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Mechanisms of cognitive dysfunction in CKD.

Viggiano D, Wagner CA, Martino G, Nedergaard M, Zoccali C, Unwin R, Capasso G.

Nat Rev Nephrol. 2020 Mar 31. doi: 10.1038/s41581-020-0266-9. [Epub ahead of print] Review.


An ocular glymphatic clearance system removes β-amyloid from the rodent eye.

Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q, Förstera B, Peng S, Shi M, Ladrón-de-Guevara A, Delle C, Sigurdsson B, Xavier ALR, Ertürk A, Libby RT, Chen L, Thrane AS, Nedergaard M.

Sci Transl Med. 2020 Mar 25;12(536). pii: eaaw3210. doi: 10.1126/scitranslmed.aaw3210.


Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.

Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD Jr, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT.

Nat Rev Neurol. 2020 Mar 9. doi: 10.1038/s41582-020-0321-y. [Epub ahead of print] Review.


Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.

Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, Liu X, Monte B, Xu F, Nostrand WV, Nedergaard M, Lee H, Wardlaw J, Benveniste H, Tannenbaum A.

Sci Rep. 2020 Feb 27;10(1):3934. doi: 10.1038/s41598-020-60586-2.


Perivascular spaces in the brain: anatomy, physiology and pathology.

Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, Doubal FN, Brown R, Ramirez J, MacIntosh BJ, Tannenbaum A, Ballerini L, Rungta RL, Boido D, Sweeney M, Montagne A, Charpak S, Joutel A, Smith KJ, Black SE; colleagues from the Fondation Leducq Transatlantic Network of Excellence on the Role of the Perivascular Space in Cerebral Small Vessel Disease.

Nat Rev Neurol. 2020 Mar;16(3):137-153. doi: 10.1038/s41582-020-0312-z. Epub 2020 Feb 24. Review.


Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.

Hauglund NL, Kusk P, Kornum BR, Nedergaard M.

J Neurosci. 2020 Mar 11;40(11):2371-2380. doi: 10.1523/JNEUROSCI.2223-19.2020. Epub 2020 Feb 11.


Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.

Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR.

Fluids Barriers CNS. 2020 Feb 11;17(1):15. doi: 10.1186/s12987-020-0176-z.


Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.

Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, Liu X, Monte B, Xu F, Van Nostrand W, Nedergaard M, Lee H, Wardlaw J, Benveniste H, Tannenbaum A.

Sci Rep. 2020 Feb 6;10(1):1990. doi: 10.1038/s41598-020-59045-9. Erratum in: Sci Rep. 2020 Feb 27;10(1):3934.


Editorial: Sleep and Mood Disorders.

Verkhratsky A, Nedergaard M, Steardo L, Li B.

Front Psychiatry. 2020 Jan 16;10:981. doi: 10.3389/fpsyt.2019.00981. eCollection 2019. No abstract available.


Cerebrospinal fluid influx drives acute ischemic tissue swelling.

Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M.

Science. 2020 Mar 13;367(6483). pii: eaax7171. doi: 10.1126/science.aax7171. Epub 2020 Jan 30.


Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus.

Reeves BC, Karimy JK, Kundishora AJ, Mestre H, Cerci HM, Matouk C, Alper SL, Lundgaard I, Nedergaard M, Kahle KT.

Trends Mol Med. 2020 Mar;26(3):285-295. doi: 10.1016/j.molmed.2019.11.008. Epub 2020 Jan 18. Review.


Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.

Yoon C, Qi Y, Mestre H, Canavesi C, Marola OJ, Cogliati A, Nedergaard M, Libby RT, Rolland JP.

Biomed Opt Express. 2019 Nov 14;10(12):6242-6257. doi: 10.1364/BOE.10.006242. eCollection 2019 Dec 1.


Glial cells in schizophrenia: a unified hypothesis.

Dietz AG, Goldman SA, Nedergaard M.

Lancet Psychiatry. 2020 Mar;7(3):272-281. doi: 10.1016/S2215-0366(19)30302-5. Epub 2019 Nov 6. Review.


State-Dependent Changes in Brain Glycogen Metabolism.

DiNuzzo M, Walls AB, Öz G, Seaquist ER, Waagepetersen HS, Bak LK, Nedergaard M, Schousboe A.

Adv Neurobiol. 2019;23:269-309. doi: 10.1007/978-3-030-27480-1_9. Review.


Astrocytes in chronic pain and itch.

Ji RR, Donnelly CR, Nedergaard M.

Nat Rev Neurosci. 2019 Nov;20(11):667-685. doi: 10.1038/s41583-019-0218-1. Epub 2019 Sep 19. Review.


In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.

Sweeney AM, Plá V, Du T, Liu G, Sun Q, Peng S, Plog BA, Kress BT, Wang X, Mestre H, Nedergaard M.

J Vis Exp. 2019 Jul 29;(149). doi: 10.3791/59774.


Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice.

Rasmussen R, Nicholas E, Petersen NC, Dietz AG, Xu Q, Sun Q, Nedergaard M.

Cell Rep. 2019 Jul 30;28(5):1182-1194.e4. doi: 10.1016/j.celrep.2019.06.082.


Longitudinal shear waves for elastic characterization of tissues in optical coherence elastography.

Zvietcovich F, Ge GR, Mestre H, Giannetto M, Nedergaard M, Rolland JP, Parker KJ.

Biomed Opt Express. 2019 Jul 1;10(7):3699-3718. doi: 10.1364/BOE.10.003699. eCollection 2019 Jul 1.


Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.

Wang M, Qin C, Luo X, Wang J, Wang X, Xie M, Hu J, Cao J, Hu T, Goldman SA, Nedergaard M, Wang W.

Theranostics. 2019 Jun 9;9(15):4474-4493. doi: 10.7150/thno.31942. eCollection 2019.


Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.

Grutzendler J, Nedergaard M.

Trends Neurosci. 2019 Aug;42(8):528-536. doi: 10.1016/j.tins.2019.05.009. Epub 2019 Jun 26. Review.


Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.

Smith NA, Bekar LK, Nedergaard M.

Neurochem Res. 2020 Jan;45(1):100-108. doi: 10.1007/s11064-019-02834-0. Epub 2019 Jun 28.


Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Liu Z, Osipovitch M, Benraiss A, Huynh NPT, Foti R, Bates J, Chandler-Militello D, Findling RL, Tesar PJ, Nedergaard M, Windrem MS, Goldman SA.

Cell Rep. 2019 Jun 25;27(13):3832-3843.e6. doi: 10.1016/j.celrep.2019.05.088.


Hydraulic resistance of periarterial spaces in the brain.

Tithof J, Kelley DH, Mestre H, Nedergaard M, Thomas JH.

Fluids Barriers CNS. 2019 Jun 20;16(1):19. doi: 10.1186/s12987-019-0140-y.


Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.

Mortensen KN, Sanggaard S, Mestre H, Lee H, Kostrikov S, Xavier ALR, Gjedde A, Benveniste H, Nedergaard M.

J Neurosci. 2019 Aug 7;39(32):6365-6377. doi: 10.1523/JNEUROSCI.1974-18.2019. Epub 2019 Jun 17.


Oxygen tension-mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia.

Zhou S, Giannetto M, DeCourcey J, Kang H, Kang N, Li Y, Zheng S, Zhao H, Simmons WR, Wei HS, Bodine DM, Low PS, Nedergaard M, Wan J.

Sci Adv. 2019 May 29;5(5):eaaw4466. doi: 10.1126/sciadv.aaw4466. eCollection 2019 May.


When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow.

Plog BA, Lou N, Pierre CA, Cove A, Kenney HM, Hitomi E, Kang H, Iliff JJ, Zeppenfeld DM, Nedergaard M, Vates GE.

J Neurosurg. 2019 May 17:1-14. doi: 10.3171/2019.2.JNS182675. [Epub ahead of print]


Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.

Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M, Hirase H.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):11010-11019. doi: 10.1073/pnas.1817347116. Epub 2019 May 16.


Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.

Lilius TO, Blomqvist K, Hauglund NL, Liu G, Stæger FF, Bærentzen S, Du T, Ahlström F, Backman JT, Kalso EA, Rauhala PV, Nedergaard M.

J Control Release. 2019 Jun 28;304:29-38. doi: 10.1016/j.jconrel.2019.05.005. Epub 2019 May 5.


PDGF-B Is Required for Development of the Glymphatic System.

Munk AS, Wang W, Bèchet NB, Eltanahy AM, Cheng AX, Sigurdsson B, Benraiss A, Mäe MA, Kress BT, Kelley DH, Betsholtz C, Møllgård K, Meissner A, Nedergaard M, Lundgaard I.

Cell Rep. 2019 Mar 12;26(11):2955-2969.e3. doi: 10.1016/j.celrep.2019.02.050.


Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.

Hablitz LM, Vinitsky HS, Sun Q, Stæger FF, Sigurdsson B, Mortensen KN, Lilius TO, Nedergaard M.

Sci Adv. 2019 Feb 27;5(2):eaav5447. doi: 10.1126/sciadv.aav5447. eCollection 2019 Feb.


Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI.

Koundal S, Liu X, Sanggaard S, Mortensen K, Wardlaw J, Nedergaard M, Benveniste H, Lee H.

Neuroscience. 2019 Apr 15;404:14-26. doi: 10.1016/j.neuroscience.2019.01.030. Epub 2019 Jan 26.


Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.

Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222.


Cisterna Magna Injection in Rats to Study Glymphatic Function.

Ramos M, Burdon Bechet N, Battistella R, Pavan C, Xavier ALR, Nedergaard M, Lundgaard I.

Methods Mol Biol. 2019;1938:97-104. doi: 10.1007/978-1-4939-9068-9_7.


Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.

Cai R, Pan C, Ghasemigharagoz A, Todorov MI, Förstera B, Zhao S, Bhatia HS, Parra-Damas A, Mrowka L, Theodorou D, Rempfler M, Xavier ALR, Kress BT, Benakis C, Steinke H, Liebscher S, Bechmann I, Liesz A, Menze B, Kerschensteiner M, Nedergaard M, Ertürk A.

Nat Neurosci. 2019 Feb;22(2):317-327. doi: 10.1038/s41593-018-0301-3. Epub 2018 Dec 31.


Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M.

Elife. 2018 Dec 18;7. pii: e40070. doi: 10.7554/eLife.40070.


Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M.

JCI Insight. 2018 Dec 6;3(23). pii: 126138. doi: 10.1172/jci.insight.126138. No abstract available.


Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH.

Nat Commun. 2018 Nov 19;9(1):4878. doi: 10.1038/s41467-018-07318-3.


The glymphatic pathway in neurological disorders.

Rasmussen MK, Mestre H, Nedergaard M.

Lancet Neurol. 2018 Nov;17(11):1016-1024. doi: 10.1016/S1474-4422(18)30318-1. Review.


Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M.

JCI Insight. 2018 Oct 18;3(20). pii: 120922. doi: 10.1172/jci.insight.120922. Erratum in: JCI Insight. 2018 Dec 6;3(23):.


Altered physiological brain variation in drug-resistant epilepsy.

Kananen J, Tuovinen T, Ansakorpi H, Rytky S, Helakari H, Huotari N, Raitamaa L, Raatikainen V, Rasila A, Borchardt V, Korhonen V, LeVan P, Nedergaard M, Kiviniemi V.

Brain Behav. 2018 Sep;8(9):e01090. doi: 10.1002/brb3.1090. Epub 2018 Aug 15.


Cerebral Metabolic Changes During Sleep.

Aalling NN, Nedergaard M, DiNuzzo M.

Curr Neurol Neurosci Rep. 2018 Jul 16;18(9):57. doi: 10.1007/s11910-018-0868-9. Review.


VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance.

Michaelsen SR, Staberg M, Pedersen H, Jensen KE, Majewski W, Broholm H, Nedergaard MK, Meulengracht C, Urup T, Villingshøj M, Lukacova S, Skjøth-Rasmussen J, Brennum J, Kjær A, Lassen U, Stockhausen MT, Poulsen HS, Hamerlik P.

Neuro Oncol. 2018 Oct 9;20(11):1462-1474. doi: 10.1093/neuonc/noy103.


Cannula Implantation into the Cisterna Magna of Rodents.

Xavier ALR, Hauglund NL, von Holstein-Rathlou S, Li Q, Sanggaard S, Lou N, Lundgaard I, Nedergaard M.

J Vis Exp. 2018 May 23;(135). doi: 10.3791/57378.


Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure.

Obara-Michlewska M, Ding F, Popek M, Verkhratsky A, Nedergaard M, Zielinska M, Albrecht J.

Neurochem Int. 2018 Sep;118:286-291. doi: 10.1016/j.neuint.2018.05.007. Epub 2018 May 14.


Understanding the role of the perivascular space in cerebral small vessel disease.

Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM.

Cardiovasc Res. 2018 Sep 1;114(11):1462-1473. doi: 10.1093/cvr/cvy113. Review.


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30.


Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.

Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M.

Sci Rep. 2018 Feb 2;8(1):2246. doi: 10.1038/s41598-018-20424-y.


Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.

Smith NA, Kress BT, Lu Y, Chandler-Militello D, Benraiss A, Nedergaard M.

Sci Signal. 2018 Jan 30;11(515). pii: eaal2039. doi: 10.1126/scisignal.aal2039.


Physiology of Astroglia.

Verkhratsky A, Nedergaard M.

Physiol Rev. 2018 Jan 1;98(1):239-389. doi: 10.1152/physrev.00042.2016. Review.


The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future.

Plog BA, Nedergaard M.

Annu Rev Pathol. 2018 Jan 24;13:379-394. doi: 10.1146/annurev-pathol-051217-111018. Review.

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