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Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization.

Müller KH, Hayward R, Rajan R, Whitehead M, Cobb AM, Ahmad S, Sun M, Goldberga I, Li R, Bashtanova U, Puszkarska AM, Reid DG, Brooks RA, Skepper JN, Bordoloi J, Chow WY, Oschkinat H, Groombridge A, Scherman OA, Harrison JA, Verhulst A, D'Haese PC, Neven E, Needham LM, Lee SF, Shanahan CM, Duer MJ.

Cell Rep. 2019 Jun 11;27(11):3124-3138.e13. doi: 10.1016/j.celrep.2019.05.038.


Evaluation of L-index interference limits on Roche cobas c502 and c702 immunoturbidimetric assays using endogenously lipemic specimens and intralipid spiking.

Hunsaker JJH, Wyness SP, Needham LL, Genzen JR.

Clin Biochem. 2019 Aug;70:18-23. doi: 10.1016/j.clinbiochem.2019.05.014. Epub 2019 May 27.


Spectrally Resolved Photodynamics of Individual Emitters in Large-Area Monolayers of Hexagonal Boron Nitride.

Stern HL, Wang R, Fan Y, Mizuta R, Stewart JC, Needham LM, Roberts TD, Wai R, Ginsberg NS, Klenerman D, Hofmann S, Lee SF.

ACS Nano. 2019 Apr 23;13(4):4538-4547. doi: 10.1021/acsnano.9b00274. Epub 2019 Mar 20.


Phlebotomy tube interference with nuclear magnetic resonance (NMR) lipoprotein subclass analysis.

Needham LL, Smy L, Lee MA, Kunzler TM, Genzen JR.

Clin Chim Acta. 2019 Jan;488:235-241. doi: 10.1016/j.cca.2018.11.010. Epub 2018 Nov 8.


FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells.

Basu S, Needham LM, Lando D, Taylor EJR, Wohlfahrt KJ, Shah D, Boucher W, Tan YL, Bates LE, Tkachenko O, Cramard J, Lagerholm BC, Eggeling C, Hendrich B, Klenerman D, Lee SF, Laue ED.

Nat Commun. 2018 Jun 28;9(1):2520. doi: 10.1038/s41467-018-04486-0.


Correction to 'Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species'.

Needham LM, Weber J, Fyfe JWB, Kabia OM, Do DT, Klimont E, Zhang Y, Rodrigues M, Dobson CM, Gandhi S, Bohndiek SE, Snaddon TN, Lee SF.

R Soc Open Sci. 2018 Mar 28;5(3):180308. doi: 10.1098/rsos.180308. eCollection 2018 Mar.


Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.

Needham LM, Weber J, Fyfe JWB, Kabia OM, Do DT, Klimont E, Zhang Y, Rodrigues M, Dobson CM, Ghandi S, Bohndiek SE, Snaddon TN, Lee SF.

R Soc Open Sci. 2018 Feb 7;5(2):171399. doi: 10.1098/rsos.171399. eCollection 2018 Feb. Erratum in: R Soc Open Sci. 2018 Mar 28;5(3):180308.


Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation.

Spasic A, Kennedy SD, Needham L, Manoharan M, Kierzek R, Turner DH, Mathews DH.

RNA. 2018 May;24(5):656-672. doi: 10.1261/rna.064527.117. Epub 2018 Feb 6.


Patterns of locomotor regulation during the pole vault approach phase.

Needham L, Exell TA, Bezodis IN, Irwin G.

J Sports Sci. 2018 Aug;36(15):1742-1748. doi: 10.1080/02640414.2017.1412236. Epub 2017 Dec 6.


Pilot study investigating the prevalence of oral Human Papilloma Viral (HPV) infection in young adults.

Knight GL, Needham L, Ward D, Roberts S.

Public Health. 2016 Mar;132:105-7. doi: 10.1016/j.puhe.2015.12.006. Epub 2016 Feb 3. No abstract available.


The pure rotational spectra of the open-shell diatomic molecules PbI and SnI.

Evans CJ, Needham LM, Walker NR, Köckert H, Zaleski DP, Stephens SL.

J Chem Phys. 2015 Dec 28;143(24):244309. doi: 10.1063/1.4938247.


Superresolution techniques, biophysics with nanostructures, and fluorescence energy transfer: general discussion.

Cordes T, Moerner W, Orrit M, Needham LM, Sekatskii S, Faez S, Prabal Goswami H, Clark A, Meixner AJ, Piatkowski L, Sandoghdar V, Skinner GM, Balzarotti F, Langbein W, Novotny L, Birkedal V, Koberling F, Michaelis J, Williams P, Chowdhury A, van Hulst N, Dahan M, Peñaherrera A, Lounis B, Bohn PW, Shi X.

Faraday Discuss. 2015;184:143-62. doi: 10.1039/c5fd90094h. Epub 2015 Nov 30. No abstract available.


Quantum optics, molecular spectroscopy and low-temperature spectroscopy: general discussion.

Orrit M, Evans G, Cordes T, Kratochvilova I, Moerner W, Needham LM, Sekatskii S, Vainer Y, Faez S, Vedral V, Prabal Goswami H, Clark A, Meixner AJ, Piatkowski L, Birkedal V, Sandoghdar V, Skinner GM, Langbein W, Du J, Koberling F, Michaelis J, Shi F, Taylor R, Chowdhury A, Lounis B, van Hulst N, El-Khoury P, Novotny L, Wrachtrup J, Farrow T, Naumov A, Gladush M, Hanson R.

Faraday Discuss. 2015;184:275-303. doi: 10.1039/c5fd90088c. Epub 2015 Nov 30. No abstract available.


Persistent organic pollutants (POPs) and metals in primiparous women: a comparison from Canada and Mexico.

Adlard B, Davis K, Liang CL, S Curren M, Rodríguez-Dozal S, Riojas-Rodríguez H, Hernández-Ávila M, Foster W, Needham L, Wong LY, Weber JP, Marro L, Leech T, Van Oostdam J.

Sci Total Environ. 2014 Dec 1;500-501:302-13. doi: 10.1016/j.scitotenv.2014.08.074. Epub 2014 Sep 16.


The Center for HIV/AIDS Vaccine Immunology (CHAVI) multi-site quality assurance program for cryopreserved human peripheral blood mononuclear cells.

Sarzotti-Kelsoe M, Needham LK, Rountree W, Bainbridge J, Gray CM, Fiscus SA, Ferrari G, Stevens WS, Stager SL, Binz W, Louzao R, Long KO, Mokgotho P, Moodley N, Mackay M, Kerkau M, McMillion T, Kirchherr J, Soderberg KA, Haynes BF, Denny TN.

J Immunol Methods. 2014 Jul;409:21-30. doi: 10.1016/j.jim.2014.05.013. Epub 2014 Jun 5.


Therapeutic potential of somatic cell nuclear transfer for degenerative disease caused by mitochondrial DNA mutations.

Greggains GD, Lister LM, Tuppen HA, Zhang Q, Needham LH, Prathalingam N, Hyslop LA, Craven L, Polanski Z, Murdoch AP, Turnbull DM, Herbert M.

Sci Rep. 2014 Jan 24;4:3844. doi: 10.1038/srep03844.


Müllerian-type, cutaneous ciliated cyst in the gluteal cleft mimicking a pilonidal cyst.

Oh JS, Bhalla VK, Needham L, Sharma S, Pipkin WL, Hatley RM, Howell CG.

Pediatr Surg Int. 2014 May;30(5):545-8. doi: 10.1007/s00383-013-3363-z. Epub 2013 Aug 4.


Changes in the concentrations of biochemical indicators of diet and nutritional status of pregnant women across pregnancy trimesters in Trujillo, Peru, 2004-2005.

Horton DK, Adetona O, Aguilar-Villalobos M, Cassidy BE, Pfeiffer CM, Schleicher RL, Caldwell KL, Needham LL, Rathbun SL, Vena JE, Naeher LP.

Nutr J. 2013 Jun 11;12:80. doi: 10.1186/1475-2891-12-80.


A phase I first-in-human study with tefinostat - a monocyte/macrophage targeted histone deacetylase inhibitor - in patients with advanced haematological malignancies.

Ossenkoppele GJ, Lowenberg B, Zachee P, Vey N, Breems D, Van de Loosdrecht AA, Davidson AH, Wells G, Needham L, Bawden L, Toal M, Hooftman L, Debnam PM.

Br J Haematol. 2013 Jul;162(2):191-201. doi: 10.1111/bjh.12359. Epub 2013 May 7.


Concentrations of select persistent organic pollutants across pregnancy trimesters in maternal and in cord serum in Trujillo, Peru.

Adetona O, Horton K, Sjodin A, Jones R, Hall DB, Aguillar-Villalobos M, Cassidy BE, Vena JE, Needham LL, Naeher LP.

Chemosphere. 2013 Jun;91(10):1426-33. doi: 10.1016/j.chemosphere.2013.01.043. Epub 2013 Feb 28.


Biomonitoring of polycyclic aromatic hydrocarbon exposure in pregnant women in Trujillo, Peru--comparison of different fuel types used for cooking.

Adetona O, Li Z, Sjödin A, Romanoff LC, Aguilar-Villalobos M, Needham LL, Hall DB, Cassidy BE, Naeher LP.

Environ Int. 2013 Mar;53:1-8. doi: 10.1016/j.envint.2012.11.010. Epub 2013 Jan 8.


Variability of urinary concentrations of polycyclic aromatic hydrocarbon metabolite in general population and comparison of spot, first-morning, and 24-h void sampling.

Li Z, Romanoff LC, Lewin MD, Porter EN, Trinidad DA, Needham LL, Patterson DG Jr, Sjödin A.

J Expo Sci Environ Epidemiol. 2013 Jan-Feb;23(1):109-10. doi: 10.1038/jes.2012.93. No abstract available.


Personal exposure to PM(2.5) and urinary hydroxy-PAH levels in bus drivers exposed to traffic exhaust, in Trujillo, Peru.

Adetona O, Sjodin A, Zheng L, Romanoff LC, Aguilar-Villalobos M, Needham LL, Hall DB, Luis A, Cassidy BE, Simpson CD, Naeher LP.

J Occup Environ Hyg. 2012;9(4):217-29. doi: 10.1080/15459624.2012.666142.


Persistent organic pollutant concentrations in first birth mothers across Mexico.

Rodríguez-Dozal S, Riojas Rodríguez H, Hernández-Ávila M, Van Oostdam J, Weber JP, Needham LL, Trip L.

J Expo Sci Environ Epidemiol. 2012 Jan-Feb;22(1):60-9. doi: 10.1038/jes.2011.31. Epub 2011 Oct 5.


Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004.

Barr DB, Wong LY, Bravo R, Weerasekera G, Odetokun M, Restrepo P, Kim DG, Fernandez C, Whitehead RD Jr, Perez J, Gallegos M, Williams BL, Needham LL.

Int J Environ Res Public Health. 2011 Aug;8(8):3063-98. doi: 10.3390/ijerph8083063. Epub 2011 Jul 25.


Dioxin exposure and cancer risk in the Seveso Women's Health Study.

Warner M, Mocarelli P, Samuels S, Needham L, Brambilla P, Eskenazi B.

Environ Health Perspect. 2011 Dec;119(12):1700-5. doi: 10.1289/ehp.1103720. Epub 2011 Aug 2.


Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.

Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):132-42. doi: 10.1124/jpet.111.183640. Epub 2011 Jul 21.


Phthalate exposure associated with self-reported diabetes among Mexican women.

Svensson K, Hernández-Ramírez RU, Burguete-García A, Cebrián ME, Calafat AM, Needham LL, Claudio L, López-Carrillo L.

Environ Res. 2011 Aug;111(6):792-6. doi: 10.1016/j.envres.2011.05.015. Epub 2011 Jun 21.


Biomarker measurements of concurrent exposure to multiple environmental chemicals and chemical classes in children.

Sexton K, Ryan AD, Adgate JL, Barr DB, Needham LL.

J Toxicol Environ Health A. 2011;74(14):927-42. doi: 10.1080/15287394.2011.573745.


Impact of the improved patsari biomass stove on urinary polycyclic aromatic hydrocarbon biomarkers and carbon monoxide exposures in rural Mexican women.

Riojas-Rodriguez H, Schilmann A, Marron-Mares AT, Masera O, Li Z, Romanoff L, Sjödin A, Rojas-Bracho L, Needham LL, Romieu I.

Environ Health Perspect. 2011 Sep;119(9):1301-7. doi: 10.1289/ehp.1002927. Epub 2011 May 27.


Dioxin exposure and age of pubertal onset among Russian boys.

Korrick SA, Lee MM, Williams PL, Sergeyev O, Burns JS, Patterson DG, Turner WE, Needham LL, Altshul L, Revich B, Hauser R.

Environ Health Perspect. 2011 Sep;119(9):1339-44. doi: 10.1289/ehp.1003102. Epub 2011 Apr 28.


Personal care product use and urinary levels of phthalate metabolites in Mexican women.

Romero-Franco M, Hernández-Ramírez RU, Calafat AM, Cebrián ME, Needham LL, Teitelbaum S, Wolff MS, López-Carrillo L.

Environ Int. 2011 Jul;37(5):867-71. doi: 10.1016/j.envint.2011.02.014. Epub 2011 Mar 22.


Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes.

Lee DH, Steffes MW, Sjödin A, Jones RS, Needham LL, Jacobs DR Jr.

PLoS One. 2011 Jan 26;6(1):e15977. doi: 10.1371/journal.pone.0015977.


Perinatal exposure to low doses of dioxin can permanently impair human semen quality.

Mocarelli P, Gerthoux PM, Needham LL, Patterson DG Jr, Limonta G, Falbo R, Signorini S, Bertona M, Crespi C, Sarto C, Scott PK, Turner WE, Brambilla P.

Environ Health Perspect. 2011 May;119(5):713-8. doi: 10.1289/ehp.1002134. Epub 2010 Dec 24.


Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys.

Burns JS, Williams PL, Sergeyev O, Korrick S, Lee MM, Revich B, Altshul L, Del Prato JT, Humblet O, Patterson DG Jr, Turner WE, Needham LL, Starovoytov M, Hauser R.

Pediatrics. 2011 Jan;127(1):e59-68. doi: 10.1542/peds.2009-3556. Epub 2010 Dec 27.


Partition of environmental chemicals between maternal and fetal blood and tissues.

Needham LL, Grandjean P, Heinzow B, Jørgensen PJ, Nielsen F, Patterson DG Jr, Sjödin A, Turner WE, Weihe P.

Environ Sci Technol. 2011 Feb 1;45(3):1121-6. doi: 10.1021/es1019614. Epub 2010 Dec 17.


Improved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals.

Kato K, Basden BJ, Needham LL, Calafat AM.

J Chromatogr A. 2011 Apr 15;1218(15):2133-7. doi: 10.1016/j.chroma.2010.10.051. Epub 2010 Oct 21.


In-vitro oxidation of bisphenol A: Is bisphenol A catechol a suitable biomarker for human exposure to bisphenol A?

Ye X, Zhou X, Needham LL, Calafat AM.

Anal Bioanal Chem. 2011 Jan;399(3):1071-9. doi: 10.1007/s00216-010-4344-x. Epub 2010 Nov 9.


Prenatal environmental tobacco smoke exposure and early childhood body mass index.

Braun JM, Daniels JL, Poole C, Olshan AF, Hornung R, Bernert JT, Khoury J, Needham LL, Barr DB, Lanphear BP.

Paediatr Perinat Epidemiol. 2010 Nov;24(6):524-34. doi: 10.1111/j.1365-3016.2010.01146.x. Epub 2010 Aug 16.


Pesticide exposure among pregnant women in Jerusalem, Israel: results of a pilot study.

Berman T, Hochner-Celnikier D, Barr DB, Needham LL, Amitai Y, Wormser U, Richter E.

Environ Int. 2011 Jan;37(1):198-203. doi: 10.1016/j.envint.2010.09.002. Epub 2010 Oct 16.


Urinary and serum metabolites of di-n-pentyl phthalate in rats.

Silva MJ, Furr J, Samandar E, Preau JL Jr, Gray LE, Needham LL, Calafat AM.

Chemosphere. 2011 Jan;82(3):431-6. doi: 10.1016/j.chemosphere.2010.09.052. Epub 2010 Oct 15.


Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.

Donald AD, Clark VL, Patel S, Day FA, Rowlands MG, Wibata J, Stimson L, Hardcastle A, Eccles SA, McNamara D, Needham LA, Raynaud FI, Aherne W, Moffat DF.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6657-60. doi: 10.1016/j.bmcl.2010.09.016. Epub 2010 Sep 21.


High-throughput sample preparation for the quantitation of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea, and propylenethiourea in human urine using 96-well-plate automated extraction and high-performance liquid chromatography-tandem mass spectrometry.

Jayatilaka NK, Angela Montesano M, Whitehead RD Jr, Schloth SJ, Needham LL, Barr DB.

Arch Environ Contam Toxicol. 2011 Jul;61(1):59-67. doi: 10.1007/s00244-010-9593-3. Epub 2010 Sep 28.


Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey.

Calafat AM, Wong LY, Silva MJ, Samandar E, Preau JL Jr, Jia LT, Needham LL.

Environ Health Perspect. 2011 Jan;119(1):50-5. doi: 10.1289/ehp.1002316. Epub 2010 Sep 22.


Quantification of cyanuric acid residue in human urine using high performance liquid chromatography-tandem mass spectrometry.

Panuwet P, Wade EL, Nguyen JV, Montesano MA, Needham LL, Barr DB.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2916-22. doi: 10.1016/j.jchromb.2010.08.019. Epub 2010 Aug 21.


Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study.

Preau JL Jr, Wong LY, Silva MJ, Needham LL, Calafat AM.

Environ Health Perspect. 2010 Dec;118(12):1748-54. doi: 10.1289/ehp.1002231. Epub 2010 Aug 25.


An estimate of phthalate exposure among pregnant women living in Trujillo, Peru.

Irvin EA, Calafat AM, Silva MJ, Aguilar-Villalobos M, Needham LL, Hall DB, Cassidy B, Naeher LP.

Chemosphere. 2010 Sep;80(11):1301-7. doi: 10.1016/j.chemosphere.2010.06.048. Epub 2010 Aug 10.


Quantification of dialkylphosphate metabolites of organophosphorus insecticides in human urine using 96-well plate sample preparation and high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

Odetokun MS, Montesano MA, Weerasekera G, Whitehead RD Jr, Needham LL, Barr DB.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2567-74. doi: 10.1016/j.jchromb.2010.04.027. Epub 2010 Apr 24.


Hypospadias and halogenated organic pollutant levels in maternal mid-pregnancy serum samples.

Carmichael SL, Herring AH, Sjödin A, Jones R, Needham L, Ma C, Ding K, Shaw GM.

Chemosphere. 2010 Jul;80(6):641-6. doi: 10.1016/j.chemosphere.2010.04.055. Epub 2010 May 21.


A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice.

Weerasekera G, Smith KD, Quirós-Alcalá L, Fernandez C, Bradman A, Eskenazi B, Needham LL, Barr DB.

J Environ Monit. 2009 Jul;11(7):1345-51. doi: 10.1039/b821841b. Epub 2009 Apr 23.


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