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Items: 9


Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.

Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):132-42. doi: 10.1124/jpet.111.183640. Epub 2011 Jul 21.


Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.

Donald AD, Clark VL, Patel S, Day FA, Rowlands MG, Wibata J, Stimson L, Hardcastle A, Eccles SA, McNamara D, Needham LA, Raynaud FI, Aherne W, Moffat DF.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6657-60. doi: 10.1016/j.bmcl.2010.09.016. Epub 2010 Sep 21.


CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.

Krige D, Needham LA, Bawden LJ, Flores N, Farmer H, Miles LE, Stone E, Callaghan J, Chandler S, Clark VL, Kirwin-Jones P, Legris V, Owen J, Patel T, Wood S, Box G, Laber D, Odedra R, Wright A, Wood LM, Eccles SA, Bone EA, Ayscough A, Drummond AH.

Cancer Res. 2008 Aug 15;68(16):6669-79. doi: 10.1158/0008-5472.CAN-07-6627.


Differential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1.

Kilger G, Needham LA, Nielsen PJ, Clements J, Vestweber D, Holzmann B.

J Biol Chem. 1995 Mar 17;270(11):5979-84.


Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin.

Clements JM, Newham P, Shepherd M, Gilbert R, Dudgeon TJ, Needham LA, Edwards RM, Berry L, Brass A, Humphries MJ.

J Cell Sci. 1994 Aug;107 ( Pt 8):2127-35.


Activation dependent and independent VLA-4 binding sites on vascular cell adhesion molecule-1.

Needham LA, Van Dijk S, Pigott R, Edwards RM, Shepherd M, Hemingway I, Jack L, Clements JM.

Cell Adhes Commun. 1994 Jun;2(2):87-99.


Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.

Fawcett J, Holness CL, Needham LA, Turley H, Gatter KC, Mason DY, Simmons DL.

Nature. 1992 Dec 3;360(6403):481-4.


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