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Items: 1 to 50 of 306

1.

MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.

Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, Mosca R, Campos Y, Tillman H, Roussel MF, Andrew Weesner J, Ellen Fremuth L, Qiu X, Han MJ, Grosveld GC, d'Azzo A.

Nat Commun. 2019 Aug 9;10(1):3623. doi: 10.1038/s41467-019-11568-0.

2.

Uncovering the genomic landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically normal FLT3-ITD AML.

Buelow DR, Pounds SB, Wang YD, Shi L, Li Y, Finkelstein D, Shurtleff S, Neale G, Inaba H, Ribeiro RC, Palumbo R, Garrison D, Orwick SJ, Blachly JS, Kroll K, Byrd JC, Gruber TA, Rubnitz JE, Baker SD.

Clin Transl Sci. 2019 Jul 26. doi: 10.1111/cts.12669. [Epub ahead of print]

PMID:
31350825
3.

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity.

Wang Y, Du X, Wei J, Long L, Tan H, Guy C, Dhungana Y, Qian C, Neale G, Fu YX, Yu J, Peng J, Chi H.

Cell Res. 2019 May;29(5):391-405. doi: 10.1038/s41422-019-0157-4. Epub 2019 Mar 25.

PMID:
30911060
4.

Will Attention by Vaccine Developers to the Host's Nuclear Hormone Levels and Immunocompetence Improve Vaccine Success?

Sealy RE, Jones BG, Surman SL, Penkert RR, Pelletier S, Neale G, Hurwitz JL.

Vaccines (Basel). 2019 Feb 27;7(1). pii: E26. doi: 10.3390/vaccines7010026. Review.

5.

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.

Karmaus PWF, Chen X, Lim SA, Herrada AA, Nguyen TM, Xu B, Dhungana Y, Rankin S, Chen W, Rosencrance C, Yang K, Fan Y, Cheng Y, Easton J, Neale G, Vogel P, Chi H.

Nature. 2019 Jan;565(7737):101-105. doi: 10.1038/s41586-018-0806-7. Epub 2018 Dec 19.

6.

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number.

Lavado A, Park JY, Paré J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X.

Dev Cell. 2018 Dec 3;47(5):576-591.e8. doi: 10.1016/j.devcel.2018.09.021. Epub 2018 Oct 25.

PMID:
30523785
7.

Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.

Shi H, Liu C, Tan H, Li Y, Nguyen TM, Dhungana Y, Guy C, Vogel P, Neale G, Rankin S, Feng Y, Peng J, Tao W, Chi H.

Immunity. 2018 Nov 20;49(5):899-914.e6. doi: 10.1016/j.immuni.2018.10.010. Epub 2018 Nov 6.

PMID:
30413360
8.

Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers.

Jones BG, Sealy RE, Penkert RR, Surman SL, Maul RW, Neale G, Xu B, Gearhart PJ, Hurwitz JL.

Int Immunol. 2019 Mar 5;31(3):141-156. doi: 10.1093/intimm/dxy074.

PMID:
30407507
9.

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.

Malik A, Sharma D, Malireddi RKS, Guy CS, Chang TC, Olsen SR, Neale G, Vogel P, Kanneganti TD.

Immunity. 2018 Sep 18;49(3):515-530.e5. doi: 10.1016/j.immuni.2018.08.024.

PMID:
30231985
10.

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells.

Yang K, Blanco DB, Chen X, Dash P, Neale G, Rosencrance C, Easton J, Chen W, Cheng C, Dhungana Y, Kc A, Awad W, Guo XJ, Thomas PG, Chi H.

Sci Immunol. 2018 Jul 6;3(25). pii: eaas9818. doi: 10.1126/sciimmunol.aas9818.

11.

Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.

Du X, Wen J, Wang Y, Karmaus PWF, Khatamian A, Tan H, Li Y, Guy C, Nguyen TM, Dhungana Y, Neale G, Peng J, Yu J, Chi H.

Nature. 2018 Jun;558(7708):141-145. doi: 10.1038/s41586-018-0177-0. Epub 2018 May 30.

12.

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.

Chapman NM, Zeng H, Nguyen TM, Wang Y, Vogel P, Dhungana Y, Liu X, Neale G, Locasale JW, Chi H.

Nat Commun. 2018 May 29;9(1):2095. doi: 10.1038/s41467-018-04392-5.

13.

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD.

Cell. 2018 May 3;173(4):920-933.e13. doi: 10.1016/j.cell.2018.02.055. Epub 2018 Mar 22.

14.

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.

Zeng H, Yu M, Tan H, Li Y, Su W, Shi H, Dhungana Y, Guy C, Neale G, Cloer C, Peng J, Wang D, Chi H.

Sci Adv. 2018 Jan 31;4(1):eaar5701. doi: 10.1126/sciadv.aar5701. eCollection 2018 Jan.

15.

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection.

Kuriakose T, Zheng M, Neale G, Kanneganti TD.

J Immunol. 2018 Feb 15;200(4):1489-1495. doi: 10.4049/jimmunol.1701538. Epub 2018 Jan 10.

16.

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D.

Nat Commun. 2017 Nov 13;8(1):1457. doi: 10.1038/s41467-017-01388-5.

17.

An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation.

Takata N, Abbey D, Fiore L, Acosta S, Feng R, Gil HJ, Lavado A, Geng X, Interiano A, Neale G, Eiraku M, Sasai Y, Oliver G.

Cell Rep. 2017 Nov 7;21(6):1534-1549. doi: 10.1016/j.celrep.2017.10.041.

18.

Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.

Morton LM, Sampson JN, Armstrong GT, Chen TH, Hudson MM, Karlins E, Dagnall CL, Li SA, Wilson CL, Srivastava DK, Liu W, Kang G, Oeffinger KC, Henderson TO, Moskowitz CS, Gibson TM, Merino DM, Wong JR, Hammond S, Neglia JP, Turcotte LM, Miller J, Bowen L, Wheeler WA, Leisenring WM, Whitton JA, Burdette L, Chung C, Hicks BD, Jones K, Machiela MJ, Vogt A, Wang Z, Yeager M, Neale G, Lear M, Strong LC, Yasui Y, Stovall M, Weathers RE, Smith SA, Howell R, Davies SM, Radloff GA, Onel K, Berrington de González A, Inskip PD, Rajaraman P, Fraumeni JF Jr, Bhatia S, Chanock SJ, Tucker MA, Robison LL.

J Natl Cancer Inst. 2017 Nov 1;109(11). doi: 10.1093/jnci/djx058.

19.

Identification of Clinical and Biologic Correlates Associated With Outcome in Children With Adrenocortical Tumors Without Germline TP53 Mutations: A St Jude Adrenocortical Tumor Registry and Children's Oncology Group Study.

Pinto EM, Rodriguez-Galindo C, Pounds SB, Wang L, Clay MR, Neale G, Garfinkle EAR, Lam CG, Levy CF, Pappo AS, Zambetti GP, Ribeiro RC.

J Clin Oncol. 2017 Dec 10;35(35):3956-3963. doi: 10.1200/JCO.2017.74.2460. Epub 2017 Oct 23.

20.

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling.

Yang K, Blanco DB, Neale G, Vogel P, Avila J, Clish CB, Wu C, Shrestha S, Rankin S, Long L, Kc A, Chi H.

Nature. 2017 Aug 31;548(7669):602-606. doi: 10.1038/nature23665. Epub 2017 Aug 23.

21.

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.

Karmaus PWF, Herrada AA, Guy C, Neale G, Dhungana Y, Long L, Vogel P, Avila J, Clish CB, Chi H.

J Exp Med. 2017 Sep 4;214(9):2629-2647. doi: 10.1084/jem.20161855. Epub 2017 Aug 7.

22.

Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD.

JCI Insight. 2017 Aug 3;2(15). pii: 92409. doi: 10.1172/jci.insight.92409. eCollection 2017 Aug 3.

23.

De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.

Ghoneim HE, Fan Y, Moustaki A, Abdelsamed HA, Dash P, Dogra P, Carter R, Awad W, Neale G, Thomas PG, Youngblood B.

Cell. 2017 Jun 29;170(1):142-157.e19. doi: 10.1016/j.cell.2017.06.007. Epub 2017 Jun 22.

24.

Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes.

Shi LZ, Saravia J, Zeng H, Kalupahana NS, Guy CS, Neale G, Chi H.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E67-E74. doi: 10.1073/pnas.1617669114. Epub 2016 Dec 19.

25.

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

Kuriakose T, Man SM, Malireddi RK, Karki R, Kesavardhana S, Place DE, Neale G, Vogel P, Kanneganti TD.

Sci Immunol. 2016 Aug 5;1(2). pii: aag2045. Epub 2016 Aug 12.

26.

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.

Van de Velde LA, Subramanian C, Smith AM, Barron L, Qualls JE, Neale G, Alfonso-Pecchio A, Jackowski S, Rock CO, Wynn TA, Murray PJ.

J Biol Chem. 2017 Jan 6;292(1):15-30. doi: 10.1074/jbc.M116.766238. Epub 2016 Nov 30.

27.

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RKS, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M, Kanneganti TD.

Cell. 2016 Oct 6;167(2):382-396.e17. doi: 10.1016/j.cell.2016.09.012. Epub 2016 Sep 29.

28.

Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy.

Kamei A, Gao G, Neale G, Loh LN, Vogel P, Thomas PG, Tuomanen EI, Murray PJ.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6153-E6161. Epub 2016 Sep 26.

29.

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H.

Immunity. 2016 Sep 20;45(3):540-554. doi: 10.1016/j.immuni.2016.08.017. Epub 2016 Sep 13.

30.

Multi-organ Mapping of Cancer Risk.

Zhu L, Finkelstein D, Gao C, Shi L, Wang Y, López-Terrada D, Wang K, Utley S, Pounds S, Neale G, Ellison D, Onar-Thomas A, Gilbertson RJ.

Cell. 2016 Aug 25;166(5):1132-1146.e7. doi: 10.1016/j.cell.2016.07.045.

31.

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.

Qi X, Man SM, Malireddi RK, Karki R, Lupfer C, Gurung P, Neale G, Guy CS, Lamkanfi M, Kanneganti TD.

J Exp Med. 2016 Sep 19;213(10):2081-97. doi: 10.1084/jem.20151938. Epub 2016 Aug 22.

32.

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.

Meliopoulos VA, Van de Velde LA, Van de Velde NC, Karlsson EA, Neale G, Vogel P, Guy C, Sharma S, Duan S, Surman SL, Jones BG, Johnson MD, Bosio C, Jolly L, Jenkins RG, Hurwitz JL, Rosch JW, Sheppard D, Thomas PG, Murray PJ, Schultz-Cherry S.

PLoS Pathog. 2016 Aug 9;12(8):e1005804. doi: 10.1371/journal.ppat.1005804. eCollection 2016 Aug.

33.

Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.

Jones BG, Penkert RR, Xu B, Fan Y, Neale G, Gearhart PJ, Hurwitz JL.

Mol Immunol. 2016 Sep;77:97-102. doi: 10.1016/j.molimm.2016.07.015. Epub 2016 Aug 3.

34.

Comparison of genome sequencing and clinical genotyping for pharmacogenes.

Yang W, Wu G, Broeckel U, Smith CA, Turner V, Haidar CE, Wang S, Carter R, Karol SE, Neale G, Crews KR, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV.

Clin Pharmacol Ther. 2016 Oct;100(4):380-8. doi: 10.1002/cpt.411. Epub 2016 Aug 18.

35.

Prognostic Significance of Major Histocompatibility Complex Class II Expression in Pediatric Adrenocortical Tumors: A St. Jude and Children's Oncology Group Study.

Pinto EM, Rodriguez-Galindo C, Choi JK, Pounds S, Liu Z, Neale G, Finkelstein D, Hicks JM, Pappo AS, Figueiredo BC, Ribeiro RC, Zambetti GP.

Clin Cancer Res. 2016 Dec 15;22(24):6247-6255. Epub 2016 Jun 15.

36.

Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation.

Drosos Y, Neale G, Ye J, Paul L, Kuliyev E, Maitra A, Means AL, Washington MK, Rehg J, Finkelstein DB, Sosa-Pineda B.

Neoplasia. 2016 Mar;18(3):172-84. doi: 10.1016/j.neo.2016.02.002.

37.

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis.

Wei J, Long L, Yang K, Guy C, Shrestha S, Chen Z, Wu C, Vogel P, Neale G, Green DR, Chi H.

Nat Immunol. 2016 Mar;17(3):277-85. doi: 10.1038/ni.3365. Epub 2016 Jan 25.

38.

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.

Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B.

Diabetes. 2016 Mar;65(3):687-98. doi: 10.2337/db15-0713. Epub 2015 Dec 2.

39.

Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia.

Karol SE, Mattano LA Jr, Yang W, Maloney KW, Smith C, Liu C, Ramsey LB, Fernandez CA, Chang TY, Neale G, Cheng C, Mardis E, Fulton R, Scheet P, San Lucas FA, Larsen EC, Loh ML, Raetz EA, Hunger SP, Devidas M, Relling MV.

Blood. 2016 Feb 4;127(5):558-64. doi: 10.1182/blood-2015-10-673848. Epub 2015 Nov 20.

40.

Vitamin A deficient mice exhibit increased viral antigens and enhanced cytokine/chemokine production in nasal tissues following respiratory virus infection despite the presence of FoxP3+ T cells.

Penkert RR, Surman SL, Jones BG, Sealy RE, Vogel P, Neale G, Hurwitz JL.

Int Immunol. 2016 Mar;28(3):139-52. doi: 10.1093/intimm/dxv064. Epub 2015 Oct 27.

41.

Maternal bile acid transporter deficiency promotes neonatal demise.

Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD.

Nat Commun. 2015 Sep 29;6:8186. doi: 10.1038/ncomms9186.

42.

Evaluation of a two-step iterative resampling procedure for internal validation of genome-wide association studies.

Kang G, Liu W, Cheng C, Wilson CL, Neale G, Yang JJ, Ness KK, Robison LL, Hudson MM, Srivastava DK.

J Hum Genet. 2015 Dec;60(12):729-38. doi: 10.1038/jhg.2015.110. Epub 2015 Sep 17.

43.

TNF Counterbalances the Emergence of M2 Tumor Macrophages.

Kratochvill F, Neale G, Haverkamp JM, Van de Velde LA, Smith AM, Kawauchi D, McEvoy J, Roussel MF, Dyer MA, Qualls JE, Murray PJ.

Cell Rep. 2015 Sep 22;12(11):1902-14. doi: 10.1016/j.celrep.2015.08.033. Epub 2015 Sep 10.

44.

Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children.

Xu H, Zhang H, Yang W, Yadav R, Morrison AC, Qian M, Devidas M, Liu Y, Perez-Andreu V, Zhao X, Gastier-Foster JM, Lupo PJ, Neale G, Raetz E, Larsen E, Bowman WP, Carroll WL, Winick N, Williams R, Hansen T, Holm JC, Mardis E, Fulton R, Pui CH, Zhang J, Mullighan CG, Evans WE, Hunger SP, Gupta R, Schmiegelow K, Loh ML, Relling MV, Yang JJ.

Nat Commun. 2015 Jun 24;6:7553. doi: 10.1038/ncomms8553.

45.

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

Man SM, Zhu Q, Zhu L, Liu Z, Karki R, Malik A, Sharma D, Li L, Malireddi RK, Gurung P, Neale G, Olsen SR, Carter RA, McGoldrick DJ, Wu G, Finkelstein D, Vogel P, Gilbertson RJ, Kanneganti TD.

Cell. 2015 Jul 2;162(1):45-58. doi: 10.1016/j.cell.2015.06.001. Epub 2015 Jun 18.

46.

An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes.

Mohankumar KM, Currle DS, White E, Boulos N, Dapper J, Eden C, Nimmervoll B, Thiruvenkatam R, Connelly M, Kranenburg TA, Neale G, Olsen S, Wang YD, Finkelstein D, Wright K, Gupta K, Ellison DW, Thomas AO, Gilbertson RJ.

Nat Genet. 2015 Aug;47(8):878-87. doi: 10.1038/ng.3323. Epub 2015 Jun 15.

47.

Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort.

Wilson CL, Liu W, Yang JJ, Kang G, Ojha RP, Neale GA, Srivastava DK, Gurney JG, Hudson MM, Robison LL, Ness KK.

Cancer. 2015 Jul 1;121(13):2262-70. doi: 10.1002/cncr.29153. Epub 2015 May 11.

48.

Low-level GATA2 overexpression promotes myeloid progenitor self-renewal and blocks lymphoid differentiation in mice.

Nandakumar SK, Johnson K, Throm SL, Pestina TI, Neale G, Persons DA.

Exp Hematol. 2015 Jul;43(7):565-77.e1-10. doi: 10.1016/j.exphem.2015.04.002. Epub 2015 Apr 20.

49.

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

Man SM, Karki R, Malireddi RK, Neale G, Vogel P, Yamamoto M, Lamkanfi M, Kanneganti TD.

Nat Immunol. 2015 May;16(5):467-75. doi: 10.1038/ni.3118. Epub 2015 Mar 16.

50.

Relationship between preventable hospital deaths and other measures of safety: an exploratory study.

Hogan H, Healey F, Neale G, Thomson R, Vincent C, Black N.

Int J Qual Health Care. 2015 Apr;27(2):161-2. doi: 10.1093/intqhc/mzv012. Epub 2015 Feb 18. No abstract available.

PMID:
25693809

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