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Items: 37

1.

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.

Benzine T, Brandt R, Lovell WC, Yamane D, Neddermann P, De Francesco R, Lemon SM, Perelson AS, Ke R, McGivern DR.

PLoS Pathog. 2017 Jun 8;13(6):e1006343. doi: 10.1371/journal.ppat.1006343. eCollection 2017 Jun.

2.

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Florian WR, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.

Nat Microbiol. 2017 Jan 23;2:17012. doi: 10.1038/nmicrobiol.2017.12. No abstract available.

PMID:
28112725
3.

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.

Nat Microbiol. 2016 Dec 19;2:16247. doi: 10.1038/nmicrobiol.2016.247. Erratum in: Nat Microbiol. 2017 Jan 23;2:17012.

PMID:
27991882
4.

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming.

Nizzoli G, Larghi P, Paroni M, Crosti MC, Moro M, Neddermann P, Caprioli F, Pagani M, De Francesco R, Abrignani S, Geginat J.

Eur J Immunol. 2016 Jul;46(7):1622-32. doi: 10.1002/eji.201546136. Epub 2016 May 17.

5.

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

Cheroni C, Donnici L, Aghemo A, Balistreri F, Bianco A, Zanoni V, Pagani M, Soffredini R, D'Ambrosio R, Rumi MG, Colombo M, Abrignani S, Neddermann P, De Francesco R.

PLoS One. 2015 Sep 25;10(9):e0138546. doi: 10.1371/journal.pone.0138546. eCollection 2015.

6.

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes.

Reghellin V, Donnici L, Fenu S, Berno V, Calabrese V, Pagani M, Abrignani S, Peri F, De Francesco R, Neddermann P.

Antimicrob Agents Chemother. 2014 Dec;58(12):7128-40. doi: 10.1128/AAC.03293-14. Epub 2014 Sep 15.

7.

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

McGivern DR, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, Asante-Appiah E, Neddermann P, De Francesco R, Howe AY, Lemon SM.

Gastroenterology. 2014 Aug;147(2):453-62.e7. doi: 10.1053/j.gastro.2014.04.021. Epub 2014 Apr 22.

8.

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW.

Gastroenterology. 2014 May;146(5):1373-85.e1-11. doi: 10.1053/j.gastro.2014.02.002. Epub 2014 Feb 8.

9.

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.

Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, Bianco A, Steckel B, Moro M, Crosti M, Romagnani C, Stölzel K, Torretta S, Pignataro L, Scheibenbogen C, Neddermann P, De Francesco R, Abrignani S, Geginat J.

Blood. 2013 Aug 8;122(6):932-42. doi: 10.1182/blood-2013-04-495424. Epub 2013 Jun 21.

10.

Hepatitis C virus-specific directly acting antiviral drugs.

Delang L, Neyts J, Vliegen I, Abrignani S, Neddermann P, De Francesco R.

Curr Top Microbiol Immunol. 2013;369:289-320. doi: 10.1007/978-3-642-27340-7_12. Review.

PMID:
23463206
11.

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.

Bianco A, Reghellin V, Donnici L, Fenu S, Alvarez R, Baruffa C, Peri F, Pagani M, Abrignani S, Neddermann P, De Francesco R.

PLoS Pathog. 2012;8(3):e1002576. doi: 10.1371/journal.ppat.1002576. Epub 2012 Mar 8.

12.

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture.

Conte I, Giuliano C, Ercolani C, Narjes F, Koch U, Rowley M, Altamura S, De Francesco R, Neddermann P, Migliaccio G, Stansfield I.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1779-83. doi: 10.1016/j.bmcl.2009.01.066. Epub 2009 Jan 27.

PMID:
19216075
13.

NS5A phosphorylation and hyperphosphorylation.

Neddermann P.

Methods Mol Biol. 2009;510:95-110. doi: 10.1007/978-1-59745-394-3_8.

PMID:
19009256
14.

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain.

Bottomley MJ, Lo Surdo P, Di Giovine P, Cirillo A, Scarpelli R, Ferrigno F, Jones P, Neddermann P, De Francesco R, Steinkühler C, Gallinari P, Carfí A.

J Biol Chem. 2008 Sep 26;283(39):26694-704. doi: 10.1074/jbc.M803514200. Epub 2008 Jul 8.

15.

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.

Jones P, Altamura S, De Francesco R, Gallinari P, Lahm A, Neddermann P, Rowley M, Serafini S, Steinkühler C.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1814-9. doi: 10.1016/j.bmcl.2008.02.025. Epub 2008 Feb 14.

PMID:
18308563
16.

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, Sambucini S, Bottomley MJ, Lo Surdo P, Carfí A, Koch U, De Francesco R, Steinkühler C, Gallinari P.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17335-40. Epub 2007 Oct 23.

17.

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.

Quintavalle M, Sambucini S, Summa V, Orsatti L, Talamo F, De Francesco R, Neddermann P.

J Biol Chem. 2007 Feb 23;282(8):5536-44. Epub 2006 Dec 13.

18.

The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation.

Quintavalle M, Sambucini S, Di Pietro C, De Francesco R, Neddermann P.

J Virol. 2006 Nov;80(22):11305-12. Epub 2006 Aug 30.

19.

Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture.

Neddermann P, Quintavalle M, Di Pietro C, Clementi A, Cerretani M, Altamura S, Bartholomew L, De Francesco R.

J Virol. 2004 Dec;78(23):13306-14.

21.

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR.

Neddermann P, Gargioli C, Muraglia E, Sambucini S, Bonelli F, De Francesco R, Cortese R.

EMBO Rep. 2003 Feb;4(2):159-65. Erratum in: EMBO Rep. 2003 Apr;4(4):439.

22.
23.

The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA.

Vannini A, Volpari C, Gargioli C, Muraglia E, Cortese R, De Francesco R, Neddermann P, Marco SD.

EMBO J. 2002 Sep 2;21(17):4393-401.

24.

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG.

J Virol. 2002 Sep;76(18):9207-17.

25.

Crystallization and preliminary X-ray diffraction studies of the transcriptional regulator TraR bound to its cofactor and to a specific DNA sequence.

Vannini A, Volpari C, Gargioli C, Muraglia E, De Francesco R, Neddermann P, Di Marco S.

Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1362-4. Epub 2002 Jul 20.

PMID:
12136156
26.
27.

Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.

Katze MG, Kwieciszewski B, Goodlett DR, Blakely CM, Neddermann P, Tan SL, Aebersold R.

Virology. 2000 Dec 20;278(2):501-13.

28.

Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.

De Francesco R, Neddermann P, Tomei L, Steinkühler C, Gallinari P, Folgori A.

Semin Liver Dis. 2000;20(1):69-83. Review.

PMID:
10895433
30.
31.

The nonstructural proteins of the hepatitis C virus: structure and functions.

Neddermann P, Tomei L, Steinkühler C, Gallinari P, Tramontano A, De Francesco R.

Biol Chem. 1997 Jun;378(6):469-76. Review.

PMID:
9224925
32.
33.

Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase.

Neddermann P, Gallinari P, Lettieri T, Schmid D, Truong O, Hsuan JJ, Wiebauer K, Jiricny J.

J Biol Chem. 1996 May 31;271(22):12767-74.

34.

Interleukin-10 induces interleukin-11 responsiveness in human myeloma cell lines.

Lu ZY, Gu ZJ, Zhang XG, Wijdenes J, Neddermann P, Rossi JF, Klein B.

FEBS Lett. 1995 Dec 27;377(3):515-8.

35.
36.

The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.

Neddermann P, Jiricny J.

J Biol Chem. 1993 Oct 5;268(28):21218-24.

37.

The repair of 5-methylcytosine deamination damage.

Wiebauer K, Neddermann P, Hughes M, Jiricny J.

EXS. 1993;64:510-22. Review. No abstract available.

PMID:
8380355

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