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Regulation of thermogenic capacity in brown and white adipocytes by the prebiotic high-esterified pectin and its postbiotic acetate.

García-Carrizo F, Cannon B, Nedergaard J, Picó C, Dols A, Rodríguez AM, Palou A.

Int J Obes (Lond). 2019 Aug 29. doi: 10.1038/s41366-019-0445-6. [Epub ahead of print]


Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?

Luijten IHN, Cannon B, Nedergaard J.

Mol Aspects Med. 2019 Aug;68:42-59. doi: 10.1016/j.mam.2019.07.002. Epub 2019 Jul 27. Review.


The answer to the question "What is the best housing temperature to translate mouse experiments to humans?" is: thermoneutrality.

Fischer AW, Cannon B, Nedergaard J.

Mol Metab. 2019 Aug;26:1-3. doi: 10.1016/j.molmet.2019.05.006. Epub 2019 May 18. No abstract available.


At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1.

Dittner C, Lindsund E, Cannon B, Nedergaard J.

Mol Metab. 2019 Jul;25:20-34. doi: 10.1016/j.molmet.2019.05.005. Epub 2019 May 26.


Glucocorticoid-Induced Obesity Develops Independently of UCP1.

Luijten IHN, Brooks K, Boulet N, Shabalina IG, Jaiprakash A, Carlsson B, Fischer AW, Cannon B, Nedergaard J.

Cell Rep. 2019 May 7;27(6):1686-1698.e5. doi: 10.1016/j.celrep.2019.04.041.


In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain.

Luijten IHN, Feldmann HM, von Essen G, Cannon B, Nedergaard J.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E729-E740. doi: 10.1152/ajpendo.00020.2019. Epub 2019 Feb 26.


Intact innervation is essential for diet-induced recruitment of brown adipose tissue.

Fischer AW, Schlein C, Cannon B, Heeren J, Nedergaard J.

Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E487-E503. doi: 10.1152/ajpendo.00443.2018. Epub 2018 Dec 21.


Brown adipose tissue as a heat-producing thermoeffector.

Nedergaard J, Cannon B.

Handb Clin Neurol. 2018;156:137-152. doi: 10.1016/B978-0-444-63912-7.00009-6. Review.


Role Differences in Healthcare: Overcoming Borders through Semiotic Skin is the Basis for Communication.

Nedergaard JI.

Integr Psychol Behav Sci. 2019 Jun;53(2):283-297. doi: 10.1007/s12124-018-9458-2.


Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity.

Hagberg CE, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina IG, Harms MJ, Shilkova O, Kozina V, Nedergaard J, Boucher J, Thorell A, Spalding KL.

Cell Rep. 2018 Sep 4;24(10):2746-2756.e5. doi: 10.1016/j.celrep.2018.08.006.


Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes.

de Jong JMA, Cannon B, Nedergaard J.

Adipocyte. 2018;7(3):166-179. doi: 10.1080/21623945.2018.1479578. Epub 2018 Jul 16.


Cell proliferation and apoptosis inhibition: essential processes for recruitment of the full thermogenic capacity of brown adipose tissue.

Nedergaard J, Wang Y, Cannon B.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jan;1864(1):51-58. doi: 10.1016/j.bbalip.2018.06.013. Epub 2018 Jun 14. Review.


Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study.

Fischer AW, Cannon B, Nedergaard J.

Mol Metab. 2018 Jan;7:161-170. doi: 10.1016/j.molmet.2017.10.009. Epub 2017 Oct 31.


What Ignites UCP1?

Cannon B, Nedergaard J.

Cell Metab. 2017 Nov 7;26(5):697-698. doi: 10.1016/j.cmet.2017.10.012.


Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice.

von Essen G, Lindsund E, Cannon B, Nedergaard J.

Am J Physiol Endocrinol Metab. 2017 Nov 1;313(5):E515-E527. doi: 10.1152/ajpendo.00097.2017. Epub 2017 Jul 5.


β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway.

Olsen JM, Csikasz RI, Dehvari N, Lu L, Sandström A, Öberg AI, Nedergaard J, Stone-Elander S, Bengtsson T.

Mol Metab. 2017 Mar 30;6(6):611-619. doi: 10.1016/j.molmet.2017.02.006. eCollection 2017 Jun.


Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.

Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C.

Nat Med. 2017 May;23(5):623-630. doi: 10.1038/nm.4316. Epub 2017 Apr 17.


The β3-adrenergic receptor is dispensable for browning of adipose tissues.

de Jong JMA, Wouters RTF, Boulet N, Cannon B, Nedergaard J, Petrovic N.

Am J Physiol Endocrinol Metab. 2017 Jun 1;312(6):E508-E518. doi: 10.1152/ajpendo.00437.2016. Epub 2017 Feb 21.


Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.

Shabalina IG, Vyssokikh MY, Gibanova N, Csikasz RI, Edgar D, Hallden-Waldemarson A, Rozhdestvenskaya Z, Bakeeva LE, Vays VB, Pustovidko AV, Skulachev MV, Cannon B, Skulachev VP, Nedergaard J.

Aging (Albany NY). 2017 Feb 15;9(2):315-339. doi: 10.18632/aging.101174.


Leptin-deficient mice are not hypothermic, they are anapyrexic.

Fischer AW, Cannon B, Nedergaard J.

Mol Metab. 2016 Nov 9;6(2):173. doi: 10.1016/j.molmet.2016.10.012. eCollection 2017 Feb. No abstract available.


UCP1 in adipose tissues: two steps to full browning.

Kalinovich AV, de Jong JM, Cannon B, Nedergaard J.

Biochimie. 2017 Mar;134:127-137. doi: 10.1016/j.biochi.2017.01.007. Epub 2017 Jan 18.


UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment.

Fischer AW, Shabalina IG, Mattsson CL, Abreu-Vieira G, Cannon B, Nedergaard J, Petrovic N.

Am J Physiol Endocrinol Metab. 2017 Jan 1;312(1):E72-E87. doi: 10.1152/ajpendo.00284.2016. Epub 2016 Dec 6.


Reply to letter to the editor: at thermoneutrality, neither the lean nor the obese freeze.

Fischer AW, Csikasz RI, von Essen G, Cannon B, Nedergaard J.

Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E639. doi: 10.1152/ajpendo.00309.2016. No abstract available.


Corrigendum: Cidea improves the metabolic profile through expansion of adipose tissue.

Abreu-Vieira G, Fischer AW, Mattsson C, de Jong JMA, Shabalina IG, Rydén M, Laurencikiene J, Arner P, Cannon B, Nedergaard J, Petrovic N.

Nat Commun. 2016 Aug 4;7:12395. doi: 10.1038/ncomms12395. No abstract available.


An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes.

Isidor MS, Winther S, Basse AL, Petersen MC, Cannon B, Nedergaard J, Hansen JB.

Adipocyte. 2015 Nov 20;5(2):175-85. doi: 10.1080/21623945.2015.1111972. eCollection 2016 Apr-Jun.


No insulating effect of obesity.

Fischer AW, Csikasz RI, von Essen G, Cannon B, Nedergaard J.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E202-13. doi: 10.1152/ajpendo.00093.2016. Epub 2016 May 17.


Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance.

Alvarez-Crespo M, Csikasz RI, Martínez-Sánchez N, Diéguez C, Cannon B, Nedergaard J, López M.

Mol Metab. 2016 Feb 10;5(4):271-282. doi: 10.1016/j.molmet.2016.01.008. eCollection 2016 Apr.


Leptin Raises Defended Body Temperature without Activating Thermogenesis.

Fischer AW, Hoefig CS, Abreu-Vieira G, de Jong JMA, Petrovic N, Mittag J, Cannon B, Nedergaard J.

Cell Rep. 2016 Feb 23;14(7):1621-1631. doi: 10.1016/j.celrep.2016.01.041. Epub 2016 Feb 11.


Cidea improves the metabolic profile through expansion of adipose tissue.

Abreu-Vieira G, Fischer AW, Mattsson C, de Jong JM, Shabalina IG, Rydén M, Laurencikiene J, Arner P, Cannon B, Nedergaard J, Petrovic N.

Nat Commun. 2015 Jun 29;6:7433. doi: 10.1038/ncomms8433. Erratum in: Nat Commun. 2016 Aug 04;7:12395.


Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria.

Shabalina IG, Kalinovich AV, Cannon B, Nedergaard J.

Arch Toxicol. 2016 May;90(5):1117-28. doi: 10.1007/s00204-015-1535-4. Epub 2015 Jun 4.


The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake.

Shabalina IG, Kramarova TV, Mattsson CL, Petrovic N, Rahman Qazi M, Csikasz RI, Chang SC, Butenhoff J, DePierre JW, Cannon B, Nedergaard J.

Toxicol Sci. 2015 Aug;146(2):334-43. doi: 10.1093/toxsci/kfv098. Epub 2015 May 21.


Single Case Method in Psychology: How to Improve as a Possible Methodology in Quantitative Research.

Krause-Kjær E, Nedergaard JI.

Integr Psychol Behav Sci. 2015 Sep;49(3):350-9. doi: 10.1007/s12124-015-9309-3. Review.


Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice.

Shabalina IG, Landreh L, Edgar D, Hou M, Gibanova N, Atanassova N, Petrovic N, Hultenby K, Söder O, Nedergaard J, Svechnikov K.

FASEB J. 2015 Aug;29(8):3274-86. doi: 10.1096/fj.15-271825. Epub 2015 Apr 21.


A stringent validation of mouse adipose tissue identity markers.

de Jong JM, Larsson O, Cannon B, Nedergaard J.

Am J Physiol Endocrinol Metab. 2015 Jun 15;308(12):E1085-105. doi: 10.1152/ajpendo.00023.2015. Epub 2015 Apr 21.


Genetic and functional characterization of clonally derived adult human brown adipocytes.

Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S.

Nat Med. 2015 Apr;21(4):389-94. doi: 10.1038/nm.3819. Epub 2015 Mar 16.


Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis.

Abreu-Vieira G, Hagberg CE, Spalding KL, Cannon B, Nedergaard J.

Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E822-9. doi: 10.1152/ajpendo.00494.2014. Epub 2015 Mar 3.


Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues.

Hansen IR, Jansson KM, Cannon B, Nedergaard J.

Biochim Biophys Acta. 2014 Dec;1841(12):1691-9.


The browning of white adipose tissue: some burning issues.

Nedergaard J, Cannon B.

Cell Metab. 2014 Sep 2;20(3):396-407. doi: 10.1016/j.cmet.2014.07.005. Epub 2014 Aug 7.


Protein kinase a-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR.

Wang Y, Sato M, Guo Y, Bengtsson T, Nedergaard J.

Exp Cell Res. 2014 Oct 15;328(1):143-55. doi: 10.1016/j.yexcr.2014.07.029. Epub 2014 Aug 4.


ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence.

Shabalina IG, Vrbacký M, Pecinová A, Kalinovich AV, Drahota Z, Houštěk J, Mráček T, Cannon B, Nedergaard J.

Biochim Biophys Acta. 2014 Dec;1837(12):2017-2030. doi: 10.1016/j.bbabio.2014.04.005. Epub 2014 Apr 24.


Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.

Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS.

EMBO J. 2014 Mar 3;33(5):418-36. doi: 10.1002/embj.201385014. Epub 2014 Jan 15.


UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.

Shabalina IG, Petrovic N, de Jong JM, Kalinovich AV, Cannon B, Nedergaard J.

Cell Rep. 2013 Dec 12;5(5):1196-203. doi: 10.1016/j.celrep.2013.10.044. Epub 2013 Nov 27.


Brown adipose tissue as an anti-obesity tissue in humans.

Chechi K, Nedergaard J, Richard D.

Obes Rev. 2014 Feb;15(2):92-106. doi: 10.1111/obr.12116. Epub 2013 Oct 25. Review.


In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation.

Wang Y, Fälting JM, Mattsson CL, Holmström TE, Nedergaard J.

Exp Cell Res. 2013 Oct 15;319(17):2718-27. doi: 10.1016/j.yexcr.2013.08.007. Epub 2013 Aug 13.


Human mediastinal adipose tissue displays certain characteristics of brown fat.

Cheung L, Gertow J, Werngren O, Folkersen L, Petrovic N, Nedergaard J, Franco-Cereceda A, Eriksson P, Fisher RM.

Nutr Diabetes. 2013 May 13;3:e66. doi: 10.1038/nutd.2013.6.


A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.

Jespersen NZ, Larsen TJ, Peijs L, Daugaard S, Homøe P, Loft A, de Jong J, Mathur N, Cannon B, Nedergaard J, Pedersen BK, Møller K, Scheele C.

Cell Metab. 2013 May 7;17(5):798-805. doi: 10.1016/j.cmet.2013.04.011.


How brown is brown fat? It depends where you look.

Nedergaard J, Cannon B.

Nat Med. 2013 May;19(5):540-1. doi: 10.1038/nm.3187. No abstract available.


ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes.

Dixen K, Basse AL, Murholm M, Isidor MS, Hansen LH, Petersen MC, Madsen L, Petrovic N, Nedergaard J, Quistorff B, Hansen JB.

Obesity (Silver Spring). 2013 Mar;21(3):516-24. doi: 10.1002/oby.20067.


UCP1 mRNA does not produce heat.

Nedergaard J, Cannon B.

Biochim Biophys Acta. 2013 May;1831(5):943-9. doi: 10.1016/j.bbalip.2013.01.009. Epub 2013 Jan 22.


An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes.

Gburcik V, Cawthorn WP, Nedergaard J, Timmons JA, Cannon B.

Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1053-60. doi: 10.1152/ajpendo.00104.2012. Epub 2012 Aug 21.

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