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Items: 1 to 50 of 93

1.

Metabolic features and regulation of the healing cycle-A new model for chronic disease pathogenesis and treatment.

Naviaux RK.

Mitochondrion. 2018 Aug 9. pii: S1567-7249(18)30105-3. doi: 10.1016/j.mito.2018.08.001. [Epub ahead of print]

2.

Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial.

Adams JB, Audhya T, Geis E, Gehn E, Fimbres V, Pollard EL, Mitchell J, Ingram J, Hellmers R, Laake D, Matthews JS, Li K, Naviaux JC, Naviaux RK, Adams RL, Coleman DM, Quig DW.

Nutrients. 2018 Mar 17;10(3). pii: E369. doi: 10.3390/nu10030369.

3.

Antipurinergic therapy for autism-An in-depth review.

Naviaux RK.

Mitochondrion. 2017 Dec 16. pii: S1567-7249(17)30262-3. doi: 10.1016/j.mito.2017.12.007. [Epub ahead of print] Review.

4.

Novel mutation in the human HPRT1 gene and the Lesch-Nyhan disease.

Nguyen KV, Naviaux RK, Nyhan WL.

Nucleosides Nucleotides Nucleic Acids. 2017 Nov 2;36(11):704-711. doi: 10.1080/15257770.2017.1395037. Epub 2017 Nov 29.

PMID:
29185864
5.

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics.

Li K, Naviaux JC, Bright AT, Wang L, Naviaux RK.

Metabolomics. 2017;13(10):122. doi: 10.1007/s11306-017-1264-1. Epub 2017 Sep 4.

6.

Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial.

Naviaux RK, Curtis B, Li K, Naviaux JC, Bright AT, Reiner GE, Westerfield M, Goh S, Alaynick WA, Wang L, Capparelli EV, Adams C, Sun J, Jain S, He F, Arellano DA, Mash LE, Chukoskie L, Lincoln A, Townsend J.

Ann Clin Transl Neurol. 2017 May 26;4(7):491-505. doi: 10.1002/acn3.424. eCollection 2017 Jul.

7.

Lesch-Nyhan disease in two families from Chiloé Island with mutations in the HPRT1 gene.

Nguyen KV, Silva S, Troncoso M, Naviaux RK, Nyhan WL.

Nucleosides Nucleotides Nucleic Acids. 2017 Jul 3;36(7):452-462. doi: 10.1080/15257770.2017.1315434. Epub 2017 May 19.

PMID:
28524722
8.

Englerin A induces an acute inflammatory response and reveals lipid metabolism and ER stress as targetable vulnerabilities in renal cell carcinoma.

Batova A, Altomare D, Creek KE, Naviaux RK, Wang L, Li K, Green E, Williams R, Naviaux JC, Diccianni M, Yu AL.

PLoS One. 2017 Mar 15;12(3):e0172632. doi: 10.1371/journal.pone.0172632. eCollection 2017.

9.

Utility of Spot Urine Specimens to Assess Tubular Secretion.

Garimella PS, Li K, Naviaux JC, Shlipak MG, Abdelmalek JA, Castro E, Capparelli EV, Naviaux RK, Ix JH.

Am J Kidney Dis. 2017 May;69(5):709-711. doi: 10.1053/j.ajkd.2016.12.016. Epub 2017 Mar 8. No abstract available.

PMID:
28284759
10.

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.

Higa KK, Grim A, Kamenski ME, van Enkhuizen J, Zhou X, Li K, Naviaux JC, Wang L, Naviaux RK, Geyer MA, Markou A, Young JW.

Psychopharmacology (Berl). 2017 May;234(9-10):1573-1586. doi: 10.1007/s00213-017-4572-2. Epub 2017 Feb 28.

11.

Reply to Roerink et al.: Metabolomics of chronic fatigue syndrome.

Naviaux RK, Gordon E.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E911-E912. doi: 10.1073/pnas.1618984114. Epub 2017 Jan 26. No abstract available.

12.

Human HPRT1 gene and the Lesch-Nyhan disease: Substitution of alanine for glycine and inversely in the HGprt enzyme protein.

Nguyen KV, Naviaux RK, Nyhan WL.

Nucleosides Nucleotides Nucleic Acids. 2017 Feb;36(2):151-157. doi: 10.1080/15257770.2016.1231319. Epub 2017 Jan 3.

PMID:
28045594
13.

Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome.

Naviaux RK, Naviaux JC, Li K, Bright AT, Alaynick WA, Wang L, Baxter A, Nathan N, Anderson W, Gordon E.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7142-E7143. Epub 2016 Nov 3. No abstract available.

14.

Metabolic features of chronic fatigue syndrome.

Naviaux RK, Naviaux JC, Li K, Bright AT, Alaynick WA, Wang L, Baxter A, Nathan N, Anderson W, Gordon E.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5472-80. doi: 10.1073/pnas.1607571113. Epub 2016 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3749.

15.

Neurometabolic Disorders: Potentially Treatable Abnormalities in Patients With Treatment-Refractory Depression and Suicidal Behavior.

Pan LA, Martin P, Zimmer T, Segreti AM, Kassiff S, McKain BW, Baca CA, Rengasamy M, Hyland K, Walano N, Steinfeld R, Hughes M, Dobrowolski SK, Pasquino M, Diler R, Perel J, Finegold DN, Peters DG, Naviaux RK, Brent DA, Vockley J.

Am J Psychiatry. 2017 Jan 1;174(1):42-50. doi: 10.1176/appi.ajp.2016.15111500. Epub 2016 Aug 13.

PMID:
27523499
16.

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice.

Wall CE, Whyte J, Suh JM, Fan W, Collins B, Liddle C, Yu RT, Atkins AR, Naviaux JC, Li K, Bright AT, Alaynick WA, Downes M, Naviaux RK, Evans RM.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8714-9. doi: 10.1073/pnas.1509930112. Epub 2015 Jun 29.

17.

Correction: Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats.

RamachandraRao SP, Matthias MA, Kokoy-Mondrogon C, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P.

PLoS Negl Trop Dis. 2015 Apr 10;9(4):e0003718. doi: 10.1371/journal.pntd.0003718. eCollection 2015 Apr. No abstract available.

18.

Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats.

RamachandraRao SP, Matthias MA, Kokoy-Mondragon C, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P.

PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003640. doi: 10.1371/journal.pntd.0003640. eCollection 2015 Mar. Erratum in: PLoS Negl Trop Dis. 2015 Apr;9(4):e0003718. PLoS Negl Trop Dis. 2015 Jun;9(6):e0003911. Mondrogon, Chanthel-Kokoy [corrected to Kokoy-Mondragon, Chanthel].

19.

Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.

Naviaux JC, Wang L, Li K, Bright AT, Alaynick WA, Williams KR, Powell SB, Naviaux RK.

Mol Autism. 2015 Jan 13;6:1. doi: 10.1186/2040-2392-6-1. eCollection 2015.

20.

Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.

Naviaux JC, Schuchbauer MA, Li K, Wang L, Risbrough VB, Powell SB, Naviaux RK.

Transl Psychiatry. 2014 Jun 17;4:e400. doi: 10.1038/tp.2014.33.

21.

Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury.

Declèves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, Sharma K.

Kidney Int. 2014 Mar;85(3):611-23. doi: 10.1038/ki.2013.462. Epub 2013 Dec 4. Erratum in: Kidney Int. 2014 Jun;85(6):1474. Kidney Int. 2017 Sep;92(3):769.

22.

A model-driven quantitative metabolomics analysis of aerobic and anaerobic metabolism in E. coli K-12 MG1655 that is biochemically and thermodynamically consistent.

McCloskey D, Gangoiti JA, King ZA, Naviaux RK, Barshop BA, Palsson BO, Feist AM.

Biotechnol Bioeng. 2014 Apr;111(4):803-15. doi: 10.1002/bit.25133. Epub 2013 Nov 19.

PMID:
24249002
23.

Assessing bioenergetic compromise in autism spectrum disorder with 31P magnetic resonance spectroscopy: preliminary report.

Golomb BA, Erickson LC, Scott-Van Zeeland AA, Koperski S, Haas RH, Wallace DC, Naviaux RK, Lincoln AJ, Reiner GE, Hamilton G.

J Child Neurol. 2014 Feb;29(2):187-93. doi: 10.1177/0883073813498466. Epub 2013 Oct 18.

24.

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.

Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K.

J Clin Invest. 2013 Nov;123(11):4888-99. doi: 10.1172/JCI66218. Epub 2013 Oct 25.

25.

Metabolic features of the cell danger response.

Naviaux RK.

Mitochondrion. 2014 May;16:7-17. doi: 10.1016/j.mito.2013.08.006. Epub 2013 Aug 24. Review.

26.

Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease.

Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK.

J Am Soc Nephrol. 2013 Nov;24(11):1901-12. doi: 10.1681/ASN.2013020126. Epub 2013 Oct 10.

27.

AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.

Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Fenstermaker AG, Silhavy JL, Scheliga JS, Toyama K, Morisaki H, Sonmez FM, Celep F, Oraby A, Zaki MS, Al-Baradie R, Faqeih EA, Saleh MA, Spencer E, Rosti RO, Scott E, Nickerson E, Gabriel S, Morisaki T, Holmes EW, Gleeson JG.

Cell. 2013 Aug 1;154(3):505-17. doi: 10.1016/j.cell.2013.07.005.

28.

Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.

Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Le TP, Schuchbauer MA, Rogac M, Tang Q, Dugan LL, Powell SB.

PLoS One. 2013;8(3):e57380. doi: 10.1371/journal.pone.0057380. Epub 2013 Mar 13.

29.

Alpers-Huttenlocher syndrome.

Saneto RP, Cohen BH, Copeland WC, Naviaux RK.

Pediatr Neurol. 2013 Mar;48(3):167-78. doi: 10.1016/j.pediatrneurol.2012.09.014. Review.

30.

Lesch-Nyhan variant syndrome: real-time rt-PCR for mRNA quantification in variable presentation in three affected family members.

Nguyen KV, Naviaux RK, Paik KK, Nakayama T, Nyhan WL.

Nucleosides Nucleotides Nucleic Acids. 2012;31(8):616-29. doi: 10.1080/15257770.2012.714028.

PMID:
22908952
31.

Lesch-Nyhan syndrome: mRNA expression of HPRT in patients with enzyme proven deficiency of HPRT and normal HPRT coding region of the DNA.

Nguyen KV, Naviaux RK, Paik KK, Nyhan WL.

Mol Genet Metab. 2012 Aug;106(4):498-501. doi: 10.1016/j.ymgme.2012.06.003. Epub 2012 Jun 19.

PMID:
22766437
32.

Oxidative shielding or oxidative stress?

Naviaux RK.

J Pharmacol Exp Ther. 2012 Sep;342(3):608-18. doi: 10.1124/jpet.112.192120. Epub 2012 Jun 13. Review.

33.

Novel mutations in the human HPRT gene.

Nguyen KV, Naviaux RK, Paik KK, Nyhan WL.

Nucleosides Nucleotides Nucleic Acids. 2011 Jun;30(6):440-5. doi: 10.1080/15257770.2011.588187.

PMID:
21780909
34.

Fibroblast immuno-diagnosis of cytochrome oxidase (COX) deficiency in mitochondrial disease.

Du A, Naviaux RK, Le T, Xu C, Sommer SS, Haas RH.

Mitochondrion. 2011 May;11(3):430-6. doi: 10.1016/j.mito.2010.12.014. Epub 2010 Dec 25.

PMID:
21187165
35.

Novel mutations in the human MCCA and MCCB gene causing methylcrotonylglycinuria.

Nguyen KV, Naviaux RK, Patra S, Barshop BA, Nyhan WL.

Mol Genet Metab. 2011 Feb;102(2):218-21. doi: 10.1016/j.ymgme.2010.10.008. Epub 2010 Oct 20.

PMID:
21071250
36.

Polymerase gamma disease through the ages.

Saneto RP, Naviaux RK.

Dev Disabil Res Rev. 2010;16(2):163-74. doi: 10.1002/ddrr.105. Review.

PMID:
20818731
37.

Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene.

Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT.

Circ Cardiovasc Genet. 2010 Oct;3(5):414-25. doi: 10.1161/CIRCGENETICS.109.924050. Epub 2010 Aug 20.

38.

The clinical diagnosis of POLG disease and other mitochondrial DNA depletion disorders.

Cohen BH, Naviaux RK.

Methods. 2010 Aug;51(4):364-73. doi: 10.1016/j.ymeth.2010.05.008. Epub 2010 Jun 15. Review.

PMID:
20558295
39.

POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.

Saneto RP, Lee IC, Koenig MK, Bao X, Weng SW, Naviaux RK, Wong LJ.

Seizure. 2010 Apr;19(3):140-6. doi: 10.1016/j.seizure.2010.01.002. Epub 2010 Feb 6.

40.

The GAAS metagenomic tool and its estimations of viral and microbial average genome size in four major biomes.

Angly FE, Willner D, Prieto-Davó A, Edwards RA, Schmieder R, Vega-Thurber R, Antonopoulos DA, Barott K, Cottrell MT, Desnues C, Dinsdale EA, Furlan M, Haynes M, Henn MR, Hu Y, Kirchman DL, McDole T, McPherson JD, Meyer F, Miller RM, Mundt E, Naviaux RK, Rodriguez-Mueller B, Stevens R, Wegley L, Zhang L, Zhu B, Rohwer F.

PLoS Comput Biol. 2009 Dec;5(12):e1000593. doi: 10.1371/journal.pcbi.1000593. Epub 2009 Dec 11.

41.

Determination of DNA mutation load in human tissues using denaturing HPLC-based heteroduplex analysis.

Lim KS, Naviaux RK, Haas RH.

Methods Mol Biol. 2009;554:287-99. doi: 10.1007/978-1-59745-521-3_18.

PMID:
19513681
42.

De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome.

Chan SS, Naviaux RK, Basinger AA, Casas KA, Copeland WC.

Mitochondrion. 2009 Sep;9(5):340-5. doi: 10.1016/j.mito.2009.05.002. Epub 2009 Jun 6.

43.

Monitoring phosphorylation of the pyruvate dehydrogenase complex.

Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon JE.

Anal Biochem. 2009 Jun 15;389(2):157-64. doi: 10.1016/j.ab.2009.03.040. Epub 2009 Mar 31.

44.

Retained features of embryonic metabolism in the adult MRL mouse.

Naviaux RK, Le TP, Bedelbaeva K, Leferovich J, Gourevitch D, Sachadyn P, Zhang XM, Clark L, Heber-Katz E.

Mol Genet Metab. 2009 Mar;96(3):133-44. doi: 10.1016/j.ymgme.2008.11.164. Epub 2009 Jan 7.

45.

Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse.

Sachadyn P, Zhang XM, Clark LD, Naviaux RK, Heber-Katz E.

Mitochondrion. 2008 Dec;8(5-6):358-66. doi: 10.1016/j.mito.2008.07.007. Epub 2008 Aug 12.

46.

Mitochondrial control of epigenetics.

Naviaux RK.

Cancer Biol Ther. 2008 Aug;7(8):1191-3. Epub 2008 Aug 4. No abstract available.

PMID:
18719362
47.

Molecular and clinical genetics of mitochondrial diseases due to POLG mutations.

Wong LJ, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, Milone M, Cohen BH, Wical B, Ganesh J, Basinger AA, Burton BK, Swoboda K, Gilbert DL, Vanderver A, Saneto RP, Maranda B, Arnold G, Abdenur JE, Waters PJ, Copeland WC.

Hum Mutat. 2008 Sep;29(9):E150-72. doi: 10.1002/humu.20824.

48.

Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells.

Saitoh A, Haas RH, Naviaux RK, Salva NG, Wong JK, Spector SA.

Antimicrob Agents Chemother. 2008 Aug;52(8):2825-30. doi: 10.1128/AAC.00434-08. Epub 2008 Jun 9.

49.

The in-depth evaluation of suspected mitochondrial disease.

Mitochondrial Medicine Society's Committee on Diagnosis, Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darin N, Wong LJ, Cohen BH, Naviaux RK.

Mol Genet Metab. 2008 May;94(1):16-37. doi: 10.1016/j.ymgme.2007.11.018. Epub 2008 Feb 1. Review.

50.

Pitfalls in the denaturing high-performance liquid chromatography analysis of mitochondrial DNA mutation.

Lim KS, Naviaux RK, Wong S, Haas RH.

J Mol Diagn. 2008 Jan;10(1):102-8. doi: 10.2353/jmoldx.2008.070081. Epub 2007 Dec 28.

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