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Items: 45


Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration.

Neal ML, Fleming SM, Budge KM, Boyle AM, Kim C, Alam G, Beier EE, Wu LJ, Richardson JR.

FASEB J. 2020 Jan;34(1):1679-1694. doi: 10.1096/fj.201900567RR. Epub 2019 Dec 4.


Model annotation and discovery with the Physiome Model Repository.

Sarwar DM, Kalbasi R, Gennari JH, Carlson BE, Neal ML, Bono B, Atalag K, Hunter PJ, Nickerson DP.

BMC Bioinformatics. 2019 Sep 6;20(1):457. doi: 10.1186/s12859-019-2987-y.


Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.

Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG.

Sci Signal. 2019 Mar 12;12(572). pii: eaau4543. doi: 10.1126/scisignal.aau4543.


Harmonizing semantic annotations for computational models in biology.

Neal ML, König M, Nickerson D, Mısırlı G, Kalbasi R, Dräger A, Atalag K, Chelliah V, Cooling MT, Cook DL, Crook S, de Alba M, Friedman SH, Garny A, Gennari JH, Gleeson P, Golebiewski M, Hucka M, Juty N, Myers C, Olivier BG, Sauro HM, Scharm M, Snoep JL, Touré V, Wipat A, Wolkenhauer O, Waltemath D.

Brief Bioinform. 2019 Mar 22;20(2):540-550. doi: 10.1093/bib/bby087. Review.


SemGen: a tool for semantics-based annotation and composition of biosimulation models.

Neal ML, Thompson CT, Kim KG, James RC, Cook DL, Carlson BE, Gennari JH.

Bioinformatics. 2019 May 1;35(9):1600-1602. doi: 10.1093/bioinformatics/bty829.


The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.

Neal ML, Boyle AM, Budge KM, Safadi FF, Richardson JR.

J Neuroinflammation. 2018 Mar 8;15(1):73. doi: 10.1186/s12974-018-1100-1.


Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease.

Budge KM, Neal ML, Richardson JR, Safadi FF.

Mol Neurobiol. 2018 Jun;55(6):5167-5176. doi: 10.1007/s12035-017-0707-z. Epub 2017 Aug 30. Review.


Qualitative causal analyses of biosimulation models.

Neal ML, Gennari JH, Cook DL.

CEUR Workshop Proc. 2016 Aug;1747. pii: Epub 2016 Nov 29.


Position statement of the American College of Surgeons Committee on Trauma on the National Academies of Sciences, Engineering and Medicine Report, A National Trauma Care System: Integrating Military and Civilian Trauma Systems to Achieve Zero Preventable Deaths After Injury.

Jenkins DH, Winchell RJ, Coimbra R, Rotondo MF, Weireter LJ, Bulger EM, Kozar RA, Nathens AB, Reilly PM, Henry SM, Jimenez MF, Chang MC, Coburn M, Dodd J, Neal ML, Rosen J, Clemency J, Hoyt DB, Stewart RM.

J Trauma Acute Care Surg. 2016 Nov;81(5):819-823. No abstract available.


Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.

Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A.

Nat Commun. 2016 Oct 5;7:12932. doi: 10.1038/ncomms12932.


Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey.

Zhou QY, Burton KJ, Neal ML, Qiao Y, Kanthasamy AG, Sun Y, Xu X, Ma Y, Li X.

Mol Brain. 2016 Aug 18;9(1):78. doi: 10.1186/s13041-016-0255-x.


Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease.

Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG.

J Neuroimmune Pharmacol. 2016 Jun;11(2):259-78. doi: 10.1007/s11481-016-9650-4. Epub 2016 Feb 2.


Semantics-Based Composition of Integrated Cardiomyocyte Models Motivated by Real-World Use Cases.

Neal ML, Carlson BE, Thompson CT, James RC, Kim KG, Tran K, Crampin EJ, Cook DL, Gennari JH.

PLoS One. 2015 Dec 30;10(12):e0145621. doi: 10.1371/journal.pone.0145621. eCollection 2015.


Addendum to 'A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET'.

Rockne RC, Trister AD, Jacobs J, Hawkins-Daarud AJ, Neal ML, Hendrickson K, Mrugala MM, Rockhill JK, Kinahan P, Krohn KA, Swanson KR.

J R Soc Interface. 2015 Nov 6;12(112). pii: 20150927. doi: 10.1098/rsif.2015.0927. No abstract available.

Free PMC Article

A patient-specific computational model of hypoxia-modulated radiation resistance in glioblastoma using 18F-FMISO-PET.

Rockne RC, Trister AD, Jacobs J, Hawkins-Daarud AJ, Neal ML, Hendrickson K, Mrugala MM, Rockhill JK, Kinahan P, Krohn KA, Swanson KR.

J R Soc Interface. 2015 Feb 6;12(103). pii: 20141174. doi: 10.1098/rsif.2014.1174. Erratum in: J R Soc Interface. 2015 Nov 6;12(112). pii: 20150927. doi: 10.1098/rsif.2015.0927.


A reappraisal of how to build modular, reusable models of biological systems.

Neal ML, Cooling MT, Smith LP, Thompson CT, Sauro HM, Carlson BE, Cook DL, Gennari JH.

PLoS Comput Biol. 2014 Oct 2;10(10):e1003849. doi: 10.1371/journal.pcbi.1003849. eCollection 2014 Oct. No abstract available.


JSim, an open-source modeling system for data analysis.

Butterworth E, Jardine BE, Raymond GM, Neal ML, Bassingthwaighte JB.

F1000Res. 2013 Dec 30;2:288. doi: 10.12688/f1000research.2-288.v1. eCollection 2013.


Ontology of physics for biology: representing physical dependencies as a basis for biological processes.

Cook DL, Neal ML, Bookstein FL, Gennari JH.

J Biomed Semantics. 2013 Dec 2;4(1):41. doi: 10.1186/2041-1480-4-41.


A C library for retrieving specific reactions from the BioModels database.

Neal ML, Galdzicki M, Gallimore JT, Sauro HM.

Bioinformatics. 2014 Jan 1;30(1):129-30. doi: 10.1093/bioinformatics/btt567. Epub 2013 Sep 29.


Representing physiological processes and their participants with PhysioMaps.

Cook DL, Neal ML, Hoehndorf R, Gkoutos GV, Gennari JH.

J Biomed Semantics. 2013 Apr 15;4 Suppl 1:S2. doi: 10.1186/2041-1480-4-S1-S2. Epub 2013 Apr 15.


From patient-specific mathematical neuro-oncology to precision medicine.

Baldock AL, Rockne RC, Boone AD, Neal ML, Hawkins-Daarud A, Corwin DM, Bridge CA, Guyman LA, Trister AD, Mrugala MM, Rockhill JK, Swanson KR.

Front Oncol. 2013 Apr 2;3:62. doi: 10.3389/fonc.2013.00062. eCollection 2013.


Response classification based on a minimal model of glioblastoma growth is prognostic for clinical outcomes and distinguishes progression from pseudoprogression.

Neal ML, Trister AD, Ahn S, Baldock A, Bridge CA, Guyman L, Lange J, Sodt R, Cloke T, Lai A, Cloughesy TF, Mrugala MM, Rockhill JK, Rockne RC, Swanson KR.

Cancer Res. 2013 May 15;73(10):2976-86. doi: 10.1158/0008-5472.CAN-12-3588. Epub 2013 Feb 11.


Discriminating survival outcomes in patients with glioblastoma using a simulation-based, patient-specific response metric.

Neal ML, Trister AD, Cloke T, Sodt R, Ahn S, Baldock AL, Bridge CA, Lai A, Cloughesy TF, Mrugala MM, Rockhill JK, Rockne RC, Swanson KR.

PLoS One. 2013;8(1):e51951. doi: 10.1371/journal.pone.0051951. Epub 2013 Jan 23.


The effect of dead-on-arrival and emergency department death classification on risk-adjusted performance in the American College of Surgeons Trauma Quality Improvement Program.

Calland JF, Nathens AB, Young JS, Neal ML, Goble S, Abelson J, Fildes JJ, Hemmila MR.

J Trauma Acute Care Surg. 2012 Nov;73(5):1086-91; discussion 1091-2. doi: 10.1097/TA.0b013e31826fc7a0.


Multiscale modeling and data integration in the virtual physiological rat project.

Beard DA, Neal ML, Tabesh-Saleki N, Thompson CT, Bassingthwaighte JB, Shimoyama M, Carlson BE.

Ann Biomed Eng. 2012 Nov;40(11):2365-78. doi: 10.1007/s10439-012-0611-7. Epub 2012 Jul 18.


Penetrating oesophageal injury: a contemporary analysis of the National Trauma Data Bank.

Patel MS, Malinoski DJ, Zhou L, Neal ML, Hoyt DB.

Injury. 2013 Jan;44(1):48-55. doi: 10.1016/j.injury.2011.11.015. Epub 2011 Dec 29.


Duplex ultrasound screening for deep vein thrombosis in asymptomatic trauma patients: a survey of individual trauma surgeon opinions and current trauma center practices.

Haut ER, Schneider EB, Patel A, Streiff MB, Haider AH, Stevens KA, Chang DC, Neal ML, Hoeft C, Nathens AB, Cornwell EE 3rd, Pronovost PJ, Efron DT.

J Trauma. 2011 Jan;70(1):27-33; discussion 33-4. doi: 10.1097/TA.0b013e3182077d55.


A simple magnetic separation method for high-yield isolation of pure primary microglia.

Gordon R, Hogan CE, Neal ML, Anantharam V, Kanthasamy AG, Kanthasamy A.

J Neurosci Methods. 2011 Jan 15;194(2):287-96. doi: 10.1016/j.jneumeth.2010.11.001. Epub 2010 Nov 11.


The attributable mortality and length of stay of trauma-related complications: a matched cohort study.

Ingraham AM, Xiong W, Hemmila MR, Shafi S, Goble S, Neal ML, Nathens AB.

Ann Surg. 2010 Aug;252(2):358-62. doi: 10.1097/SLA.0b013e3181e623bf.


Multiple ontologies in action: composite annotations for biosimulation models.

Gennari JH, Neal ML, Galdzicki M, Cook DL.

J Biomed Inform. 2011 Feb;44(1):146-54. doi: 10.1016/j.jbi.2010.06.007. Epub 2010 Jun 30.


Trauma and Injury Severity Score (TRISS) coefficients 2009 revision.

Schluter PJ, Nathens A, Neal ML, Goble S, Cameron CM, Davey TM, McClure RJ.

J Trauma. 2010 Apr;68(4):761-70. doi: 10.1097/TA.0b013e3181d3223b.


The Trauma Quality Improvement Program: pilot study and initial demonstration of feasibility.

Hemmila MR, Nathens AB, Shafi S, Calland JF, Clark DE, Cryer HG, Goble S, Hoeft CJ, Meredith JW, Neal ML, Pasquale MD, Pomphrey MD, Fildes JJ.

J Trauma. 2010 Feb;68(2):253-62. doi: 10.1097/TA.0b013e3181cfc8e6.


Composite annotations: requirements for mapping multiscale data and models to biomedical ontologies.

Cook DL, Mejino JL, Neal ML, Gennari JH.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2791-4. doi: 10.1109/IEMBS.2009.5333830.


Current progress in patient-specific modeling.

Neal ML, Kerckhoffs R.

Brief Bioinform. 2010 Jan;11(1):111-26. doi: 10.1093/bib/bbp049. Epub 2009 Dec 2. Review.


Bridging biological ontologies and biosimulation: the ontology of physics for biology.

Cook DL, Mejino JL, Neal ML, Gennari JH.

AMIA Annu Symp Proc. 2008 Nov 6:136-40.


Integration of multi-scale biosimulation models via light-weight semantics.

Gennari JH, Neal ML, Carlson BE, Cook DL.

Pac Symp Biocomput. 2008:414-25.


Subject-specific model estimation of cardiac output and blood volume during hemorrhage.

Neal ML, Bassingthwaighte JB.

Cardiovasc Eng. 2007 Sep;7(3):97-120.


Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation.

Kerckhoffs RC, Neal ML, Gu Q, Bassingthwaighte JB, Omens JH, McCulloch AD.

Ann Biomed Eng. 2007 Jan;35(1):1-18. Epub 2006 Nov 8.


Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.

Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW.

Ann N Y Acad Sci. 2002 Nov;977:45-64.


Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium.

Aliev G, Smith MA, Seyidova D, Neal ML, Shi J, Loizidou M, Turmaine M, Friedland RP, Taylor I, Burnstock G, Perry G, Lamanna JC.

J Submicrosc Cytol Pathol. 2002 Jan;34(1):37-50.


The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease.

Aliev G, Smith MA, Seyidov D, Neal ML, Lamb BT, Nunomura A, Gasimov EK, Vinters HV, Perry G, LaManna JC, Friedland RP.

Brain Pathol. 2002 Jan;12(1):21-35. Review.


The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro.

Aliev G, Seyidov D, Neal ML, Shi J, Vigan T, Hernandez A, Folco G, Soas AH, Zimina TV, Smith MA, Perry G, Lamanna JC, Friedland RP.

J Submicrosc Cytol Pathol. 2001 Jan-Apr;33(1-2):141-9.


Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits.

Aliev G, Smith MA, Turmaine M, Neal ML, Zimina TV, Friedland RP, Perry G, LaManna JC, Burnstock G.

Exp Mol Pathol. 2001 Aug;71(1):40-54.


Perceived continuing education needs of RDs and DTRs.

Flynn C, Bryk JA, Neal ML.

J Am Diet Assoc. 1991 Aug;91(8):933-9.


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