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Items: 37

1.

Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist.

Arnesen H, Haj-Yasein NN, Tungen JE, Soedling H, Matthews J, Paulsen SM, Nebb HI, Sylte I, Hansen TV, Sæther T.

Bioorg Med Chem. 2019 Sep 15;27(18):4059-4068. doi: 10.1016/j.bmc.2019.07.032. Epub 2019 Jul 19.

2.

Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity.

Gomez A, Bindesbøll C, Satheesh SV, Grimaldi G, Hutin D, MacPherson L, Ahmed S, Tamblyn L, Cho T, Nebb HI, Moen A, Anonsen JH, Grant DM, Matthews J.

Biochem J. 2018 Dec 11;475(23):3827-3846. doi: 10.1042/BCJ20180347.

3.

Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects.

Sæther T, Paulsen SM, Tungen JE, Vik A, Aursnes M, Holen T, Hansen TV, Nebb HI.

Eur J Med Chem. 2018 Jul 15;155:736-753. doi: 10.1016/j.ejmech.2018.06.034. Epub 2018 Jun 18.

4.

LXRα Regulates Hepatic ChREBPα Activity and Lipogenesis upon Glucose, but Not Fructose Feeding in Mice.

Fan Q, Nørgaard RC, Bindesbøll C, Lucas C, Dalen KT, Babaie E, Itkonen HM, Matthews J, Nebb HI, Grønning-Wang LM.

Nutrients. 2017 Jun 29;9(7). pii: E678. doi: 10.3390/nu9070678.

5.

Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ.

Moldes-Anaya A, Sæther T, Uhlig S, Nebb HI, Larsen T, Eilertsen HC, Paulsen SM.

Mar Drugs. 2017 May 25;15(6). pii: E148. doi: 10.3390/md15060148.

6.

Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells.

Haj-Yasein NN, Berg O, Jernerén F, Refsum H, Nebb HI, Dalen KT.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jun;1862(6):623-635. doi: 10.1016/j.bbalip.2017.02.009. Epub 2017 Feb 17.

PMID:
28219719
7.

TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors.

Bindesbøll C, Tan S, Bott D, Cho T, Tamblyn L, MacPherson L, Grønning-Wang L, Nebb HI, Matthews J.

Biochem J. 2016 Apr 1;473(7):899-910. doi: 10.1042/BJ20151077. Epub 2016 Jan 26.

PMID:
26814197
8.

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity.

Bindesbøll C, Fan Q, Nørgaard RC, MacPherson L, Ruan HB, Wu J, Pedersen TÅ, Steffensen KR, Yang X, Matthews J, Mandrup S, Nebb HI, Grønning-Wang LM.

J Lipid Res. 2015 Apr;56(4):771-85. doi: 10.1194/jlr.M049130. Epub 2015 Feb 27.

9.

Fatty acids regulate perilipin5 in muscle by activating PPARδ.

Bindesbøll C, Berg O, Arntsen B, Nebb HI, Dalen KT.

J Lipid Res. 2013 Jul;54(7):1949-63. doi: 10.1194/jlr.M038992. Epub 2013 Apr 20.

10.

Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury.

Lei P, Baysa A, Nebb HI, Valen G, Skomedal T, Osnes JB, Yang Z, Haugen F.

Basic Res Cardiol. 2013 Jan;108(1):323. doi: 10.1007/s00395-012-0323-z. Epub 2012 Dec 25.

PMID:
23266787
11.

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites.

Boergesen M, Pedersen TÅ, Gross B, van Heeringen SJ, Hagenbeek D, Bindesbøll C, Caron S, Lalloyer F, Steffensen KR, Nebb HI, Gustafsson JÅ, Stunnenberg HG, Staels B, Mandrup S.

Mol Cell Biol. 2012 Feb;32(4):852-67. doi: 10.1128/MCB.06175-11. Epub 2011 Dec 12.

12.

Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture.

Wang YY, Ryg U, Dahle MK, Steffensen KR, Thiemermann C, Chaudry IH, Reinholt FP, Collins JL, Nebb HI, Aasen AO, Gustafsson JÅ, Wang JE.

Surg Infect (Larchmt). 2011 Aug;12(4):283-9. doi: 10.1089/sur.2010.066. Epub 2011 Aug 4.

PMID:
21815813
13.

Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe).

Solaas K, Legry V, Retterstol K, Berg PR, Holven KB, Ferrières J, Amouyel P, Lien S, Romeo J, Valtueña J, Widhalm K, Ruiz JR, Dallongeville J, Tonstad S, Rootwelt H, Halvorsen B, Nenseter MS, Birkeland KI, Thorsby PM, Meirhaeghe A, Nebb HI.

BMC Med Genet. 2010 Oct 12;11:144. doi: 10.1186/1471-2350-11-144.

14.

Expression of liver X receptors in pregnancies complicated by preeclampsia.

Weedon-Fekjær MS, Johnsen GM, Anthonisen EH, Sugulle M, Nebb HI, Duttaroy AK, Staff AC.

Placenta. 2010 Sep;31(9):818-24. doi: 10.1016/j.placenta.2010.06.015. Epub 2010 Jul 22.

PMID:
20655109
15.

Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease.

Dahl TB, Haukeland JW, Yndestad A, Ranheim T, Gladhaug IP, Damås JK, Haaland T, Løberg EM, Arntsen B, Birkeland K, Bjøro K, Ulven SM, Konopski Z, Nebb HI, Aukrust P, Halvorsen B.

J Clin Endocrinol Metab. 2010 Jun;95(6):3039-47. doi: 10.1210/jc.2009-2148. Epub 2010 Apr 14.

PMID:
20392873
16.

Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells.

Weedon-Fekjaer MS, Dalen KT, Solaas K, Staff AC, Duttaroy AK, Nebb HI.

J Lipid Res. 2010 Jul;51(7):1886-96. doi: 10.1194/jlr.M004978. Epub 2010 Mar 10.

17.

LXRbeta deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp.

Holm S, Voshol PJ, Gustafsson JA, Nebb HI.

Biochem Biophys Res Commun. 2010 Feb 12;392(3):436-41. doi: 10.1016/j.bbrc.2010.01.042. Epub 2010 Jan 15.

PMID:
20079709
18.

Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose.

Anthonisen EH, Berven L, Holm S, Nygård M, Nebb HI, Grønning-Wang LM.

J Biol Chem. 2010 Jan 15;285(3):1607-15. doi: 10.1074/jbc.M109.082685. Epub 2009 Nov 20.

19.

Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c.

Qin Y, Dalen KT, Gustafsson JA, Nebb HI.

Biochim Biophys Acta. 2009 Feb;1791(2):140-7. doi: 10.1016/j.bbalip.2008.12.003. Epub 2008 Dec 24.

PMID:
19136075
20.

LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues.

Dalen KT, Dahl T, Holter E, Arntsen B, Londos C, Sztalryd C, Nebb HI.

Biochim Biophys Acta. 2007 Feb;1771(2):210-27. Epub 2006 Dec 8.

PMID:
17234449
21.

22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes.

Kase ET, Andersen B, Nebb HI, Rustan AC, Thoresen GH.

Biochim Biophys Acta. 2006 Dec;1761(12):1515-22. Epub 2006 Sep 20.

PMID:
17055780
22.

PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.

Dalen KT, Ulven SM, Arntsen BM, Solaas K, Nebb HI.

J Lipid Res. 2006 May;47(5):931-43. Epub 2006 Feb 17.

23.

Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line.

Tobin KA, Harsem NK, Dalen KT, Staff AC, Nebb HI, Duttaroy AK.

J Lipid Res. 2006 Apr;47(4):815-23. Epub 2006 Jan 3.

24.

Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line.

Weedon-Fekjaer MS, Duttaroy AK, Nebb HI.

Placenta. 2005 Nov;26(10):721-8. Epub 2004 Dec 9.

PMID:
16226121
25.

LXR is crucial in lipid metabolism.

Ulven SM, Dalen KT, Gustafsson JA, Nebb HI.

Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):59-63. Review.

PMID:
15913974
26.

Sulfur-substituted and alpha-methylated fatty acids as peroxisome proliferator-activated receptor activators.

Larsen LN, Granlund L, Holmeide AK, Skattebøl L, Nebb HI, Bremer J.

Lipids. 2005 Jan;40(1):49-57.

PMID:
15825830
27.

Effects of structural changes of fatty acids on lipid accumulation in adipocytes and primary hepatocytes.

Granlund L, Larsen LN, Nebb HI, Pedersen JI.

Biochim Biophys Acta. 2005 Feb 21;1687(1-3):23-30.

PMID:
15708350
28.

Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment.

Granlund L, Pedersen JI, Nebb HI.

Biochim Biophys Acta. 2005 Feb 21;1687(1-3):11-22.

PMID:
15708349
29.

Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid.

Haugen F, Zahid N, Dalen KT, Hollung K, Nebb HI, Drevon CA.

J Lipid Res. 2005 Jan;46(1):143-53. Epub 2004 Oct 16.

30.

Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue.

Ulven SM, Dalen KT, Gustafsson JA, Nebb HI.

J Lipid Res. 2004 Nov;45(11):2052-62. Epub 2004 Aug 1.

31.

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma.

Dalen KT, Schoonjans K, Ulven SM, Weedon-Fekjaer MS, Bentzen TG, Koutnikova H, Auwerx J, Nebb HI.

Diabetes. 2004 May;53(5):1243-52.

32.

Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha.

Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI.

J Biol Chem. 2003 Nov 28;278(48):48283-91. Epub 2003 Sep 11.

33.

Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator.

Granlund L, Juvet LK, Pedersen JI, Nebb HI.

J Lipid Res. 2003 Aug;44(8):1441-52. Epub 2003 May 16.

34.

On the role of liver X receptors in lipid accumulation in adipocytes.

Juvet LK, Andresen SM, Schuster GU, Dalen KT, Tobin KA, Hollung K, Haugen F, Jacinto S, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI.

Mol Endocrinol. 2003 Feb;17(2):172-82.

PMID:
12554745
35.

Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism.

Ross SE, Erickson RL, Gerin I, DeRose PM, Bajnok L, Longo KA, Misek DE, Kuick R, Hanash SM, Atkins KB, Andresen SM, Nebb HI, Madsen L, Kristiansen K, MacDougald OA.

Mol Cell Biol. 2002 Aug;22(16):5989-99.

36.

Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis.

Tobin KA, Ulven SM, Schuster GU, Steineger HH, Andresen SM, Gustafsson JA, Nebb HI.

J Biol Chem. 2002 Mar 22;277(12):10691-7. Epub 2002 Jan 7.

37.

Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.

Tobin KA, Steineger HH, Alberti S, Spydevold O, Auwerx J, Gustafsson JA, Nebb HI.

Mol Endocrinol. 2000 May;14(5):741-52.

PMID:
10809236

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