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Items: 1 to 50 of 397

1.

Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes.

Kopf S, Groener JB, Kender Z, Fleming T, Brune M, Riedinger C, Volk N, Herpel E, Pesta D, Szendrödi J, Wielpütz MO, Kauczor HU, Katus HA, Kreuter M, Nawroth PP.

Respiration. 2018 Jun 6:1-12. doi: 10.1159/000488909. [Epub ahead of print]

PMID:
29874679
2.

Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.

Mendler M, Kopf S, Groener JB, Riedinger C, Fleming TH, Nawroth PP, Okun JG.

Acta Diabetol. 2018 Jun;55(6):585-592. doi: 10.1007/s00592-018-1130-2. Epub 2018 Mar 15.

PMID:
29546577
3.

Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation - results of an observational pilot study.

Schmitt FCF, Salgado E, Friebe J, Schmoch T, Uhle F, Fleming T, Zemva J, Kihm L, Nusshag C, Morath C, Zeier M, Bruckner T, Mehrabi A, Nawroth PP, Weigand MA, Hofer S, Brenner T.

Transpl Int. 2018 Jul;31(7):751-760. doi: 10.1111/tri.13148. Epub 2018 Mar 30.

PMID:
29505681
4.

Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.

Zemva J, Pfaff D, Groener JB, Fleming T, Herzig S, Teleman A, Nawroth PP, Tyedmers J.

Exp Clin Endocrinol Diabetes. 2018 Feb 8. doi: 10.1055/s-0043-122382. [Epub ahead of print]

PMID:
29421830
5.

High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans.

Riedinger C, Mendler M, Schlotterer A, Fleming T, Okun J, Hammes HP, Herzig S, Nawroth PP.

J Biol Chem. 2018 Mar 30;293(13):4845-4859. doi: 10.1074/jbc.M117.805879. Epub 2018 Feb 2.

PMID:
29414769
6.

Meta-analysis of metabolic surgery versus medical treatment for microvascular complications in patients with type 2 diabetes mellitus.

Billeter AT, Scheurlen KM, Probst P, Eichel S, Nickel F, Kopf S, Fischer L, Diener MK, Nawroth PP, Müller-Stich BP.

Br J Surg. 2018 Feb;105(3):168-181. doi: 10.1002/bjs.10724. Review.

PMID:
29405276
7.

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A.

Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733. Epub 2018 Jan 20.

PMID:
29353241
8.

Analysis of Immune Cells in Single Sciatic Nerves and Dorsal Root Ganglion from a Single Mouse Using Flow Cytometry.

Hidmark AS, Nawroth PP, Fleming T.

J Vis Exp. 2017 Dec 6;(130). doi: 10.3791/56538.

PMID:
29286468
9.

Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.

Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M.

J Diabetes Complications. 2018 Feb;32(2):130-138. doi: 10.1016/j.jdiacomp.2017.11.007. Epub 2017 Nov 22.

PMID:
29223856
10.

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.

Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, Christian S, Hess-Stumpp H, Augustin HG, Müller-Decker K, Nawroth PP, Herzig S, Berriel Diaz M.

Cell Metab. 2017 Dec 5;26(6):842-855.e5. doi: 10.1016/j.cmet.2017.09.018. Epub 2017 Oct 19.

PMID:
29056512
11.

Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.

Kumar V, Fleming T, Terjung S, Gorzelanny C, Gebhardt C, Agrawal R, Mall MA, Ranzinger J, Zeier M, Madhusudhan T, Ranjan S, Isermann B, Liesz A, Deshpande D, Häring HU, Biswas SK, Reynolds PR, Hammes HP, Peperkok R, Angel P, Herzig S, Nawroth PP.

Nucleic Acids Res. 2017 Oct 13;45(18):10595-10613. doi: 10.1093/nar/gkx705.

12.

The quest for more research on painful diabetic neuropathy.

Nawroth PP, Bendszus M, Pham M, Jende J, Heiland S, Ries S, Schumann C, Schmelz M, Schuh-Hofer S, Treede RD, Kuner R, Oikonomou D, Groener JB, Kopf S.

Neuroscience. 2017 Sep 20. pii: S0306-4522(17)30667-X. doi: 10.1016/j.neuroscience.2017.09.023. [Epub ahead of print]

PMID:
28942323
13.

Purification and Characterization of the Soluble form of the Receptor for Advanced Glycation End-Products (sRAGE): A Novel Fast, Economical and Convenient Method.

Kumar V, Sulaj A, Fleming T, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2018 Mar;126(3):141-147. doi: 10.1055/s-0043-110478. Epub 2017 Sep 19. German.

PMID:
28926869
14.

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.

Zemva J, Fink CA, Fleming TH, Schmidt L, Loft A, Herzig S, Knieß RA, Mayer M, Bukau B, Nawroth PP, Tyedmers J.

Redox Biol. 2017 Oct;13:674-686. doi: 10.1016/j.redox.2017.08.007. Epub 2017 Aug 12.

15.

Dietary sugars, not lipids, drive hypothalamic inflammation.

Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX.

Mol Metab. 2017 Jun 20;6(8):897-908. doi: 10.1016/j.molmet.2017.06.008. eCollection 2017 Aug.

16.

Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy.

Marquardt A, Al-Dabet MM, Ghosh S, Kohli S, Manoharan J, ElWakiel A, Gadi I, Bock F, Nazir S, Wang H, Lindquist JA, Nawroth PP, Madhusudhan T, Mertens PR, Shahzad K, Isermann B.

J Am Soc Nephrol. 2017 Nov;28(11):3182-3189. doi: 10.1681/ASN.2016101123. Epub 2017 Jul 10.

PMID:
28696246
17.

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B.

Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7.

18.

Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes.

Hidmark A, Spanidis I, Fleming TH, Volk N, Eckstein V, Groener JB, Kopf S, Nawroth PP, Oikonomou D.

Clin Ther. 2017 Jun;39(6):1132-1144.e2. doi: 10.1016/j.clinthera.2017.05.340. Epub 2017 May 27.

19.

The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A.

Wagner R, Machann J, Guthoff M, Nawroth PP, Nadalin S, Saleem MA, Heyne N, Königsrainer A, Fend F, Schick F, Fritsche A, Stefan N, Häring HU, Schleicher E, Siegel-Axel DI.

Sci Rep. 2017 May 23;7(1):2261. doi: 10.1038/s41598-017-02210-4.

20.

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP.

Int J Mol Sci. 2017 May 5;18(5). pii: E984. doi: 10.3390/ijms18050984. Review.

21.

Genetic Polymorphisms of Antioxidant and Antiglycation Enzymes and Diabetic Complications. How Much Can we Learn from the Genes?

Oikonomou D, Groener JB, Cheko R, Kender Z, Kihm L, Fleming T, Kopf S, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2017 Apr 25. doi: 10.1055/s-0043-106442. [Epub ahead of print]

PMID:
28444665
22.

Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes - What We Know so Far and the Missing Links.

Groener JB, Oikonomou D, Cheko R, Kender Z, Zemva J, Kihm L, Muckenthaler M, Peters V, Fleming T, Kopf S, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2017 Apr 13. doi: 10.1055/s-0043-106443. [Epub ahead of print]

PMID:
28407670
23.

STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.

Hidmark AS, Nawroth PP, Fleming T.

J Neuroimmunol. 2017 May 15;306:76-82. doi: 10.1016/j.jneuroim.2017.03.008. Epub 2017 Mar 11.

PMID:
28385191
24.

ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy.

Sulaj A, Kopf S, Gröne E, Gröne HJ, Hoffmann S, Schleicher E, Häring HU, Schwenger V, Herzig S, Fleming T, Nawroth PP, von Bauer R.

J Diabetes Complications. 2017 Jun;31(6):1058-1065. doi: 10.1016/j.jdiacomp.2017.01.002. Epub 2017 Jan 21.

PMID:
28325697
25.

Osteointegration and Resorption of Intravertebral and Extravertebral Calcium Phosphate Cement.

Klein R, Tetzlaff R, Weiss C, Schäfer MK, Tanner M, Wiedenhöfer B, Grafe I, Meeder PJ, Noeldge G, Nawroth PP, Kasperk C.

Clin Spine Surg. 2017 Apr;30(3):E291-E296. doi: 10.1097/BSD.0b013e3182aab2df.

PMID:
28323714
26.

The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology.

Schmoch T, Uhle F, Siegler BH, Fleming T, Morgenstern J, Nawroth PP, Weigand MA, Brenner T.

Int J Mol Sci. 2017 Mar 17;18(3). pii: E657. doi: 10.3390/ijms18030657. Review.

27.

Renal Function in Type 2 Diabetes Following Gastric Bypass.

Billeter AT, Kopf S, Zeier M, Scheurlen K, Fischer L, Schulte TM, Kenngott HG, Israel B, Knefeli P, Büchler MW, Nawroth PP, Müller-Stich BP.

Dtsch Arztebl Int. 2016 Dec 9;113(49):827-833. doi: 10.3238/arztebl.2016.0827.

28.

A scavenger peptide prevents methylglyoxal induced pain in mice.

Brings S, Fleming T, De Buhr S, Beijer B, Lindner T, Wischnjow A, Kender Z, Peters V, Kopf S, Haberkorn U, Mier W, Nawroth PP.

Biochim Biophys Acta. 2017 Mar;1863(3):654-662. doi: 10.1016/j.bbadis.2016.12.001. Epub 2016 Dec 6.

29.

ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions.

Sharma KR, Heckler K, Stoll SJ, Hillebrands JL, Kynast K, Herpel E, Porubsky S, Elger M, Hadaschik B, Bieback K, Hammes HP, Nawroth PP, Kroll J.

Sci Rep. 2016 Nov 16;6:37172. doi: 10.1038/srep37172.

30.

Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.

Ekim Üstünel B, Friedrich K, Maida A, Wang X, Krones-Herzig A, Seibert O, Sommerfeld A, Jones A, Sijmonsma TP, Sticht C, Gretz N, Fleming T, Nawroth PP, Stremmel W, Rose AJ, Berriel-Diaz M, Blüher M, Herzig S.

Nat Commun. 2016 Nov 9;7:13267. doi: 10.1038/ncomms13267.

31.

Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.

Mendler M, Riedinger C, Schlotterer A, Volk N, Fleming T, Herzig S, Nawroth PP, Morcos M.

J Diabetes Complications. 2017 Feb;31(2):304-310. doi: 10.1016/j.jdiacomp.2016.09.014. Epub 2016 Oct 1.

PMID:
27776915
32.

Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system.

Wolter J, Schild L, Bock F, Hellwig A, Gadi I, Al-Dabet MM, Ranjan S, Rönicke R, Nawroth PP, Petersen KU, Mawrin C, Shahzad K, Isermann B.

J Thromb Haemost. 2016 Nov;14(11):2212-2226. doi: 10.1111/jth.13494. Epub 2016 Oct 20.

PMID:
27590316
33.

The effect of lifestyle intervention in obesity on the soluble form of activated leukocyte cell adhesion molecule.

Sulaj A, Zemva J, Zech U, Woehning A, Brune M, Rudofsky G, Nawroth PP, Fleming T, von Bauer R.

BMC Endocr Disord. 2016 Oct 13;16(1):56.

34.

Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy.

Shahzad K, Bock F, Al-Dabet MM, Gadi I, Nazir S, Wang H, Kohli S, Ranjan S, Mertens PR, Nawroth PP, Isermann B.

Sci Rep. 2016 Oct 10;6:34228. doi: 10.1038/srep34228.

35.

Prion Aggregates Are Recruited to the Insoluble Protein Deposit (IPOD) via Myosin 2-Based Vesicular Transport.

Kumar R, Nawroth PP, Tyedmers J.

PLoS Genet. 2016 Sep 30;12(9):e1006324. doi: 10.1371/journal.pgen.1006324. eCollection 2016 Sep.

36.

Characterization of aggregate load and pattern in living yeast cells by flow cytometry.

Hidalgo IH, Fleming T, Eckstein V, Herzig S, Nawroth PP, Tyedmers J.

Biotechniques. 2016 Sep 1;61(3):137-48. doi: 10.2144/000114452. eCollection 2016.

37.

Hyperglycemia in Stroke Impairs Polarization of Monocytes/Macrophages to a Protective Noninflammatory Cell Type.

Khan MA, Schultz S, Othman A, Fleming T, Lebrón-Galán R, Rades D, Clemente D, Nawroth PP, Schwaninger M.

J Neurosci. 2016 Sep 7;36(36):9313-25. doi: 10.1523/JNEUROSCI.0473-16.2016.

38.

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.

Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gaertner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S.

Blood. 2016 Nov 17;128(20):2435-2449. Epub 2016 Aug 29.

39.

Methylglyoxal is associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus.

Jensen TM, Vistisen D, Fleming T, Nawroth PP, Rossing P, Jørgensen ME, Lauritzen T, Sandbaek A, Witte DR.

Diabet Med. 2016 Dec;33(12):1625-1631. doi: 10.1111/dme.13201. Epub 2016 Aug 25.

PMID:
27504739
40.

Reduced glyoxalase 1 activity in carotid artery plaques of nondiabetic patients with increased hemoglobin A1c level.

Peters AS, Lercher M, Fleming TH, Nawroth PP, Bischoff MS, Dihlmann S, Böckler D, Hakimi M.

J Vasc Surg. 2016 Oct;64(4):990-4. doi: 10.1016/j.jvs.2016.04.025. Epub 2016 Jul 29.

PMID:
27478003
41.

Reply.

Pham M, Nawroth PP, Bendszus M.

Ann Neurol. 2016 Aug;80(2):309-10. doi: 10.1002/ana.24692. Epub 2016 Jun 24. No abstract available.

PMID:
27253614
42.

Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.

Ejdesjö A, Brings S, Fleming T, Fred RG, Nawroth PP, Eriksson UJ.

Reprod Toxicol. 2016 Jul;62:62-70. doi: 10.1016/j.reprotox.2016.04.015. Epub 2016 Apr 22.

PMID:
27109771
43.

Erratum to: Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial.

Nowotny B, Zahiragic L, Bierwagen A, Kabisch S, Groener JB, Nowotny PJ, Fleitmann AK, Firouzi P, Herder C, Pacini G, Erlund I, Landberg R, Haering HU, Pfeiffer AF, Nawroth PP, Roden M.

Diabetologia. 2016 Jun;59(6):1329. No abstract available.

PMID:
26961504
44.

Diabetic Retinopathy Screening Ratio Is Improved When Using a Digital, Nonmydriatic Fundus Camera Onsite in a Diabetes Outpatient Clinic.

Roser P, Kalscheuer H, Groener JB, Lehnhoff D, Klein R, Auffarth GU, Nawroth PP, Schuett F, Rudofsky G.

J Diabetes Res. 2016;2016:4101890. doi: 10.1155/2016/4101890. Epub 2016 Jan 21.

45.

Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study.

Uhle F, Lichtenstern C, Brenner T, Fleming T, Koch C, Hecker A, Heiss C, Nawroth PP, Hofer S, Weigand MA, Weismüller K.

Mediators Inflamm. 2015;2015:691491. doi: 10.1155/2015/691491. Epub 2015 Dec 31.

46.

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.

Shahzad K, Bock F, Al-Dabet MM, Gadi I, Kohli S, Nazir S, Ghosh S, Ranjan S, Wang H, Madhusudhan T, Nawroth PP, Isermann B.

J Am Soc Nephrol. 2016 Aug;27(8):2270-5. doi: 10.1681/ASN.2015060676. Epub 2016 Feb 1.

47.

Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia.

Achouiti A, de Vos AF, van 't Veer C, Florquin S, Tanck MW, Nawroth PP, Bierhaus A, van der Poll T, van Zoelen MA.

PLoS One. 2016 Jan 29;11(1):e0141000. doi: 10.1371/journal.pone.0141000. eCollection 2016.

48.

A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice.

Wortmann M, Hakimi M, Fleming T, Peters AS, Sijmonsma TP, Herzig S, Nawroth PP, Böckler D, Dihlmann S.

J Diabetes Res. 2016;2016:2981639. doi: 10.1155/2016/2981639. Epub 2015 Dec 15.

49.

Novel Endothelial Cell-Specific AQP1 Knockout Mice Confirm the Crucial Role of Endothelial AQP1 in Ultrafiltration during Peritoneal Dialysis.

Zhang W, Freichel M, van der Hoeven F, Nawroth PP, Katus H, Kälble F, Zitron E, Schwenger V.

PLoS One. 2016 Jan 13;11(1):e0145513. doi: 10.1371/journal.pone.0145513. eCollection 2016.

50.

Combined Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Sleeve Gastrectomy or Gastric Bypass?-a Controlled Matched Pair Study of 34 Patients.

Billeter AT, Senft J, Gotthardt D, Knefeli P, Nickel F, Schulte T, Fischer L, Nawroth PP, Büchler MW, Müller-Stich BP.

Obes Surg. 2016 Aug;26(8):1867-74. doi: 10.1007/s11695-015-2006-y.

PMID:
26660688

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