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Genetics and functions of the retinoic acid pathway, with special emphasis on the eye.

Thompson B, Katsanis N, Apostolopoulos N, Thompson DC, Nebert DW, Vasiliou V.

Hum Genomics. 2019 Dec 3;13(1):61. doi: 10.1186/s40246-019-0248-9. Review.


SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside.

Nebert DW, Liu Z.

Hum Genomics. 2019 Sep 14;13(Suppl 1):51. doi: 10.1186/s40246-019-0233-3. Review.


Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".

Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW.

Hum Genomics. 2019 Feb 19;13(1):11. doi: 10.1186/s40246-019-0191-9. Review.


In utero gene expression in the Slc39a8(neo/neo) knockdown mouse.

Chen J, Gálvez-Peralta M, Zhang X, Deng J, Liu Z, Nebert DW.

Sci Rep. 2018 Jul 16;8(1):10703. doi: 10.1038/s41598-018-29109-y.


Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology, and tumor formation.

Liu L, Geng X, Cai Y, Copple B, Yoshinaga M, Shen J, Nebert DW, Wang H, Liu Z.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G569-G579. doi: 10.1152/ajpgi.00165.2018. Epub 2018 Jun 21. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G908.


Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.

Uno S, Nebert DW, Makishima M.

Food Chem Toxicol. 2018 Mar;113:73-82. doi: 10.1016/j.fct.2018.01.029. Epub 2018 Jan 31.


Corrigendum to "Personalized medicine: Genetic risk prediction of drug response" [Pharmacol. Ther. 175 (2017) 75-90.].

Zhang G, Nebert DW.

Pharmacol Ther. 2018 Mar;183:205-206. doi: 10.1016/j.pharmthera.2017.12.001. Epub 2018 Jan 8. No abstract available.


Personalized medicine: Genetic risk prediction of drug response.

Zhang G, Nebert DW.

Pharmacol Ther. 2017 Jul;175:75-90. doi: 10.1016/j.pharmthera.2017.02.036. Epub 2017 Feb 14. Review. Erratum in: Pharmacol Ther. 2017 Dec 10;:.


Feedback control of AHR signalling regulates intestinal immunity.

Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B.

Nature. 2017 Feb 9;542(7640):242-245. doi: 10.1038/nature21080. Epub 2017 Feb 1.


Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.

Jorge-Nebert LF, Zhang G, Wilson KM, Jiang Z, Butler R, Gluckman JL, Pinney SM, Nebert DW.

Hum Genomics. 2016 Nov 28;10(1):39.


Letter to the editor for "Update of the human and mouse Fanconi anemia genes".

Nebert DW, Dong H, Bruford EA, Thompson DC, Joenje H, Vasiliou V.

Hum Genomics. 2016 Jul 4;10(1):25. doi: 10.1186/s40246-016-0081-3. No abstract available.


Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake.

McDermott JR, Geng X, Jiang L, Gálvez-Peralta M, Chen F, Nebert DW, Liu Z.

Oncotarget. 2016 Jun 7;7(23):35327-40. doi: 10.18632/oncotarget.9205.


SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation.

Park JH, Hogrebe M, Grüneberg M, DuChesne I, von der Heiden AL, Reunert J, Schlingmann KP, Boycott KM, Beaulieu CL, Mhanni AA, Innes AM, Hörtnagel K, Biskup S, Gleixner EM, Kurlemann G, Fiedler B, Omran H, Rutsch F, Wada Y, Tsiakas K, Santer R, Nebert DW, Rust S, Marquardt T.

Am J Hum Genet. 2015 Dec 3;97(6):894-903. doi: 10.1016/j.ajhg.2015.11.003.


Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8.

Boycott KM, Beaulieu CL, Kernohan KD, Gebril OH, Mhanni A, Chudley AE, Redl D, Qin W, Hampson S, Küry S, Tetreault M, Puffenberger EG, Scott JN, Bezieau S, Reis A, Uebe S, Schumacher J, Hegele RA, McLeod DR, Gálvez-Peralta M, Majewski J, Ramaekers VT; Care4Rare Canada Consortium, Nebert DW, Innes AM, Parboosingh JS, Abou Jamra R.

Am J Hum Genet. 2015 Dec 3;97(6):886-93. doi: 10.1016/j.ajhg.2015.11.002.


Update of the human and mouse Fanconi anemia genes.

Dong H, Nebert DW, Bruford EA, Thompson DC, Joenje H, Vasiliou V.

Hum Genomics. 2015 Nov 24;9:32. doi: 10.1186/s40246-015-0054-y. Review.


What do animal experiments tell us that in vitro systems cannot? The Human Toxome Project.

Nebert DW, Ingelman-Sundberg M.

Regul Toxicol Pharmacol. 2016 Mar;75:1-4. doi: 10.1016/j.yrtph.2015.09.027. Epub 2015 Sep 26. No abstract available.


Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated wild-type and ZIP14 knockout mice.

Jorge-Nebert LF, Gálvez-Peralta M, Landero Figueroa J, Somarathna M, Hojyo S, Fukada T, Nebert DW.

Toxicol Sci. 2015 Jan;143(1):26-35. doi: 10.1093/toxsci/kfu204. Epub 2014 Oct 7.


Improved drug therapy: triangulating phenomics with genomics and metabolomics.

Monte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V.

Hum Genomics. 2014 Sep 1;8:16. doi: 10.1186/s40246-014-0016-9. Review.


Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress.

Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B.

Toxicol Sci. 2014 Sep;141(1):68-77. doi: 10.1093/toxsci/kfu106. Epub 2014 Jun 3.


Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals.

Gálvez-Peralta M, Wang Z, Bao S, Knoell DL, Nebert DW.

Int J Toxicol. 2014 May;33(3):246-258. Epub 2014 Apr 10.


Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta.

Uno S, Sakurai K, Nebert DW, Makishima M.

Toxicology. 2014 Feb 28;316:34-42. doi: 10.1016/j.tox.2013.12.005. Epub 2014 Jan 3.


Oral cadmium in mice carrying 5 versus 2 copies of the Slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity.

Schneider SN, Liu Z, Wang B, Miller ML, Afton SE, Soleimani M, Nebert DW.

Int J Toxicol. 2014 Jan-Feb;33(1):14-20. doi: 10.1177/1091581813513530. Epub 2013 Dec 17.


Update of the human and mouse SERPIN gene superfamily.

Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V.

Hum Genomics. 2013 Oct 30;7:22. doi: 10.1186/1479-7364-7-22. Review.


Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways.

Divanovic S, Dalli J, Jorge-Nebert LF, Flick LM, Gálvez-Peralta M, Boespflug ND, Stankiewicz TE, Fitzgerald JM, Somarathna M, Karp CL, Serhan CN, Nebert DW.

J Immunol. 2013 Sep 15;191(6):3347-57. doi: 10.4049/jimmunol.1300699. Epub 2013 Aug 16.


Glutathione defense mechanism in liver injury: insights from animal models.

Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V.

Food Chem Toxicol. 2013 Oct;60:38-44. doi: 10.1016/j.fct.2013.07.008. Epub 2013 Jul 12. Review.


Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.

Iqbal J, Sun L, Cao J, Yuen T, Lu P, Bab I, Leu NA, Srinivasan S, Wagage S, Hunter CA, Nebert DW, Zaidi M, Avadhani NG.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11115-20. doi: 10.1073/pnas.1220919110. Epub 2013 Jun 17.


Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.

Nebert DW, Shi Z, Gálvez-Peralta M, Uno S, Dragin N.

Mol Pharmacol. 2013 Sep;84(3):304-13. doi: 10.1124/mol.113.086637. Epub 2013 Jun 12. Review.


Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.

Dong H, Shertzer HG, Genter MB, Gonzalez FJ, Vasiliou V, Jefcoate C, Nebert DW.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):727-32. doi: 10.1016/j.bbrc.2013.05.051. Epub 2013 May 18.


ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.

Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL.

Cell Rep. 2013 Feb 21;3(2):386-400. doi: 10.1016/j.celrep.2013.01.009. Epub 2013 Feb 9.


Human cytochromes P450 in health and disease.

Nebert DW, Wikvall K, Miller WL.

Philos Trans R Soc Lond B Biol Sci. 2013 Jan 6;368(1612):20120431. doi: 10.1098/rstb.2012.0431. Print 2013 Feb 19. Review.


Genetic risk prediction: individualized variability in susceptibility to toxicants.

Nebert DW, Zhang G, Vesell ES.

Annu Rev Pharmacol Toxicol. 2013;53:355-75. doi: 10.1146/annurev-pharmtox-011112-140241. Review.


A new home for Human Genomics.

Vasiliou V, Nebert DW.

Hum Genomics. 2012 Jul 5;6:1. doi: 10.1186/1479-7364-6-1. No abstract available.


ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition.

Nebert DW, Gálvez-Peralta M, Hay EB, Li H, Johansson E, Yin C, Wang B, He L, Soleimani M.

Metallomics. 2012 Nov;4(11):1218-25. doi: 10.1039/c2mt20177a. Epub 2012 Oct 22.


Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct.

Gálvez-Peralta M, Shi Z, Chen J, Miller ML, Nebert DW.

Int J Cancer. 2013 May 1;132(9):2065-75. doi: 10.1002/ijc.27897. Epub 2012 Dec 4.


Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics.

Brocker C, Vasiliou M, Carpenter S, Carpenter C, Zhang Y, Wang X, Kotchoni SO, Wood AJ, Kirch HH, Kopečný D, Nebert DW, Vasiliou V.

Planta. 2013 Jan;237(1):189-210. doi: 10.1007/s00425-012-1749-0. Epub 2012 Sep 25.


Erratum to: Perceptions of genetic research in three rural Appalachian Ohio communities.

Fullenkamp AN, Haynes EN, Succop P, Nebert DW, Meloncon L.

J Community Genet. 2013 Jan;4(1):19. doi: 10.1007/s12687-012-0115-z. No abstract available.


NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.

Levova K, Moserova M, Nebert DW, Phillips DH, Frei E, Schmeiser HH, Arlt VM, Stiborova M.

Toxicol Appl Pharmacol. 2012 Dec 15;265(3):360-7. doi: 10.1016/j.taap.2012.09.004. Epub 2012 Sep 13.


Personalized medicine: temper expectations.

Nebert DW, Zhang G.

Science. 2012 Aug 24;337(6097):910; author reply 910-1. doi: 10.1126/science.337.6097.910-a. No abstract available.


Perceptions of genetic research in three rural Appalachian Ohio communities.

Fullenkamp AN, Haynes EN, Meloncon L, Succop P, Nebert DW.

J Community Genet. 2013 Jan;4(1):9-17. doi: 10.1007/s12687-012-0112-2. Epub 2012 Aug 5.


Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice.

Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV.

Neurotoxicol Teratol. 2012 Jul;34(4):450-7. doi: 10.1016/ Epub 2012 May 10.


ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero.

Gálvez-Peralta M, He L, Jorge-Nebert LF, Wang B, Miller ML, Eppert BL, Afton S, Nebert DW.

PLoS One. 2012;7(5):e36055. doi: 10.1371/journal.pone.0036055. Epub 2012 May 1.


Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice.

Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV.

Genes Brain Behav. 2012 Apr;11(3):269-77. doi: 10.1111/j.1601-183X.2011.00762.x. Epub 2012 Feb 2. Erratum in: Genes Brain Behav. 2012 Jun;11(4):500.


Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.

Jackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V.

Hum Genomics. 2011 Oct;5(6):691-702. Review.


Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.

Stiborová M, Levová K, Bárta F, Shi Z, Frei E, Schmeiser HH, Nebert DW, Phillips DH, Arlt VM.

Toxicol Sci. 2012 Feb;125(2):345-58. doi: 10.1093/toxsci/kfr306. Epub 2011 Nov 15.


Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis.

Chen Y, Krishan M, Nebert DW, Shertzer HG.

Chem Res Toxicol. 2012 Jan 13;25(1):94-100. doi: 10.1021/tx200242a. Epub 2011 Dec 6.


Lipid metabolism and body composition in Gclm(-/-) mice.

Kendig EL, Chen Y, Krishan M, Johansson E, Schneider SN, Genter MB, Nebert DW, Shertzer HG.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):338-48. doi: 10.1016/j.taap.2011.09.017. Epub 2011 Sep 24.


Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

Arlt VM, Levová K, Bárta F, Shi Z, Evans JD, Frei E, Schmeiser HH, Nebert DW, Phillips DH, Stiborová M.

Chem Res Toxicol. 2011 Oct 17;24(10):1710-9. doi: 10.1021/tx200259y. Epub 2011 Sep 29.


Update on the aldehyde dehydrogenase gene (ALDH) superfamily.

Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V.

Hum Genomics. 2011 May;5(4):283-303.


Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression.

Wang B, He L, Dong H, Dalton TP, Nebert DW.

Biochem Biophys Res Commun. 2011 Jul 1;410(2):289-94. doi: 10.1016/j.bbrc.2011.05.134. Epub 2011 May 31.

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