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Items: 1 to 50 of 320

1.

Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.

Garcia-Agudo LF, Janova H, Sendler LE, Arinrad S, Steixner AA, Hassouna I, Balmuth E, Ronnenberg A, Schopf N, van der Flier FJ, Begemann M, Martens H, Weber MS, Boretius S, Nave KA, Ehrenreich H.

FASEB J. 2019 May 15:fj201900337R. doi: 10.1096/fj.201900337R. [Epub ahead of print]

PMID:
31090455
2.

Myelinating glia-specific deletion of Fbxo7 in mice triggers axonal degeneration in the central nervous system together with peripheral neuropathy.

Joseph S, Vingill S, Jahn O, Fledrich R, Werner HB, Katona I, Möbius W, Mitkovski M, Huang Y, Weis J, Sereda MW, Schulz JB, Nave KA, Stegmüller J.

J Neurosci. 2019 May 13. pii: 3094-18. doi: 10.1523/JNEUROSCI.3094-18.2019. [Epub ahead of print]

PMID:
31085610
3.

Publisher Correction: NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies.

Fledrich R, Akkermann D, Schütza V, Abdelaal TA, Hermes D, Schäffner E, Soto-Bernardini MC, Götze T, Klink A, Kusch K, Krueger M, Kungl T, Frydrychowicz C, Möbius W, Brück W, Mueller WC, Bechmann I, Sereda MW, Schwab MH, Nave KA, Stassart RM.

Nat Commun. 2019 Apr 16;10(1):1840. doi: 10.1038/s41467-019-09886-4.

4.

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies.

Fledrich R, Akkermann D, Schütza V, Abdelaal TA, Hermes D, Schäffner E, Soto-Bernardini MC, Götze T, Klink A, Kusch K, Krueger M, Kungl T, Frydrychowicz C, Möbius W, Brück W, Mueller WC, Bechmann I, Sereda MW, Schwab MH, Nave KA, Stassart RM.

Nat Commun. 2019 Apr 1;10(1):1467. doi: 10.1038/s41467-019-09385-6. Erratum in: Nat Commun. 2019 Apr 16;10(1):1840.

5.

Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease.

Stumpf SK, Berghoff SA, Trevisiol A, Spieth L, Düking T, Schneider LV, Schlaphoff L, Dreha-Kulaczewski S, Bley A, Burfeind D, Kusch K, Mitkovski M, Ruhwedel T, Guder P, Röhse H, Denecke J, Gärtner J, Möbius W, Nave KA, Saher G.

Acta Neuropathol. 2019 Mar 27. doi: 10.1007/s00401-019-01985-2. [Epub ahead of print]

PMID:
30919030
6.

Virus-triggered spinal cord demyelination is followed by a peripheral neuropathy resembling features of Guillain-Barré Syndrome.

Leitzen E, Raddatz BB, Jin W, Goebbels S, Nave KA, Baumgärtner W, Hansmann F.

Sci Rep. 2019 Mar 14;9(1):4588. doi: 10.1038/s41598-019-40964-1.

7.

Conditional Mutagenesis in Oligodendrocyte Lineage Cells.

Goebbels S, Nave KA.

Methods Mol Biol. 2019;1936:249-274. doi: 10.1007/978-1-4939-9072-6_15.

PMID:
30820904
8.

Time to revisit oligodendrocytes in multiple sclerosis.

Nave KA, Ehrenreich H.

Nat Med. 2019 Mar;25(3):364-366. doi: 10.1038/s41591-019-0388-4. No abstract available.

PMID:
30804516
9.

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.

Erwig MS, Patzig J, Steyer AM, Dibaj P, Heilmann M, Heilmann I, Jung RB, Kusch K, Möbius W, Jahn O, Nave KA, Werner HB.

Elife. 2019 Jan 23;8. pii: e43888. doi: 10.7554/eLife.43888.

10.

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.

Belin S, Ornaghi F, Shackleford G, Wang J, Scapin C, Lopez-Anido C, Silvestri N, Robertson N, Williamson C, Ishii A, Taveggia C, Svaren J, Bansal R, Schwab MH, Nave K, Fratta P, D'Antonio M, Poitelon Y, Feltri ML, Wrabetz L.

Hum Mol Genet. 2019 Jan 21. doi: 10.1093/hmg/ddz021. [Epub ahead of print] No abstract available.

11.

Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A).

Prukop T, Stenzel J, Wernick S, Kungl T, Mroczek M, Adam J, Ewers D, Nabirotchkin S, Nave KA, Hajj R, Cohen D, Sereda MW.

PLoS One. 2019 Jan 16;14(1):e0209752. doi: 10.1371/journal.pone.0209752. eCollection 2019.

12.

Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons.

Lüders KA, Nessler S, Kusch K, Patzig J, Jung RB, Möbius W, Nave KA, Werner HB.

Glia. 2019 Apr;67(4):634-649. doi: 10.1002/glia.23549. Epub 2019 Jan 14.

PMID:
30637801
13.

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.

Belin S, Ornaghi F, Shackleford G, Wang J, Scapin C, Lopez-Anido C, Silvestri N, Robertson N, Williamson C, Ishii A, Taveggia C, Svaren J, Bansal R, Schwab MH, Nave K, Fratta P, D'Antonio M, Poitelon Y, Feltri ML, Wrabetz L.

Hum Mol Genet. 2019 Apr 15;28(8):1260-1273. doi: 10.1093/hmg/ddy420. Erratum in: Hum Mol Genet. 2019 Jan 21;:.

PMID:
30535360
14.

Enhanced axonal Neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model.

Scapin C, Ferri C, Pettinato E, Zambroni D, Bianchi F, Del Carro U, Belin S, Caruso D, Mitro N, Pellegatta M, Taveggia C, Schwab MH, Nave KA, Laura Feltri M, Wrabetz L, D'Antonio M.

Hum Mol Genet. 2018 Nov 27. doi: 10.1093/hmg/ddy411. [Epub ahead of print]

PMID:
30481294
15.

Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination.

Wang J, Ho WY, Lim K, Feng J, Tucker-Kellogg G, Nave KA, Ling SC.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10941-E10950. doi: 10.1073/pnas.1809821115. Epub 2018 Oct 29.

16.

Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I.

Deakin IH, Godlewska BR, Walker MA, Huang GJ, Schwab MH, Nave KA, Law AJ, Harrison PJ.

Transl Psychiatry. 2018 Oct 22;8(1):229. doi: 10.1038/s41398-018-0288-2.

17.

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.

Schirmer L, Möbius W, Zhao C, Cruz-Herranz A, Ben Haim L, Cordano C, Shiow LR, Kelley KW, Sadowski B, Timmons G, Pröbstel AK, Wright JN, Sin JH, Devereux M, Morrison DE, Chang SM, Sabeur K, Green AJ, Nave KA, Franklin RJ, Rowitch DH.

Elife. 2018 Sep 11;7. pii: e36428. doi: 10.7554/eLife.36428.

18.

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy.

Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM, Sereda MW.

Nat Commun. 2018 Aug 2;9(1):3025. doi: 10.1038/s41467-018-05420-0.

19.

The Axon-Myelin Unit in Development and Degenerative Disease.

Stassart RM, Möbius W, Nave KA, Edgar JM.

Front Neurosci. 2018 Jul 11;12:467. doi: 10.3389/fnins.2018.00467. eCollection 2018. Review.

20.

Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia.

Weil MT, Heibeck S, Töpperwien M, Tom Dieck S, Ruhwedel T, Salditt T, Rodicio MC, Morgan JR, Nave KA, Möbius W, Werner HB.

J Neurosci. 2018 Jul 18;38(29):6586-6596. doi: 10.1523/JNEUROSCI.1034-18.2018. Epub 2018 Jun 25.

21.

A New Paradigm in Earth Environmental Monitoring with the CYGNSS Small Satellite Constellation.

Ruf CS, Chew C, Lang T, Morris MG, Nave K, Ridley A, Balasubramaniam R.

Sci Rep. 2018 Jun 8;8(1):8782. doi: 10.1038/s41598-018-27127-4.

22.

Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice.

Cathomas F, Azzinnari D, Bergamini G, Sigrist H, Buerge M, Hoop V, Wicki B, Goetze L, Soares S, Kukelova D, Seifritz E, Goebbels S, Nave KA, Ghandour MS, Seoighe C, Hildebrandt T, Leparc G, Klein H, Stupka E, Hengerer B, Pryce CR.

Genes Brain Behav. 2019 Jan;18(1):e12475. doi: 10.1111/gbb.12475. Epub 2018 Apr 17.

PMID:
29566304
23.

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.

He X, Zhang L, Queme LF, Liu X, Lu A, Waclaw RR, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR.

Nat Med. 2018 Mar;24(3):338-351. doi: 10.1038/nm.4483. Epub 2018 Feb 12.

24.

Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.

Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H.

Mol Psychiatry. 2018 Feb 9. doi: 10.1038/s41380-017-0011-3. [Epub ahead of print]

PMID:
29426955
25.

Skin Biopsy Findings in Patients With CMT1A: Baseline Data From the CLN-PXT3003-01 Study Provide New Insights Into the Pathophysiology of the Disorder.

Duchesne M, Danigo A, Richard L, Vallat JM, Attarian S, Gonnaud PM, Lacour A, Péréon Y, Stojkovic T, Nave KA, Bertrand V, Nabirotchkin S, Cohen D, Demiot C, Magy L.

J Neuropathol Exp Neurol. 2018 Apr 1;77(4):274-281. doi: 10.1093/jnen/nly001.

PMID:
29408953
26.

A bloody brake on myelin repair.

Nave KA, Ehrenreich H.

Nature. 2018 Jan 4;553(7686):31-32. doi: 10.1038/d41586-017-08232-2. No abstract available.

PMID:
29300019
27.

Microglia ablation alleviates myelin-associated catatonic signs in mice.

Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H, Nave KA.

J Clin Invest. 2018 Feb 1;128(2):734-745. doi: 10.1172/JCI97032. Epub 2017 Dec 18.

28.

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system.

Micu I, Plemel JR, Caprariello AV, Nave KA, Stys PK.

Nat Rev Neurosci. 2017 Dec 14;19(1):58. doi: 10.1038/nrn.2017.166.

PMID:
29238086
29.

Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis.

Wang L, Winnewisser J, Federle C, Jessberger G, Nave KA, Werner HB, Kyewski B, Klein L, Hinterberger M.

Front Immunol. 2017 Nov 9;8:1511. doi: 10.3389/fimmu.2017.01511. eCollection 2017.

30.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

31.

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system.

Micu I, Plemel JR, Caprariello AV, Nave KA, Stys PK.

Nat Rev Neurosci. 2018 Jan;19(1):49-58. doi: 10.1038/nrn.2017.128. Epub 2017 Nov 9. Review. Erratum in: Nat Rev Neurosci. 2017 Dec 14;19(1):58.

PMID:
29118449
32.

Glial Cell Evolution: The Origins of a Lipid Store.

Nave KA, Tzvetanova ID, Schirmeier S.

Cell Metab. 2017 Nov 7;26(5):701-702. doi: 10.1016/j.cmet.2017.10.011.

33.

Myelin dynamics: protecting and shaping neuronal functions.

Saab AS, Nave KA.

Curr Opin Neurobiol. 2017 Dec;47:104-112. doi: 10.1016/j.conb.2017.09.013. Epub 2017 Nov 20. Review.

PMID:
29065345
34.

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

Lüders KA, Patzig J, Simons M, Nave KA, Werner HB.

Glia. 2017 Nov;65(11):1762-1776. doi: 10.1002/glia.23193. Epub 2017 Aug 24.

PMID:
28836307
35.

Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.

Wehr MC, Hinrichs W, Brzózka MM, Unterbarnscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave KA, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ.

EMBO Mol Med. 2017 Oct;9(10):1448-1462. doi: 10.15252/emmm.201707691.

36.

Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination.

Ghidinelli M, Poitelon Y, Shin YK, Ameroso D, Williamson C, Ferri C, Pellegatta M, Espino K, Mogha A, Monk K, Podini P, Taveggia C, Nave KA, Wrabetz L, Park HT, Feltri ML.

PLoS Biol. 2017 Jun 21;15(6):e2001408. doi: 10.1371/journal.pbio.2001408. eCollection 2017 Jun.

37.

Oligodendroglial myelination requires astrocyte-derived lipids.

Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG.

PLoS Biol. 2017 May 26;15(5):e1002605. doi: 10.1371/journal.pbio.1002605. eCollection 2017 May.

38.

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, González GA, Sentürk A, Acker-Palmer A, Lubec G, Lilley K, Franklin RJM, Nave KA, Kotter MRN.

Acta Neuropathol. 2017 Jul;134(1):167-168. doi: 10.1007/s00401-017-1712-z. No abstract available.

PMID:
28484846
39.

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy.

Kleinecke S, Richert S, de Hoz L, Brügger B, Kungl T, Asadollahi E, Quintes S, Blanz J, McGonigal R, Naseri K, Sereda MW, Sachsenheimer T, Lüchtenborg C, Möbius W, Willison H, Baes M, Nave KA, Kassmann CM.

Elife. 2017 May 4;6. pii: e23332. doi: 10.7554/eLife.23332.

40.

Monitoring ATP dynamics in electrically active white matter tracts.

Trevisiol A, Saab AS, Winkler U, Marx G, Imamura H, Möbius W, Kusch K, Nave KA, Hirrlinger J.

Elife. 2017 Apr 17;6. pii: e24241. doi: 10.7554/eLife.24241.

41.

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain.

Feldman EL, Nave KA, Jensen TS, Bennett DLH.

Neuron. 2017 Mar 22;93(6):1296-1313. doi: 10.1016/j.neuron.2017.02.005. Review.

42.

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo.

Supplie LM, Düking T, Campbell G, Diaz F, Moraes CT, Götz M, Hamprecht B, Boretius S, Mahad D, Nave KA.

J Neurosci. 2017 Apr 19;37(16):4231-4242. doi: 10.1523/JNEUROSCI.0756-16.2017. Epub 2017 Mar 17.

43.

Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice.

Winchenbach J, Düking T, Berghoff SA, Stumpf SK, Hülsmann S, Nave KA, Saher G.

F1000Res. 2016 Dec 30;5:2934. doi: 10.12688/f1000research.10509.1. eCollection 2016.

44.

Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins.

Khan S, Stott SR, Chabrat A, Truckenbrodt AM, Spencer-Dene B, Nave KA, Guillemot F, Levesque M, Ang SL.

J Neurosci. 2017 Mar 1;37(9):2305-2316. doi: 10.1523/JNEUROSCI.2414-16.2016. Epub 2017 Jan 27.

45.

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.

Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M.

Cell Rep. 2017 Jan 10;18(2):314-323. doi: 10.1016/j.celrep.2016.12.053.

46.

OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.

Ehrenreich H, Mitjans M, Van der Auwera S, Centeno TP, Begemann M, Grabe HJ, Bonn S, Nave KA.

Mol Psychiatry. 2018 Feb;23(2):476-486. doi: 10.1038/mp.2016.208. Epub 2016 Dec 6.

47.

Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates.

Tognatta R, Sun W, Goebbels S, Nave KA, Nishiyama A, Schoch S, Dimou L, Dietrich D.

Glia. 2017 Feb;65(2):342-359. doi: 10.1002/glia.23095. Epub 2016 Nov 3.

PMID:
27807896
48.

A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination.

Goebbels S, Wieser GL, Pieper A, Spitzer S, Weege B, Yan K, Edgar JM, Yagensky O, Wichert SP, Agarwal A, Karram K, Renier N, Tessier-Lavigne M, Rossner MJ, Káradóttir RT, Nave KA.

Nat Neurosci. 2017 Jan;20(1):10-15. doi: 10.1038/nn.4425. Epub 2016 Oct 24.

PMID:
27775720
49.

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB.

Elife. 2016 Aug 9;5. pii: e17119. doi: 10.7554/eLife.17119.

50.

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice.

Vingill S, Brockelt D, Lancelin C, Tatenhorst L, Dontcheva G, Preisinger C, Schwedhelm-Domeyer N, Joseph S, Mitkovski M, Goebbels S, Nave KA, Schulz JB, Marquardt T, Lingor P, Stegmüller J.

EMBO J. 2016 Sep 15;35(18):2008-25. doi: 10.15252/embj.201593585. Epub 2016 Aug 5.

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