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β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons.

Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu X, Xiang YK.

Elife. 2019 Oct 14;8. pii: e49464. doi: 10.7554/eLife.49464. [Epub ahead of print]


β2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions.

Man KNM, Navedo MF, Horne MC, Hell JW.

Annu Rev Pharmacol Toxicol. 2019 Sep 27. doi: 10.1146/annurev-pharmtox-010919-023404. [Epub ahead of print]


A stochastic model of ion channel cluster formation in the plasma membrane.

Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF.

J Gen Physiol. 2019 Sep 2;151(9):1116-1134. doi: 10.1085/jgp.201912327. Epub 2019 Aug 1.


Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF.

J Clin Invest. 2019 Jun 4;129(8):3140-3152. doi: 10.1172/JCI124705.


A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia.

Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF.

Elife. 2019 Mar 1;8. pii: e42214. doi: 10.7554/eLife.42214.


β-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes.

Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE.

J Physiol. 2019 Apr;597(8):2139-2162. doi: 10.1113/JP277283. Epub 2019 Mar 12.


Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.

Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11465-E11474. doi: 10.1073/pnas.1816614115. Epub 2018 Nov 19.


Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating.

Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF.

Biochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1341-1355. doi: 10.1016/j.bbamcr.2018.06.013. Epub 2018 Jun 28.


Corrigendum: Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing.

Shen Y, Pfluger T, Ferreira F, Liang J, Navedo MF, Zeng Q, Reid B, Zhao M.

Sci Rep. 2018 Jun 27;8:46997. doi: 10.1038/srep46997.


Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell.

Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK.

Nat Commun. 2018 Mar 13;9(1):1050. doi: 10.1038/s41467-018-03459-7.


Going with the flow: contextual fine-tuning of vascular reactivity.

Navedo MF, Amberg GC.

J Physiol. 2018 Apr 1;596(7):1127-1128. doi: 10.1113/JP275924. Epub 2018 Feb 25. No abstract available.


A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics.

Sato D, Dixon RE, Santana LF, Navedo MF.

PLoS Comput Biol. 2018 Jan 16;14(1):e1005906. doi: 10.1371/journal.pcbi.1005906. eCollection 2018 Jan.


Regulation of microvascular function by voltage-gated potassium channels: New tricks for an "ancient" dog.

Nystoriak MA, Navedo MF.

Microcirculation. 2018 Jan;25(1). doi: 10.1111/micc.12435.


Coronary microvascular Kv1 channels as regulatory sensors of intracellular pyridine nucleotide redox potential.

Dwenger MM, Ohanyan V, Navedo MF, Nystoriak MA.

Microcirculation. 2018 Jan;25(1). doi: 10.1111/micc.12426. Review.


Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes.

Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo MF.

Sci Rep. 2017 Oct 25;7(1):14058. doi: 10.1038/s41598-017-14565-9.


Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders.

Nieves-Cintrón M, Syed AU, Nystoriak MA, Navedo MF.

Microcirculation. 2018 Jan;25(1). doi: 10.1111/micc.12423. Review.


Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia.

Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E.

Channels (Austin). 2017 Jul 4;11(4):340-346. doi: 10.1080/19336950.2017.1293220. Epub 2017 Feb 10.


Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.

Tajada S, Moreno CM, O'Dwyer S, Woods S, Sato D, Navedo MF, Santana LF.

J Gen Physiol. 2017 Jun 5;149(6):639-659. doi: 10.1085/jgp.201611709. Epub 2017 May 15.


Calcium Channels in Vascular Smooth Muscle.

Ghosh D, Syed AU, Prada MP, Nystoriak MA, Santana LF, Nieves-Cintrón M, Navedo MF.

Adv Pharmacol. 2017;78:49-87. doi: 10.1016/bs.apha.2016.08.002. Epub 2016 Oct 14. Review.


Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.

Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9659. doi: 10.1126/scisignal.aaf9659.


Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9647. doi: 10.1126/scisignal.aaf9647.


Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels.

Hell JW, Navedo MF, VanHook AM.

Sci Signal. 2017 Jan 24;10(463). pii: eaam6582. doi: 10.1126/scisignal.aam6582.


Potassium channels in the heart: structure, function and regulation.

Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V.

J Physiol. 2017 Apr 1;595(7):2209-2228. doi: 10.1113/JP272864. Epub 2016 Nov 13. Review.


Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing.

Shen Y, Pfluger T, Ferreira F, Liang J, Navedo MF, Zeng Q, Reid B, Zhao M.

Sci Rep. 2016 Jun 10;6:26525. doi: 10.1038/srep26525. Erratum in: Sci Rep. 2018 Jun 27;8:46997.


Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.

EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21.


Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.

Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF.

J Biol Chem. 2016 Mar 4;291(10):4912. doi: 10.1074/jbc.A114.622811. No abstract available.


Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels.

Chaplin NL, Nieves-Cintrón M, Fresquez AM, Navedo MF, Amberg GC.

Circ Res. 2015 Dec 4;117(12):1013-23. doi: 10.1161/CIRCRESAHA.115.306996. Epub 2015 Sep 21.


Graded Ca²⁺/calmodulin-dependent coupling of voltage-gated CaV1.2 channels.

Dixon RE, Moreno CM, Yuan C, Opitz-Araya X, Binder MD, Navedo MF, Santana LF.

Elife. 2015 Feb 25;4. doi: 10.7554/eLife.05608.


Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.

Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF.

J Biol Chem. 2015 Mar 20;290(12):7918-29. doi: 10.1074/jbc.M114.622811. Epub 2015 Feb 10. Erratum in: J Biol Chem. 2016 Mar 4;291(10):4912.


Mission CaMKIIγ: shuttle calmodulin from membrane to nucleus.

Malik ZA, Stein IS, Navedo MF, Hell JW.

Cell. 2014 Oct 9;159(2):235-7. doi: 10.1016/j.cell.2014.09.023.


AKAP5 keeps L-type channels and NFAT on their toes.

Navedo MF, Hell JW.

Cell Rep. 2014 Jun 12;7(5):1341-1342. doi: 10.1016/j.celrep.2014.05.052.


Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.

Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.

J Gen Physiol. 2014 May;143(5):559-75. doi: 10.1085/jgp.201311050.


AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.

Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF.

Circ Res. 2014 Feb 14;114(4):607-15. doi: 10.1161/CIRCRESAHA.114.302168. Epub 2013 Dec 9.


Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α.

Gulia J, Navedo MF, Gui P, Chao JT, Mercado JL, Santana LF, Davis MJ.

Am J Physiol Cell Physiol. 2013 Sep;305(5):C568-77. doi: 10.1152/ajpcell.00381.2011. Epub 2013 Jun 26.


Calcium dynamics in vascular smooth muscle.

Amberg GC, Navedo MF.

Microcirculation. 2013 May;20(4):281-9. doi: 10.1111/micc.12046. Review.


CaV1.2 sparklets in heart and vascular smooth muscle.

Navedo MF, Santana LF.

J Mol Cell Cardiol. 2013 May;58:67-76. doi: 10.1016/j.yjmcc.2012.11.018. Epub 2012 Dec 6. Review.


Capturing single L-type Ca(2+) channel function with optics.

Nystoriak MA, Nieves-Cintrón M, Navedo MF.

Biochim Biophys Acta. 2013 Jul;1833(7):1657-64. doi: 10.1016/j.bbamcr.2012.10.027. Epub 2012 Nov 1. Review.


Local regulation of L-type Ca²⁺ channel sparklets in arterial smooth muscle.

Navedo MF, Amberg GC.

Microcirculation. 2013 May;20(4):290-8. doi: 10.1111/micc.12021. Review.


Anchored phosphatases modulate glucose homeostasis.

Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD.

EMBO J. 2012 Oct 17;31(20):3991-4004. doi: 10.1038/emboj.2012.244. Epub 2012 Aug 31. Erratum in: EMBO J. 2012 Nov 28;31(23):4481.


Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels.

Dixon RE, Yuan C, Cheng EP, Navedo MF, Santana LF.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1749-54. doi: 10.1073/pnas.1116731109. Epub 2012 Jan 17.


Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle.

Takeda Y, Nystoriak MA, Nieves-Cintrón M, Santana LF, Navedo MF.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2285-94. doi: 10.1152/ajpheart.00488.2011. Epub 2011 Oct 7.


Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein.

Cheng EP, Yuan C, Navedo MF, Dixon RE, Nieves-Cintrón M, Scott JD, Santana LF.

Circ Res. 2011 Jul 22;109(3):255-61. doi: 10.1161/CIRCRESAHA.111.248252. Epub 2011 Jun 23.


Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels.

Nichols CB, Rossow CF, Navedo MF, Westenbroek RE, Catterall WA, Santana LF, McKnight GS.

Circ Res. 2010 Sep 17;107(6):747-56. doi: 10.1161/CIRCRESAHA.109.216127. Epub 2010 Jul 29.


Natural inequalities: why some L-type Ca2+ channels work harder than others.

Santana LF, Navedo MF.

J Gen Physiol. 2010 Aug;136(2):143-7. doi: 10.1085/jgp.200910391. No abstract available.


Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure.

Zhang J, Ren C, Chen L, Navedo MF, Antos LK, Kinsey SP, Iwamoto T, Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1472-83. doi: 10.1152/ajpheart.00964.2009. Epub 2010 Feb 19.


Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome.

Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF.

Circ Res. 2010 Mar 5;106(4):748-56. doi: 10.1161/CIRCRESAHA.109.213363. Epub 2010 Jan 28.


Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells.

Navedo MF, Takeda Y, Nieves-Cintrón M, Molkentin JD, Santana LF.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C211-20. doi: 10.1152/ajpcell.00267.2009. Epub 2009 Oct 21.


Molecular and biophysical mechanisms of Ca2+ sparklets in smooth muscle.

Santana LF, Navedo MF.

J Mol Cell Cardiol. 2009 Oct;47(4):436-44. doi: 10.1016/j.yjmcc.2009.07.008. Epub 2009 Jul 16. Review.


The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension.

Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, Santana LF.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15623-8. doi: 10.1073/pnas.0808759105. Epub 2008 Oct 1.


Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor.

Nieves-Cintrón M, Caballero-Rivera D, Silva WI, Navedo MF, Lasalde-Dominicci JA.

J Neurosci Res. 2008 Oct;86(13):2884-94. doi: 10.1002/jnr.21749.

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