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Items: 1 to 50 of 199

1.

Neutrophil Effector Functions Are Not Impaired in Duffy Antigen Receptor for Chemokines (DARC)-Null Black South Africans.

Naidoo KK, Ngubane A, Gaza P, Moodley A, Ndung'u T, Thobakgale CF.

Front Immunol. 2019 Mar 26;10:551. doi: 10.3389/fimmu.2019.00551. eCollection 2019.

2.

Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes.

Naidoo L, Mzobe Z, Jin SW, Rajkoomar E, Reddy T, Brockman MA, Brumme ZL, Ndung'u T, Mann JK.

Virology. 2019 Feb 21;531:192-202. doi: 10.1016/j.virol.2019.02.011. [Epub ahead of print]

PMID:
30927712
3.

Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.

Roider J, Ngoepe A, Muenchhoff M, Adland E, Groll A, Ndung'u T, Kløverpris H, Goulder P, Leslie A.

Front Immunol. 2019 Feb 12;10:213. doi: 10.3389/fimmu.2019.00213. eCollection 2019.

4.

Correction for Ojwach et al., "Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection".

Ojwach DBA, MacMillan D, Reddy T, Novitsky V, Brumme ZL, Brockman MA, Ndung'u T, Mann JK.

J Virol. 2019 Jan 17;93(3). pii: e01924-18. doi: 10.1128/JVI.01924-18. Print 2019 Feb 1. No abstract available.

5.

Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome Is Associated With Dysregulation of IL-7/IL-7 Receptor Signaling Pathway in T Cells and Monocyte Activation.

Akilimali NA, Muema DM, Specht C, Chang CC, Moosa MS, Levitz SM, Lewin SR, French MA, Ndungʼu T.

J Acquir Immune Defic Syndr. 2019 Apr 15;80(5):596-604. doi: 10.1097/QAI.0000000000001946.

PMID:
30649031
6.

Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children.

Muenchhoff M, Adland E, Roider J, Kløverpris H, Leslie A, Boehm S, Keppler OT, Ndung'u T, Goulder PJR.

J Infect Dis. 2019 Apr 16;219(9):1407-1417. doi: 10.1093/infdis/jiy668.

PMID:
30624717
7.

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.

Mori M, Leitman E, Walker B, Ndung'u T, Carrington M, Goulder P.

J Infect Dis. 2019 Apr 16;219(9):1456-1463. doi: 10.1093/infdis/jiy692.

PMID:
30520960
8.

Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells.

Attaf M, Malik A, Severinsen MC, Roider J, Ogongo P, Buus S, Ndung'u T, Leslie A, Kløverpris HN, Matthews PC, Sewell AK, Goulder P.

Front Immunol. 2018 Nov 14;9:2539. doi: 10.3389/fimmu.2018.02539. eCollection 2018.

9.

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants.

Ogunshola F, Anmole G, Miller RL, Goering E, Nkosi T, Muema D, Mann J, Ismail N, Chopera D, Ndung'u T, Brockman MA, Ndhlovu ZM.

Nat Commun. 2018 Nov 27;9(1):5023. doi: 10.1038/s41467-018-07209-7.

10.

A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts.

Kaida A, Dietrich JJ, Laher F, Beksinska M, Jaggernath M, Bardsley M, Smith P, Cotton L, Chitneni P, Closson K, Lewis DA, Smit JA, Ndung'u T, Brockman M, Gray G.

BMC Infect Dis. 2018 Oct 3;18(1):499. doi: 10.1186/s12879-018-3380-6.

11.

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults.

Roider J, Maehara T, Ngoepe A, Ramsuran D, Muenchhoff M, Adland E, Aicher T, Kazer SW, Jooste P, Karim F, Kuhn W, Shalek AK, Ndung'u T, Morris L, Moore PL, Pillai S, Kløverpris H, Goulder P, Leslie A.

Front Immunol. 2018 Sep 12;9:1975. doi: 10.3389/fimmu.2018.01975. eCollection 2018.

12.

A FRESH approach: Combining basic science and social good.

Ndung'u T, Dong KL, Kwon DS, Walker BD.

Sci Immunol. 2018 Sep 14;3(27). pii: eaau2798. doi: 10.1126/sciimmunol.aau2798.

PMID:
30217812
13.

Unmet needs of high-risk mothers reduce success of antiretroviral treatment in HIV-infected infants.

Mvo Z, Ntlantsana V, Bengu N, Millar J, Roider J, Bhoola R, Krishna M, Graza Y, Van Lobenstein J, Kapongo C, Kogielambal C, Sprenger K, Archary M, Ndung'u T, Goulder P.

S Afr Med J. 2018 Jul 25;108(8):609-610. doi: 10.7196/SAMJ.2018.v108i8.13376.

15.

Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome.

Yoon HA, Nakouzi A, Chang CC, Kuniholm MH, Carreño LJ, Wang T, Ndung'u T, Lewin SR, French MA, Pirofski LA.

J Infect Dis. 2019 Jan 9;219(3):420-428. doi: 10.1093/infdis/jiy447.

PMID:
30010905
16.

Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection.

Ojwach DBA, MacMillan D, Reddy T, Novitsky V, Brumme ZL, Brockman MA, Ndung'u T, Mann JK.

J Virol. 2018 Sep 12;92(19). pii: e00811-18. doi: 10.1128/JVI.00811-18. Print 2018 Oct 1. Erratum in: J Virol. 2019 Jan 17;93(3):.

17.

Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load.

Baiyegunhi O, Ndlovu B, Ogunshola F, Ismail N, Walker BD, Ndung'u T, Ndhlovu ZM.

J Virol. 2018 Jul 17;92(15). pii: e00659-18. doi: 10.1128/JVI.00659-18. Print 2018 Aug 1.

18.

Individuals with HIV-1 Subtype C Infection and Cryptococcal Meningitis Exhibit Viral Genetic Intermixing of HIV-1 Between Plasma and Cerebrospinal Fluid and a High Prevalence of CXCR4-Using Variants.

Sojane K, Kangethe RT, Chang CC, Moosa MS, Lewin SR, French MA, Ndung'u T.

AIDS Res Hum Retroviruses. 2018 Jul;34(7):607-620. doi: 10.1089/AID.2017.0209. Epub 2018 May 23.

19.

Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity.

Chung AW, Mabuka JM, Ndlovu B, Licht A, Robinson H, Ramlakhan Y, Ghebremichael M, Reddy T, Goulder PJR, Walker BD, Ndung'u T, Alter G.

AIDS. 2018 Jun 19;32(10):1207-1217. doi: 10.1097/QAD.0000000000001812.

PMID:
29620716
20.

Evaluation of a synthetic peptide for the detection of anti-Mycobacterium tuberculosis curli pili IgG antibodies in patients with pulmonary tuberculosis.

Naidoo N, Pillay B, Bubb M, Pym A, Chiliza T, Naidoo K, Ndung'u T, Kasprowicz VO, Pillay M.

Tuberculosis (Edinb). 2018 Mar;109:80-84. doi: 10.1016/j.tube.2018.01.007. Epub 2018 Feb 3.

PMID:
29559125
21.

Soluble CD14 as a Diagnostic Biomarker for Smear-Negative HIV-Associated Tuberculosis.

Liu Y, Ndumnego OC, Chen T, Kim RS, Jenny-Avital ER, Ndung'u T, Wilson D, Achkar JM.

Pathogens. 2018 Feb 27;7(1). pii: E26. doi: 10.3390/pathogens7010026.

22.

Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides.

Seipone ID, Singh R, Patel VB, Singh A, Gordon ML, Muema DM, Dheda K, Ndung'u T.

PLoS One. 2018 Feb 2;13(2):e0192060. doi: 10.1371/journal.pone.0192060. eCollection 2018.

23.

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.

Ramsuran V, Naranbhai V, Horowitz A, Qi Y, Martin MP, Yuki Y, Gao X, Walker-Sperling V, Del Prete GQ, Schneider DK, Lifson JD, Fellay J, Deeks SG, Martin JN, Goedert JJ, Wolinsky SM, Michael NL, Kirk GD, Buchbinder S, Haas D, Ndung'u T, Goulder P, Parham P, Walker BD, Carlson JM, Carrington M.

Science. 2018 Jan 5;359(6371):86-90. doi: 10.1126/science.aam8825. Epub 2018 Jan 4.

24.

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.

Ngcapu S, Theys K, Libin P, Marconi VC, Sunpath H, Ndung'u T, Gordon ML.

Viruses. 2017 Nov 8;9(11). pii: E330. doi: 10.3390/v9110330.

25.

Plasma But Not Cerebrospinal Fluid Interleukin 7 and Interleukin 5 Levels Pre-Antiretroviral Therapy Commencement Predict Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome.

Akilimali NA, Chang CC, Muema DM, Reddy T, Moosa MS, Lewin SR, French MA, Ndung'u T.

Clin Infect Dis. 2017 Oct 16;65(9):1551-1559. doi: 10.1093/cid/cix598.

26.

Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals.

Mwimanzi F, Toyoda M, Mahiti M, Mann JK, Martin JN, Bangsberg D, Brockman MA, Goulder P, Kirchhoff F, Brumme ZL, Ndung'u T, Ueno T.

J Virol. 2017 Dec 14;92(1). pii: e01409-17. doi: 10.1128/JVI.01409-17. Print 2018 Jan 1.

27.

Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape.

Leitman EM, Thobakgale CF, Adland E, Ansari MA, Raghwani J, Prendergast AJ, Tudor-Williams G, Kiepiela P, Hemelaar J, Brener J, Tsai MH, Mori M, Riddell L, Luzzi G, Jooste P, Ndung'u T, Walker BD, Pybus OG, Kellam P, Naranbhai V, Matthews PC, Gall A, Goulder PJR.

J Exp Med. 2017 Nov 6;214(11):3239-3261. doi: 10.1084/jem.20162123. Epub 2017 Oct 5.

28.

Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.

Dong KL, Moodley A, Kwon DS, Ghebremichael MS, Dong M, Ismail N, Ndhlovu ZM, Mabuka JM, Muema DM, Pretorius K, Lin N, Walker BD, Ndung'u T.

Lancet HIV. 2018 Jan;5(1):e35-e44. doi: 10.1016/S2352-3018(17)30146-7. Epub 2017 Oct 1.

PMID:
28978417
29.

Cellular Architecture of Spinal Granulomas and the Immunological Response in Tuberculosis Patients Coinfected with HIV.

Bhattacharya D, Danaviah S, Muema DM, Akilimali NA, Moodley P, Ndung'u T, Das G.

Front Immunol. 2017 Sep 11;8:1120. doi: 10.3389/fimmu.2017.01120. eCollection 2017.

30.

Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies.

Mabuka JM, Dugast AS, Muema DM, Reddy T, Ramlakhan Y, Euler Z, Ismail N, Moodley A, Dong KL, Morris L, Walker BD, Alter G, Ndung'u T.

Front Immunol. 2017 Sep 8;8:1104. doi: 10.3389/fimmu.2017.01104. eCollection 2017.

31.

A35 Viral evolution and innate immune responses during acute HIV-1 infection and their association with disease pathogenesis.

Hassan AS, Hare J, Kamini G, Yindom LM, Kamali A, Karita E, Kilemba W, Price MA, Borrow P, Bjorkman P, Albert J, Kaleebu P, Allan S, Fast P, Hunter E, Gilmour J, Ndung'u T, Rowland-Jones S, Sanders EJ, Esbjornsson J.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.034. doi: 10.1093/ve/vew036.034. eCollection 2017 Mar. No abstract available.

32.

Reduced Expression of Siglec-7, NKG2A, and CD57 on Terminally Differentiated CD56-CD16+ Natural Killer Cell Subset Is Associated with Natural Killer Cell Dysfunction in Chronic HIV-1 Clade C Infection.

Zulu MZ, Naidoo KK, Mncube Z, Jaggernath M, Goulder PJR, Ndung'u T, Altfeld M, Thobakgale CF.

AIDS Res Hum Retroviruses. 2017 Dec;33(12):1205-1213. doi: 10.1089/AID.2017.0095. Epub 2017 Sep 21.

PMID:
28810810
33.

Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy.

Muenchhoff M, Healy M, Singh R, Roider J, Groll A, Kindra C, Sibaya T, Moonsamy A, McGregor C, Phan MQ, Palma A, Kloverpris H, Leslie A, Bobat R, LaRussa P, Ndung'u T, Goulder P, Sobieszczyk ME, Archary M.

AIDS Res Hum Retroviruses. 2018 Jan;34(1):46-55. doi: 10.1089/AID.2016.0261. Epub 2017 Sep 6.

34.

Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.

Naidoo VL, Mann JK, Noble C, Adland E, Carlson JM, Thomas J, Brumme CJ, Thobakgale-Tshabalala CF, Brumme ZL, Brockman MA, Goulder PJR, Ndung'u T.

J Virol. 2017 Aug 10;91(17). pii: e00518-17. doi: 10.1128/JVI.00518-17. Print 2017 Sep 1.

35.

Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.

Lee GQ, Orlova-Fink N, Einkauf K, Chowdhury FZ, Sun X, Harrington S, Kuo HH, Hua S, Chen HR, Ouyang Z, Reddy K, Dong K, Ndung'u T, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M.

J Clin Invest. 2017 Jun 30;127(7):2689-2696. doi: 10.1172/JCI93289. Epub 2017 Jun 19.

36.

PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort.

Sharp CP, Gregory WF, Hattingh L, Malik A, Adland E, Daniels S, van Zyl A, Carlson JM, Wareing S, Ogwu A, Shapiro R, Riddell L, Chen F, Ndung'u T, Goulder PJR, Klenerman P, Simmonds P, Jooste P, Matthews PC.

Wellcome Open Res. 2017 Apr 7;2:26. doi: 10.12688/wellcomeopenres.11135.1.

37.

Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis.

Chang CC, Kangethe R, Omarjee S, Hiramen K, Gosnell B, Sojane K, Moosa MS, Lewin SR, French MA, Ndung'u T.

Open Forum Infect Dis. 2017 Feb 12;4(2):ofx032. doi: 10.1093/ofid/ofx032. eCollection 2017 Spring.

38.

Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression.

Kiguoya MW, Mann JK, Chopera D, Gounder K, Lee GQ, Hunt PW, Martin JN, Ball TB, Kimani J, Brumme ZL, Brockman MA, Ndung'u T.

J Virol. 2017 Jun 9;91(13). pii: e00253-17. doi: 10.1128/JVI.00253-17. Print 2017 Jul 1.

39.

Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.

Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS.

Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10.

40.

HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection.

Laher F, Ranasinghe S, Porichis F, Mewalal N, Pretorius K, Ismail N, Buus S, Stryhn A, Carrington M, Walker BD, Ndung'u T, Ndhlovu ZM.

J Virol. 2017 Mar 13;91(7). pii: e02477-16. doi: 10.1128/JVI.02477-16. Print 2017 Apr 1.

41.

Complex Subtype Diversity of HIV-1 Among Drug Users in Major Kenyan Cities.

Gounder K, Oyaro M, Padayachi N, Zulu TM, de Oliveira T, Wylie J, Ndung'u T.

AIDS Res Hum Retroviruses. 2017 May;33(5):500-510. doi: 10.1089/AID.2016.0321. Epub 2017 Mar 1.

42.

The role of mucosal-associated invariant T cells in infectious diseases.

Wong EB, Ndung'u T, Kasprowicz VO.

Immunology. 2017 Jan;150(1):45-54. doi: 10.1111/imm.12673. Epub 2016 Oct 26. Review.

43.

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.

Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast AJ, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg CB, Walker BD, Ndung'u T, Jooste P, Moore PL, Morris L, Goulder P.

Sci Transl Med. 2016 Sep 28;8(358):358ra125. doi: 10.1126/scitranslmed.aag1048.

44.

Interleukin 1-Beta (IL-1β) Production by Innate Cells Following TLR Stimulation Correlates With TB Recurrence in ART-Treated HIV-Infected Patients.

Thobakgale C, Naidoo K, McKinnon LR, Werner L, Samsunder N, Karim SA, Ndungʼu T, Altfeld M, Naidoo K.

J Acquir Immune Defic Syndr. 2017 Feb 1;74(2):213-220. doi: 10.1097/QAI.0000000000001181.

45.

Paediatric non-progression following grandmother-to-child HIV transmission.

Tsai MH, Muenchhoff M, Adland E, Carlqvist A, Roider J, Cole DK, Sewell AK, Carlson J, Ndung'u T, Goulder PJ.

Retrovirology. 2016 Sep 8;13(1):65. doi: 10.1186/s12977-016-0300-y.

46.

CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.

Koofhethile CK, Ndhlovu ZM, Thobakgale-Tshabalala C, Prado JG, Ismail N, Mncube Z, Mkhize L, van der Stok M, Yende N, Walker BD, Goulder PJR, Ndung'u T.

J Virol. 2016 Jul 11;90(15):6818-6831. doi: 10.1128/JVI.00276-16. Print 2016 Aug 1.

47.

Impact of pre-adapted HIV transmission.

Carlson JM, Du VY, Pfeifer N, Bansal A, Tan VY, Power K, Brumme CJ, Kreimer A, DeZiel CE, Fusi N, Schaefer M, Brockman MA, Gilmour J, Price MA, Kilembe W, Haubrich R, John M, Mallal S, Shapiro R, Frater J, Harrigan PR, Ndung'u T, Allen S, Heckerman D, Sidney J, Allen TM, Goulder PJ, Brumme ZL, Hunter E, Goepfert PA.

Nat Med. 2016 Jun;22(6):606-13. doi: 10.1038/nm.4100. Epub 2016 May 16.

48.

Association of Polymorphisms in the Regulatory Region of the Cyclophilin a Gene (PPIA) with Gene Expression and HIV/AIDS Disease Progression.

Madlala P, Singh R, An P, Werner L, Mlisana K, Abdool Karim SS, Winkler CA, Ndungʼu T.

J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):465-73. doi: 10.1097/QAI.0000000000001028.

49.

Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes.

Reddy K, Ooms M, Letko M, Garrett N, Simon V, Ndung'u T.

AIDS. 2016 Jul 17;30(11):1723-9. doi: 10.1097/QAD.0000000000001113.

50.

Diagnostic Accuracy of the HemoCue Hb 301, STAT-Site MHgb and URIT-12 Point-of-Care Hemoglobin Meters in a Central Laboratory and a Community Based Clinic in Durban, South Africa.

Jaggernath M, Naicker R, Madurai S, Brockman MA, Ndung'u T, Gelderblom HC.

PLoS One. 2016 Apr 5;11(4):e0152184. doi: 10.1371/journal.pone.0152184. eCollection 2016.

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