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Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes.

Groener JB, Valkanou A, Kender Z, Pfeiffenberger J, Kihm L, Fleming T, Nawroth PP, Kopf S.

PLoS One. 2019 Sep 19;14(9):e0222771. doi: 10.1371/journal.pone.0222771. eCollection 2019.


Serum uromodulin and Roux-en-Y gastric bypass: improvement of a marker reflecting nephron mass.

Scheurlen KM, Billeter AT, Kopf S, Herbst V, Block M, Nawroth PP, Zeier M, Scherberich JE, Müller-Stich BP.

Surg Obes Relat Dis. 2019 Aug;15(8):1319-1325. doi: 10.1016/j.soard.2019.05.002. Epub 2019 May 15.


The combination of loss of glyoxalase1 and obesity results in hyperglycemia.

Lodd E, Wiggenhauser LM, Morgenstern J, Fleming TH, Poschet G, Büttner M, Tabler CT, Wohlfart DP, Nawroth PP, Kroll J.

JCI Insight. 2019 Jun 20;4(12). pii: 126154. doi: 10.1172/jci.insight.126154. eCollection 2019 Jun 20.


Metabolic surgery improves renal injury independent of weight loss: a meta-analysis.

Scheurlen KM, Probst P, Kopf S, Nawroth PP, Billeter AT, Müller-Stich BP.

Surg Obes Relat Dis. 2019 Jun;15(6):1006-1020. doi: 10.1016/j.soard.2019.03.013. Epub 2019 Mar 20.


CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.

Schmöhl F, Peters V, Schmitt CP, Poschet G, Büttner M, Li X, Weigand T, Poth T, Volk N, Morgenstern J, Fleming T, Nawroth PP, Kroll J.

Cell Mol Life Sci. 2019 May 9. doi: 10.1007/s00018-019-03127-z. [Epub ahead of print]


Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.

Griggs RB, Santos DF, Laird DE, Doolen S, Donahue RR, Wessel CR, Fu W, Sinha GP, Wang P, Zhou J, Brings S, Fleming T, Nawroth PP, Susuki K, Taylor BK.

Neurobiol Dis. 2019 Jul;127:76-86. doi: 10.1016/j.nbd.2019.02.019. Epub 2019 Feb 23.


An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial.

Karusheva Y, Kunstein L, Bierwagen A, Nowotny B, Kabisch S, Groener JB, Fleitmann AK, Herder C, Pacini G, Strassburger K, Häring HU, Nawroth PP, Pfeiffer AFH, Burkart V, Müssig K, Roden M, Szendroedi J.

Nutr Metab (Lond). 2018 Dec 29;15:90. doi: 10.1186/s12986-018-0324-5. eCollection 2018.


Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions.

Peters AS, Wortmann M, Fleming TH, Nawroth PP, Bruckner T, Böckler D, Hakimi M.

Vasa. 2019 Mar;48(2):186-192. doi: 10.1024/0301-1526/a000762. Epub 2018 Nov 13.


BRAF V600E and Retinoic Acid in Radioiodine-Refractory Papillary Thyroid Cancer.

Groener JB, Gelen D, Mogler C, Herpel E, Toth C, Kender Z, Peichl M, Haufe S, Haberkorn U, Sulaj A, Zemva J, Kopf S, Nawroth PP, Brune M, Rudofsky G.

Horm Metab Res. 2019 Jan;51(1):69-75. doi: 10.1055/a-0765-9078. Epub 2018 Nov 5.


Deep phenotyping neuropathy: An underestimated complication in patients with pre-diabetes and type 2 diabetes associated with albuminuria.

Kopf S, Groener JB, Kender Z, Fleming T, Bischoff S, Jende J, Schumann C, Ries S, Bendszus M, Schuh-Hofer S, Treede RD, Nawroth PP.

Diabetes Res Clin Pract. 2018 Dec;146:191-201. doi: 10.1016/j.diabres.2018.10.020. Epub 2018 Oct 31.


Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.

Nigro C, Leone A, Longo M, Prevenzano I, Fleming TH, Nicolò A, Parrillo L, Spinelli R, Formisano P, Nawroth PP, Beguinot F, Miele C.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):73-85. doi: 10.1016/j.bbadis.2018.10.014. Epub 2018 Oct 18.


Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.

Schumacher D, Morgenstern J, Oguchi Y, Volk N, Kopf S, Groener JB, Nawroth PP, Fleming T, Freichel M.

Mol Metab. 2018 Dec;18:143-152. doi: 10.1016/j.molmet.2018.09.005. Epub 2018 Sep 19.


Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes.

Shahzad K, Gadi I, Nazir S, Al-Dabet MM, Kohli S, Bock F, Breitenstein L, Ranjan S, Fuchs T, Halloul Z, Nawroth PP, Pelicci PG, Braun-Dullaeus RC, Camerer E, Esmon CT, Isermann B.

Commun Biol. 2018 Aug 6;1:104. doi: 10.1038/s42003-018-0108-5. eCollection 2018.


Diabetic Pulmopathy: A New Clinical Challenge for Diabetology.

Kopf S, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2018 Sep;126(9):590-591. doi: 10.1055/a-0715-2743. Epub 2018 Sep 27. No abstract available.


The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.

Gerst F, Jaghutriz BA, Staiger H, Schulte AM, Lorza-Gil E, Kaiser G, Panse M, Haug S, Heni M, Schütz M, Stadion M, Schürmann A, Marzetta F, Ibberson M, Sipos B, Fend F, Fleming T, Nawroth PP, Königsrainer A, Nadalin S, Wagner S, Peter A, Fritsche A, Richter D, Solimena M, Häring HU, Ullrich S, Wagner R.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4373-4383. doi: 10.1210/jc.2018-00791.


Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes.

Kopf S, Groener JB, Kender Z, Fleming T, Brune M, Riedinger C, Volk N, Herpel E, Pesta D, Szendrödi J, Wielpütz MO, Kauczor HU, Katus HA, Kreuter M, Nawroth PP.

Respiration. 2018;96(1):29-40. doi: 10.1159/000488909. Epub 2018 Jun 6.


Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.

Mendler M, Kopf S, Groener JB, Riedinger C, Fleming TH, Nawroth PP, Okun JG.

Acta Diabetol. 2018 Jun;55(6):585-592. doi: 10.1007/s00592-018-1130-2. Epub 2018 Mar 15.


Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation - results of an observational pilot study.

Schmitt FCF, Salgado E, Friebe J, Schmoch T, Uhle F, Fleming T, Zemva J, Kihm L, Nusshag C, Morath C, Zeier M, Bruckner T, Mehrabi A, Nawroth PP, Weigand MA, Hofer S, Brenner T.

Transpl Int. 2018 Jul;31(7):751-760. doi: 10.1111/tri.13148. Epub 2018 Mar 30.


Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.

Zemva J, Pfaff D, Groener JB, Fleming T, Herzig S, Teleman A, Nawroth PP, Tyedmers J.

Exp Clin Endocrinol Diabetes. 2019 Apr;127(4):203-214. doi: 10.1055/s-0043-122382. Epub 2018 Feb 8. Review.


High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans.

Riedinger C, Mendler M, Schlotterer A, Fleming T, Okun J, Hammes HP, Herzig S, Nawroth PP.

J Biol Chem. 2018 Mar 30;293(13):4845-4859. doi: 10.1074/jbc.M117.805879. Epub 2018 Feb 2.


Meta-analysis of metabolic surgery versus medical treatment for microvascular complications in patients with type 2 diabetes mellitus.

Billeter AT, Scheurlen KM, Probst P, Eichel S, Nickel F, Kopf S, Fischer L, Diener MK, Nawroth PP, Müller-Stich BP.

Br J Surg. 2018 Feb;105(3):168-181. doi: 10.1002/bjs.10724. Review.


Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A.

Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733. Epub 2018 Jan 20.


Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry.

Hidmark AS, Nawroth PP, Fleming T.

J Vis Exp. 2017 Dec 6;(130). doi: 10.3791/56538.


Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.

Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M.

J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.


Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.

Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, Christian S, Hess-Stumpp H, Augustin HG, Müller-Decker K, Nawroth PP, Herzig S, Berriel Diaz M.

Cell Metab. 2017 Dec 5;26(6):842-855.e5. doi: 10.1016/j.cmet.2017.09.018. Epub 2017 Oct 19.


Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.

Kumar V, Fleming T, Terjung S, Gorzelanny C, Gebhardt C, Agrawal R, Mall MA, Ranzinger J, Zeier M, Madhusudhan T, Ranjan S, Isermann B, Liesz A, Deshpande D, Häring HU, Biswas SK, Reynolds PR, Hammes HP, Peperkok R, Angel P, Herzig S, Nawroth PP.

Nucleic Acids Res. 2017 Oct 13;45(18):10595-10613. doi: 10.1093/nar/gkx705.


The Quest for more Research on Painful Diabetic Neuropathy.

Nawroth PP, Bendszus M, Pham M, Jende J, Heiland S, Ries S, Schumann C, Schmelz M, Schuh-Hofer S, Treede RD, Kuner R, Oikonomou D, Groener JB, Kopf S.

Neuroscience. 2018 Sep 1;387:28-37. doi: 10.1016/j.neuroscience.2017.09.023. Epub 2017 Sep 20. Review.


Purification and Characterization of the Soluble form of the Receptor for Advanced Glycation End-Products (sRAGE): A Novel Fast, Economical and Convenient Method.

Kumar V, Sulaj A, Fleming T, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2018 Mar;126(3):141-147. doi: 10.1055/s-0043-110478. Epub 2017 Sep 19. German.


Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.

Zemva J, Fink CA, Fleming TH, Schmidt L, Loft A, Herzig S, Knieß RA, Mayer M, Bukau B, Nawroth PP, Tyedmers J.

Redox Biol. 2017 Oct;13:674-686. doi: 10.1016/j.redox.2017.08.007. Epub 2017 Aug 12.


Dietary sugars, not lipids, drive hypothalamic inflammation.

Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX.

Mol Metab. 2017 Jun 20;6(8):897-908. doi: 10.1016/j.molmet.2017.06.008. eCollection 2017 Aug.


Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy.

Marquardt A, Al-Dabet MM, Ghosh S, Kohli S, Manoharan J, ElWakiel A, Gadi I, Bock F, Nazir S, Wang H, Lindquist JA, Nawroth PP, Madhusudhan T, Mertens PR, Shahzad K, Isermann B.

J Am Soc Nephrol. 2017 Nov;28(11):3182-3189. doi: 10.1681/ASN.2016101123. Epub 2017 Jul 10.


Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B.

Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7.


Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes.

Hidmark A, Spanidis I, Fleming TH, Volk N, Eckstein V, Groener JB, Kopf S, Nawroth PP, Oikonomou D.

Clin Ther. 2017 Jun;39(6):1132-1144.e2. doi: 10.1016/j.clinthera.2017.05.340. Epub 2017 May 27.


The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A.

Wagner R, Machann J, Guthoff M, Nawroth PP, Nadalin S, Saleem MA, Heyne N, Königsrainer A, Fend F, Schick F, Fritsche A, Stefan N, Häring HU, Schleicher E, Siegel-Axel DI.

Sci Rep. 2017 May 23;7(1):2261. doi: 10.1038/s41598-017-02210-4.


Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP.

Int J Mol Sci. 2017 May 5;18(5). pii: E984. doi: 10.3390/ijms18050984. Review.


Genetic Polymorphisms of Antioxidant and Antiglycation Enzymes and Diabetic Complications. How Much Can we Learn from the Genes?

Oikonomou D, Groener JB, Cheko R, Kender Z, Kihm L, Fleming T, Kopf S, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2018 Jan;126(1):7-13. doi: 10.1055/s-0043-106442. Epub 2017 Apr 25. Review.


Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes - What We Know so Far and the Missing Links.

Groener JB, Oikonomou D, Cheko R, Kender Z, Zemva J, Kihm L, Muckenthaler M, Peters V, Fleming T, Kopf S, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2019 Sep;127(8):497-504. doi: 10.1055/s-0043-106443. Epub 2017 Apr 13.


STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.

Hidmark AS, Nawroth PP, Fleming T.

J Neuroimmunol. 2017 May 15;306:76-82. doi: 10.1016/j.jneuroim.2017.03.008. Epub 2017 Mar 11.


ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy.

Sulaj A, Kopf S, Gröne E, Gröne HJ, Hoffmann S, Schleicher E, Häring HU, Schwenger V, Herzig S, Fleming T, Nawroth PP, von Bauer R.

J Diabetes Complications. 2017 Jun;31(6):1058-1065. doi: 10.1016/j.jdiacomp.2017.01.002. Epub 2017 Jan 21.


Osteointegration and Resorption of Intravertebral and Extravertebral Calcium Phosphate Cement.

Klein R, Tetzlaff R, Weiss C, Schäfer MK, Tanner M, Wiedenhöfer B, Grafe I, Meeder PJ, Noeldge G, Nawroth PP, Kasperk C.

Clin Spine Surg. 2017 Apr;30(3):E291-E296. doi: 10.1097/BSD.0b013e3182aab2df.


The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology.

Schmoch T, Uhle F, Siegler BH, Fleming T, Morgenstern J, Nawroth PP, Weigand MA, Brenner T.

Int J Mol Sci. 2017 Mar 17;18(3). pii: E657. doi: 10.3390/ijms18030657. Review.


Renal Function in Type 2 Diabetes Following Gastric Bypass.

Billeter AT, Kopf S, Zeier M, Scheurlen K, Fischer L, Schulte TM, Kenngott HG, Israel B, Knefeli P, Büchler MW, Nawroth PP, Müller-Stich BP.

Dtsch Arztebl Int. 2016 Dec 9;113(49):827-833. doi: 10.3238/arztebl.2016.0827.


A scavenger peptide prevents methylglyoxal induced pain in mice.

Brings S, Fleming T, De Buhr S, Beijer B, Lindner T, Wischnjow A, Kender Z, Peters V, Kopf S, Haberkorn U, Mier W, Nawroth PP.

Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):654-662. doi: 10.1016/j.bbadis.2016.12.001. Epub 2016 Dec 6.


ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions.

Sharma KR, Heckler K, Stoll SJ, Hillebrands JL, Kynast K, Herpel E, Porubsky S, Elger M, Hadaschik B, Bieback K, Hammes HP, Nawroth PP, Kroll J.

Sci Rep. 2016 Nov 16;6:37172. doi: 10.1038/srep37172.


Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.

Ekim Üstünel B, Friedrich K, Maida A, Wang X, Krones-Herzig A, Seibert O, Sommerfeld A, Jones A, Sijmonsma TP, Sticht C, Gretz N, Fleming T, Nawroth PP, Stremmel W, Rose AJ, Berriel-Diaz M, Blüher M, Herzig S.

Nat Commun. 2016 Nov 9;7:13267. doi: 10.1038/ncomms13267.


Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.

Mendler M, Riedinger C, Schlotterer A, Volk N, Fleming T, Herzig S, Nawroth PP, Morcos M.

J Diabetes Complications. 2017 Feb;31(2):304-310. doi: 10.1016/j.jdiacomp.2016.09.014. Epub 2016 Oct 1.


Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system.

Wolter J, Schild L, Bock F, Hellwig A, Gadi I, Al-Dabet MM, Ranjan S, Rönicke R, Nawroth PP, Petersen KU, Mawrin C, Shahzad K, Isermann B.

J Thromb Haemost. 2016 Nov;14(11):2212-2226. doi: 10.1111/jth.13494. Epub 2016 Oct 20.


The effect of lifestyle intervention in obesity on the soluble form of activated leukocyte cell adhesion molecule.

Sulaj A, Zemva J, Zech U, Woehning A, Brune M, Rudofsky G, Nawroth PP, Fleming T, von Bauer R.

BMC Endocr Disord. 2016 Oct 13;16(1):56.


Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy.

Shahzad K, Bock F, Al-Dabet MM, Gadi I, Nazir S, Wang H, Kohli S, Ranjan S, Mertens PR, Nawroth PP, Isermann B.

Sci Rep. 2016 Oct 10;6:34228. doi: 10.1038/srep34228.


Prion Aggregates Are Recruited to the Insoluble Protein Deposit (IPOD) via Myosin 2-Based Vesicular Transport.

Kumar R, Nawroth PP, Tyedmers J.

PLoS Genet. 2016 Sep 30;12(9):e1006324. doi: 10.1371/journal.pgen.1006324. eCollection 2016 Sep.

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