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Items: 35


Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.

Lu Y, Zheng Y, Coyaud É, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught B, Sun Q, Neculai D.

Science. 2019 Oct 25;366(6464):460-467. doi: 10.1126/science.aau6391. Epub 2019 Oct 24.


Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D.

Nat Commun. 2019 Aug 6;10(1):3521. doi: 10.1038/s41467-019-11425-0.


CD36 mediates albumin transcytosis by dermal but not lung microvascular endothelial cells: role in fatty acid delivery.

Raheel H, Ghaffari S, Khosraviani N, Mintsopoulos V, Auyeung D, Wang C, Kim YH, Mullen B, Sung HK, Ho M, Fairn G, Neculai D, Febbraio M, Heit B, Lee WL.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L740-L750. doi: 10.1152/ajplung.00127.2018. Epub 2019 Jan 31.


Plasmodium falciparum-CD36 Structure-Function Relationships Defined by Ortholog Scanning Mutagenesis.

Cabrera A, Neculai D, Tran V, Lavstsen T, Turner L, Kain KC.

J Infect Dis. 2019 Feb 23;219(6):945-954. doi: 10.1093/infdis/jiy607.


A Subpopulation of Intracellular Neisseria gonorrhoeae Escapes Autophagy-Mediated Killing Inside Epithelial Cells.

Lu P, Wang S, Lu Y, Neculai D, Sun Q, van der Veen S.

J Infect Dis. 2019 Jan 1;219(1):133-144. doi: 10.1093/infdis/jiy237.


Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity.

Hu L, Xu J, Xie X, Zhou Y, Tao P, Li H, Han X, Wang C, Liu J, Xu P, Neculai D, Xia Z.

Nat Commun. 2017 Oct 9;8(1):814. doi: 10.1038/s41467-017-01290-0.


Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins.

Korzhnev DM, Neculai D, Dhe-Paganon S, Arrowsmith CH, Bezsonova I.

J Biomol NMR. 2016 Nov;66(3):209-219. Epub 2016 Oct 22.


In silico predicted structural and functional insights of all missense mutations on 2B domain of K1/K10 causing genodermatoses.

Banerjee S, Wu Q, Ying Y, Li Y, Shirota M, Neculai D, Li C.

Oncotarget. 2016 Aug 16;7(33):52766-52780. doi: 10.18632/oncotarget.10599.


Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration.

Jiang Y, Cai Y, Zhang W, Yin Z, Hu C, Tong T, Lu P, Zhang S, Neculai D, Tuan RS, Ouyang HW.

Stem Cells Transl Med. 2016 Jun;5(6):733-44. doi: 10.5966/sctm.2015-0192. Epub 2016 Apr 29.


Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.

Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S.

J Biol Chem. 2016 Apr 15;291(16):8414-27. doi: 10.1074/jbc.M116.720201. Epub 2016 Feb 23.


Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling.

Achar YJ, Balogh D, Neculai D, Juhasz S, Morocz M, Gali H, Dhe-Paganon S, Venclovas Č, Haracska L.

Nucleic Acids Res. 2015 Dec 2;43(21):10277-91. doi: 10.1093/nar/gkv896. Epub 2015 Sep 8.


A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.

Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, Lee WL.

Cardiovasc Res. 2015 Nov 1;108(2):268-77. doi: 10.1093/cvr/cvv218. Epub 2015 Sep 2.


CD36 and malaria: friends or foes? A decade of data provides some answers.

Cabrera A, Neculai D, Kain KC.

Trends Parasitol. 2014 Sep;30(9):436-44. doi: 10.1016/ Epub 2014 Aug 8. Review.


Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells.

Ji J, Sharma V, Qi S, Guarch ME, Zhao P, Luo Z, Fan W, Wang Y, Mbabaali F, Neculai D, Esteban MA, McPherson JD, Batada NN.

Stem Cell Reports. 2014 Jan 2;2(1):44-51. doi: 10.1016/j.stemcr.2013.11.004. eCollection 2014 Jan 14.


Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.

Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S.

Nature. 2013 Dec 5;504(7478):172-6. doi: 10.1038/nature12684. Epub 2013 Oct 27.


Scavenger receptors in homeostasis and immunity.

Canton J, Neculai D, Grinstein S.

Nat Rev Immunol. 2013 Sep;13(9):621-34. doi: 10.1038/nri3515. Epub 2013 Aug 9. Review.


Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F.

Nucleic Acids Res. 2013 Jul;41(12):6332-46. doi: 10.1093/nar/gkt322. Epub 2013 Apr 25.


A strategy for modulation of enzymes in the ubiquitin system.

Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS.

Science. 2013 Feb 1;339(6119):590-5. doi: 10.1126/science.1230161. Epub 2013 Jan 3.


Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.

Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN.

J Biol Chem. 2012 Jul 6;287(28):23900-10. doi: 10.1074/jbc.M112.359653. Epub 2012 May 15.


A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

Sheng Y, Hong JH, Doherty R, Srikumar T, Shloush J, Avvakumov GV, Walker JR, Xue S, Neculai D, Wan JW, Kim SK, Arrowsmith CH, Raught B, Dhe-Paganon S.

Mol Cell Proteomics. 2012 Aug;11(8):329-41. doi: 10.1074/mcp.O111.013706. Epub 2012 Apr 10.


Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells.

Ji J, Ng SH, Sharma V, Neculai D, Hussein S, Sam M, Trinh Q, Church GM, McPherson JD, Nagy A, Batada NN.

Stem Cells. 2012 Mar;30(3):435-40. doi: 10.1002/stem.1011.


An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.

Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16.


Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.

Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG.

J Mol Biol. 2009 Sep 25;392(3):701-22. doi: 10.1016/j.jmb.2009.07.030. Epub 2009 Jul 17.


Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F.

Mol Cell. 2008 Oct 24;32(2):259-75. doi: 10.1016/j.molcel.2008.10.002.


Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing.

Lee KP, Dey M, Neculai D, Cao C, Dever TE, Sicheri F.

Cell. 2008 Jan 11;132(1):89-100. doi: 10.1016/j.cell.2007.10.057.


Seasonal variations in mood and behavior in Romanian postgraduate students.

Soriano JJ, Ciupagea C, Rohan KJ, Neculai DB, Yousufi SM, Guzman A, Postolache TT.

ScientificWorldJournal. 2007 Jun 12;7:870-9.


Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M.

Cell. 2007 Jun 15;129(6):1165-76.


Structure of the unphosphorylated STAT5a dimer.

Neculai D, Neculai AM, Verrier S, Straub K, Klumpp K, Pfitzner E, Becker S.

J Biol Chem. 2005 Dec 9;280(49):40782-7. Epub 2005 Sep 28.


Preparation of [LAl(mu-S)2MCp2] (M = Ti, Zr) from the structurally characterized lithium complexes [[LAl(SH)[SLi(thf)2]]2] and [[LAl[(SLi)2(thf)3]]2]2 THF.

Jancik V, Roesky HW, Neculai D, Neculai AM, Herbst-Irmer R.

Angew Chem Int Ed Engl. 2004 Nov 19;43(45):6192-6. No abstract available.


A dynamic zinc redox switch.

Neculai AM, Neculai D, Griesinger C, Vorholt JA, Becker S.

J Biol Chem. 2005 Jan 28;280(4):2826-30. Epub 2004 Nov 17.


Preparation and structure of the first germanium(II) hydroxide: the congener of an unknown low-valent carbon analogue.

Pineda LW, Jancik V, Roesky HW, Neculai D, Neculai AM.

Angew Chem Int Ed Engl. 2004 Mar 5;43(11):1419-21. No abstract available.


Preparation of monomeric [LAl(NH2)2]--a main-group metal diamide containing two terminal NH2 groups.

Jancik V, Pineda LW, Pinkas J, Roesky HW, Neculai D, Neculai AM, Herbst-Irmer R.

Angew Chem Int Ed Engl. 2004 Apr 13;43(16):2142-5. No abstract available.


Elucidation of a Sc(I) complex by DFT calculations and reactivity studies.

Neculai AM, Cummins CC, Neculai D, Roesky HW, Bunkòczi G, Walfort B, Stalke D.

Inorg Chem. 2003 Dec 29;42(26):8803-10.


Formation and characterization of the first monoalumoxane, LAlO.B(C6F5)3.

Neculai D, Roesky HW, Neculai AM, Magull J, Walfort B, Stalke D.

Angew Chem Int Ed Engl. 2002 Nov 15;41(22):4294-6. No abstract available.


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