey A, Szent-Gyorgyi C, Bruchez MP, Bain DJ, Kwiatkowski AV, O'Donnell AF, Brodsky JL.

J Biol Chem. 2018 Jul 13;293(28):11006-11021. doi: 10.1074/jbc.RA117.001293. Epub 2018 May 21.

6.

Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase.

Ye Z, Needham PG, Estabrooks SK, Whitaker SK, Garcia BL, Misra S, Brodsky JL, Camacho CJ.

Sci Rep. 2017 May 11;7(1):1789. doi: 10.1038/s41598-017-01880-4.

7.

Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members.

Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5087-5091. doi: 10.1016/j.bmcl.2016.08.080. Epub 2016 Aug 25.

8.

Toward an Enhanced Sampling Molecular Dynamics Method for Studying Ligand-Induced Conformational Changes in Proteins.

Andersen OJ, Grouleff J, Needham P, Walker RC, Jensen F.

J Phys Chem B. 2015 Nov 19;119(46):14594-603. doi: 10.1021/acs.jpcb.5b07816. Epub 2015 Nov 4.

PMID:
26482713
9.

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.

Needham PG, Patel HJ, Chiosis G, Thibodeau PH, Brodsky JL.

J Mol Biol. 2015 Sep 11;427(18):2948-65. doi: 10.1016/j.jmb.2015.04.010. Epub 2015 Apr 23.

10.

Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae.

Buck TM, Jordan R, Lyons-Weiler J, Adelman JL, Needham PG, Kleyman TR, Brodsky JL.

Physiol Genomics. 2015 Jun;47(6):198-214. doi: 10.1152/physiolgenomics.00101.2014. Epub 2015 Mar 10.

11.

Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.

Surlow BA, Cooley BM, Needham PG, Brodsky JL, Patton-Vogt J.

J Biol Chem. 2014 Nov 7;289(45):31591-604. doi: 10.1074/jbc.M114.581157. Epub 2014 Sep 25.

12.

The source of chemical bonding.

Needham P.

Stud Hist Philos Sci. 2014 Mar;45:1-13.

PMID:
24984444
13.

ESCRT regulates surface expression of the Kir2.1 potassium channel.

Kolb AR, Needham PG, Rothenberg C, Guerriero CJ, Welling PA, Brodsky JL.

Mol Biol Cell. 2014 Jan;25(2):276-89. doi: 10.1091/mbc.E13-07-0394. Epub 2013 Nov 13.

14.

Cross-sector emergency planning for water supply utilities and healthcare facilities.

Welter G, Socher M, Needham P, Bieber S, Bonnaffon H.

J Healthc Risk Manag. 2013;32(4):5-14. doi: 10.1002/jhrm.21105.

PMID:
23609972
15.

How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD.

Needham PG, Brodsky JL.

Biochim Biophys Acta. 2013 Nov;1833(11):2447-57. doi: 10.1016/j.bbamcr.2013.03.018. Epub 2013 Apr 2. Review.

16.

Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis.

Donnelly BF, Needham PG, Snyder AC, Roy A, Khadem S, Brodsky JL, Subramanya AR.

J Biol Chem. 2013 May 3;288(18):13124-35. doi: 10.1074/jbc.M113.455394. Epub 2013 Mar 12.

17.

The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation.

Needham PG, Mikoluk K, Dhakarwal P, Khadem S, Snyder AC, Subramanya AR, Brodsky JL.

J Biol Chem. 2011 Dec 23;286(51):43611-21. doi: 10.1074/jbc.M111.288928. Epub 2011 Oct 25.

18.

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock.

Botha M, Chiang AN, Needham PG, Stephens LL, Hoppe HC, Külzer S, Przyborski JM, Lingelbach K, Wipf P, Brodsky JL, Shonhai A, Blatch GL.

Cell Stress Chaperones. 2011 Jul;16(4):389-401. doi: 10.1007/s12192-010-0250-6. Epub 2010 Dec 30.

19.

Laparoscopic appendicectomy: calculating the cost.

Needham PJ, Laughlan KA, Botterill ID, Ambrose NS.

Ann R Coll Surg Engl. 2009 Oct;91(7):606-8. doi: 10.1308/003588409X432383. Epub 2009 Jun 25.

20.

Laparoscopic appendicectomy: training implications.

Laughlan KA, Needham PJ, Botterill ID, Ambrose NS.

Ann R Coll Surg Engl. 2009 May;91(4):352; author reply 353. doi: 10.1308/003588409X428360. No abstract available.

21.

Postoperative biochemical liver function after major hepatic resection in children.

Needham P, Dasgupta D, Davies J, Stringer MD.

J Pediatr Surg. 2008 Sep;43(9):1610-8. doi: 10.1016/j.jpedsurg.2007.12.056.

PMID:
18778994
22.

Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities.

Needham PG, Masison DC.

Arch Biochem Biophys. 2008 Oct 15;478(2):167-74. doi: 10.1016/j.abb.2008.07.023. Epub 2008 Aug 6.

23.

Coupled ATP and DNA binding of adeno-associated virus Rep40 helicase.

Dignam SS, Collaco RF, Bieszczad J, Needham P, Trempe JP, Dignam JD.

Biochemistry. 2007 Jan 16;46(2):568-76.

PMID:
17209567
25.

Adeno-associated virus interactions with B23/Nucleophosmin: identification of sub-nucleolar virion regions.

Bevington JM, Needham PG, Verrill KC, Collaco RF, Basrur V, Trempe JP.

Virology. 2007 Jan 5;357(1):102-13. Epub 2006 Sep 7.

26.

Adeno-associated virus rep protein-mediated inhibition of transcription of the adenovirus major late promoter in vitro.

Needham PG, Casper JM, Kalman-Maltese V, Verrill K, Dignam JD, Trempe JP.

J Virol. 2006 Jul;80(13):6207-17.

27.

Goal setting as a measure of outcome in palliative care.

Needham PR, Newbury J.

Palliat Med. 2004 Jul;18(5):444-51.

PMID:
15332422
28.

Who makes good use of memory aids? Results of a survey of people with acquired brain injury.

Evans JJ, Wilson BA, Needham P, Brentnall S.

J Int Neuropsychol Soc. 2003 Sep;9(6):925-35.

PMID:
14632251
29.

Chemical substances and intensive properties.

Needham P.

Ann N Y Acad Sci. 2003 May;988:99-113.

PMID:
12796093
30.

Neurological, cognitive and attributional predictors of posttraumatic stress symptoms after traumatic brain injury.

Williams WH, Evans JJ, Needham P, Wilson BA.

J Trauma Stress. 2002 Oct;15(5):397-400.

PMID:
12392227
31.
32.

Is knowledge a dangerous thing?

Needham P.

Nurs Times. 2000 Dec 7-13;96(49):39-40. No abstract available.

PMID:
11965959
33.

Chronic, but not acute, dosing of antipsychotic drugs alters neurotensin binding in rat brain regions.

Holtom PE, Needham PL, Bennett GW, Aspley S.

Br J Pharmacol. 2000 Nov;131(5):990-6.

34.

A highly sensitive and selective radioimmunoassay for the measurement of neurotensin.

Holtom PE, Wasuntarawat C, Moss SH, Aspley S, Needham PL, Bennett GW.

J Neurosci Methods. 2000 Jul 31;100(1-2):151-6.

PMID:
11040378
35.

Further evidence that behavioral tests and neuropeptide mRNA and tissue level alterations can differentiate between typical and atypical antipsychotic drugs.

Bauer R, Mayr A, Lederer W, Needham PL, Kilpatrick IC, Fleischhacker WW, Marksteiner J.

Neuropsychopharmacology. 2000 Jul;23(1):46-55.

36.

A comparison of the acute effects of zotepine and other antipsychotics on rat cortical dopamine release, in vivo.

Rowley HL, Needham PL, Kilpatrick IC, Heal DJ.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Feb;361(2):187-92.

PMID:
10685875
37.
38.

Audit of prostate cancer: validity and feasibility of registry-based staging.

Silcocks P, Needham P, Hemsley F.

Public Health. 1999 Jul;113(4):157-60.

PMID:
10483075
39.
40.
41.

GUS expression patterns from a tobacco yellow dwarf virus-based episomal vector.

Needham PD, Atkinson RG, Morris BAM, Gardner RC, Gleave AP.

Plant Cell Rep. 1998 May;17(8):631-639. doi: 10.1007/s002990050456.

PMID:
30736517
42.

Zotepine: preclinical tests predict antipsychotic efficacy and an atypical profile.

Needham PL, Atkinson J, Skill MJ, Heal DJ.

Psychopharmacol Bull. 1996;32(1):123-8.

PMID:
8927661
43.

Radiotherapy for bone pain.

Needham PR, Mithal NP, Hoskin PJ.

J R Soc Med. 1994 Sep;87(9):503-5.

44.

Retreatment with radiotherapy for painful bone metastases.

Mithal NP, Needham PR, Hoskin PJ.

Int J Radiat Oncol Biol Phys. 1994 Jul 30;29(5):1011-4.

PMID:
7521863
45.

Radiotherapy for painful bone metastases.

Needham PR, Hoskin PJ.

Palliat Med. 1994;8(2):95-104. Review.

PMID:
7521723
46.

Reserpinization severs the cooperative but not the oppositional interaction between D1 and D2 receptors.

Needham PL, Skill MJ, Cowan A, Redfern RJ, Heal DJ.

Neuropharmacology. 1993 Jun;32(6):515-7.

PMID:
8101637
47.

Steroids in advanced cancer: survey of current practice.

Needham PR, Daley AG, Lennard RF.

BMJ. 1992 Oct 24;305(6860):999. No abstract available.

48.

Multiple neuroectodermal tumors arising in a mature cystic teratoma of the ovary.

Oláh KS, Needham PG, Jones B.

Gynecol Oncol. 1989 Aug;34(2):222-5.

PMID:
2753429
49.

The management of severe disseminated intravascular coagulopathy complicating placental abruption in the second trimester of pregnancy.

Oláh KS, Gee H, Needham PG.

Br J Obstet Gynaecol. 1988 Apr;95(4):419-20. No abstract available.

PMID:
3382618
50.

The selective dopamine antagonist properties of BRL 34778: a novel substituted benzamide.

Brown F, Campbell W, Clark MS, Graves DS, Hadley MS, Hatcher J, Mitchell P, Needham P, Riley G, Semple J.

Psychopharmacology (Berl). 1988;94(3):350-8.

PMID:
3128811

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