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VEGF-C Sustains VEGFR2 Activation under Bevacizumab Therapy and Promotes Glioblastoma Maintenance.

Michaelsen SR, Staberg M, Pedersen H, Jensen KE, Majewski W, Broholm H, Nedergaard MK, Meulengracht C, Urup T, Villingshøj M, Lukacova S, Skjøth-Rasmussen J, Brennum J, Kjær A, Lassen U, Stockhausen MT, Poulsen HS, Hamerlik P.

Neuro Oncol. 2018 Jun 25. doi: 10.1093/neuonc/noy103. [Epub ahead of print]


Cannula Implantation into the Cisterna Magna of Rodents.

Xavier ALR, Hauglund NL, von Holstein-Rathlou S, Li Q, Sanggaard S, Lou N, Lundgaard I, Nedergaard M.

J Vis Exp. 2018 May 23;(135). doi: 10.3791/57378.


Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure.

Obara-Michlewska M, Ding F, Popek M, Verkhratsky A, Nedergaard M, Zielinska M, Albrecht J.

Neurochem Int. 2018 May 14. pii: S0197-0186(18)30020-2. doi: 10.1016/j.neuint.2018.05.007. [Epub ahead of print]


Understanding the role of the perivascular space in cerebral small vessel disease.

Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM.

Cardiovasc Res. 2018 May 2. doi: 10.1093/cvr/cvy113. [Epub ahead of print]


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Review.


Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.

Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M.

Sci Rep. 2018 Feb 2;8(1):2246. doi: 10.1038/s41598-018-20424-y.


Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.

Smith NA, Kress BT, Lu Y, Chandler-Militello D, Benraiss A, Nedergaard M.

Sci Signal. 2018 Jan 30;11(515). pii: eaal2039. doi: 10.1126/scisignal.aal2039.


Physiology of Astroglia.

Verkhratsky A, Nedergaard M.

Physiol Rev. 2018 Jan 1;98(1):239-389. doi: 10.1152/physrev.00042.2016.


The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future.

Plog BA, Nedergaard M.

Annu Rev Pathol. 2018 Jan 24;13:379-394. doi: 10.1146/annurev-pathol-051217-111018.


Voluntary running enhances glymphatic influx in awake behaving, young mice.

von Holstein-Rathlou S, Petersen NC, Nedergaard M.

Neurosci Lett. 2018 Jan 1;662:253-258. doi: 10.1016/j.neulet.2017.10.035. Epub 2017 Oct 25.


Brain energetics during the sleep-wake cycle.

DiNuzzo M, Nedergaard M.

Curr Opin Neurobiol. 2017 Dec;47:65-72. doi: 10.1016/j.conb.2017.09.010. Epub 2017 Oct 9. Review.


Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane.

Benveniste H, Lee H, Ding F, Sun Q, Al-Bizri E, Makaryus R, Probst S, Nedergaard M, Stein EA, Lu H.

Anesthesiology. 2017 Dec;127(6):976-988. doi: 10.1097/ALN.0000000000001888.


Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J.

J Clin Invest. 2017 Sep 1;127(9):3210-3219. doi: 10.1172/JCI90603. Epub 2017 Sep 1. Review.


Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?

Oberheim Bush NA, Nedergaard M.

Neurochem Res. 2017 Sep;42(9):2577-2587. doi: 10.1007/s11064-017-2363-0. Epub 2017 Aug 19. Review.


Perivascular spaces, glymphatic dysfunction, and small vessel disease.

Mestre H, Kostrikov S, Mehta RI, Nedergaard M.

Clin Sci (Lond). 2017 Aug 10;131(17):2257-2274. doi: 10.1042/CS20160381. Print 2017 Sep 1. Review.


Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Windrem MS, Osipovitch M, Liu Z, Bates J, Chandler-Militello D, Zou L, Munir J, Schanz S, McCoy K, Miller RH, Wang S, Nedergaard M, Findling RL, Tesar PJ, Goldman SA.

Cell Stem Cell. 2017 Aug 3;21(2):195-208.e6. doi: 10.1016/j.stem.2017.06.012. Epub 2017 Jul 20.


Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T.

Lee H, Mortensen K, Sanggaard S, Koch P, Brunner H, Quistorff B, Nedergaard M, Benveniste H.

Magn Reson Med. 2018 Mar;79(3):1568-1578. doi: 10.1002/mrm.26779. Epub 2017 Jun 19.


SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.

Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Aalling N, Wang S, Benraiss A, Lou N, Goldman SA, Nedergaard M.

J Neurosci. 2017 Apr 26;37(17):4493-4507. doi: 10.1523/JNEUROSCI.3199-16.2017. Epub 2017 Mar 23.


Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport.

Ratner V, Gao Y, Lee H, Elkin R, Nedergaard M, Benveniste H, Tannenbaum A.

Neuroimage. 2017 May 15;152:530-537. doi: 10.1016/j.neuroimage.2017.03.021. Epub 2017 Mar 18.


Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.

de Leon MJ, Li Y, Okamura N, Tsui WH, Saint-Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H.

J Nucl Med. 2017 Sep;58(9):1471-1476. doi: 10.2967/jnumed.116.187211. Epub 2017 Mar 16.


Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

Kjaerby C, Rasmussen R, Andersen M, Nedergaard M.

Neurochem Res. 2017 Jun;42(6):1810-1822. doi: 10.1007/s11064-017-2195-y. Epub 2017 Feb 16. Review.


Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.

Wang M, Ding F, Deng S, Guo X, Wang W, Iliff JJ, Nedergaard M.

J Neurosci. 2017 Mar 15;37(11):2870-2877. doi: 10.1523/JNEUROSCI.2112-16.2017. Epub 2017 Feb 10.


Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.

Mol Neurodegener. 2017 Jan 12;12(1):3. doi: 10.1186/s13024-016-0147-7. No abstract available.


Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke.

Cotrina ML, Lou N, Tome-Garcia J, Goldman J, Nedergaard M.

Neuroscience. 2017 Feb 20;343:483-494. doi: 10.1016/j.neuroscience.2016.12.012. Epub 2016 Dec 18.


Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R.

Mol Neurodegener. 2016 Dec 8;11(1):74. Erratum in: Mol Neurodegener. 2017 Jan 12;12 (1):3.


A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice.

Xie L, Kang H, Nedergaard M.

J Nat Sci. 2016;2(2). pii: e176.


NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.

Wang F, Wang X, Shapiro LA, Cotrina ML, Liu W, Wang EW, Gu S, Wang W, He X, Nedergaard M, Huang JH.

Brain Struct Funct. 2017 Apr;222(3):1543-1556. doi: 10.1007/s00429-016-1292-z. Epub 2016 Sep 1.


Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.

Wei HS, Kang H, Rasheed ID, Zhou S, Lou N, Gershteyn A, McConnell ED, Wang Y, Richardson KE, Palmer AF, Xu C, Wan J, Nedergaard M.

Neuron. 2016 Aug 17;91(4):851-862. doi: 10.1016/j.neuron.2016.07.016. Epub 2016 Aug 4.


Glymphatic clearance controls state-dependent changes in brain lactate concentration.

Lundgaard I, Lu ML, Yang E, Peng W, Mestre H, Hitomi E, Deane R, Nedergaard M.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2112-2124. doi: 10.1177/0271678X16661202. Epub 2016 Jan 1.


Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used.

Rasmussen R, Nedergaard M, Petersen NC.

Sci Rep. 2016 Jul 26;6:30433. doi: 10.1038/srep30433.


The homeostatic astroglia emerges from evolutionary specialization of neural cells.

Verkhratsky A, Nedergaard M.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150428. doi: 10.1098/rstb.2015.0428. Review.


Impairment of the glymphatic system after diabetes.

Jiang Q, Zhang L, Ding G, Davoodi-Bojd E, Li Q, Li L, Sadry N, Nedergaard M, Chopp M, Zhang Z.

J Cereb Blood Flow Metab. 2017 Apr;37(4):1326-1337. doi: 10.1177/0271678X16654702. Epub 2016 Jan 1.


Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.

Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA.

Nat Commun. 2016 Jun 7;7:11758. doi: 10.1038/ncomms11758.


Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.

Peng W, Achariyar TM, Li B, Liao Y, Mestre H, Hitomi E, Regan S, Kasper T, Peng S, Ding F, Benveniste H, Nedergaard M, Deane R.

Neurobiol Dis. 2016 Sep;93:215-25. doi: 10.1016/j.nbd.2016.05.015. Epub 2016 May 24.


Changes in the composition of brain interstitial ions control the sleep-wake cycle.

Ding F, O'Donnell J, Xu Q, Kang N, Goldman N, Nedergaard M.

Science. 2016 Apr 29;352(6285):550-5. doi: 10.1126/science.aad4821.


Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro.

Staberg M, Michaelsen SR, Olsen LS, Nedergaard MK, Villingshøj M, Stockhausen MT, Hamerlik P, Poulsen HS.

Cancer Cell Int. 2016 Apr 26;16:34. doi: 10.1186/s12935-016-0309-2. eCollection 2016.



Nedergaard M, Goldman SA.

Sci Am. 2016 Mar;314(3):44-9. No abstract available.


Comparison of (18)F-FET and (18)F-FLT small animal PET for the assessment of anti-VEGF treatment response in an orthotopic model of glioblastoma.

Nedergaard MK, Michaelsen SR, Perryman L, Erler J, Poulsen HS, Stockhausen MT, Lassen U, Kjaer A.

Nucl Med Biol. 2016 Mar;43(3):198-205. doi: 10.1016/j.nucmedbio.2015.12.002. Epub 2015 Dec 22.


Optimal-mass-transfer-based estimation of glymphatic transport in living brain.

Ratner V, Zhu L, Kolesov I, Nedergaard M, Benveniste H, Tannenbaum A.

Proc SPIE Int Soc Opt Eng. 2015 Feb 21;9413. pii: 94131J. Epub 2015 Mar 20.


Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.

Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1074-9. doi: 10.1073/pnas.1520398113. Epub 2016 Jan 11.


Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?

Kiviniemi V, Wang X, Korhonen V, Keinänen T, Tuovinen T, Autio J, LeVan P, Keilholz S, Zang YF, Hennig J, Nedergaard M.

J Cereb Blood Flow Metab. 2016 Jun;36(6):1033-45. doi: 10.1177/0271678X15622047. Epub 2015 Dec 21.


Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.

McConnell ED, Wei HS, Reitz KM, Kang H, Takano T, Vates GE, Nedergaard M.

J Cereb Blood Flow Metab. 2016 Sep;36(9):1537-52. doi: 10.1177/0271678X15608389. Epub 2015 Oct 14.


Distinct functional states of astrocytes during sleep and wakefulness: Is norepinephrine the master regulator?

O'Donnell J, Ding F, Nedergaard M.

Curr Sleep Med Rep. 2015 Mar;1(1):1-8. Epub 2015 Jan 29.


Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.

Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK.

Cell Death Differ. 2016 Apr;23(4):596-607. doi: 10.1038/cdd.2015.124. Epub 2015 Oct 9.


Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma.

Persson M, Nedergaard MK, Brandt-Larsen M, Skovgaard D, Jørgensen JT, Michaelsen SR, Madsen J, Lassen U, Poulsen HS, Kjaer A.

J Nucl Med. 2016 Feb;57(2):272-8. doi: 10.2967/jnumed.115.161703. Epub 2015 Oct 1.


Implications of the discovery of brain lymphatic pathways.

Iliff JJ, Goldman SA, Nedergaard M.

Lancet Neurol. 2015 Oct;14(10):977-9. doi: 10.1016/S1474-4422(15)00221-5. No abstract available.


A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.

Ribeiro Xavier AL, Kress BT, Goldman SA, Lacerda de Menezes JR, Nedergaard M.

J Neurosci. 2015 Aug 26;35(34):11848-61. doi: 10.1523/JNEUROSCI.1217-15.2015.


The Effect of Body Posture on Brain Glymphatic Transport.

Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, Logan J, Nedergaard M, Benveniste H.

J Neurosci. 2015 Aug 5;35(31):11034-44. doi: 10.1523/JNEUROSCI.1625-15.2015.


Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals.

Benveniste H, Hof PR, Nedergaard M, Bechter K.

J Comp Neurol. 2015 Sep 1;523(13):2017-8. doi: 10.1002/cne.23850. No abstract available.


Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia.

Makaryus R, Lee H, Feng T, Park JH, Nedergaard M, Jacob Z, Enikolopov G, Benveniste H.

Anesthesiology. 2015 Sep;123(3):557-68. doi: 10.1097/ALN.0000000000000762.

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