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Items: 1 to 50 of 92

1.

Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems.

Kamal MM, Akter S, Lin CN, Nazzal S.

Arch Pharm Res. 2020 Mar 10. doi: 10.1007/s12272-020-01225-2. [Epub ahead of print] Review.

PMID:
32152852
2.

A full factorial experimental design to study the effect of flavoring agents on the mechanical properties of curcumin chewing gum tablets with high solids content.

Al Hagbani T, Kamal MM, Nazzal S.

Drug Dev Ind Pharm. 2020 Mar 5:1-8. doi: 10.1080/03639045.2020.1734019. [Epub ahead of print]

PMID:
32090628
3.

Development and evaluation of paclitaxel nanoemulsion for cancer therapy.

Shakhwar S, Darwish R, Kamal MM, Nazzal S, Pallerla S, Abu Fayyad A.

Pharm Dev Technol. 2020 Apr;25(4):510-516. doi: 10.1080/10837450.2019.1706564. Epub 2019 Dec 26.

PMID:
31858867
4.

Ceramide-Rubusoside Nanomicelles, a Potential Therapeutic Approach to Target Cancers Carrying p53 Missense Mutations.

Khiste SK, Liu Z, Roy KR, Uddin MB, Hosain SB, Gu X, Nazzal S, Hill RA, Liu YY.

Mol Cancer Ther. 2020 Feb;19(2):564-574. doi: 10.1158/1535-7163.MCT-19-0366. Epub 2019 Oct 23.

PMID:
31645443
5.
6.

Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications.

Darweesh RS, Ayoub NM, Nazzal S.

Int J Nanomedicine. 2019 Sep 19;14:7643-7663. doi: 10.2147/IJN.S223941. eCollection 2019. Review.

7.

Novel olive oil phenolic (-)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities.

Qusa MH, Siddique AB, Nazzal S, El Sayed KA.

Int J Pharm. 2019 Oct 5;569:118596. doi: 10.1016/j.ijpharm.2019.118596. Epub 2019 Aug 5.

PMID:
31394181
8.

Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer.

Hendricks A, Gieseler F, Nazzal S, Bräsen JH, Lucius R, Sipos B, Claasen JH, Becker T, Hinz S, Burmeister G, Schafmayer C, Schrader C.

BMC Cancer. 2019 May 9;19(1):429. doi: 10.1186/s12885-019-5631-3.

9.

Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity.

Siddique AB, Ebrahim H, Mohyeldin M, Qusa M, Batarseh Y, Fayyad A, Tajmim A, Nazzal S, Kaddoumi A, El Sayed K.

PLoS One. 2019 Apr 9;14(4):e0214798. doi: 10.1371/journal.pone.0214798. eCollection 2019.

10.

STEMI mimicker in a 26-year-old man.

Lee HS, Pai R, Nazzal S, Mukherjee A.

BMJ Case Rep. 2019 Feb 1;12(2). pii: bcr-2018-224894. doi: 10.1136/bcr-2018-224894.

PMID:
30709890
11.

D-optimal mixture design: Formulation development, mechanical characterization, and optimization of curcumin chewing gums using oppanol® B 12 elastomer as a gum-base.

Al Hagbani T, Altomare C, Salawi A, Nazzal S.

Int J Pharm. 2018 Dec 20;553(1-2):210-219. doi: 10.1016/j.ijpharm.2018.10.047. Epub 2018 Oct 19.

PMID:
30347275
12.

The physiochemical, mechanical, and adhesive properties of solvent-cast vitamin E/Soluplus® films.

Salawi A, Nazzal S.

Int J Pharm. 2018 Dec 1;552(1-2):378-387. doi: 10.1016/j.ijpharm.2018.10.018. Epub 2018 Oct 9.

PMID:
30308273
13.

Mechanical Characterization and Dissolution of Chewing Gum Tablets (CGTs) Containing Co-compressed Health in Gum® and Curcumin/Cyclodextrin Inclusion Complex.

Al Hagbani T, Altomare C, Kamal MM, Nazzal S.

AAPS PharmSciTech. 2018 Nov;19(8):3742-3750. doi: 10.1208/s12249-018-1174-1. Epub 2018 Sep 25.

PMID:
30255470
14.

Medicated Chewing Gums (MCGs): Composition, Production, and Mechanical Testing.

Al Hagbani T, Nazzal S.

AAPS PharmSciTech. 2018 Oct;19(7):2908-2920. doi: 10.1208/s12249-018-1123-z. Epub 2018 Aug 7.

PMID:
30088152
15.

Association Between the Frank Sign and Cardiovascular Events.

Nazzal S, Blum A.

South Med J. 2018 Aug;111(8):504-509. doi: 10.14423/SMJ.0000000000000845.

PMID:
30075478
16.

The rheological and textural characterization of Soluplus®/Vitamin E composites.

Salawi A, Nazzal S.

Int J Pharm. 2018 Jul 30;546(1-2):255-262. doi: 10.1016/j.ijpharm.2018.05.049. Epub 2018 May 21.

PMID:
29792987
17.

Development of a new class of sulforaphane-enabled self-emulsifying drug delivery systems (SFN-SEDDS) by high throughput screening: A case study with curcumin.

Kamal MM, Nazzal S.

Int J Pharm. 2018 Mar 25;539(1-2):147-156. doi: 10.1016/j.ijpharm.2018.01.045. Epub 2018 Feb 27.

PMID:
29414123
18.

Novel sulforaphane-enabled self-microemulsifying delivery systems (SFN-SMEDDS) of taxanes: Formulation development and in vitro cytotoxicity against breast cancer cells.

Kamal MM, Nazzal S.

Int J Pharm. 2018 Jan 30;536(1):187-198. doi: 10.1016/j.ijpharm.2017.11.063. Epub 2017 Nov 28.

PMID:
29195916
19.

Development and in-vitro characterization of nanoemulsions loaded with paclitaxel/γ-tocotrienol lipid conjugates.

Abu-Fayyad A, Kamal MM, Carroll JL, Dragoi AM, Cody R, Cardelli J, Nazzal S.

Int J Pharm. 2018 Jan 30;536(1):146-157. doi: 10.1016/j.ijpharm.2017.11.062. Epub 2017 Dec 2.

20.

Implications of Anomalous Left Coronary Artery Origin.

Agbor-Etang BB, La VT, Nazzal SB, Pai RG.

Am J Med. 2018 Jan;131(1):e21-e22. doi: 10.1016/j.amjmed.2017.09.038. Epub 2017 Oct 12. No abstract available.

PMID:
29031591
21.

Development of postcompressional textural tests to evaluate the mechanical properties of medicated chewing gum tablets with high drug loadings.

Al Hagbani T, Nazzal S.

J Texture Stud. 2018 Feb;49(1):30-37. doi: 10.1111/jtxs.12287. Epub 2017 Aug 15.

PMID:
28776678
22.

Gemcitabine-vitamin E conjugates: Synthesis, characterization, entrapment into nanoemulsions, and in-vitro deamination and antitumor activity.

Abu-Fayyad A, Nazzal S.

Int J Pharm. 2017 Aug 7;528(1-2):463-470. doi: 10.1016/j.ijpharm.2017.06.031. Epub 2017 Jun 13.

23.
24.

Cholecalciferol (D₃) Versus Ergocalciferol (D₂) in Older Adults.

Dereje S, Muradov I, Nazzal S, Nguyen T.

Consult Pharm. 2017 Jun 1;32(6):337-339. doi: 10.4140/TCP.n.2017.337. Review.

PMID:
28595683
25.

Diagonal Earlobe Crease (Frank's Sign): A Predictor of Cerebral Vascular Events.

Nazzal S, Hijazi B, Khalila L, Blum A.

Am J Med. 2017 Nov;130(11):1324.e1-1324.e5. doi: 10.1016/j.amjmed.2017.03.059. Epub 2017 Apr 29.

PMID:
28460854
26.

Development and qualification of an LC-MS/MS method for investigating the biological implications of micelle entrapped paclitaxel in cell culture and rats.

Kaddoumi A, Gill KK, Elfakhri K, Nazzal S.

Biomed Chromatogr. 2017 Sep;31(9). doi: 10.1002/bmc.3960. Epub 2017 Mar 21.

PMID:
28205290
27.

Curcumin complexation with cyclodextrins by the autoclave process: Method development and characterization of complex formation.

Hagbani TA, Nazzal S.

Int J Pharm. 2017 Mar 30;520(1-2):173-180. doi: 10.1016/j.ijpharm.2017.01.063. Epub 2017 Feb 5.

PMID:
28167265
28.
29.

PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability.

Abu-Fayyad A, Behery F, Sallam AA, Alqahtani S, Ebrahim H, El Sayed KA, Kaddoumi A, Sylvester PW, Carroll JL, Cardelli JA, Nazzal S.

Eur J Pharm Biopharm. 2015 Oct;96:185-95. doi: 10.1016/j.ejpb.2015.07.022. Epub 2015 Jul 30.

PMID:
26235392
30.

pH-Dependent Solubility and Dissolution Behavior of Carvedilol--Case Example of a Weakly Basic BCS Class II Drug.

Hamed R, Awadallah A, Sunoqrot S, Tarawneh O, Nazzal S, AlBaraghthi T, Al Sayyad J, Abbas A.

AAPS PharmSciTech. 2016 Apr;17(2):418-26. doi: 10.1208/s12249-015-0365-2. Epub 2015 Jul 23.

31.

Evaluation of the growth and osteogenic differentiation of ASCs cultured with PL and seeded on PLGA scaffolds.

Awidi A, Ababneh N, Alkilani H, Salah B, Nazzal S, Zoghool M, Shomaf M.

J Mater Sci Mater Med. 2015 Feb;26(2):84. doi: 10.1007/s10856-015-5404-8. Epub 2015 Feb 3.

PMID:
25644098
32.

Cellular uptake, antioxidant and antiproliferative activity of entrapped α-tocopherol and γ-tocotrienol in poly (lactic-co-glycolic) acid (PLGA) and chitosan covered PLGA nanoparticles (PLGA-Chi).

Alqahtani S, Simon L, Astete CE, Alayoubi A, Sylvester PW, Nazzal S, Shen Y, Xu Z, Kaddoumi A, Sabliov CM.

J Colloid Interface Sci. 2015 May 1;445:243-251. doi: 10.1016/j.jcis.2014.12.083. Epub 2015 Jan 10.

PMID:
25622049
33.

PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication.

Gill KK, Kaddoumi A, Nazzal S.

J Drug Target. 2015 Apr;23(3):222-31. doi: 10.3109/1061186X.2014.997735. Epub 2014 Dec 30. Review.

PMID:
25547369
34.

Smartphone expedites parasitology diagnosis.

Blum A, Nazzal S, Peretz A.

Isr Med Assoc J. 2014 Jul;16(7):463. No abstract available.

35.

δ-Tocotrienol oxazine derivative antagonizes mammary tumor cell compensatory response to CoCl2-induced hypoxia.

Ananthula S, Parajuli P, Behery FA, Alayoubi AY, Nazzal S, El Sayed K, Sylvester PW.

Biomed Res Int. 2014;2014:285752. doi: 10.1155/2014/285752. Epub 2014 Jul 22.

36.

Enhanced solubility and oral bioavailability of γ-tocotrienol using a self-emulsifying drug delivery system (SEDDS).

Alqahtani S, Alayoubi A, Nazzal S, Sylvester PW, Kaddoumi A.

Lipids. 2014 Aug;49(8):819-29. doi: 10.1007/s11745-014-3923-6. Epub 2014 Jun 17.

PMID:
24934591
37.

Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling.

Sallam AA, Mohyeldin MM, Foudah AI, Akl MR, Nazzal S, Meyer SA, Liu YY, El Sayed KA.

Org Biomol Chem. 2014 Jul 28;12(28):5295-303. doi: 10.1039/c4ob00553h.

PMID:
24927150
38.

Oxazine derivatives of γ- and δ-tocotrienol display enhanced anticancer activity in vivo.

Ananthula S, Parajuli P, Behery FA, Alayoubi AY, El Sayed KA, Nazzal S, Sylvester PW.

Anticancer Res. 2014 Jun;34(6):2715-26.

PMID:
24922632
39.

Entrapment into nanoemulsions potentiates the anticancer activity of tocotrienols against the highly malignant (+SA) mouse mammary epithelial cells.

Alayoubi A, Ayoub NM, Malaviya A, Sylvester PW, Nazzal S.

J Nanosci Nanotechnol. 2014 May;14(5):4002-5.

PMID:
24734680
40.

Effect of lipid viscosity and high-pressure homogenization on the physical stability of "Vitamin E" enriched emulsion.

Alayoubi A, Abu-Fayyad A, Rawas-Qalaji MM, Sylvester PW, Nazzal S.

Pharm Dev Technol. 2015;20(5):555-61. doi: 10.3109/10837450.2014.898655. Epub 2014 Mar 12.

PMID:
24621375
41.

Thermoresponsive fluconazole gels for topical delivery: rheological and mechanical properties, in vitro drug release and anti-fungal efficacy.

Gandra SC, Nguyen S, Nazzal S, Alayoubi A, Jung R, Nesamony J.

Pharm Dev Technol. 2015 Jan;20(1):41-9. doi: 10.3109/10837450.2013.846376. Epub 2013 Oct 25.

PMID:
24160864
42.

Effect of PEG surface conformation on anticancer activity and blood circulation of nanoemulsions loaded with tocotrienol-rich fraction of palm oil.

Alayoubi A, Alqahtani S, Kaddoumi A, Nazzal S.

AAPS J. 2013 Oct;15(4):1168-79. doi: 10.1208/s12248-013-9525-z. Epub 2013 Aug 30.

43.

Modeling the effect of sonication parameters on size and dispersion temperature of solid lipid nanoparticles (SLNs) by response surface methodology (RSM).

Siddiqui A, Alayoubi A, El-Malah Y, Nazzal S.

Pharm Dev Technol. 2014 May;19(3):342-6. doi: 10.3109/10837450.2013.784336. Epub 2013 Apr 16.

PMID:
23590412
44.

Nonlinear absorption kinetics of self-emulsifying drug delivery systems (SEDDS) containing tocotrienols as lipophilic molecules: in vivo and in vitro studies.

Alqahtani S, Alayoubi A, Nazzal S, Sylvester PW, Kaddoumi A.

AAPS J. 2013 Jul;15(3):684-95. doi: 10.1208/s12248-013-9481-7. Epub 2013 Apr 10.

45.

Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin.

Liu JJ, Nazzal S, Chang TS, Tsai T.

J Cosmet Sci. 2013 Jan-Feb;64(1):9-17.

PMID:
23449127
46.

The effect of emulsifying wax on the physical properties of CTAB-based solid lipid nanoparticles (SLN).

Siddiqui A, Alayoubi A, Nazzal S.

Pharm Dev Technol. 2014 Feb;19(1):125-8. doi: 10.3109/10837450.2012.751401. Epub 2013 Jan 7.

PMID:
23294366
47.

Concurrent delivery of tocotrienols and simvastatin by lipid nanoemulsions potentiates their antitumor activity against human mammary adenocarcenoma cells.

Alayoubi AY, Anderson JF, Satyanarayanajois SD, Sylvester PW, Nazzal S.

Eur J Pharm Sci. 2013 Feb 14;48(3):385-92. doi: 10.1016/j.ejps.2012.12.011. Epub 2012 Dec 20.

PMID:
23262057
48.

Stability and in vitro antiproliferative activity of bioactive "Vitamin E" fortified parenteral lipid emulsions.

Alayoubi A, Kanthala S, Satyanarayanajois SD, Anderson JF, Sylvester PW, Nazzal S.

Colloids Surf B Biointerfaces. 2013 Mar 1;103:23-30. doi: 10.1016/j.colsurfb.2012.10.003. Epub 2012 Oct 12.

PMID:
23201715
49.

Powdered self-emulsified lipid formulations of meloxicam as solid dosage forms for oral administration.

Agarwal V, Alayoubi A, Siddiqui A, Nazzal S.

Drug Dev Ind Pharm. 2013 Nov;39(11):1681-9. doi: 10.3109/03639045.2012.729594. Epub 2012 Oct 17.

PMID:
23072611
50.

"Real-time" disintegration analysis and D-optimal experimental design for the optimization of diclofenac sodium fast-dissolving films.

El-Malah Y, Nazzal S.

Pharm Dev Technol. 2013 Nov-Dec;18(6):1355-60. doi: 10.3109/10837450.2012.700936. Epub 2012 Jul 11.

PMID:
22780708

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