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Items: 1 to 50 of 166

1.

Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.

Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X.

Nat Commun. 2019 Oct 7;10(1):4605. doi: 10.1038/s41467-019-12578-8.

2.

Neuronal p38α mediates age-associated neural stem cell exhaustion and cognitive decline.

Moreno-Cugnon L, Revuelta M, Arrizabalaga O, Colie S, Moreno-Valladares M, Jimenez-Blasco D, Gil-Bea F, Llarena I, Bolaños JP, Nebreda AR, Matheu A.

Aging Cell. 2019 Sep 27:e13044. doi: 10.1111/acel.13044. [Epub ahead of print]

3.

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules.

Casadomé-Perales Á, Matteis L, Alleva M, Infantes-Rodríguez C, Palomares-Pérez I, Saito T, Saido TC, Esteban JA, Nebreda AR, de la Fuente JM, Dotti CG.

Nanomedicine (Lond). 2019 Sep;14(18):2409-2422. doi: 10.2217/nnm-2018-0496. Epub 2019 Aug 28.

PMID:
31456488
4.

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.

Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X.

Nat Commun. 2019 Aug 8;10(1):3562. doi: 10.1038/s41467-019-11594-y. Erratum in: Nat Commun. 2019 Oct 7;10(1):4605.

5.

Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38α through TGF-β and JNK signaling.

Batlle R, Andrés E, Gonzalez L, Llonch E, Igea A, Gutierrez-Prat N, Berenguer-Llergo A, Nebreda AR.

Nat Commun. 2019 Jul 11;10(1):3071. doi: 10.1038/s41467-019-10946-y.

6.

Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism.

Martín-Segura A, Casadomé-Perales Á, Fazzari P, Mas JM, Artigas L, Valls R, Nebreda AR, Dotti CG.

Front Neurol. 2019 Jun 25;10:675. doi: 10.3389/fneur.2019.00675. eCollection 2019.

7.

Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory.

Navarrete M, Cuartero MI, Palenzuela R, Draffin JE, Konomi A, Serra I, Colié S, Castaño-Castaño S, Hasan MT, Nebreda ÁR, Esteban JA.

Nat Commun. 2019 Jul 4;10(1):2968. doi: 10.1038/s41467-019-10830-9.

8.

Autophagy-induced senescence is regulated by p38α signaling.

Slobodnyuk K, Radic N, Ivanova S, Llado A, Trempolec N, Zorzano A, Nebreda AR.

Cell Death Dis. 2019 May 15;10(6):376. doi: 10.1038/s41419-019-1607-0.

9.

Regulation of death receptor signaling by the autophagy protein TP53INP2.

Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A.

EMBO J. 2019 May 15;38(10). pii: e99300. doi: 10.15252/embj.201899300. Epub 2019 Apr 12.

PMID:
30979779
10.

p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury.

Rius-Pérez S, Tormos AM, Pérez S, Finamor I, Rada P, Valverde ÁM, Nebreda AR, Sastre J, Taléns-Visconti R.

Sci Rep. 2019 Mar 7;9(1):3775. doi: 10.1038/s41598-019-39428-3.

11.

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.

Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Nebreda AR, Lengyel E.

Cell Metab. 2019 Jan 8;29(1):141-155.e9. doi: 10.1016/j.cmet.2018.08.007. Epub 2018 Aug 30.

PMID:
30174305
12.

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.

Hu P, Nebreda AR, Hanenberg H, Kinnebrew GH, Ivan M, Yoder MC, Filippi MD, Broxmeyer HE, Kapur R.

Nat Commun. 2018 Aug 29;9(1):3518. doi: 10.1038/s41467-018-05955-2.

13.

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.

Matesanz N, Nikolic I, Leiva M, Pulgarín-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodríguez E, Beiroa D, Caballero A, Martín-García E, Acín-Pérez R, Hernández-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enríquez JA, Nogueiras R, Marcos M, Sabio G.

PLoS Biol. 2018 Jul 6;16(7):e2004455. doi: 10.1371/journal.pbio.2004455. eCollection 2018 Jul.

14.

Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis.

Youssif C, Cubillos-Rojas M, Comalada M, Llonch E, Perna C, Djouder N, Nebreda AR.

EMBO Mol Med. 2018 Jul;10(7). pii: e8403. doi: 10.15252/emmm.201708403.

15.

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR.

Cancer Cell. 2018 Jun 11;33(6):1094-1110.e8. doi: 10.1016/j.ccell.2018.04.010. Epub 2018 May 24.

16.

Publisher Correction: MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer.

Gawrzak S, Rinaldi L, Gregorio S, Arenas EJ, Salvador F, Urosevic J, Figueras-Puig C, Rojo F, Del Barco Barrantes I, Cejalvo JM, Palafox M, Guiu M, Berenguer-Llergo A, Symeonidi A, Bellmunt A, Kalafatovic D, Arnal-Estapé A, Fernández E, Müllauer B, Groeneveld R, Slobodnyuk K, Stephan-Otto Attolini C, Saura C, Arribas J, Cortes J, Rovira A, Muñoz M, Lluch A, Serra V, Albanell J, Prat A, Nebreda AR, Benitah SA, Gomis RR.

Nat Cell Biol. 2018 Aug;20(8):990. doi: 10.1038/s41556-018-0052-0.

PMID:
29674681
17.

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver.

Pérez S, Rius-Pérez S, Tormos AM, Finamor I, Nebreda ÁR, Taléns-Visconti R, Sastre J.

Redox Biol. 2018 Jun;16:276-284. doi: 10.1016/j.redox.2018.02.017. Epub 2018 Feb 17.

18.

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.

Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS, Batlle E.

Nature. 2018 Feb 22;554(7693):538-543. doi: 10.1038/nature25492. Epub 2018 Feb 14.

19.

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer.

Gawrzak S, Rinaldi L, Gregorio S, Arenas EJ, Salvador F, Urosevic J, Figueras-Puig C, Rojo F, Del Barco Barrantes I, Cejalvo JM, Palafox M, Guiu M, Berenguer-Llergo A, Symeonidi A, Bellmunt A, Kalafatovic D, Arnal-Estapé A, Fernández E, Müllauer B, Groeneveld R, Slobodnyuk K, Stephan-Otto Attolini C, Saura C, Arribas J, Cortes J, Rovira A, Muñoz M, Lluch A, Serra V, Albanell J, Prat A, Nebreda AR, Benitah SA, Gomis RR.

Nat Cell Biol. 2018 Feb;20(2):211-221. doi: 10.1038/s41556-017-0021-z. Epub 2018 Jan 22. Erratum in: Nat Cell Biol. 2018 Apr 19;:.

PMID:
29358704
20.

Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α.

Del Barco Barrantes I, Stephan-Otto Attolini C, Slobodnyuk K, Igea A, Gregorio S, Gawrzak S, Gomis RR, Nebreda AR.

Stem Cell Reports. 2018 Jan 9;10(1):257-271. doi: 10.1016/j.stemcr.2017.11.021. Epub 2017 Dec 28.

21.

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators.

De Mol E, Szulc E, Di Sanza C, Martínez-Cristóbal P, Bertoncini CW, Fenwick RB, Frigolé-Vivas M, Masín M, Hunter I, Buzón V, Brun-Heath I, García J, De Fabritiis G, Estébanez-Perpiñá E, McEwan IJ, Nebreda ÁR, Salvatella X.

Structure. 2018 Jan 2;26(1):145-152.e3. doi: 10.1016/j.str.2017.11.007. Epub 2017 Dec 7.

22.

Induction of oxidative metabolism by the p38α/MK2 pathway.

Trempolec N, Muñoz JP, Slobodnyuk K, Marin S, Cascante M, Zorzano A, Nebreda AR.

Sci Rep. 2017 Sep 12;7(1):11367. doi: 10.1038/s41598-017-11309-7.

23.

Failure to Inactivate Nuclear GSK3β by Ser389-Phosphorylation Leads to Focal Neuronal Death and Prolonged Fear Response.

Thornton TM, Hare B, Colié S, Pendlebury WW, Nebreda AR, Falls W, Jaworski DM, Rincon M.

Neuropsychopharmacology. 2018 Jan;43(2):393-405. doi: 10.1038/npp.2017.187. Epub 2017 Aug 17.

24.

p38α regulates cytokine-induced IFNγ secretion via the Mnk1/eIF4E pathway in Th1 cells.

Salvador-Bernáldez M, Mateus SB, Del Barco Barrantes I, Arthur SC, Martínez-A C, Nebreda AR, Salvador JM.

Immunol Cell Biol. 2017 Oct;95(9):814-823. doi: 10.1038/icb.2017.51. Epub 2017 Jun 14.

PMID:
28611474
25.

Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population.

Gómez-Miragaya J, Palafox M, Paré L, Yoldi G, Ferrer I, Vila S, Galván P, Pellegrini P, Pérez-Montoyo H, Igea A, Muñoz P, Esteller M, Nebreda AR, Urruticoechea A, Morilla I, Pernas S, Climent F, Soler-Monso MT, Petit A, Serra V, Prat A, González-Suárez E.

Stem Cell Reports. 2017 May 9;8(5):1392-1407. doi: 10.1016/j.stemcr.2017.03.026. Epub 2017 Apr 27.

26.

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations.

Kuzmanic A, Sutto L, Saladino G, Nebreda AR, Gervasio FL, Orozco M.

Elife. 2017 Apr 26;6. pii: e22175. doi: 10.7554/eLife.22175.

27.

Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling β-amyloid production.

Colié S, Sarroca S, Palenzuela R, Garcia I, Matheu A, Corpas R, Dotti CG, Esteban JA, Sanfeliu C, Nebreda AR.

Sci Rep. 2017 Mar 31;7:45306. doi: 10.1038/srep45306.

28.

A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling.

Terriente-Félix A, Pérez L, Bray SJ, Nebreda AR, Milán M.

Dis Model Mech. 2017 Apr 1;10(4):399-407. doi: 10.1242/dmm.028118. Epub 2017 Feb 24.

29.

p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging.

Tormos AM, Rius-Pérez S, Jorques M, Rada P, Ramirez L, Valverde ÁM, Nebreda ÁR, Sastre J, Taléns-Visconti R.

PLoS One. 2017 Feb 6;12(2):e0171738. doi: 10.1371/journal.pone.0171738. eCollection 2017.

30.

Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer.

Jaeger S, Igea A, Arroyo R, Alcalde V, Canovas B, Orozco M, Nebreda AR, Aloy P.

Cancer Res. 2017 Jan 15;77(2):459-469. doi: 10.1158/0008-5472.CAN-16-0097. Epub 2016 Nov 22.

31.

New insights into Cdk2 regulation during meiosis.

Isoda M, Mikolcevic P, Nebreda AR.

Cell Cycle. 2016 Oct 17;15(20):2681-2. doi: 10.1080/15384101.2016.1204856. Epub 2016 Jul 6. No abstract available.

32.

Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope.

Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y, Nebreda AR.

Nat Commun. 2016 Mar 30;7:11084. doi: 10.1038/ncomms11084.

33.

Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis.

Clemente-Ruiz M, Murillo-Maldonado JM, Benhra N, Barrio L, Pérez L, Quiroga G, Nebreda AR, Milán M.

Dev Cell. 2016 Feb 8;36(3):290-302. doi: 10.1016/j.devcel.2016.01.008.

34.

Long term p38-a deficiency up-regulates antioxidant enzymes through compensatory NF-?B activation.

Tormos AM, Pérez-Garrido S, Taléns-Visconti R, Nebreda ÁR, Sastre J.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S52. doi: 10.1016/j.freeradbiomed.2014.10.823. Epub 2014 Dec 10.

PMID:
26461407
35.

The Stress Kinase p38α as a Target for Cancer Therapy.

Igea A, Nebreda AR.

Cancer Res. 2015 Oct 1;75(19):3997-4002. doi: 10.1158/0008-5472.CAN-15-0173. Epub 2015 Sep 16. Review.

36.

Targeting of non-oncogene addiction.

Igea A, Gupta J, Nebreda AR.

Aging (Albany NY). 2015 Aug;7(8):525-6. No abstract available.

PMID:
26298432
Free PMC Article
37.

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors.

Gupta J, Igea A, Papaioannou M, Lopez-Casas PP, Llonch E, Hidalgo M, Gorgoulis VG, Nebreda AR.

Oncotarget. 2015 Apr 20;6(11):8539-51.

38.

Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.

Gupta J, Nebreda AR.

FEBS J. 2015 May;282(10):1841-57. doi: 10.1111/febs.13250. Epub 2015 Mar 16. Review.

39.

Oxidative Stress Is a Central Target for Physical Exercise Neuroprotection Against Pathological Brain Aging.

García-Mesa Y, Colie S, Corpas R, Cristòfol R, Comellas F, Nebreda AR, Giménez-Llort L, Sanfeliu C.

J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):40-9. doi: 10.1093/gerona/glv005. Epub 2015 Feb 26.

PMID:
25720862
40.

MAPK signaling control of colon cancer metastasis.

Urosevic J, Nebreda AR, Gomis RR.

Cell Cycle. 2014;13(17):2641-2. doi: 10.4161/15384101.2014.946374. No abstract available.

41.

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR, Gomis RR.

Nat Cell Biol. 2014 Jul;16(7):685-94. doi: 10.1038/ncb2977. Epub 2014 Jun 1.

PMID:
24880666
42.

Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival.

Gupta J, del Barco Barrantes I, Igea A, Sakellariou S, Pateras IS, Gorgoulis VG, Nebreda AR.

Cancer Cell. 2014 Apr 14;25(4):484-500. doi: 10.1016/j.ccr.2014.02.019. Epub 2014 Mar 27.

43.

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.

Pereira L, Igea A, Canovas B, Dolado I, Nebreda AR.

EMBO Mol Med. 2013 Nov;5(11):1759-74. doi: 10.1002/emmm.201302732. Epub 2013 Sep 24.

44.

p38 MAPK: a dual role in hepatocyte proliferation through reactive oxygen species.

Tormos AM, Taléns-Visconti R, Nebreda AR, Sastre J.

Free Radic Res. 2013 Nov;47(11):905-16. doi: 10.3109/10715762.2013.821200. Epub 2013 Oct 4. Review.

PMID:
23906070
45.

Multi-phosphorylation of the intrinsically disordered unique domain of c-Src studied by in-cell and real-time NMR spectroscopy.

Amata I, Maffei M, Igea A, Gay M, Vilaseca M, Nebreda AR, Pons M.

Chembiochem. 2013 Sep 23;14(14):1820-7. doi: 10.1002/cbic.201300139. Epub 2013 Jun 6.

PMID:
23744817
46.

Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism.

Pérez Y, Maffei M, Igea A, Amata I, Gairí M, Nebreda AR, Bernadó P, Pons M.

Sci Rep. 2013;3:1295. doi: 10.1038/srep01295.

47.

SnapShot: p38 MAPK substrates.

Trempolec N, Dave-Coll N, Nebreda AR.

Cell. 2013 Feb 14;152(4):924-924.e1. doi: 10.1016/j.cell.2013.01.047. No abstract available.

48.

SnapShot: p38 MAPK signaling.

Trempolec N, Dave-Coll N, Nebreda AR.

Cell. 2013 Jan 31;152(3):656-656.e1. doi: 10.1016/j.cell.2013.01.029. No abstract available.

49.

Liver-specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice.

Tormos AM, Arduini A, Talens-Visconti R, del Barco Barrantes I, Nebreda AR, Sastre J.

Hepatology. 2013 May;57(5):1950-61. doi: 10.1002/hep.26174. Epub 2013 Jan 25.

PMID:
23354775
50.

Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.

Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A.

Dev Cell. 2012 Nov 13;23(5):1020-31. doi: 10.1016/j.devcel.2012.09.016. Epub 2012 Oct 25.

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